scholarly journals Association between VEGF Gene Polymorphisms and the Susceptibility to Lung Cancer: An Updated Meta-Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-16
Author(s):  
Fengming Yang ◽  
Zhiqiang Qin ◽  
Chuchu Shao ◽  
Weitao Liu ◽  
Ling Ma ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Gene Polymorphisms ◽  
Lung Cancer Risk ◽  
Cancer Susceptibility ◽  
Meta Analysis ◽  
Vegf Gene ◽  
Case Control Studies ◽  
Asian Populations ◽  
Endothelial Growth Factor

Background and Objective. The association between vascular endothelial growth factor (VEGF) gene polymorphisms (-2578C/A, +936C/T, and -460C/T) and lung cancer risk has been extensively studied in the last decades, but currently available results remain controversial or ambiguous. Therefore, we conducted a meta-analysis to assess whether the relationship between the VEGF gene and lung cancer susceptibility exists.Methods. The meta-analysis was conducted by searching the databases PubMed, Embase, and Web of Science covering all eligible studies published up to October 1, 2017. The pooled odds ratios (ORs) as well as their 95% confidence intervals (CIs) were utilized to evaluate the possible associations. Publication bias of relevant studies was examined via Begg’s funnel plots and Egger’s regression tests.Results. This meta-analysis included 13 published case–control studies covering 4477 patients with lung cancer and 4346 healthy controls, who had been accrued from December 1992 to July 2012. For the overall eligible data collected in our meta-analysis, it indicated that VEGF +936C/T, -460C/T, and -2578C/A polymorphisms did not correlate with the elevated lung cancer risk in all genetic comparison models. Moreover, VEGF +460T/C polymorphism was found to be significantly associated with susceptibility to lung cancer in these models (allele model: pooled OR = 1.12, 95% CI: 1.00–1.26,P= 0.184; homozygote model: pooled OR = 1.51, 95% CI: 1.12–2.03,P= 0.821), but no significant results were detected in Caucasian populations.Conclusions. VEGF +936C/T, -460C/T, and -2578C/A polymorphisms were not associated with the risk of lung cancer. The VEGF +460T/C polymorphism might be a risk factor for lung cancer only in Asian populations.

GSTM1 polymorphism and lung cancer risk among East Asian populations: a meta-analysis

Tumor Biology ◽  
2014 ◽  
Vol 35 (7) ◽  
pp. 6493-6500 ◽  
Author(s):  
Yan Zhao ◽  
Junjie Zeng ◽  
Yanxi Zhang ◽  
Su Lu ◽  
Erjiang Zhao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
East Asian ◽  
Asian Populations ◽  
Gstm1 Polymorphism

scholarly journals Association of VEGF Gene Polymorphisms with Susceptibility to Diabetic Retinopathy: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 52 (05) ◽  
pp. 264-279
Author(s):  
Xiaorong Li ◽  
Juping Liu ◽  
Qianhui Yang ◽  
Yan Zhang ◽  
Xiaomin Zhang
Keyword(s):  
Diabetic Retinopathy ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Vascular Endothelial ◽  
Nucleotide Polymorphisms ◽  
Vegf Gene ◽  
Asian Populations ◽  
Increased Risk ◽  
Endothelial Growth Factor

AbstractThe associations between vascular endothelial growth factor (VEGF) gene polymorphisms and risk of type 2 diabetic retinopathy (DR) – proliferative diabetic retinopathy (PDR), and nonproliferative diabetic retinopathy (NPDR) – remain unclear. A systematic search and meta-analysis using odds ratio (OR) with 95% confidence interval (CI) was performed to evaluate the association. Our study concluded 26 studies containing 10 single nucleotide polymorphisms (SNPs). In Asian populations, rs3025039 polymorphism was associated with DR risk, while in overall populations and Caucasians, the DR risk was increased by association with rs2010963. There was a significant association between rs25648 and rs833061 and DR risk in Caucasians. DR risks were found to be significantly associated between rs3025021, rs13207351, and rs2146323 in either overall populations, Caucasians or Asians. Besides, in overall and Asian populations, rs699947 and rs3025039 were associated with PDR risk. rs1570360, rs3025039, and rs833061 played a key role in PDR etiology in Caucasians. rs2010963 was associated with increased risk of PDR in overall populations. A significant association between rs699947, rs3025039, and rs833061 and NPDR risk in overall populations and Asians was found. A significant association was observed between rs2010963 and increased NPDR risk in overall and Caucasian populations. This study provides a new insight into the parthenogenesis of diabetic retinopathy. Targeting VEGF SNPs may be a potential of therapeutic approach for the treatment of DR, PDR, and NPDR.

