scholarly journals Parosteal Osteosarcoma: A Benign-Looking Tumour, Amenable to a Variety of Surgical Reconstruction

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Yogi Prabowo ◽  
Achmad Fauzi Kamal ◽  
Evelina Kodrat ◽  
Marcel Prasetyo ◽  
Samuel Maruanaya ◽  
...  
Keyword(s):  
Treatment Options ◽  
Surgical Reconstruction ◽  
Parosteal Osteosarcoma ◽  
Knee Arthrodesis ◽  
Tertiary Referral Hospital ◽  
Reconstruction Methods ◽  
Excellent Functional Outcome ◽  
Surface Osteosarcoma ◽  
Well Differentiated ◽  
Extracorporeal Irradiation

Osteosarcoma arising from cortical surface is classified into parosteal, periosteal and high-grade surface osteosarcoma. Along the spectrum, parosteal osteosarcoma occupies the well-differentiated end. It is a relatively rare disease entity, comprised only 4% of all osteosarcomas and barely reported in the literature. The objective of this study is to describe cases of parosteal osteosarcoma as well as a variety of treatment options amenable to such entity. Six cases of parosteal osteosarcoma were identified based on histopathological reports in a tertiary referral hospital in Jakarta, Indonesia between January 2001 and December 2019. The mean age was 29.8 years old; four of them (66.7%) were male. Distal end of femur was the most commonly involved bone (five cases, 83.3%). The patients were treated with wide excision followed by several different reconstruction methods: replacement with endoprosthesis, extracorporeal irradiation, knee arthrodesis, or prophylactic fixation. One of our patients presented with dedifferentiated component, and therefore was treated by limb ablation. While two cases died of pulmonary metastasis, other patients reported fair to excellent functional outcome.

scholarly journals Contribution of anterolateral ligament injuries to the knee joint instability and modern methods of their diagnostics

2020 ◽  
Vol 17 (3) ◽  
pp. 372-380
Author(s):  
O. O. Kostrub ◽  
Iu. V. Poliachenko ◽  
V. V. Кotiuk ◽  
M. A. Gerasimenko ◽  
V. B. Mazevych ◽  
...  
Keyword(s):  
Cruciate Ligament ◽  
Treatment Options ◽  
Functional Anatomy ◽  
Anterolateral Ligament ◽  
Surgical Reconstruction ◽  
Rotational Instability ◽  
Anatomical Features ◽  
Reconstruction Methods ◽  
Anterior Cruciate ◽  
Diagnostic Capabilities

Untreated damage to the anterolateral ligament of the knee is one of the residual rotational instability causes in patients with the ruptures of the anterior cruciate ligament after its perfect surgical reconstruction. The contribution of anterolateral ligament damage to rotational instability of the knee, its anatomical features, diagnostics and treatment have been widely discussed in the literature in recent decades. However, the insights in the fundamental issues of its anatomy and functional anatomy, and therefore the reconstruction methods and expediency are diametrically positive. Differences in the anatomy data lead to the uncertainty in diagnostic criteria and optimal treatment options. Anterolateral ligament in its nature is beyond the current-day diagnostic capabilities of magnetic resonance imaging. We have identified the reasons for disagreement among the researchers in the anatomy of an anterolateral ligament, the best ways to diagnose and treat its damage. We have suggested the ways to address these issues in this article.

Immunotherapy and potential predictive biomarkers in the treatment of neuroendocrine neoplasia

2020 ◽  
Author(s):  
Guanghui Xu ◽  
Yuhao Wang ◽  
Hushan Zhang ◽  
Xueke She ◽  
Jianjun Yang
Keyword(s):  
Current Knowledge ◽  
Checkpoint Inhibitors ◽  
Treatment Options ◽  
Predictive Biomarkers ◽  
The Body ◽  
Low Grade ◽  
Ablative Therapies ◽  
Cancer Types ◽  
New Treatment ◽  
Well Differentiated

Neuroendocrine neoplasias (NENs) are a heterogeneous group of rare tumors scattered throughout the body. Surgery, locoregional or ablative therapies as well as maintenance treatments are applied in well-differentiated, low-grade NENs, whereas cytotoxic chemotherapy is usually applied in high-grade neuroendocrine carcinomas. However, treatment options for patients with advanced or metastatic NENs are limited. Immunotherapy has provided new treatment approaches for many cancer types, including neuroendocrine tumors, but predictive biomarkers of immune checkpoint inhibitors (ICIs) in the treatment of NENs have not been fully reported. By reviewing the literature and international congress abstracts, we summarize the current knowledge of ICIs, potential predicative biomarkers in the treatment of NENs, implications and efficacy of ICIs as well as biomarkers for NENs of gastroenteropancreatic system, lung NENs and Merkel cell carcinoma in clinical practice.

