scholarly journals A Case Report of Mammary Analogue Secretory Carcinoma with Aggressive Clinical and Histological Presentation

2021 ◽  
pp. 1-3
Author(s):  
Daliah Abdulhafeez ◽  
◽  
Abdullah Ghafouri ◽  
Keyword(s):  
Clinical Presentation ◽  
Salivary Gland Tumor ◽  
High Grade ◽  
Disease Course ◽  
Secretory Carcinoma ◽  
Gland Tumor ◽  
Mammary Analogue Secretory Carcinoma ◽  
First Case ◽  
Wide Range ◽  
High Grade Transformation

Mammary analogue secretory carcinoma is a rare salivary gland tumor that has a wide range of clinical presentation ranging from indolent, local and slowly growing tumors to a very aggressive, infiltrative and widely metastasizing forms. We report a case of an unfortunate patient whose tumor had a very quick ominous disease course with aggressive clinical and histological presentation. This case is the first case, to our knowledge, to be reported in the literature from Saudi Arabia of MASC with features of high grade transformation

scholarly journals Secretory Carcinoma of Salivary Gland with High-Grade Histology Arising in Hard Palate: A Case Report

Reports ◽  
2020 ◽  
Vol 3 (2) ◽  
pp. 6
Author(s):  
Kiyofumi Takabatake ◽  
Keisuke Nakano ◽  
Hotaka Kawai ◽  
Saori Yoshida ◽  
Haruka Omori ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Hard Palate ◽  
Relevant Literature ◽  
Salivary Gland Tumor ◽  
World Health ◽  
Fusion Product ◽  
Low Grade ◽  
High Grade ◽  
Secretory Carcinoma ◽  
High Grade Transformation

Secretory carcinoma (SC) is a recently described salivary gland tumor reported in the fourth edition of World Health Organization classification of head and neck tumors. SC is characterized by strong S-100 protein, mammaglobin, and vimentin immunoexpression, and harbors a t(12;15)(p13;q25) translocation which leads to ETV6-NTRK3 fusion product. Histologically, SC displays a lobulated growth pattern and is often composed of microcystic, tubular, and solid structures with abundant eosinophilic homogenous or bubbly secretion. SC is generally recognized as low-grade malignancy with low-grade histopathologic features, and metastasis is relatively uncommon. In this case, we described a SC of hard palate that underwent high grade transformation and metastasis to the cervical lymph node in a 54-year-old patient. In addition, this case showed different histological findings between primary lesion and metastasis lesion. Therefore, the diagnosis was confirmed by the presence of ETV6 translocation. Here, we report a case that occurred SC with high-grade transformation in the palate, and a review of the relevant literature is also presented.

Mammary Analogue Secretory Carcinoma of Salivary Glands With High-grade Transformation

2014 ◽  
Vol 38 (1) ◽  
pp. 23-33 ◽  
Author(s):  
Alena Skálová ◽  
Tomas Vanecek ◽  
Hanna Majewska ◽  
Jan Laco ◽  
Petr Grossmann ◽  
...  
Keyword(s):  
Salivary Glands ◽  
High Grade ◽  
Secretory Carcinoma ◽  
Mammary Analogue Secretory Carcinoma ◽  
High Grade Transformation

scholarly journals A Challenging Case of Mammary Analogue Secretory Carcinoma: Case Study with Ultrastructural and Cytogenetic Correlation

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Joseph Mathew ◽  
Michael Carvalho ◽  
Katherine Chorneyko ◽  
Samih Salama
Keyword(s):  
Salivary Gland ◽  
Gene Rearrangement ◽  
Salivary Gland Tumor ◽  
Molecular Testing ◽  
Suspected Case ◽  
Secretory Carcinoma ◽  
Gland Tumor ◽  
Mammary Analogue Secretory Carcinoma ◽  
Not Otherwise Specified

Mammary analogue secretory carcinoma (MASC) is a rare salivary gland tumor analogous to secretory carcinoma of the breast. The diagnosis of MASC can be challenging due to substantial morphologic and immunohistochemical similarities with other salivary gland tumors. The differential diagnosis of MASC is broad and includes intraductal carcinoma, acinic cell carcinoma, and adenocarcinoma, not otherwise specified. Although molecular testing for ETV6 gene rearrangement is characteristic of MASC and has not been shown in any other salivary gland tumor, a particular challenge arises when such testing is unavailable, or when molecular testing for ETV6 gene rearrangement is negative in a suspected case of MASC. Our study presents the diagnostic workup of a challenging case of MASC with immunohistochemistry, electron microscopy, and cytogenetic studies performed to resolve the diagnosis.

scholarly journals Adenomatoid Hyperplasia of The Oral Cavity: A Diagnostic Dilemma

2021 ◽  
Author(s):  
Ali ALTINDAĞ ◽  
Poyzan Bozkurt ◽  
Burak Bilecenoğlu ◽  
Kaan Orhan
Keyword(s):  
Oral Cavity ◽  
Correct Diagnosis ◽  
Age Distribution ◽  
Salivary Gland Tumor ◽  
Histological Evaluation ◽  
Gland Tumor ◽  
Diagnostic Dilemma ◽  
Location Data ◽  
Wide Range ◽  
Review Study

This review study presents literature review and discusses the clinical significance of Adenomatoid Hyperplasia, a commonly misdiagnosed lesion. This rare entity has been seldom presented and is not well enough described in the literature. Only 15 reports with 95 cases could be attained during the online literature search using the keywords: Adenomatoid, Tumor, Hyperplasia, Minor salivary Glands. Data revealed a tendency towards the male gender. Age distribution of patients did not reveal a tendency towards a specific age group but presented a peak incidence in the 4th and 5th decades. Location data revealed a tendency towards the palate, especially the hard palate. Most of the presented cases were asymptomatic and the most common initial diagnosis made was salivary gland tumor. It was concluded that, adenomatoid hyperplasia of the oral cavity may resemble a wide range of pathologies and in order to differentiate and to achieve a correct diagnosis, histological evaluation is fundamental.

