scholarly journals Safety and Clinical Efficacy of Yangxue Qingnao Granules in the Treatment of Chronic Cerebral Circulation Insufficiency: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Jianbo Guo ◽  
Xingjiang Xiong ◽  
Yu Cao ◽  
Yukun Ding ◽  
Qingyong He
Keyword(s):  
Blood Flow ◽  
Flow Velocity ◽  
Clinical Efficacy ◽  
Blood Flow Velocity ◽  
Cerebral Circulation ◽  
Meta Analysis ◽  
Poor Quality ◽  
Small Sample ◽  
Mean Difference ◽  
Routine Treatment

To evaluate the safety and clinical efficacy of Yangxue Qingnao (YXQN) granules in the treatment of chronic cerebral circulation insufficiency (CCCI), electronic databases—PubMed, Embase, CNKI, VIP, and Wangfang—were searched for randomized controlled trials (RCTs) published up to January 2019. GRADE and RevMan 5.3.0 were used for grading and analysis, respectively. Fifteen trials involving 1211 CCCI patients were included. Subgroup analysis was performed owing to study heterogeneity. Compared to nimodipine plus routine treatment, YXQN granules plus routine treatment were more effective in increasing basilar artery (BA) blood flow velocity (mean difference (MD) = 3.34, 95% confidence interval (CI) = [2.31, 4.37], P<0.00001), vertebral artery (VA) blood flow velocity (MD = 0.52, 95% CI = [0.27, 0.76], P<0.0001), and internal carotid artery (ICA) blood flow velocity (MD = 7.46, 95% CI = [2.01, 12.90], P=0.007). In improving the clinical efficacy of traditional Chinese medicine (TCM) for symptoms such as headache, dizziness, and insomnia, YXQN granules plus routine treatment were shown to be superior to the following control treatments: nimodipine plus routine treatment (mean difference (M-H) = 4.21, 95% CI = [2.49, 7.12], P<0.00001), flunarizine plus routine treatment (mean difference (M-H) = 3.92, 95% CI = [1.36, 11.29], P=0.01), troxerutin plus routine treatment (mean difference (M-H) = 4.79, 95% CI = [2.20, 10.42], P<0.00001), and routine treatment (mean difference (M-H) = 6.13, 95% CI = [1.48, 25.34], P=0.01). Risk of bias was assessed in 15 trials. One analysis was graded using GRADE and showed poor results. Adverse events were not reported explicitly in all but one trial. Thus, this meta-analysis suggests that YXQN granules may be beneficial for patients with CCCI. However, owing to the poor quality of the clinical trials and small sample sizes, a definite conclusion on the efficacy and safety of YXQN granules cannot be drawn from existing information.

Effect of menopause on cerebral artery blood flow velocity and cerebrovascular reactivity: Systematic review and meta-analysis

Maturitas ◽  
2021 ◽  
Vol 148 ◽  
pp. 24-32
Author(s):  
Stefanie L Ruediger ◽  
Jodie L Koep ◽  
Shelley E Keating ◽  
Faith K Pizzey ◽  
Jeff S Coombes ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Flow ◽  
Flow Velocity ◽  
Cerebral Artery ◽  
Blood Flow Velocity ◽  
Meta Analysis ◽  
Cerebrovascular Reactivity ◽  
Artery Blood Flow

Hemodynamics, cerebral circulation, and oxygen saturation in Cheyne-Stokes respiration

1997 ◽  
Vol 83 (4) ◽  
pp. 1184-1191 ◽  
Author(s):  
Karl A. Franklin ◽  
Erik Sandström ◽  
Göran Johansson ◽  
Eva M. Bålfors
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Oxygen Saturation ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Cerebral Circulation ◽  
Cerebral Blood Flow Velocity ◽  
Blood Gases ◽  
Oxygen Administration