scholarly journals Trauma in Oculoplastic Surgery A Review

2020 ◽  
Vol 76 (3) ◽  
pp. 103-110
Author(s):  
Adam Kopecký ◽  
Jan Němčanský
Keyword(s):  
Treatment Options ◽  
Surgical Reconstruction ◽  
Local Antibiotics ◽  
Lacrimal System ◽  
Aesthetic Results ◽  
Immediate Surgery ◽  
Systemic Antibiotics ◽  
Multi Disciplinary Team ◽  
Complex Injuries ◽  
Oculoplastic Surgery

The aim of this article is to present the basics of traumatology in oculoplastic surgery and to review the literature about this topic. This review sums up the problematic of injuries of the eyelid, lacrimal system and orbit. The most important types of trauma, their treatment options, and the most common complications are described. In majority of oculoplastic traumas, surgical reconstruction is the treatment of choice. The surgery is often performer immediately, but sometimes the reconstruction of eyelid and lacrimal injuries can be postponed up to 48 hours, if the immediate surgery is not possible. Although the recommendations from the literature on this topic are variable, most of the patients require at least local antibiotics, more complex traumas systemic antibiotics. Careful diagnostics and correctly performed surgical treatment, either only by ophthalmologist, or oculoplastic surgeon, or a multi-disciplinary team for more complex injuries, are the key to good functional and aesthetic results of the reconstruction.

scholarly journals Rehabilitation of an Auricular Defect using Spectacle Retained Silicone Ear Prosthesis and Ear Stent

2012 ◽  
Vol 2 (1) ◽  
pp. 29-33 ◽  
Author(s):  
Kasim Mohamed ◽  
Anandkumar Vaidyanathan ◽  
Umamaheswari Mani ◽  
Yadharth Bhatia ◽  
Padmanabhan Thallam Veeravalli
Keyword(s):  
Surgical Intervention ◽  
Treatment Options ◽  
Cost Effective ◽  
Surgical Reconstruction ◽  
Facial Structure ◽  
Patient’S Satisfaction ◽  
Facial Prosthesis ◽  
Correct Direction ◽  
Auricular Defects ◽  
The Needy

ABSTRACT Auricular defects resulting from skin cancer, trauma or congenital cause present reconstructive challenges. Surgical reconstruction may provide effective results for smaller and larger defects. However, some patients do not prefer surgical intervention for rehabilitation due to fear of pain. The use of silicone material for fabrication of facial prosthesis has made it possible to acceptably restore what has been lost. The application of skill and resources in the correct direction can provide the needy patients good treatment options that are cost-effective and esthetically acceptable. This article describes a simple clinical technique to rehabilitate patients with auricular defects. The purpose of this treatment was to minimize the extent of surgical intervention and to restore the lost facial structure to patient's satisfaction in a manner that was both cosmetically elegant and cost-effective. How to cite this article Mohamed K, Vaidyanathan A, Mani U, Bhatia Y, Veeravalli PT. Rehabilitation of an Auricular Defect using Spectacle Retained Silicone Ear Prosthesis and Ear Stent. Int J Prosthodont Restor Dent 2012;2(1):29-33.

scholarly journals Clinical and Molecular Spectrum of Liposarcoma

2018 ◽  
Vol 36 (2) ◽  
pp. 151-159 ◽  
Author(s):  
Alex Thomas John Lee ◽  
Khin Thway ◽  
Paul H. Huang ◽  
Robin Lewis Jones
Keyword(s):  
Malignant Tumors ◽  
Treatment Options ◽  
Chromosomal Translocation ◽  
Myxoid Liposarcoma ◽  
Adipocytic Differentiation ◽  
Well Differentiated ◽  
Pharmaceutical Agents ◽  
Active Investigation ◽  
Treatment Sensitivity

Liposarcomas are rare malignant tumors of adipocytic differentiation. The classification of liposarcomas into four principal subtypes reflects the distinct clinical behavior, treatment sensitivity, and underlying biology encompassed by these diseases. Increasingly, clinical management decisions and the development of investigational therapeutics are informed by an improved understanding of subtype-specific molecular pathology. Well-differentiated liposarcoma is the most common subtype and is associated with indolent behavior, local recurrence, and insensitivity to radiotherapy and chemotherapy. Dedifferentiated liposarcoma represents focal progression of well-differentiated disease into a more aggressive, metastasizing, and fatal malignancy. Both of these subtypes are characterized by recurrent amplifications within chromosome 12, resulting in the overexpression of disease-driving genes that have been the focus of therapeutic targeting. Myxoid liposarcoma is characterized by a pathognomonic chromosomal translocation that results in an oncogenic fusion protein, whereas pleomorphic liposarcoma is a karyotypically complex and especially poor-prognosis subtype that accounts for less than 10% of liposarcoma diagnoses. A range of novel pharmaceutical agents that aim to target liposarcoma-specific biology are under active investigation and offer hope of adding to the limited available treatment options for recurrent or inoperable disease.

