scholarly journals Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Chonlaphat Sukasem ◽  
Chonlawat Chaichan ◽  
Thapanat Nakkrut ◽  
Patompong Satapornpong ◽  
Kanoot Jaruthamsophon ◽  
...  
Keyword(s):  
Case Control Study ◽  
Strong Association ◽  
Case Control ◽  
Stevens Johnson Syndrome ◽  
Thai Population ◽  
Johnson Syndrome ◽  
Cutaneous Reactions ◽  
Systemic Symptoms ◽  
Maculopapular Exanthema ◽  
Control Study

The HLA-B∗15:02 allele has been reported to have a strong association with carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) in Thai patients. The HLA-B alleles associated with carbamazepine-induced maculopapular exanthema (MPE) and the drug reaction with eosinophilia and systemic symptoms (DRESS) among the Thai population have never been reported. The aim of the present study was to carry out an analysis of the involvement of HLA-B alleles in carbamazepine-induced cutaneous adverse drug reactions (cADRs) in the Thai population. A case-control study was performed by genotyping the HLA-B alleles of Thai carbamazepine-induced hypersensitivity reaction patients (17 MPE, 16 SJS/TEN, and 5 DRESS) and 271 carbamazepine-tolerant controls. We also recruited 470 healthy Thai candidate subjects who had not taken carbamazepine. HLA-B∗15:02 showed a significant association with carbamazepine-induced MPE (P=0.0022, odds ratio (OR) (95% confidence interval [CI]) = 7.27 (2.04–25.97)) and carbamazepine-induced SJS/TEN (P=4.46×10−13; OR (95% CI) = 70.91(19.67–255.65)) when compared with carbamazepine-tolerant controls. Carbamazepine-induced SJS/TEN also showed an association with HLA-B∗15:21 allele (P=0.013; OR (95% CI) = 9.54 (1.61–56.57)) when compared with carbamazepine-tolerant controls. HLA-B∗58:01 allele was significantly related to carbamazepine-induced MPE (P=0.007; OR (95% CI) = 4.73 (1.53–14.66)) and DRESS (P=0.0315; OR (95% CI) = 7.55 (1.20–47.58)) when compared with carbamazepine-tolerant controls. These alleles may serve as markers to predict carbamazepine-induced cADRs in the Thai population.

HLA-A*24:07 as a potential biomarker for carbamazepine-induced Stevens–Johnson syndrome/toxic epidermal necrolysis in Filipino patients

2021 ◽  
Author(s):  
Francis Capule ◽  
Pramote Tragulpiankit ◽  
Surakameth Mahasirimongkol ◽  
Jiraphun Jittikoon ◽  
Nuanjun Wichukchinda ◽  
...  
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Medical Records ◽  
Odds Ratio ◽  
Genomic Dna ◽  
Case Control Study ◽  
Case Control ◽  
Stevens Johnson Syndrome ◽  
Johnson Syndrome ◽  
Potential Biomarker ◽  
Control Study

Aim: A case-control study was conducted in Filipino patients to determine the association between HLA alleles and carbamazepine-induced Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). Materials & methods: A retrospective review of medical records and data collection were performed. A total of 10 carbamazepine-induced SJS/TEN cases and 40 tolerant controls were recruited. Genomic DNA extracted from saliva samples was genotyped. Statistical analysis was done. Results: The HLA-B75 serotype (p = 0.003; odds ratio [OR] = 13.8; 95% CI = 2.5–76.8), HLA-B*15:21 (p = 0.041; OR = 4.7; 95% CI = 1.1–20.8) and HLA-A*24:07 (p = 0.032; OR = 6; 95% CI = 1.2–30.7) were significantly associated with carbamazepine-induced SJS/TEN. Conclusion: The HLA-B75 serotype, HLA-B*15:21 or HLA-A*24:07 may be used for pharmacogenetic screening prior to prescribing carbamazepine in Filipinos.

scholarly journals Stevens-Johnson Syndrome Associated with Drugs and Vaccines in Children: A Case-Control Study

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e68231 ◽  
Author(s):  
Umberto Raucci ◽  
Rossella Rossi ◽  
Roberto Da Cas ◽  
Concita Rafaniello ◽  
Nadia Mores ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Stevens Johnson Syndrome ◽  
Johnson Syndrome ◽  
Control Study

Incidence of Stevens-Johnson syndrome following combination drug use of allopurinol, carbamazepine and phenytoin in Taiwan: A case-control study