Franklin, Karl A., Erik Sandström, Göran Johansson, and Eva M. Bålfors. Hemodynamics, cerebral circulation, and oxygen saturation in Cheyne-Stokes respiration. J. Appl. Physiol. 83(4): 1184–1191, 1997.—Because cardiovascular disorders and stroke may induce Cheyne-Stokes respiration, our purpose was to study the interaction among cerebral activity, cerebral circulation, blood pressure, and blood gases during Cheyne-Stokes respiration. Ten patients with heart failure or a previous stroke were investigated during Cheyne-Stokes respiration with recordings of daytime polysomnography, cerebral blood flow velocity, intra-arterial blood pressure, and intra-arterial oxygen saturation with and without oxygen administration. There were simultaneous changes in wakefulness, cerebral blood flow velocity, and respiration with accompanying changes in blood pressure and heart rate ∼10 s later. Cerebral blood flow velocity, blood pressure, and heart rate had a minimum occurrence in apnea and a maximum occurrence during hyperpnea. The apnea-induced oxygen desaturations were diminished during oxygen administration, but the hemodynamic alterations persisted. Oxygen desaturations were more severe and occurred earlier according to intra-arterial measurements than with finger oximetry. It is not possible to explain Cheyne-Stokes respiration by alterations in blood gases and circulatory time alone. Cheyne-Stokes respiration may be characterized as a state of phase-linked cyclic changes in cerebral, respiratory, and cardiovascular functions probably generated by variations in central nervous activity.

Head Position and Cerebral Blood Flow Velocity in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis

2014 ◽  
Vol 37 (6) ◽  
pp. 401-408 ◽  
Author(s):  
Verónica V. Olavarría ◽  
Hisatomi Arima ◽  
Craig S. Anderson ◽  
Alejandro M. Brunser ◽  
Paula Muñoz-Venturelli ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Cerebral Blood Flow Velocity ◽  
Meta Analysis ◽  
Head Position

Cerebral Blood Flow Velocity in the Human Newborn: The Value of Its Determination

PEDIATRICS ◽  
1982 ◽  
Vol 70 (1) ◽  
pp. 147-152
Author(s):  
Joseph J. Volpe ◽  
Jeffrey M. Perlman ◽  
Alan Hill ◽  
Joseph B. McMenamin
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Brain Injury ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Cerebral Circulation ◽  
Cerebral Blood Flow Velocity ◽  
Doppler Frequency ◽  
Systemic Hemodynamic ◽  
Human Newborn

An ultrasonic technique based on measurement of the Doppler frequency shift produced by the movement of red blood cells in an insonated vessel has been useful for measurement of cerebral blood flow velocity in the newborn. When the transducer is applied to the anterior fontanel, flow velocity in each anterior cerebral artery can be determined noninvasively. Reliable application ofthe technique requires utilization of both the audible and visible signals produced by the instrument. Experience and awareness of the anatomy are also important in interpretation. Serial measurements of cerebral blood flow velocity have provided useful information concerning changes in the cerebral circulation under important neonatal circumstances. Examples of the latter include PDA, pneumothorax, hydrocephalus, and hyperviscosity. Most of the changes in the cerebral circulation appear to reflect directly systemic hemodynamic changes. This relation between cerebral and systemic hemodynamic events is compatible with other observations, indicating that in the human newborn—particularly the infant most at risk for hypoxic-ischemic and/or hemorrhagic brain injury—the cerebral circulation is pressure passive. Indeed, the changes in the cerebral circulation observed so far with the Doppler technique may have important implications for the genesis of neonatal ischemic and hemorrhagic brain injury.

Episodes of Apnea and Bradycardia in the Preterm Newborn: Impact on Cerebral Circulation

PEDIATRICS ◽  
1985 ◽  
Vol 76 (3) ◽  
pp. 333-338 ◽  
Author(s):  
Jeffrey M. Perlman ◽  
Joseph J. Volpe
Keyword(s):  
Heart Rate ◽  
Blood Flow ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Cerebral Circulation ◽  
Cerebral Blood Flow Velocity ◽  
Base Line ◽  
Diastolic Flow ◽  
Arterial Blood ◽  
Severe Bradycardia

The effect of episodes of apnea with bradycardia on cerebral circulation was studied during 101 episodes in 15 premature infants. The objectives of the study were to determine whether important alterations occur in cerebral hemodynamics with apnea and bradycardia cardia and whether such alterations relate to systemic hemodynamic events. The transcutaneous Doppler technique was used to measure blood flow velocity in the anterior cerebral arteries. With episodes of apnea complicated by mild-to-moderate bradycardia (heart rate &lt;120 or &gt;80), a decrease in diastolic flow velocity was noted with little or no change in systolic flow velocity. With episodes complicated by severe bradycardia (heart rate &lt;80), the diastolic flow velocity fell to the electronic base line, and a progressive decrease in systolic flow velocity also was observed. Accompanying the changes in cerebral blood flow velocity were similar changes in arterial blood pressure. These data suggest potential deleterious hypoxic-ischemic effects on brain from apnea with severe bradycardia in the preterm infant.

