Bidirectional Interaction of Thyroid-Kidney Organs in Disease States

Purpose. Thyroid hormones play an important role in growth, development, and physiology of the kidney. The kidney plays a key role in the metabolism, degradation, and excretion of thyroid hormones and its metabolites. The aim of this study is to investigate the prevalence of disease states of thyroid-kidney organs and detecting the correlation between thyroid and kidney function abnormalities. Materials and Methods. In this retrospective study, a total of forty-five patients with thyroid and kidney dysfunction were investigated. Clinical features, laboratory data at initial presentation, management, and outcomes were collected. The paper has been written based on searching PubMed and Google Scholar to identify potentially relevant articles or abstracts. Median, percentage, mean ± standard deviation (SD), and the two-tailed t-test were used for statistical analyses. The correlation between variables was assessed by Pearson’s, Spearman’s correlation tests and regression analyses. Results. The mean ± SD of age of study patients was 48.2 ± 22.93 years (ranging from 1 to 90 years). There was no correlation between serum thyroid-stimulating hormone, free thyroxine levels with estimated glomerular filtration rate, and proteinuria. No association between antimicrosomal antibodies with estimated glomerular filtration rate was seen. Cardiovascular disease was the most common complication of overt hypothyroidism in kidney dysfunction patients. Conclusion. The present study showed more prevalence of primary hypothyroidism in comparison with other thyroid dysfunctions in patients with kidney dysfunction. Reduced mean values of thyroid function profiles after treatment suggest that this thyroid disease should be considered and ameliorated with thyroid hormone replacement therapy in patients with kidney disease.

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Change in Glomerular Filtration Rate with Febuxostat in Patients with Advanced Chronic Renal Failure

10.53350/pjmhs2115113293 ◽

2021 ◽

Vol 15 (11) ◽

pp. 3293-3295

Author(s):

Ishtiaq Alam ◽

Faheem Usman Sulehri ◽

Muhammad Abdul Azim Baig ◽

Maira Bhatti ◽

Fouzia Perveen ◽

...

Keyword(s):

Glomerular Filtration Rate ◽

Kidney Disease ◽

Serum Creatinine ◽

Serum Creatinine Level ◽

Glomerular Filtration ◽

Filtration Rate ◽

Estimated Glomerular Filtration Rate ◽

Mean Value ◽

Kidney Dysfunction ◽

The Mean

Background: Chronic kidney disease (CKD), is defined as progressive loss in kidney function. The study evaluated the mean change in estimated glomerular filtration rate (eGFR) with febuxostat in patients of advanced chronic kidney dysfunction with hyperuricemia. Methodology: A prospective observational study was conducted at the department of Nephrology, Sheikh Zayed Hospital, Lahore for 6 months, from January 2019 to October 2019. At baselines, the blood sample was obtained and sent to the laboratory for assessment of serum creatinine level. The eGFR was calculated by using the MDRD formula. Patients were then advised to take one oral Febuxostat 40 mg daily for 6 months. After 6 months, the blood sample was obtained for assessment of serum creatinine level. Results: The mean age of the patients was 40.72±14.90 years, male to female ratio was 1:1. The mean value of eGFR at baseline was 23.53±11.09 and its mean value at 6th month was 34.28+12.31, which was significant (p<0.001). Conclusion: Febuxostat effectively improved estimated glomerular filtration rate (eGFR) in patients presenting with advanced chronic kidney dysfunction with hyperuricemia. Keywords: Hyperuricemia, Kidney, Disease, Febuxostat, Dysfunction, Glomerular, Filtration

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Assessment of kidney dysfunction with cystatin C- and creatinine-based estimated glomerular filtration rate and predicting type 2 diabetes: Toranomon Hospital Health Management Center Study 21

Diabetes Research and Clinical Practice ◽

10.1016/j.diabres.2016.01.026 ◽

2016 ◽

Vol 113 ◽

pp. 60-68

Author(s):

Yoriko Heianza ◽

Shigeko Hara ◽

Kazumi Saito ◽

Hiroshi Tsuji ◽

Shiro Tanaka ◽

...

