scholarly journals A Challenging Case of Mammary Analogue Secretory Carcinoma: Case Study with Ultrastructural and Cytogenetic Correlation

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Joseph Mathew ◽  
Michael Carvalho ◽  
Katherine Chorneyko ◽  
Samih Salama
Keyword(s):  
Salivary Gland ◽  
Gene Rearrangement ◽  
Salivary Gland Tumor ◽  
Molecular Testing ◽  
Suspected Case ◽  
Secretory Carcinoma ◽  
Gland Tumor ◽  
Mammary Analogue Secretory Carcinoma ◽  
Not Otherwise Specified

Mammary analogue secretory carcinoma (MASC) is a rare salivary gland tumor analogous to secretory carcinoma of the breast. The diagnosis of MASC can be challenging due to substantial morphologic and immunohistochemical similarities with other salivary gland tumors. The differential diagnosis of MASC is broad and includes intraductal carcinoma, acinic cell carcinoma, and adenocarcinoma, not otherwise specified. Although molecular testing for ETV6 gene rearrangement is characteristic of MASC and has not been shown in any other salivary gland tumor, a particular challenge arises when such testing is unavailable, or when molecular testing for ETV6 gene rearrangement is negative in a suspected case of MASC. Our study presents the diagnostic workup of a challenging case of MASC with immunohistochemistry, electron microscopy, and cytogenetic studies performed to resolve the diagnosis.

scholarly journals Mammary Analogue Secretory Carcinoma

2016 ◽  
Vol 140 (9) ◽  
pp. 997-1001 ◽  
Author(s):  
Todd M. Stevens ◽  
Vishwas Parekh
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Salivary Gland Tumor ◽  
Acinic Cell Carcinoma ◽  
Low Grade ◽  
Secretory Carcinoma ◽  
Duct Carcinoma ◽  
Mammary Analogue Secretory Carcinoma ◽  
Acinic Cell ◽  
Not Otherwise Specified

Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumor that shares the same histologic appearance and ETV6 gene (12p13) rearrangement as secretory carcinoma of the breast. Prior to its recognition, MASC cases were commonly labeled acinic cell carcinoma and adenocarcinoma, not otherwise specified. Despite distinctive histologic features, MASC may be difficult to distinguish from other salivary gland tumors, in particular zymogen-poor acinic cell carcinoma and low-grade salivary duct carcinoma. Although characteristic morphologic and immunohistochemical features form the basis of a diagnosis of MASC, the presence of an ETV6-NTRK3 gene fusion is confirmatory. Given its recent recognition the true prognostic import of MASC is not yet clearly defined.

scholarly journals Mammary analogue secretory carcinoma: a rare salivary gland tumor

2020 ◽  
Vol 6 (5) ◽  
pp. 998
Author(s):  
Shashikant Anil Pol ◽  
Surinder K. Singhal ◽  
Nitin Gupta ◽  
Himanshu Bayad
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Tumor ◽  
Needle Aspiration ◽  
Good Prognosis ◽  
Low Grade ◽  
Secretory Carcinoma ◽  
Mammary Analogue Secretory Carcinoma ◽  
Grade Malignancy ◽  
Enhanced Computed Tomography ◽  
Slow Growing

<p>Mammary analogue secretary carcinoma are salivary gland tumors similar to secretary carcinoma of breast histologically. It usually affects adults with mean age group of 45 years. Clinically it is usually slow growing, low grade malignancy with favorable prognosis. We are reporting a case of 47 years old female presented with complaints of swelling behind left ear for last 7 years. It was slow growing, painless and persistent. On examination, 4 x 3 cm swelling was present just below left ear lobule. It was nontender, firm, irregular in shape with smooth surface with slight mobility and overlying skin pinchable. Fine needle aspiration cytology suggested benign tumor with cystic change. On contrast enhanced computed tomography scan, there was a lobulated hypodense lesion measuring 24×35×32 mm with internal septations and enhancement of wall in expected location of superficial as well as deep lobe of left parotid gland. Patient underwent left total conservative parotidectomy and histopathology came out to be secretory analogue mammary carcinoma. Subsequently she received post-operative radiotherapy. Patient is on regular follow up and disease free till date. Usually mammary analogue secretory carcinoma is a low-grade malignancy with good prognosis. Immunohistochemistry is confirmatory which shows positivity for S-100 protein and mammaglobin.</p>

scholarly journals A Case Report of Mammary Analogue Secretory Carcinoma with Aggressive Clinical and Histological Presentation

