scholarly journals Is There a Relationship between the Stratum Corneum Thickness and That of the Viable Parts of Tumour Cells in Basal Cell Carcinoma?

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Olav A. Foss ◽  
Patricia Mjønes ◽  
Silje Fismen ◽  
Eidi Christensen
Keyword(s):  
Basal Cell Carcinoma ◽  
Stratum Corneum ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Drug Uptake ◽  
Skin Tumour ◽  
Tumour Thickness ◽  
Significant Difference ◽  
Thickness Measurements ◽  
Viable Tumour

Basal cell carcinoma (BCC) is an invasive epithelial skin tumour. The thickness of the outermost epidermal layer of the skin, the stratum corneum (SC), influences drug uptake and penetration into tumour and may thereby affect the response of BCC to topical treatment. The aim was to investigate a possible relationship between the thickness of the SC and that of the viable part of BCC. Histopathological evaluations of the corresponding SC and viable tumour thickness measurements of individual BCCs of different subtypes were explored. A total of 53 BCCs from 46 patients were studied. The median tumour thickness was 1.7 mm (0.8–3.0 mm), with a significant difference between subtypes (p<0.001). The SC had a median thickness of 0.3 mm (0.2–0.4 mm), with no difference between tumour subtypes (p=0.415). Additionally, no significant association between the thickness of the SC and that of the viable part of the tumour was demonstrated (p=0.381). In conclusion our results indicate that SC thickness is relatively constant in BCC.

Occurrence and recurrence of basal cell carcinoma of the head and neck in negroid and albinoid africans

1987 ◽  
Vol 101 (12) ◽  
pp. 1324-1328 ◽  
Author(s):  
S. A. Ademiluyi ◽  
G. T. A. Ijaduola
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Recurrence Rate ◽  
Basal Cell ◽  
Neck Region ◽  
Head And Neck Region ◽  
Outdoor Workers ◽  
Significant Difference

SummaryA study of sixty patients with basal cell carcinoma of the head and neck region carried out over a six-year period (1979–1985) is hereby presented. Sixteen (26.72 percent) were albinos and 44 (73.28 per cent) negroids. Forty-eight (80 per cent) were outdoor workers. The negroid patients presented between the 3rd and 4th decades while the albinos presented a decade earlier. The commonest site involved in the head and neck was the forehead. The midface showed the highest recurrence rate in both groups, even after adequate excision. The frequency of recurrence in tumours presenting with a size of 2–5 cm. diameter was significantly higher in the albinos than in the negroid (P<0.05), whereas, with tumours of a size larger than 5 cm., there was no statistically significant difference between the albino and the negroid. However, the overall recurrence rate was significantly higher in the albinos (P<0.005). The mortality among the albinos was 25 per cent while there were no deaths in the negroid Africans.

scholarly journals Analysis of polymorphism in the survivin gene promoter as a potential risk factor for head and neck cancers development

2013 ◽  
Vol 141 (5-6) ◽  
pp. 304-307 ◽  
Author(s):  
Marija Kostic ◽  
Nadja Nikolic ◽  
Branislav Ilic ◽  
Jelena Carkic ◽  
Sanja Milenkovic ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Risk Factor ◽  
Basal Cell Carcinoma ◽  
Cancer Risk ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Control Group ◽  
Survivin Gene ◽  
Significant Difference

