scholarly journals Natural Killer Cells in the Orchestration of Chronic Inflammatory Diseases

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Luca Parisi ◽  
Barbara Bassani ◽  
Marco Tremolati ◽  
Elisabetta Gini ◽  
Giampietro Farronato ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Chronic Diseases ◽  
Immune Cell ◽  
Inflammatory Diseases ◽  
Lymphoid Cells ◽  
System Response ◽  
Cell Phenotype ◽  
Killer Cells ◽  
And Function

Inflammation, altered immune cell phenotype, and functions are key features shared by diverse chronic diseases, including cardiovascular, neurodegenerative diseases, diabetes, metabolic syndrome, and cancer. Natural killer cells are innate lymphoid cells primarily involved in the immune system response tonon-self-components but their plasticity is largely influenced by the pathological microenvironment. Altered NK phenotype and function have been reported in several pathological conditions, basically related to impaired or enhanced toxicity. Here we reviewed and discussed the role of NKs in selected, different, and “distant” chronic diseases, cancer, diabetes, periodontitis, and atherosclerosis, placing NK cells as crucial orchestrator of these pathologic conditions.

scholarly journals When a Friend Becomes Your Enemy: Natural Killer Cells in Atherosclerosis and Atherosclerosis-Associated Risk Factors

2022 ◽  
Vol 12 ◽  
Author(s):  
Maria Teresa Palano ◽  
Martina Cucchiara ◽  
Matteo Gallazzi ◽  
Federica Riccio ◽  
Lorenzo Mortara ◽  
...  
Keyword(s):  
Risk Factors ◽  
Immune System ◽  
Natural Killer Cells ◽  
Natural Killer ◽  
Nk Cell ◽  
Current Knowledge ◽  
Cell Phenotype ◽  
Killer Cells ◽  
Associated Risk Factors ◽  
And Function

Atherosclerosis (ATS), the change in structure and function of arteries with associated lesion formation and altered blood flow, is the leading cause of cardiovascular disease, the number one killer worldwide. Beyond dyslipidemia, chronic inflammation, together with aberrant phenotype and function of cells of both the innate and adaptive immune system, are now recognized as relevant contributors to atherosclerosis onset and progression. While the role of macrophages and T cells in atherosclerosis has been addressed in several studies, Natural Killer cells (NKs) represent a poorly explored immune cell type, that deserves attention, due to NKs’ emerging contribution to vascular homeostasis. Furthermore, the possibility to re-polarize the immune system has emerged as a relevant tool to design new therapies, with some succesfull exmples in the field of cancer immunotherapy. Thus, a deeper knowledge of NK cell pathophysiology in the context of atherosclerosis and atherosclerosis-associated risk factors could help developing new preventive and treatment strategies, and decipher the complex scenario/history from “the risk factors for atherosclerosis” Here, we review the current knowledge about NK cell phenotype and activities in atherosclerosis and selected atherosclerosis risk factors, namely type-2 diabetes and obesity, and discuss the related NK-cell oriented environmental signals.

scholarly journals Type 3 innate lymphoid cells induce proliferation of CD94+ natural killer cells

2017 ◽  
Vol 140 (4) ◽  
pp. 1156-1159.e7 ◽  
Author(s):  
Shuo Li ◽  
Hideaki Morita ◽  
Beate Rückert ◽  
Tadech Boonpiyathad ◽  
Avidan Neumann ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Killer Cells ◽  
Type 3

scholarly journals Human natural killer cells: their origin, receptors and function

2002 ◽  
Vol 32 (5) ◽  
pp. 1205 ◽  
Author(s):  
Lorenzo Moretta ◽  
Cristina Bottino ◽  
Daniela Pende ◽  
Maria Cristina Mingari ◽  
Roberto Biassoni ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Killer Cells ◽  
Human Natural Killer Cells ◽  
And Function

scholarly journals “Multi-Omics” Analyses of the Development and Function of Natural Killer Cells

2017 ◽  
Vol 8 ◽  
Author(s):  
Yonggang Zhou ◽  
Xiuxiu Xu ◽  
Zhigang Tian ◽  
Haiming Wei
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Killer Cells ◽  
And Function

scholarly journals An Anti-inflammatory microRNA Signature Distinguishes Group 3 Innate Lymphoid Cells From Natural Killer Cells in Human Decidua

2020 ◽  
Vol 11 ◽  
Author(s):  
Andrea Pelosi ◽  
Claudia Alicata ◽  
Nicola Tumino ◽  
Tiziano Ingegnere ◽  
Fabrizio Loiacono ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Killer Cells ◽  
Group 3 ◽  
Anti Inflammatory ◽  
Human Decidua

Alterations in expression and function of signal transducing proteins in tumor-associated T and natural killer cells in ovarian carcinoma

1997 ◽  
Vol 25 (2) ◽  
pp. 218S-218S ◽  
Author(s):  
PAOLA LAI ◽  
HANNAH RABINOWICH ◽  
PEGGY A. CROWLEY-NOWICK ◽  
MARIA C. BELL ◽  
GIOVANNI MANTOVANI ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Ovarian Carcinoma ◽  
Natural Killer ◽  
Killer Cells ◽  
And Function

Activation of natural killer cells by heat-killed Listeria monocytogenes requires additional signals from lymphoid cells

1996 ◽  
Vol 50 (1-2) ◽  
pp. 81-85 ◽  
Author(s):  
Sabine Daugelat ◽  
Christoph H. Ladel ◽  
Inge E.A. Flesch ◽  
Stefan H.E. Kaufmann
Keyword(s):  
Listeria Monocytogenes ◽  
Natural Killer Cells ◽  
Natural Killer ◽  
Lymphoid Cells ◽  
Killer Cells

Origin, phenotype and function of human natural killer cells in pregnancy

2011 ◽  
Vol 32 (11) ◽  
pp. 517-523 ◽  
Author(s):  
Paola Vacca ◽  
Lorenzo Moretta ◽  
Alessandro Moretta ◽  
Maria Cristina Mingari
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Killer Cells ◽  
Human Natural Killer Cells ◽  
And Function ◽  
In Pregnancy
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