Serum Levels of miR-143 Predict Survival in Critically Ill Patients

Background and Aims. Recent data suggested a potential role of miR-143 as a biomarker for systemic inflammation and infection. However, its role in critical illness and sepsis is only poorly understood. Methods. We determined circulating levels of miR-143 in 218 critically ill patients, of which 135 fulfilled sepsis criteria, and compared them to 76 healthy controls. Results were correlated with clinical records. Results. In the total cohort of critically ill patients from a medical intensive care unit (ICU), miR-143 serum levels tended to be lower compared to healthy control samples, but this difference did not reach statistical significance. In ICU patients, serum levels of miR-143 were independent of disease etiology, including the presence of sepsis, or severity of disease. Importantly, low miR-143 serum levels were associated with an unfavorable short- and long-term prognosis in ICU patients. Our study identified different optimal cut-off values at which low miR-143 serum levels predicted mortality with a high diagnostic accuracy. In line with this, concentrations of circulating miR-143 correlated with markers of organ failure such as creatinine, bilirubin, or lactate in our cohort of critically ill patients. Conclusion. Low miR-143 serum levels are indicative for an unfavorable short- and long-term prognosis in critically ill patients admitted to a medical ICU. Our data suggest a previously unrecognized role for miR-143 measurements as a novel prognostic marker in critically ill patients.

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miR-155 Predicts Long-Term Mortality in Critically Ill Patients Younger than 65 Years

Mediators of Inflammation ◽

10.1155/2019/6714080 ◽

2019 ◽

Vol 2019 ◽

pp. 1-8 ◽

Cited By ~ 1

Author(s):

Frank Tacke ◽

Martina E. Spehlmann ◽

Mihael Vucur ◽

Fabian Benz ◽

Mark Luedde ◽

...

Keyword(s):

Critical Illness ◽

Critically Ill ◽

Critically Ill Patients ◽

Prognostic Biomarker ◽

Serum Levels ◽

Disease Etiology ◽

Age Related ◽

Age Dependent ◽

Similar Accuracy

Introduction. Alterations in miR-155 serum levels have been described in inflammatory and infectious diseases. Moreover, a role for miR-155 in aging and age-related diseases was recently suggested. We therefore analyzed a potential age-dependent prognostic value of circulating miR-155 as a serum-based marker in critical illness. Methods. Concentrations of circulating miR-155 were determined in 218 critically ill patients and 76 healthy controls. Results. By using qPCR, we demonstrate that miR-155 serum levels are elevated in patients with critical illness when compared to controls. Notably, levels of circulating miR-155 were independent on the severity of disease, the disease etiology, or the presence of sepsis. In the total cohort, miR-155 was not an indicator for patient survival. Intriguingly, when patients were subdivided according to their age upon admission to the ICU into those younger than 65 years, lower levels of miR-155 turned out as a strong marker, indicating patient mortality with a similar accuracy than other markers frequently used to evaluate critically ill patients on a medical ICU. Conclusion. In summary, the data provided within this study suggest an age-specific role of miR-155 as a prognostic biomarker in patients younger than 65 years. Our study is the first to describe an age-dependent miRNA-based prognostic biomarker in human diseases.

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Short- and long-term prognosis of acute critically ill patients with systemic rheumatic diseases

Medicine ◽

10.1097/md.0000000000026164 ◽

2021 ◽

Vol 100 (35) ◽

pp. e26164

Author(s):

Paul Chabert ◽

William Danjou ◽

Mehdi Mezidi ◽

Julien Berthiller ◽

Audrey Bestion ◽

...

Keyword(s):

Critically Ill ◽

Rheumatic Diseases ◽

Critically Ill Patients ◽

Systemic Rheumatic Diseases ◽

Short And Long Term ◽

Long Term Prognosis

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Short- and long-term prognosis of critically-ill patients referred to the ICU from the Emergency Department of a tertiary hospital

Medicina Clínica (English Edition) ◽

10.1016/j.medcle.2016.10.051 ◽

2017 ◽

Vol 148 (5) ◽

pp. 197-203

Author(s):

Renata García-Gigorro ◽

Helena Dominguez Aguado ◽

Jesús Abelardo Barea Mendoza ◽

Rubén Viejo Moreno ◽

Jose Angel Sánchez Izquierdo ◽

...