Surgical Reconstruction Options in Chronic Distal Biceps Tendon Ruptures – Case Report and Literature Review

2019 ◽  
Author(s):  
Hans-Joachim Riesner ◽  
Carsten Hackenbroch ◽  
Patricia Lang ◽  
Gerhard Achatz ◽  
Hans-Georg Palm ◽  
...  
Keyword(s):  
Biceps Tendon ◽  
Treatment Options ◽  
Surgical Techniques ◽  
Functional Results ◽  
Surgical Reconstruction ◽  
Medical Database ◽  
Distal Biceps Tendon ◽  
Distal Biceps ◽  
Tendon Ruptures ◽  
Tendon Grafts

Abstract Introduction Chronic distal biceps tendon ruptures are rare and conservative or operative treatment options are suitable. There is a consensus in the literature in case of acute traumatic ruptures the operative refixation should be preferred. Disagreement exists in the best way of care of old ruptures (> 4 weeks) of distal biceps tendon. Several kinds of refixation possibilities up to tendon grafts are described. Aim of this publication is showing an overview of the literature of the approved methods in reconstruction of the distal biceps tendon using autogenous and allogenic grafts, comparing the outcomes and transferring them on an own case. Material and Methods A literature research was carried out using the online medical database “PubMed” with the following keywords “chronic rupture distal biceps tendon, surgical techniques”. 59 citations were found concerning the topic, 37 publications were relevant for this work. Results There is consensus that even in chronic ruptures the operative management of the distal biceps tendon generates the best results. Consistently the experiences and results of only little patient collectives are reported. Numerous techniques of surgery are described without predominance of one method. Reinsertions of the tendon butts are reported in different techniques: with achilles, palmaris longus, fascia lata, triceps, quadriceps and semitendinosus tendon grafts. All together they showed postoperative satisfactory results. Conclusion With surgical treatment of chronic ruptured distal biceps tendons comparable outcomes can be achieved by primary refixation and graft augmentations. In case of graft augmentations several tissue options are available which showed in all cases satisfactory functional results in the end.

Parosteal osteosarcoma associated with a low-grade component mimicking well-differentiated liposarcoma: a case report

2020 ◽  
Vol 50 (1) ◽  
pp. 243-248
Author(s):  
P. Sohier ◽  
M. Rodrigues ◽  
P. Anract ◽  
A. Feydy ◽  
F. Larousserie
Keyword(s):  
Case Report ◽  
Low Grade ◽  
Parosteal Osteosarcoma ◽  
Well Differentiated

scholarly journals Refractory carcinoid syndrome: a review of treatment options

2016 ◽  
Vol 9 (2) ◽  
pp. 127-137 ◽  
Author(s):  
Rachel P. Riechelmann ◽  
Allan A. Pereira ◽  
Juliana F. M. Rego ◽  
Frederico P. Costa
Keyword(s):  
Carcinoid Syndrome ◽  
Treatment Options ◽  
Somatostatin Analogs ◽  
Current Treatment ◽  
Phase Iii ◽  
Treatment Sequence ◽  
First Line ◽  
Phase Iii Trials ◽  
Recent Phase ◽  
Well Differentiated

Carcinoid syndrome (CSy) is a constellation of symptoms that may commonly present in patients with well differentiated neuroendocrine tumors (NETs), with somatostatin analogs (SSAs) being the first-line option for symptom management. However, symptomatic progression eventually occurs and in this scenario of a refractory CSy; several treatment options have been studied such as dose escalation of SSA, interferon and liver-directed therapies. Nevertheless, recent phase III trials have contributed to the understanding and management of this condition. We performed a comprehensive review of interventional studies examining refractory CSy to provide the evidence for current treatment options and propose a treatment sequence.

scholarly journals Well Differentiated Intrahepatic Cholangiocarcinoma in the Setting of Biliary Papillomatosis: A Case Report and Review of the Literature

2005 ◽  
Vol 19 (12) ◽  
pp. 731-733 ◽  
Author(s):  
Heather Cox ◽  
Michael Ma ◽  
Ronald Bridges ◽  
Estifanos Debru ◽  
Oliver Bathe ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Intrahepatic Cholangiocarcinoma ◽  
Treatment Options ◽  
Transformation Rate ◽  
Review Of The Literature ◽  
Biliary Papillomatosis ◽  
Computed Tomography Scans ◽  
Extrahepatic Bile Ducts ◽  
Well Differentiated ◽  
Pain History

A 64-year-old man presented with long-standing, vague, epigastric abdominal pain. History, physical examination and laboratory studies were noncontributory. However, serial computed tomography scans revealed a rapidly progressive mass in segment 2 of the liver. Surprisingly, surgical pathology revealed a well-differentiated intrahepatic cholangiocarcinoma associated with biliary papillomatosis (BP). BP is a rare, benign and potentially fatal disease of the intra- and extrahepatic bile ducts. It is typified by numerous multicentric papillary fronds arising from biliary columnar epithelium. Most patients present with symptoms of jaundice and cholangitis. Although a benign disease, a review of the literature demonstrated that BP often recurs after surgical resection, carries a poor prognosis and has a moderately high malignant transformation rate. Treatment options for BP include surgical resection, transplant, ablation, stenting and/or bypass.

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