scholarly journals The MPO−463G>A Polymorphism and Lung Cancer Risk: A Meta-Analysis Based on 22 Case–Control Studies

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e65778 ◽  
Author(s):  
Jun-Ping Yang ◽  
Wen-Bo Wang ◽  
Xiao-Xi Yang ◽  
Lei Yang ◽  
Li Ren ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies

Meta-analysis of association between cytokine gene polymorphisms and lung cancer risk

2011 ◽  
Vol 39 (5) ◽  
pp. 5187-5194 ◽  
Author(s):  
Wen-jia Peng ◽  
Qian He ◽  
Jin-xia Yang ◽  
Bing-xiang Wang ◽  
Man-man Lu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Gene Polymorphisms ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Cytokine Gene ◽  
Cytokine Gene Polymorphisms

scholarly journals ERCC2/XPD Lys751Gln and Asp312Asn Gene Polymorphism and Lung Cancer Risk: A Meta-Analysis Involving 22 Case–Control Studies

2010 ◽  
Vol 5 (9) ◽  
pp. 1337-1345 ◽  
Author(s):  
Ping Zhan ◽  
Qin Wang ◽  
Shu-Zhen Wei ◽  
Jing Wang ◽  
Qian Qian ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Gene Polymorphism ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies

XRCC1 gene polymorphisms and lung cancer susceptibility: a meta-analysis of 44 case–control studies

2012 ◽  
Vol 39 (10) ◽  
pp. 9535-9547 ◽  
Author(s):  
Liping Dai ◽  
Fujiao Duan ◽  
Peng Wang ◽  
Chunhua Song ◽  
Kaijuan Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Gene Polymorphisms ◽  
Cancer Susceptibility ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Xrcc1 Gene ◽  
Lung Cancer Susceptibility

scholarly journals Associations between I/D polymorphism in the ACE gene and lung cancer: an updated systematic review and a meta-analysis

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Junjian Chen ◽  
Mao Sun ◽  
Min Zhou ◽  
Renfu Lu
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Case Control ◽  
Rank Test ◽  
Case Control Studies ◽  
Funnel Plot ◽  
Random Ratio ◽  
Q Statistic

Abstract Background We evaluated the association between the I/D polymorphism in the ACE gene and lung cancer risk by performing a meta-analysis. Methods The heterogeneity in the study was tested using the Cochran χ2-based Q statistic test and I2 test, and then the random ratio or fixed effect was utilized to merge the odds ratios (ORs) and 95% confidence intervals (CIs) to estimate the strength of the association between ACE polymorphisms and susceptibility to lung cancer. Sensitivity analysis was also performed. Using funnel plot and Begg’s rank test, we investigated the publication bias. All statistical analyses were performed using Stata 12.0 and RevMan 5.3. Results A total of 4307 participants (2181 patients; 2126 controls) were included in the 12 case–control studies. No significant association was found between the ACE I/D polymorphism and lung cancer risk (II vs. ID + DD: OR = 1.22, 95% CI = 0.89–1.68; II + ID vs. DD: OR = 1.21, 95% CI = 0.90–1.63; I vs. D: OR = 1.15, 95% CI = 0.95–1.39). In the subgroup analysis by ethnicity, no significant association between the ACE I/D polymorphism and lung cancer risk was found among Asian and Caucasian populations for the comparisons of II vs. ID + DD, II + ID vs. DD, and I vs. D genetic models. Conclusion The ACE I/D polymorphism is not associated with the risk of lung cancer.

The association of APE1 Asp148Glu gene polymorphisms and lung cancer risk: an updated meta-analysis

Tumor Biology ◽  
2013 ◽  
Vol 35 (4) ◽  
pp. 3597-3603 ◽  
Author(s):  
Wen Chen ◽  
Qin Wang ◽  
Mang Liu ◽  
Xiao-bing Ding
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Gene Polymorphisms ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Ape1 Asp148glu
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