Keyword(s):

Emergency Department ◽

Critically Ill ◽

Critically Ill Patients ◽

Tertiary Hospital ◽

Short And Long Term ◽

Long Term Prognosis

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Elevated Omentin Serum Levels Predict Long-Term Survival in Critically Ill Patients

Disease Markers ◽

10.1155/2016/3149243 ◽

2016 ◽

Vol 2016 ◽

pp. 1-9 ◽

Cited By ~ 8

Author(s):

Mark Luedde ◽

Fabian Benz ◽

Jennifer Niedeggen ◽

Mihael Vucur ◽

Hans-Joerg Hippe ◽

...

Keyword(s):

Critical Illness ◽

Critically Ill ◽

Critically Ill Patients ◽

Serum Levels ◽

Healthy Controls ◽

Serum Concentrations ◽

Term Survival ◽

Icu Patients ◽

Icu Treatment

Introduction. Omentin, a recently described adipokine, was shown to be involved in the pathophysiology of inflammatory and infectious diseases. However, its role in critical illness and sepsis is currently unknown. Materials and Methods. Omentin serum concentrations were measured in 117 ICU-patients (84 with septic and 33 with nonseptic disease etiology) admitted to the medical ICU. Results were compared with 50 healthy controls. Results. Omentin serum levels of critically ill patients at admission to the ICU or after 72 hours of ICU treatment were similar compared to healthy controls. Moreover, circulating omentin levels were independent of sepsis and etiology of critical illness. Notably, serum concentrations of omentin could not be linked to concentrations of inflammatory cytokines or routinely used sepsis markers. While serum levels of omentin were not predictive for short term survival during ICU treatment, low omentin concentrations were an independent predictor of patients’ overall survival. Omentin levels strongly correlated with that of other adipokines (e.g., leptin receptor or adiponectin), which have also been identified as prognostic markers in critical illness. Conclusions. Although circulating omentin levels did not differ between ICU-patients and controls, elevated omentin levels were predictive for an impaired patients’ long term survival.

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Association between frailty and short- and long-term outcomes among critically ill patients: a multicentre prospective cohort study

Canadian Medical Association Journal ◽

10.1503/cmaj.130639 ◽

2013 ◽

Vol 186 (2) ◽

pp. E95-E102 ◽

Cited By ~ 226

Author(s):

S. M. Bagshaw ◽

H. T. Stelfox ◽

R. C. McDermid ◽

D. B. Rolfson ◽

R. T. Tsuyuki ◽

...

Keyword(s):

Cohort Study ◽

Critically Ill ◽

Prospective Cohort Study ◽

Critically Ill Patients ◽

Prospective Cohort ◽

Long Term Outcomes ◽

Short And Long Term

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Nutrition support in critically ill COVID-19 patients

World Nutrition Journal ◽

10.25220/wnj.v04.s3.0006 ◽

2020 ◽

Vol 4 (1-3) ◽

pp. 8

Author(s):

Abdolreza Norouzy

Keyword(s):

Older Adults ◽

At Risk ◽

Critically Ill ◽

Diagnosis And Treatment ◽

Nutrition Support ◽

Patients At Risk ◽

Short And Long Term ◽

Long Term Prognosis ◽

Poor Outcomes

Diagnosis and treatment of malnutrition should be considered in the management of COVID-19 patients to improve both short- and long-term prognosis. Patients at risk for poor outcomes and higher mortality following infection with COVID-19, namely older adults and polymorbid individuals, should be checked for malnutrition through screening and assessment.

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Association of Serum Calprotectin Concentrations with Mortality in Critically Ill and Septic Patients

Diagnostics ◽

10.3390/diagnostics10110990 ◽

2020 ◽

Vol 10 (11) ◽

pp. 990

Author(s):

Theresa H. Wirtz ◽

Lukas Buendgens ◽

Ralf Weiskirchen ◽

Sven H. Loosen ◽

Nina Haehnsen ◽

...

