scholarly journals Extreme Elevation of Alkaline Phosphatase in a Pregnancy Complicated by Gestational Diabetes and Infant with Neonatal Alloimmune Thrombocytopenia

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Svjetlana Lozo ◽  
Amir Atabeygi ◽  
Michael Healey
Keyword(s):  
Alkaline Phosphatase ◽  
Gestational Diabetes ◽  
Similar Case ◽  
Case Reports ◽  
Alloimmune Thrombocytopenia

There have been few case reports of isolated elevation of alkaline phosphatase beyond the normal physiologic amount with subsequent return to baseline after delivery. Here we present a similar case of extreme elevation of alkaline phosphatase in a pregnancy complicated by gestational diabetes and subsequently by neonatal alloimmune thrombocytopenia (NAIT).

scholarly journals Spontaneous liver rupture in a pregnant woman associated with HELLP syndrome

2019 ◽  
Vol 24 (3) ◽  
pp. 132-138
Author(s):  
T. M. Bunyatov ◽  
I. A. Kozlov ◽  
B. N. Gurmikov ◽  
Yu. A. Stepanova ◽  
V. S. Shirokov ◽  
...  
Keyword(s):  
Hellp Syndrome ◽  
Similar Case ◽  
Case Reports ◽  
Endovascular Embolization ◽  
Syndrome Patient ◽  
Liver Rupture ◽  
Right Hepatic Artery ◽  
Appropriate Treatment ◽  
Threatening Condition ◽  
Life Threatening

Spontaneous liver rupture is rare and highly dangerous, life-threatening condition occurring in 1–2% of pregnant women with preeclampsia and eclampsia. There are more than 100 similar case reports in the literature. It is believed that liver rupture is caused by HELLP syndrome as one of the signs of preeclampsia. The results of surgical treatment is still unsatisfactory. Appropriate treatment strategy is absent because of rareness of this condition. It is presented case report of a woman with spontaneous liver rupture associated with HELLP syndrome. Patient underwent perihepatic tamponade, endovascular embolization of right hepatic artery followed by right-sided hemihepatectomy.

scholarly journals Eagle’s syndrome: a piercing matter

2018 ◽  
Vol 11 (1) ◽  
pp. e226611 ◽  
Author(s):  
Matthew Zammit ◽  
Charmaine Chircop ◽  
Veronica Attard ◽  
Melvin D’Anastasi
Keyword(s):  
Unusual Case ◽  
Internal Carotid ◽  
Similar Case ◽  
Case Reports ◽  
Carotid Artery Dissection ◽  
Artery Dissection ◽  
Radiological Imaging ◽  
Internal Carotid Artery Dissection ◽  
Eagle’S Syndrome ◽  
Bilateral Carotid

We present an unusual case of Eagle’s syndrome with bilateral internal carotid artery dissection in a 45-year-old man. Initial symptomatology included ipsilateral headaches and facial sensory symptoms. A right horner’s syndrome was present on clinical examination. Radiological imaging revealed an old infarct, with bilateral carotid dissections and bilateral elongated styloid processes consistent with Eagle’s syndrome. Despite initiation of secondary prevention with antiplatelet therapy, he had two further ischaemic events. The case highlights the symptomatology and complications of Eagle’s syndrome, with its management discussed through a review of similar case reports.

Complex Irreducible Dorsal Dislocation of Thumb Interphalangeal Joint: Controversies and Consensus in Management

2020 ◽  
Vol 25 (03) ◽  
pp. 378-383
Author(s):  
Leon Alexander
Keyword(s):  
Similar Case ◽  
Case Reports ◽  
Interphalangeal Joint ◽  
Digital Nerve ◽  
Sesamoid Bone ◽  
Flexor Pollicis Longus ◽  
Joint Dislocation ◽  
Comparative Review ◽  
Flexor Pollicis Longus Tendon ◽  
Broad Consensus

Dislocations of thumb interphalangeal (IP) joint are rare injuries due to inherent stability of the joint. This report presents a case of complex irreducible dorsal IP joint dislocation of thumb due to interposition of four structures – volar plate, sesamoid bone, flexor pollicis longus tendon and digital nerve which is perhaps the only case reported so far in literature where more than three structures have been implicated for this joint irreducibility. The author presents a comparative review of similar case reports previously reported in literature listing the controversies in management and forming a broad consensus in the management of these difficult injuries. Finally, an algorithm for the management of these injures has been proposed in this article which maybe helpful for other operators in tackling these injuries so as to deliver predictable treatment outcomes.

scholarly journals Hypoadrenalism as the Single Presentation of Autoimmune Polyglandular Syndrome Type-1

