Reduced Transferrin Levels in Active Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) is an inflammatory disease of unclear etiopathogenesis and challenging diagnosis, frequently complicated by anemia and malnutrition. C-reactive protein (CRP) remains the only biochemical marker of clinical relevance. The aim of this study was to test hypothesis that transferrin, coinfluenced by inflammation, malnutrition, anemia, and oxidative stress, may better reflect global IBD patient’s condition than any other more specific index. Transferrin and other indices of inflammation, anemia, malnutrition, and oxidative stress were measured in 137 IBD patients (Crohn’s disease (CD): n=63 and ulcerative colitis (UC): n=74) and 97 controls. Transferrin is reduced in active CD and UC and negatively correlates with the disease activity scores (CD: ρ=-0.49; UC: ρ=-0.52). In UC, transferrin correlates negatively with CRP, erythrocyte sedimentation rate (ESR), leukocytes, platelets, interleukin-6, interleukin-10, and TNF-α and positively with albumins, cholesterol, hemoglobin, hematocrit, erythrocytes, iron, and paraoxonase-1. In CD, transferrin correlates negatively with CRP, leukocytes, platelets, interleukin-1, and interleukin-6 and positively with albumins, iron, catalase, glutathione peroxidase-1, superoxide dismutase-1, and paraoxonase-1. The associations with inflammation and anemia/malnutrition were more pronounced in UC and with oxidative stress in CD. As UC activity marker, transferrin outperforms ESR and hemoglobin, indices used in calculating the disease clinical severity score.

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Interrelations between interleukin-6, interleukin-1 beta, plasma C-reactive protein values, and in vitro C-reactive protein generation in patients with inflammatory bowel disease.

Gut ◽

10.1136/gut.35.1.77 ◽

1994 ◽

Vol 35 (1) ◽

pp. 77-83 ◽

Cited By ~ 51

Author(s):

M Z Mazlam ◽

H J Hodgson

Keyword(s):

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Interleukin 6 ◽

Interleukin 1 ◽

Interleukin 1 Beta ◽

C Reactive Protein ◽

Reactive Protein ◽

Inflammatory Bowel

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Erythrocyte Deformability and Oxidative Stress in Inflammatory Bowel Disease

Digestive Diseases and Sciences ◽

10.1007/s10620-011-1882-9 ◽

2011 ◽

Vol 57 (2) ◽

pp. 458-464 ◽

Cited By ~ 14

Author(s):

Tulay Akman ◽

Mesut Akarsu ◽

Hale Akpinar ◽

Halil Resmi ◽

Ebru Sezer

Keyword(s):

Oxidative Stress ◽

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Erythrocyte Deformability ◽

Inflammatory Bowel ◽

And Oxidative Stress

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Tumor necrosis factor-?, interleukin-1?, and interleukin-6 expression in inflammatory bowel disease

Digestive Diseases and Sciences ◽

10.1007/bf01300378 ◽

1992 ◽

Vol 37 (6) ◽

pp. 818-826 ◽

Cited By ~ 208

Author(s):

Chris Stevens ◽

Gerd Walz ◽

Chander Singaram ◽

Mark L. Lipman ◽

Bernd Zanker ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Tumor Necrosis Factor ◽

Bowel Disease ◽

Interleukin 6 ◽

Tumor Necrosis ◽

Interleukin 1 ◽

Inflammatory Bowel ◽

Necrosis Factor

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Protective effect of Plumericin in inflammatory bowel disease: regulation of inflammatory and oxidative stress response in vitro and in vivo

10.1055/s-0039-3399684 ◽

2019 ◽

Author(s):

SF Rapa ◽

B Waltenberger ◽

R Di Paola ◽

G Autore ◽

S Cuzzocrea ◽

...

Keyword(s):

Oxidative Stress ◽

Inflammatory Bowel Disease ◽

Stress Response ◽

Protective Effect ◽

Bowel Disease ◽

Oxidative Stress Response ◽

Inflammatory Bowel ◽

And Oxidative Stress

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Platelet-derived growth factor-BB reflects clinical, inflammatory and angiogenic disease activity and oxidative stress in inflammatory bowel disease

Clinical Biochemistry ◽

10.1016/j.clinbiochem.2009.08.002 ◽

2009 ◽

Vol 42 (16-17) ◽

pp. 1602-1609 ◽

Cited By ~ 20

Author(s):

Malgorzata Krzystek-Korpacka ◽

Katarzyna Neubauer ◽

Malgorzata Matusiewicz

Keyword(s):

Oxidative Stress ◽

Inflammatory Bowel Disease ◽

Growth Factor ◽

Disease Activity ◽

Bowel Disease ◽

Platelet Derived Growth Factor ◽

Inflammatory Bowel ◽

And Oxidative Stress

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Erratum to: Erythrocyte Deformability and Oxidative Stress in Inflammatory Bowel Disease

Digestive Diseases and Sciences ◽

10.1007/s10620-011-2004-4 ◽

2011 ◽

Vol 57 (3) ◽

pp. 824-824

Author(s):