Keyword(s):

Overall Survival ◽

Critically Ill ◽

Critically Ill Patients ◽

University Hospital ◽

Therapeutic Interventions ◽

Neutrophil Granulocytes ◽

Icu Patients ◽

Long Term Outcome ◽

Icu Admission

Background: Calprotectin is present in the cytosol of neutrophil granulocytes and released upon activation. Fecal calprotectin is applied in the clinical management of inflammatory bowel disease whereas serum calprotectin has been discussed as a biomarker in inflammatory disorders. However, its long-term prognostic relevance in critical illness remains unclear. Our aim was to investigate serum calprotectin concentrations as a prognostic biomarker in critically ill and septic patients. Methods: Serum calprotectin concentrations were analyzed in 165 critically ill patients (108 with sepsis, 57 without sepsis) included in our observational study. Patients were enrolled upon admission to the medical intensive care unit (ICU) of the RWTH Aachen University Hospital. Calprotectin concentrations were compared to 24 healthy controls and correlated with clinical parameters, therapeutic interventions, and survival. Results: Serum calprotectin concentrations were significantly increased in ICU patients as well as in septic patients compared to respective controls (p < 0.001 for ICU patients and p = 0.001 for septic patients). Lower calprotectin concentrations were measured in patients with comorbidities i.e., coronary artery disease. Calprotectin concentrations strongly correlated with the C-reactive protein (p < 0.001) and were closely associated to parameters of mechanical ventilation (i.a. inspiratory oxygen fraction, FiO2; p < 0.001). The overall survival was significantly impaired in septic patients with high baseline calprotectin concentrations (p = 0.036). However, patients with increasing calprotectin serum concentrations within the first week of ICU admission showed an improved overall survival (p = 0.009). Conclusions: In summary, serum calprotectin concentrations are significantly increased in critically ill patients with sepsis. High calprotectin concentrations at ICU admission predict long-term mortality risk, whereas increasing calprotectin concentrations are associated with a favorable long-term outcome.

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Low Myostatin Serum Levels Are Associated with Poor Outcome in Critically Ill Patients

Diagnostics ◽

10.3390/diagnostics10080574 ◽

2020 ◽

Vol 10 (8) ◽

pp. 574

Author(s):

Theresa H. Wirtz ◽

Sven H. Loosen ◽

Lukas Buendgens ◽

Berkan Kurt ◽

Samira Abu Jhaisha ◽

...

Keyword(s):

Critically Ill ◽

Critically Ill Patients ◽

Cox Regression ◽

Muscle Growth ◽

Serum Levels ◽

Serum Concentrations ◽

Icu Patients ◽

Cox Regression Analysis ◽

Independent Prognostic Marker ◽

Unfavorable Clinical Outcome

Background: Growth differentiation factor 8, GDF-8 (Myostatin), is a protein released by myocytes inhibiting muscle growth and differentiation. Serum concentrations of Myostatin can predict poor survival in different chronic diseases, but its role in critical illness and sepsis is obscure. Our aim was to investigate Myostatin levels as a potential prognostic biomarker in critically ill patients with sepsis. Methods: We therefore measured Myostatin serum concentrations in 165 critically ill patients (106 with sepsis, 59 without sepsis) upon admission to the medical intensive care unit (ICU), in comparison to 14 healthy controls. Results: Myostatin levels were significantly decreased in ICU patients compared to controls but did not differ in patients with or without sepsis. However, Myostatin concentrations were significantly lower in patients requiring mechanical ventilation and indicated a trend towards dependency of intravenous vasopressors. Interestingly, we observed a negative correlation between Myostatin levels and markers of systemic inflammation. Strikingly, overall survival (OS) was significantly impaired in patients with low Myostatin levels in all critically ill patients. Low Myostatin levels at baseline turned out as an independent prognostic marker for OS in multivariate Cox-regression analysis (HR: 0.433, 95% CI: 0.211–0.889, p = 0.023). Conclusions: In summary, serum Myostatin concentrations are significantly decreased in critically ill patients and associated with disease severity. Low Myostatin levels also identify a subgroup of ICU patients that are more likely to face an unfavorable clinical outcome in terms of OS.

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