2021 ◽  
pp. 1-3
Author(s):  
Daliah Abdulhafeez ◽  
◽  
Abdullah Ghafouri ◽  
Keyword(s):  
Clinical Presentation ◽  
Salivary Gland Tumor ◽  
High Grade ◽  
Disease Course ◽  
Secretory Carcinoma ◽  
Gland Tumor ◽  
Mammary Analogue Secretory Carcinoma ◽  
First Case ◽  
Wide Range ◽  
High Grade Transformation

Mammary analogue secretory carcinoma is a rare salivary gland tumor that has a wide range of clinical presentation ranging from indolent, local and slowly growing tumors to a very aggressive, infiltrative and widely metastasizing forms. We report a case of an unfortunate patient whose tumor had a very quick ominous disease course with aggressive clinical and histological presentation. This case is the first case, to our knowledge, to be reported in the literature from Saudi Arabia of MASC with features of high grade transformation

scholarly journals A strongly suspected case of adult T-cell leukemia/lymphoma manifested as salivary gland tumor.

1987 ◽  
Vol 90 (7) ◽  
pp. 1063-1070 ◽  
Author(s):  
TSUNEYOSHI FUNAI ◽  
YASUHIRO SERIZAWA ◽  
ATSUROU SEKI ◽  
MASATOSHI IMOTO ◽  
TOORU KIKAWADA ◽  
...  
Keyword(s):  
Salivary Gland ◽  
T Cell ◽  
Salivary Gland Tumor ◽  
Suspected Case ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Gland Tumor ◽  
Adult T Cell Leukemia

scholarly journals Atypical Presentation of Mammary Analogue Secretory Carcinoma of the Lip

2020 ◽  
pp. 014556132095775
Author(s):  
Abdulkader Yassin-Kassab ◽  
Danielle Gainor ◽  
Ahmed Saeed Sufyan
Keyword(s):  
Salivary Gland ◽  
Mucoepidermoid Carcinoma ◽  
Atypical Presentation ◽  
Rare Tumor ◽  
Secretory Carcinoma ◽  
Carcinoma Of The Breast ◽  
Case Presentation ◽  
Mammary Analogue Secretory Carcinoma ◽  
Not Otherwise Specified ◽  
Low Incidence

Mammary analogue secretory carcinoma (MASC) of the salivary gland is a rare tumor that was first described by Skalova et al in 2010, and since then, only a few hundred cases have been reported in the literature. Prior to Skalova’s report, MASC was histologically misclassified as acinic cell carcinoma (ACC), pleomorphic adenoma, mucoepidermoid carcinoma, or adenocarcinoma, not otherwise specified. Mammary analogue secretory carcinoma has a low incidence rate overall, accounting for less than 0.3% of all salivary gland tumors. Histopathologic and cytogenic analysis of MASC is identical to secretory carcinoma of the breast, leading to the proposed name by Skalova. The purpose of this case presentation is to describe an atypical presentation of MASC, to compare this case with the classic description of MASC, and to contrast the various features of MASC to ACC in order to improve the accuracy of future diagnoses and help guide treatment.

scholarly journals Mammary Analogue Secretory Carcinoma of the Palate: Case Report and Review of the Literature

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Christian Boliere ◽  
James Murphy ◽  
Mohammed Qaisi ◽  
Frances Manosca ◽  
Henry Fung
Keyword(s):  
Salivary Gland ◽  
Minor Salivary Gland ◽  
Salivary Gland Tumor ◽  
Conclusive Evidence ◽  
Histopathological Diagnosis ◽  
Low Grade ◽  
Secretory Carcinoma ◽  
Mammary Analogue Secretory Carcinoma ◽  
A Minor ◽  
Malignant Salivary Gland Tumors

Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumor, with a limited number of published reports. Less than three hundred cases have been reported in the literature and only 18 of these cases have been reported in minor palatal salivary glands, though publication bias is likely a factor. We present a case of a 57-year-old male who was diagnosed with MASC tumor presenting in a minor salivary gland and briefly review the current literature. MASC has a variety of histological features and different range of clinical behaviors. The histopathological diagnosis of MASC can be difficult, and the immunohistochemical profile of MASC is still being updated. The gold standard for MASC diagnosis is cytogenetics, with the majority having a translocation t(12;15)(p133;q25). Presently, there is no conclusive evidence that MASC should be treated differently than any other low-grade malignant salivary gland tumors, though high-grade transformation has been described.

scholarly journals Secretory carcinoma — impact of translocation and gene fusions on salivary gland tumor

2017 ◽  
Vol 29 (5) ◽  
pp. 379-384 ◽  
Author(s):  
Ryoko Inaki ◽  
◽  
Masanobu Abe ◽  
Liang Zong ◽  
Takahiro Abe ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Tumor ◽  
Gene Fusions ◽  
Secretory Carcinoma ◽  
Gland Tumor
Sign in / Sign up

Export Citation Format

Share Document