2018 ◽  
Vol 45 (9) ◽  
pp. 1080-1087 ◽  
Author(s):  
Fei-Kai Syu ◽  
Hsiu-Yung Pan ◽  
Po-Chun Chuang ◽  
Yi-Syun Huang ◽  
Chi-Yung Cheng ◽  
...  
Keyword(s):  
Drug Use ◽  
Case Control Study ◽  
Case Control ◽  
Stevens Johnson Syndrome ◽  
Combination Drug ◽  
Johnson Syndrome ◽  
Control Study

Risk of Stevens-Johnson syndrome and toxic epider mal necrolysis during first weeks of antiepileptic therapy: a case-control study

The Lancet ◽  
1999 ◽  
Vol 353 (9171) ◽  
pp. 2190-2194 ◽  
Author(s):  
Berthold Rzany ◽  
Osvaldo Correia ◽  
Judith P Kelly ◽  
Luigi Naldi ◽  
Ariane Auquier ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Stevens Johnson Syndrome ◽  
Antiepileptic Therapy ◽  
Johnson Syndrome ◽  
Control Study

scholarly journals Genetic association study of prolylcarboxypeptidase polymorphisms with susceptibility to essential hypertension in the Yi minority of China: A case–control study based on an isolated population

2020 ◽  
Vol 21 (2) ◽  
pp. 147032032091958 ◽  
Author(s):  
Yanrui Wu ◽  
Hongju Yang ◽  
Chunjie Xiao
Keyword(s):  
Essential Hypertension ◽  
Case Control Study ◽  
Strong Association ◽  
Case Control ◽  
Negative Regulator ◽  
Mountainous Area ◽  
Nucleotide Polymorphisms ◽  
Kinin System ◽  
Kallikrein Kinin System ◽  
Control Study

Objective: Prolylcarboxypeptidase (PRCP) is a negative regulator of the pressor actions of the renin–angiotensin–aldosterone system. It is also involved in the kallikrein–kinin system. This gene has an important role in blood pressure (BP) regulation. Methods: A case–control study was performed for 615 Yi participants (303 cases and 312 controls) from a remote mountainous area in Yunnan Province of China. For the PRCP gene, 11 tag single-nucleotide polymorphisms were genotyped using the polymerase chain reaction-restriction fragment length polymorphism method. Results: The PRCP gene rs12290550 was associated with the occurrence of essential hypertension (EH) and BP traits. Logistic regression analysis indicated that the rs12290550 T allele was significantly linked to the risk of EH (odds ratio (OR) = 1.85, 95% confidence interval (CI) 1.44–2.39, p = 0.2 × 10−5). Under Bonferroni correction, the H7 TAGCACTAACA haplotype containing the risk allele rs12290550 T increased the risk of EH (OR = 4.53, 95% CI 2.29–8.93, p = 0.2×10−5). Conclusions: The findings of this study demonstrate the strong association of the PRCP gene with EH. rs12290550 may be a useful genetic predictor of EH in the Yi minority.

Possible Cefotaxime-Induced Stevens–Johnson Syndrome

2003 ◽  
Vol 37 (6) ◽  
pp. 812-814 ◽  
Author(s):  
Evagelos N Liberopoulos ◽  
George L Liamis ◽  
Moses S Elisaf
Keyword(s):  
Case Control Study ◽  
Causality Assessment ◽  
Clinical Manifestations ◽  
Underlying Mechanism ◽  
Upper Urinary Tract ◽  
Stevens Johnson Syndrome ◽  
Case Summary ◽  
Johnson Syndrome ◽  
Increased Risk ◽  
Control Study

OBJECTIVE: To report a case of possible cefotaxime-induced Stevens–Johnson syndrome (SJS). CASE SUMMARY: A 72-year-old woman with an upper urinary tract infection developed erosions and blisters on the skin and the mucous membranes, as well as fever and prostration, soon after the administration of cefotaxime. This presentation is consistent with the features of SJS. Resolution of the clinical manifestations was observed after discontinuation of the drug; all other drugs, infections, or immunologic disorders that could have caused this syndrome were carefully excluded. An objective causality assessment revealed that SJS was possibly associated with the use of cefotaxime. DISCUSSION: Although cephalosporins have been associated with an increased risk for SJS and cefotaxime has been suspected of being associated with SJS in a previous case–control study, this is the first full report for cefotaxime-related SJS in the literature. An immunologically mediated reaction may be the underlying mechanism. CONCLUSIONS: Although cefotaxime administration seems to be the underlying cause of the SJS observed in our patient, establishment of a definite causal relationship requires additional cases and supportive data.

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