Study on the correlation between hemodynamic status of the transverse sinus-sigmoid sinus and the clinical efficacy of sigmoid sinus wall reconstruction

2021 ◽  
pp. 159101992110620
Author(s):  
Zhenfeng Li ◽  
Long Jin
Keyword(s):  
Blood Flow ◽  
Pressure Distribution ◽  
Flow Velocity ◽  
Clinical Efficacy ◽  
Blood Flow Velocity ◽  
Transverse Sinus ◽  
Sigmoid Sinus ◽  
Pulsatile Tinnitus ◽  
Sinus Wall ◽  
Sinus Stenosis

Background and Purpose For patients with pulsatile tinnitus who have both transverse sinus stenosis and sigmoid sinus wall anomalies, sigmoid sinus wall reconstruction surgery is the first-choice treatment when the trans-stenotic pressure gradient less than 10 mmHg. However, not all patients are cured by surgery. We hypothesized the abnormal hemodynamics caused by transverse sinus stenosis is associated with the clinical efficacy of surgery. Methods Eight pulsatile tinnitus patients treated with surgery were retrospectively reviewed (4 rehabilitated, 4 nonrehabilitated). All patients had radiologically diagnosed transverse sinus stenosis and sigmoid sinus wall anomalies. A numerical simulation of the hemodynamics of the transverse sinus-sigmoid sinus was performed using computational fluid dynamics technology. Changes in the blood flow patterns before and after surgery were observed. The blood flow velocity at the stenosis, vorticity of blood flow in the sigmoid sinus and wall pressure distribution in the sigmoid sinus wall anomalies area were compared. Results The blood flow velocity in the stenosis (preoperative P = 0.04, postoperative P = 0.004) and vorticity in the sigmoid sinus (preoperative P = 0.02, postoperative P = 0.007) pre- and post-surgery were significantly higher in the non-rehabilitation group than in the rehabilitation group. No significant difference was found in the wall pressure distribution in the sigmoid sinus wall anomalies area (preoperative P = 0.12, postoperative P = 0.24). Conclusions There is a clear correlation between the abnormal hemodynamic status caused by transverse sinus stenosis and the clinical efficacy of surgery. The blood flow velocity at the stenosis and vorticity of blood flow in the sigmoid sinus are factors influencing the clinical efficacy of surgery.

scholarly journals State of cerebral circulation in neurosensoral deaf in combination stable voltage stenocardia

2021 ◽  
Vol 20 (6) ◽  
pp. 20-25
Author(s):  
S. S. Arifov ◽  
◽  
D. А. Каlandarova ◽  
Keyword(s):  
Blood Flow ◽  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Cerebral Circulation ◽  
Sensorineural Hearing ◽  
Duplex Scanning ◽  
Exertional Angina ◽  
Antianginal Drugs

The aim of this study was to study the state of cerebral circulation using duplex scanning of extra- and intracranial vessels in sensorineural hearing loss in combination with stable exertional angina. The study included 43 patients with diagnosed sensorineural hearing loss in combination with stable exertional angina at the age of 30 to 63 years, who had not previously received antianginal drugs. With the help of color duplex scanning, cerebral circulation in the extra- and intracranial vessels was studied. 19 people (44,2%) had the first degree, and 16 people (37,2%) had the second degree of hearing loss. In 9,3% of cases, the average air conduction rate in patients did not reach 26 dB. In 9,3% of patients, an increase in thresholds was observed only in the ultra-high-frequency zone (10 000–20 000 Hz). In patients with sensorineural hearing loss in combination with stable exertional angina, there was a change in the linear blood flow velocity in the extra- and intracranial vessels. In the common carotid and vertebral arteries, an increase in the linear blood flow velocity and the Gosling pulsative index was revealed. In the intracranial segment, a decrease in the linear velocity of blood flow in the vertebral and main arteries was found, which in 42% of patients was combined with a decrease in the anatomical reserve of blood vessels due to a disconnected variant of the structure of the circle of Willis and / or the presence of obstructed venous outflow.

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