Introduction. Association studies have shown that gene polymorphisms in various classes of genes can modulate cancer risk. The -31G/C polymorphism in the promoter of survivin gene, affects the expression of the anti-apoptotic protein survivin which in turn may predispose an individual to some types of cancer. Objective. The aim of the study was to determine whether the survivin promoter -31G/C polymorphism could be a susceptibility factor for squamous cell carcinoma (SCC) of the oral cavity and basal cell carcinoma (BCC) of the skin. Methods. The DNA obtained from 88 patients with SCC, 60 patients with BCC and 111 healthy individuals was subjected to polymerase chain reaction-restriction fragment length polymorphism analysis (PCR- RFLP) in order to determine genotype and allele frequencies in patients and control groups. Logistic regression was used for cancer risk assessment. Results. The following distribution of genotypes was obtained: CC genotype 15% in the SCC group, 13% in the BCC group and 12% in controls; CG genotype 41% in SCCs, 35% in BCCs, 48% in controls; GG genotype 44% in SCCs, 52% in BCCs and 40% in controls. Allelic frequencies were as follows: G allele 0.65 in SCCs, 0.69 in BCCs and 0.64 in the control group; C allele 0.35 in SCCs, 0.31 in BCCs and 0.36 in the control group. There was no statistically significant difference in allele or genotype frequencies between the patients and controls (p>0.05). Conclusion. In Serbian population, -31G/C polymorphism in the promoter of the survivin gene cannot be considered as a risk factor for oral squamous cell carcinoma and skin basal cell carcinoma.

Haplotypes of (−794(CATT)5–8/−173G>C) MIF gene polymorphisms and its soluble levels in basal cell carcinoma in western Mexican population

2020 ◽  
Vol 69 (1) ◽  
pp. 41-46
Author(s):  
Elizabeth Guevara-Gutiérrez ◽  
María José Castro-Jonguitud ◽  
Susana Elizabeth De la Torre-Flores ◽  
José Francisco Muñoz-Valle ◽  
Alberto Tlacuilo-Parra ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Gene Polymorphisms ◽  
Macrophage Migration Inhibitory Factor ◽  
Serum Levels ◽  
Study Groups ◽  
Significant Difference ◽  
Pcr Rflp ◽  
Different Types

Basal cell carcinoma (BCC) is the most common dermatological neoplasms in Caucasian populations. In Mexico, a prevalence of 3.9 per 1000 habitants is estimated. Recently, the macrophage migration inhibitory factor (MIF) has been related to different types of cancer. Therefore, this study aimed to investigate the genetic association of haplotypes of [-794(CATT)5-8/-173G>C]MIF gene polymorphisms and its soluble levels in BCC. A total of 360 individuals were recruited for the study, that is, 180 of the total amounts were patients with BCC histologically confirmed and the remaining 180 individuals were identified as control subjects (CS). Both polymorphisms were genotyped by PCR and PCR-RFLP (restriction fragment length polymorphism), and MIF serum levels were measured by ELISA kit. A borderline difference was found between the 55 genotype and the susceptibility to BCC (5.6% vs 1.7% in BCC and CS, respectively, OR=3.7 and p=0.04). Furthermore, the haplotype 7G showed a significant association with BCC (p=0.02, OR=1.99). Concerning MIF soluble levels, patients with BCC showed a media of 2.1 ng/mL and CS showed 4.4 ng/mL, the comparison between groups was significant (p<0.01). Our findings suggest that the 55 genotype and the haplotype 7G are associated with the susceptibility to BCC; furthermore, a significant difference was found between MIF soluble levels in both study groups.

Skin cancer

2011 ◽  
Author(s):  
Thankamma Ajithkumar ◽  
Ann Barrett ◽  
Helen Hatcher ◽  
Natalie Cook
Keyword(s):  
Skin Cancer ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Skin Tumour ◽  
The Usa ◽  
Slow Growing

Basal cell carcinoma (BCC) is a slow growing, locally invasive (hence called rodent ulcer) malignant epidermal skin tumour. The exact incidence is difficult to obtain although there is a worldwide trend in increasing incidence. Approximately 1 million new cases are diagnosed per year in the USA....

scholarly journals Pre-Treatment Deep Curettage Can Significantly Reduce Tumour Thickness in Thick Basal Cell Carcinoma While Maintaining a Favourable Cosmetic Outcome When Used in Combination with Topical Photodynamic Therapy

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Eidi Christensen ◽  
Cato Mørk ◽  
Olav Andreas Foss
Keyword(s):  
Photodynamic Therapy ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Tumour Response ◽  
Cosmetic Outcome ◽  
Term Outcome ◽  
Tumour Thickness ◽  
Complete Tumour ◽  
Pre Treatment