Tulay Akman ◽

Mesut Akarsu ◽

Hale Akpinar ◽

Halil Resmi ◽

Ebru Taylan

Keyword(s):

Oxidative Stress ◽

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Erythrocyte Deformability ◽

Inflammatory Bowel ◽

And Oxidative Stress

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37 Monitoring the evolution of inflammatory bowel disease (IBD) in pediatric and adult cohorts of patients to identify biomarkers to predict cancer risk

Journal for ImmunoTherapy of Cancer ◽

10.1136/jitc-2020-sitc2020.0037 ◽

2020 ◽

Vol 8 (Suppl 3) ◽

pp. A38-A38

Author(s):

Shilpa Ravindran ◽

Heba Sidahmed ◽

Harshitha Manjunath ◽

Rebecca Mathew ◽

Tanwir Habib ◽

...

Keyword(s):

Oxidative Stress ◽

Gene Expression ◽

Colorectal Cancer ◽

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Mesenchymal Transition ◽

Increased Risk ◽

Hamad Medical Corporation ◽

Inflammatory Bowel ◽

Left And Right

BackgroundPatients with inflammatory bowel disease (IBD) have increased risk of developing colorectal cancer (CRC), depending on the duration and severity of the disease. The evolutionary process in IBD is driven by chronic inflammation leading to epithelial-to-mesenchymal transition (EMT) events in colonic fibrotic areas. EMT plays a determinant role in tumor formation and progression, through the acquisition of ‘stemness’ properties and the generation of neoplastic cells. The aim of this study is to monitor EMT/cancer initiating tracts in IBD in association with the deep characterization of inflammation in order to assess the mechanisms of IBD severity and progression towards malignancy.Methods10 pediatric and 20 adult IBD patients, admitted at Sidra Medicine (SM) and Hamad Medical Corporation (HMC) respectively, have been enrolled in this study, from whom gut tissue biopsies (from both left and right side) were collected. Retrospectively collected tissues (N=10) from patients with malignancy and history of IBD were included in the study. DNA and RNA were extracted from fresh small size (2–4 mm in diameter) gut tissues using the BioMasher II (Kimble) and All Prep DNA/RNA kits (Qiagen). MicroRNA (miRNA; N=700) and gene expression (N=800) profiling have been performed (cCounter platform; Nanostring) as well as the methylation profiling microarray (Infinium Methylation Epic Bead Chip kit, Illumina) to interrogate up to 850,000 methylation sites across the genome.ResultsDifferential miRNA profile (N=27 miRNA; p<0.05) was found by the comparison of tissues from pediatric and adult patients. These miRNAs regulate: i. oxidative stress damage (e.g., miR 99b), ii. hypoxia induced autophagy; iii. genes associated with the susceptibility to IBD (ATG16L1, NOD2, IRGM), iv. immune responses, such as TH17 T cell subset (miR 29). N=6 miRNAs (miR135b, 10a196b, 125b, let7c, 375) linked with the regulation of Wnt/b-catenin, EM-transaction, autophagy, oxidative stress and play role also in cell proliferation and mobilization and colorectal cancer development were differentially expressed (p<0.05) in tissues from left and right sides of gut. Gene expression signature, including genes associated with inflammation, stemness and fibrosis, has also been performed for the IBD tissues mentioned above. Methylation sites at single nucleotide resolution have been analyzed.ConclusionsAlthough the results warrant further investigation, differential genomic profiling suggestive of altered pathways involved in oxidative stress, EMT, and of the possible stemness signature was found. The integration of data from multiple platforms will provide insights of the overall molecular determinants in IBD patients along with the evolution of the disease.Ethics ApprovalThis study was approved by Sidra Medicine and Hamad Medical Corporation Ethics Boards; approval number 180402817 and MRC-02-18-096, respectively.

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Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies

Oxidative Medicine and Cellular Longevity ◽

10.1155/2017/4535194 ◽

2017 ◽

Vol 2017 ◽

pp. 1-18 ◽

Cited By ~ 96

Author(s):

Tian Tian ◽

Ziling Wang ◽

Jinhua Zhang

Keyword(s):

Oxidative Stress ◽

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Defense Mechanisms ◽

Gastrointestinal Disease ◽

Mucosal Immune Response ◽

Stress Signaling ◽

Substantial Progress ◽

Inflammatory Bowel ◽

Underlying Mechanisms

Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease whose incidence has risen worldwide in recent years. Accumulating evidence shows that oxidative stress plays an essential role in the pathogenesis and progression of IBD. This review highlights the generation of reactive oxygen species (ROS) and antioxidant defense mechanisms in the gastrointestinal (GI) tract, the involvement of oxidative stress signaling in the initiation and progression of IBD and its relationships with genetic susceptibility and the mucosal immune response. In addition, potential therapeutic strategies for IBD that target oxidative stress signaling are reviewed and discussed. Though substantial progress has been made in understanding the role of oxidative stress in IBD in humans and experimental animals, the underlying mechanisms are still not well defined. Thus, further studies are needed to validate how oxidative stress signaling is involved in and contributes to the development of IBD.

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