2021 ◽  
Author(s):  
Nadim H Nasser ◽  
Nadra G  Samra ◽  
Deeb D Naccache
Keyword(s):  
Similar Case ◽  
Case Reports ◽  
Addison’S Disease ◽  
Hereditary Disease ◽  
Addison's Disease ◽  
Chronic Mucocutaneous Candidiasis ◽  
Autoimmune Polyglandular Syndrome ◽  
Single Presentation ◽  
Autoimmune Polyglandular Syndrome Type

Abstract Type-1 autoimmune polyglandular syndrome (APS1) is a rare hereditary disease affecting nearly 600 patients worldwide. The first of its cardinal manifestations, chronic mucocutaneous candidiasis (CMC), hypoparathyroidism (HPT), or Addison’s disease (AD), presents in childhood. Additional non-classical landmarks of APS1 continue to develop as late as the fifth decade of life. Two-thirds of patients develop the full triad before 25 years of age. Only 20% of patients develop the entire triad simultaneously. Addison's disease is rarely reported as the first manifestation.According to APS1 classifications, restricted criteria for a single cardinal component, although elements of suspicion are not sufficient to diagnose APS1.This case report is peculiar as hypoadrenalism was the first and only manifestation of APS1 for nearly three decades since its diagnosis. Theoretically, exceptions from the protocol of APS1 diagnostic criteria would be recognized as acceptable for diagnosis in the future, when similar case reports of only one component of APS1 appear.

Hepatotoxicity Associated with Cisplatin Chemotherapy

1993 ◽  
Vol 27 (4) ◽  
pp. 438-441 ◽  
Author(s):  
Robert J. Cersosimo
Keyword(s):  
Squamous Cell Carcinoma ◽  
Alkaline Phosphatase ◽  
Lactate Dehydrogenase ◽  
Cell Carcinoma ◽  
Liver Damage ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Case Reports ◽  
Normal Limits ◽  
Case Summary

OBJECTIVE: To report a case of possible cisplatin-associated hepatotoxicity. CASE SUMMARY: A 69-year-old man received three cycles of cisplatin (100 mg/m2) and fluorouracil (1000 mg/m2/d for five days) for management of squamous cell carcinoma of the head and neck. Liver enzyme concentrations were within normal limits prior to each cycle of therapy but the aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and lactate dehydrogenase concentrations increased on the second day of each cycle. The concentrations began to decline on day 3 of each course, despite continued fluorouracil administration, and returned to normal by day 10. The patient's antiemetic therapy included metoclopramide in cycle 1 and ondansetron in cycles 2 and 3, which may have contributed to the enzyme elevations. DISCUSSION: Case reports of cisplatin-associated hepatotoxicity are reviewed. An association between cisplatin administration and hepatotoxicity is proposed in this patient. CONCLUSIONS: This patient may have experienced cisplatin-induced liver damage. Metoclopramide and ondansetron may have contributed to this effect.

scholarly journals Appendiceal malakoplakia masquerading as a cecal mass

2020 ◽  
Vol 2020 (5) ◽  
Author(s):  
Tashinga Musonza ◽  
Jose Antonio Tschen
Keyword(s):  
Tumor Marker ◽  
Similar Case ◽  
Case Reports ◽  
Inflammatory Marker ◽  
English Literature ◽  
Contemporary Literature ◽  
Precursor Lesion ◽  
Neoplastic Processes ◽  
Appendiceal Mass ◽  
Immunocompromised State

Abstract Appendiceal malakoplakia masquerading as a cecal mass is uniquely rare. The presence of an infiltrate of granular eosinophilic macrophages containing Michaelis–Gutmann bodies on histopathology is pathognomonic of malakoplakia. Cutaneous, gastrointestinal and most commonly urogenital malakoplakia is reported in association with an immunocompromised state, infectious, inflammatory and neoplastic processes. Presentation varies from microscopic disease to plaques, nodules, polypoid lesions and small masses. However, a cecal mass postea proven appendiceal malakoplakia deserves special attention. We could not find similar case reports in the English literature. The pathogenesis of malakoplakia is poorly understood, and it is unclear if it is a harbinger of malignancy, a precursor lesion or an inflammatory marker. In the setting of a dominant appendiceal mass, post-treatment endoscopic and tumor marker surveillance is paramount but, however, undefined in contemporary literature.

scholarly journals Surgical Repair of an Atraumatic Avulsion of Patellar Tendon at the Tibial Tuberosity in an Adult Patient

2015 ◽  
Vol 2015 ◽  
pp. 1-3
Author(s):  
Lorenzo Maria Di Giacomo ◽  
M. Shahid Khan ◽  
Michele Bisaccia ◽  
R. Rende ◽  
G. Rinonapoli ◽  
...  
Keyword(s):  
Patellar Tendon ◽  
Similar Case ◽  
Surgical Repair ◽  
Suture Material ◽  
Case Reports ◽  
Successful Management ◽  
Rare Injury ◽  
Early Return ◽  
Return To Activity