Topical photodynamic therapy (PDT) has limitations in the treatment of thick skin tumours. The aim of the study was to evaluate the effect of pre-PDT deep curettage on tumour thickness in thick (≥2 mm) basal cell carcinoma (BCC). Additionally, 3-month treatment outcome and change of tumour thickness from diagnosis to treatment were investigated. At diagnosis, mean tumour thickness was 2.3 mm (range 2.0–4.0). Pre- and post-curettage biopsies were taken from each tumour prior to PDT. Of 32 verified BCCs, tumour thickness was reduced by 50% after deep curettage(P≤0.001). Mean tumour thickness was also reduced from diagnosis to treatment. At 3-month followup, complete tumour response was found in 93% and the cosmetic outcome was rated excellent or good in 100% of cases. In conclusion, deep curettage significantly reduces BCC thickness and may with topical PDT provide a favourable clinical and cosmetic short-term outcome.

scholarly journals Immunohistochemical Expression of CK19, AR, PHLDA1, CD10 and Ki67 in the Differentiation between Trichoepithelioma and Basal Cell Carcinoma: A Systematic Review

2021 ◽  
Vol 55 (5) ◽  
Author(s):  
Eileen Liesl A. Cubillan ◽  
Jolene Kristine G. Gatmaitan-Dumlao
Keyword(s):  
Systematic Review ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Odds Ratio ◽  
High Sensitivity ◽  
High Specificity ◽  
Diagnostic Odds Ratio ◽  
Biological Behavior ◽  
Significant Difference

Background. Basal cell carcinoma (BCC) and trichoepithelioma (TE) are follicular adnexal neoplasms that arise from the follicular germ but with divergent biological behavior. The gold standard in the differentiation is through histopathological examination using hematoxylin and eosin (H and E) stain. There are cases, however, when the distinction is not straightforward. Objective. To assess the association and diagnostic accuracy of the immunohistochemical (IHC) expressions of CD10, Ki67, CK19, androgen receptor (AR), and PHLDA1 in distinguishing between basal cell carcinoma and trichoepithelioma. Methods. We conducted a comprehensive search on cross-sectional studies on human tissue from 2000 to 2020 in MEDLINE (PubMed), CENTRAL and EMBASE for comparative studies and reference lists. The data were summarized and analyzed using Microsoft Excel and RevMan. We used Chi-square test for independence, summary receiver operator curves (sROC), and diagnostic odds ratio (OR). Results. We included 15 articles containing 686 BCC and 367 TE in the systematic review. The pooled staining of biomarkers showed a significant difference in the staining of CK19 (p<0.05) and AR (p<0.0001), and PHLDA1 (p<0.0001). Diagnostic odds ratio was used to confirm these associations. AR was found to have the highest odds in the diagnosis of BCC (OR 27.92, 95% CI 10.69, 72.86). The pattern of staining of CD10 is significant (p<0.001) with staining of both tumor and stroma (OR 8.09, 95% CI 4.57, 13.53) and staining of tumor alone (OR 8.15, 95% CI 4.56, 14.35) (p<0.001) in the diagnosis of BCC. CD10 stromal staining, on the other hand, is significantly associated with the diagnosis of TE (OR 7.26, 95% CI 5.06, 10.44) (p<0.0001). There is no significant association between Ki67 staining (OR 1.22, 95% CI 0.48, 3.09) (p=0.67) and the diagnosis of BCC. The forest plot and sROC showed that AR had high specificity across all included studies in the diagnosis of basal cell carcinoma, while PHLDA1 demonstrated high specificity and high sensitivity in diagnosing trichoepithelioma. Conclusion. The biomarkers AR and PHLDA1 are useful as an initial panel to distinguish between BCC and TE, given that both showed high sensitivity as well as significant association with BCC and TE respectively. CD10 and CK19 may also be used with AR and PHLDA1 for further confirmation.

Sign in / Sign up

Export Citation Format

Share Document