scholarly journals Mammary analogue secretory carcinoma: a rare salivary gland tumor

2020 ◽  
Vol 6 (5) ◽  
pp. 998
Author(s):  
Shashikant Anil Pol ◽  
Surinder K. Singhal ◽  
Nitin Gupta ◽  
Himanshu Bayad
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Tumor ◽  
Needle Aspiration ◽  
Good Prognosis ◽  
Low Grade ◽  
Secretory Carcinoma ◽  
Mammary Analogue Secretory Carcinoma ◽  
Grade Malignancy ◽  
Enhanced Computed Tomography ◽  
Slow Growing

<p>Mammary analogue secretary carcinoma are salivary gland tumors similar to secretary carcinoma of breast histologically. It usually affects adults with mean age group of 45 years. Clinically it is usually slow growing, low grade malignancy with favorable prognosis. We are reporting a case of 47 years old female presented with complaints of swelling behind left ear for last 7 years. It was slow growing, painless and persistent. On examination, 4 x 3 cm swelling was present just below left ear lobule. It was nontender, firm, irregular in shape with smooth surface with slight mobility and overlying skin pinchable. Fine needle aspiration cytology suggested benign tumor with cystic change. On contrast enhanced computed tomography scan, there was a lobulated hypodense lesion measuring 24×35×32 mm with internal septations and enhancement of wall in expected location of superficial as well as deep lobe of left parotid gland. Patient underwent left total conservative parotidectomy and histopathology came out to be secretory analogue mammary carcinoma. Subsequently she received post-operative radiotherapy. Patient is on regular follow up and disease free till date. Usually mammary analogue secretory carcinoma is a low-grade malignancy with good prognosis. Immunohistochemistry is confirmatory which shows positivity for S-100 protein and mammaglobin.</p>

MASC UNMASKED- A CASE REPORT AND WHAT WE KNOW TILL DATE

2021 ◽  
pp. 88-90
Author(s):  
Farhanul Huda ◽  
Lokavarapu Manoj Joshua ◽  
Saumya Agrawal ◽  
Ashok Singh
Keyword(s):  
Pleomorphic Adenoma ◽  
Adjuvant Radiotherapy ◽  
Perineural Invasion ◽  
Radical Surgery ◽  
Histopathological Examination ◽  
Salivary Gland Tumor ◽  
Incomplete Resection ◽  
Secretory Carcinoma ◽  
Gland Tumor ◽  
Parotid Region

We report a case of MASC (mammary analogue of secretory carcinoma) in a 24-year-old male who presented with swelling in the parotid region and provisional diagnosed as pleomorphic adenoma and supercial parotidectomy was done. On histopathological examination and immunohistochemistry, it was diagnosed as MASC which is a less common variant of salivary gland tumor and completely a pathological diagnosis, not possible to diagnose preoperatively. It shows resemblance to pleomorphic adenoma both clinically and histopathologically. The treatment varies from simple excisions to radical surgery with or without neck dissections, adjuvant radiotherapy and or adjuvant systemic chemotherapy. Post-operative radiotherapy is reserved for patients with close surgical margins (5mm), incomplete resection, perineural invasion and / T3 or T4 tumours which are not present in our case.

scholarly journals Oncogenic Orphan Nuclear Receptor NR4A3 Interacts and Cooperates with MYB in Acinic Cell Carcinoma

Cancers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2433
Author(s):  
David Y. Lee ◽  
Kathryn J. Brayer ◽  
Yoshitsugu Mitani ◽  
Eric A. Burns ◽  
Pulivarthi H. Rao ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Salivary Gland Tumor ◽  
Binding Domain ◽  
Acinic Cell Carcinoma ◽  
High Grade ◽  
Orphan Nuclear Receptor ◽  
Acinic Cell ◽  
High Grade Transformation ◽  
Domain Transformation

Acinic cell carcinoma (AcCC) is a morphologically distinctive salivary gland malignancy often associated with chromosome rearrangements leading to overexpression of the NR4A3 transcription factor. However, little is known about how NR4A3 contributes to AcCC biology. Detailed RNA-sequencing of 21 archived AcCC samples revealed fusion reads arising from recurrent t(4;9), t(9;12), t(8;9) or t(2;4) chromosomal translocations, which positioned highly active enhancers adjacent to the promoter of the NR4A3 gene or the closely related NR4A2 gene, resulting in their aberrant overexpression. Transcriptome analyses revealed several distinct subgroups of AcCC tumors, including a subgroup that overexpressed both NR4A3 and MSANTD3. A poor survival subset of the tumors with high-grade transformation expressed NR4A3 and POMC as well as MYB, an oncogene that is the major driver in a different type of salivary gland tumor, adenoid cystic carcinoma. The combination of NR4A3 and MYB showed cooperativity in regulating a distinct set of genes. In addition, the ligand binding domain of NR4A3 directly bound the Myb DNA binding domain. Transformation assays indicated that, while overexpressed NR4A3 was sufficient to generate transformed colonies, the combination of NR4A3 plus Myb was more potent, leading to anchorage-independent growth and increased cellular invasiveness. The results confirm that NR4A3 and NR4A2 are the main driver genes of AcCC and suggest that concurrent overexpression of NR4A3 and MYB defines a subset of AcCC patients with high-grade transformation that display exceptionally poor outcome.

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