Atraumatic avulsion of the tibial attachment of patellar tendon in adults is a very rare injury with only few published case reports. Here we are sharing the successful management and follow-up of a similar case with a different suture material for repair of the tendon, the FiberWire. We believe that the management we are discussing allows for early return to activity with good functional outcome.

scholarly journals Surgical Treatment of a Patient with Human Tail and Multiple Abnormalities of the Spinal Cord and Column

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Chunquan Cai ◽  
Ouyan Shi ◽  
Changhong Shen
Keyword(s):  
Spinal Cord ◽  
Rare Case ◽  
Similar Case ◽  
Case Reports ◽  
Surgical Excision ◽  
Low Back ◽  
Caudal Appendage ◽  
Dark Pigmentation ◽  
Human Tail ◽  
Multiple Abnormalities

The dorsal cutaneous appendage, or so-called human tail, is often considered to be a cutaneous marker of underlying occult dysraphism. The authors present a case of human tail occurring in a 9-month-old infant with multiple abnormalities of the spinal cord and spine. Examination revealed unremarkable except for a caudal appendage and a dark pigmentation area in the low back. Neuroradiological scans revealed cleft vertebrae and bifid ribbon, split cord malformations, block vertebrae, and hemivertebra. Surgical excision of the tail and untethering the spinal cord by removal of the septum were performed. The infant had an uneventful postoperative period and was unchanged neurologically for 18 months of followup. To our knowledge, no similar case reports exist in the literature. The specific features in a rare case with a human tail treated surgically are discussed in light of the available literature.

scholarly journals Self-limiting severe neutropenia in a patient with COVID-19

2021 ◽  
Vol 14 (11) ◽  
pp. e247057
Author(s):  
Ram Singh ◽  
Brajesh Kumar Ratre ◽  
Prashant Sirohiya ◽  
Sushma Bhatnagar
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Expert Opinion ◽  
Similar Case ◽  
Case Reports ◽  
Severe Neutropenia ◽  
Aggressive Approach ◽  
Close Observation ◽  
Undue Risk ◽  
Immunocompetent Patients

Neutropenia is a rare haematological complication of COVID-19 infection in immunocompetent patients. There is sparse literature on neutropenia in patients with COVID-19, except a few case reports. We encountered a similar case in an intensive care unit that developed severe neutropenia on day 24 of illness. Neutropenia resolved spontaneously on 4th day of its appearance. The patient was isolated and kept under close observation, antibiotics were upgraded and strict asepsis was maintained. Thus, we observed in a patient with no comorbidities and uncomplicated neutropenia that strict measures to prevent infection may suffice and the undue risk of hematopoietic therapy can be avoided. An expert opinion should always be sought in such cases as the presence of complications may require an aggressive approach.

scholarly journals Hypophosphatasia in children. Three faces of one disease

2020 ◽  
Vol 3 (2) ◽  
pp. 136-141
Author(s):  
S.A. Boykov ◽  
◽  
I.Yu. Chernyak ◽  
N.S. Shatokhina ◽  
E.Yu. Gurkina ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Clinical Symptoms ◽  
Bone Mineralization ◽  
Case Reports ◽  
Molecular Genetic ◽  
Case Series ◽  
Alp Activity ◽  
Systemic Manifestations ◽  
Molecular Genetic Test ◽  
Reduced Mobility

Hypophosphatasia (HPP) is a rare multisystem inherited metabolic disorder caused by mutations in ALPL gene that encodes tissue nonspecific alkaline phosphatase responsible for bone mineralization. HPP is characterized by impaired bone mineralization, skeletal abnormalities, and systemic manifestations which result in significant morbidity and mortality. Clinical presentations of HPP vary greatly. Early (perinatal and infantile) HPP is characterized by the most severe symptoms, i.e., respiratory and neurological disorders are of crucial importance being the leading causes of death. Progressive skeletal impairment, rickets-like deformities, reduced mobility, and severe disability are typical of childhood-onset HPP. The biochemical hallmark of HPP is low alkaline phosphatase (ALP) activity. HPP diagnosis is verified by clinical symptoms in combination with persistently low ALP activity (adjusted for age and sex). Molecular genetic test to identify ALPL gene mutation is performed as needed. Three case reports addresses authors’ experience with the diagnosis and treatment for HPP.Keywords: hypophosphatasia, case series, alkaline phosphatase, impaired bone mineralization, asfotase alfa.For citation: Boykov S.A., Chernyak I.Yu., Shatokhina N.S. et al. Hypophosphatasia in children. Three faces of one disease. Russian Journal of Woman and Child Health. 2020;3(2):136–141. DOI: 10.32364/2618-8430-2020-3-2-136-141.

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