Keyword(s):

Type 2 Diabetes ◽

Glomerular Filtration Rate ◽

Glomerular Filtration ◽

Filtration Rate ◽

Estimated Glomerular Filtration Rate ◽

Health Management ◽

Kidney Dysfunction ◽

Toranomon Hospital ◽

Center Study

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Relationship between Plasma Proprotein Convertase Subtilisin/Kexin Type 9 and Estimated Glomerular Filtration Rate in the General Chinese Population

Cardiorenal Medicine ◽

10.1159/000490766 ◽

2018 ◽

Vol 8 (4) ◽

pp. 311-320 ◽

Cited By ~ 2

Author(s):

Hui-Wen Zhang ◽

Xi Zhao ◽

Rui-Xia Xu ◽

Yuan-Lin Guo ◽

Cheng-Gang Zhu ◽

...

Keyword(s):

Glomerular Filtration Rate ◽

Linear Regression ◽

Glomerular Filtration ◽

Filtration Rate ◽

Estimated Glomerular Filtration Rate ◽

Lipid Lowering ◽

Proprotein Convertase ◽

Kidney Dysfunction ◽

Significant Difference ◽

Spearman’S Correlation

Background: Elevated levels of proprotein convertase subtilisin/kexin type 9 (PCSK9) have been reported to be related to dyslipidemia, including patients with kidney dysfunction. However, its association with estimated glomerular filtration rate (eGFR) in individuals with normal serum creatinine (SCr) has not been determined. Methods: A total of 2,089 subjects with normal SCr and without lipid-lowering treatment were consecutively enrolled in this study. Plasma PCSK9 levels were measured by ELISA kit and eGFR was evaluated by the Chronic Kidney Disease Epidemiology Collaboration equation. Subjects were divided into a normal eGFR group (n = 1,205, ≥90 mL/min/1.73 m2) and a decreased eGFR group (n = 884, < 90 mL/min/1.73 m2). Baseline characteristics and laboratory findings were compared between the two groups. Spearman’s correlation and linear regression were performed to determine the association between PCSK9 and eGFR. Results: No significant difference in PCSK9 levels was found between the normal eGFR group and the decreased eGFR group (236.84 ± 67.87 vs. 239.98 ± 68.72 ng/mL, p = 0.303). In Spearman’s correlation and multivariable linear regression analysis, no association of PCSK9 levels with eGFR was detected in the total cohort (r = –0.039, p = 0.079; adjusted β = –0.013, p = 0.630). This result remained the same in the subgroups of normal eGFR (r = –0.038, p = 0.190; adjusted β = –0.031, p = 0.367) and decreased eGFR (r = –0.054, p = 0.109; adjusted β = –0.034, p = 0.319). Conclusion: In this single-center study with moderate sample size, the data showed no relationship of PCSK9 levels with normal or decreased eGFR in untreated patients with normal SCr, suggesting that further studies may be needed to understand the relationship between PCSK9 and lipid disorder in different stage of kidney dysfunction.

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Study on relationship between stroke and kidney dysfunction based on estimated glomerular filtration rate (eGFR)

Bangladesh Journal of Physiology and Pharmacology ◽

10.3329/bjpp.v29i1-2.20062 ◽

2014 ◽

Vol 29 (1-2) ◽

pp. 12-16

Author(s):

Sharmin Jahan ◽

Rokeya Begum ◽

Qazi Shamima Akhter

Keyword(s):

Glomerular Filtration Rate ◽

Glomerular Filtration ◽

Filtration Rate ◽

Estimated Glomerular Filtration Rate ◽

Control Group ◽

Normal Person ◽

Stroke Patients ◽

Kidney Dysfunction ◽

Group A ◽

Group B

Background: Stroke is one of the commonest causes of severe disability and accounts for a large proportion of health care resources. Kidney diseases are related to stroke and reduced estimated glomerular filtration rate (eGFR) appears to be a significant independent prognostic factor for short as well as long term mortality in stroke patients. Objective: The present study has been designed to assess the relationship between stroke and kidney dysfunction based on eGFR. Methods: The present study was a case control study. The study was conducted in the Department of Physiology, Dhaka Medical College and Hospital (DMCH), Dhaka from 1st July 2010 to 30th June 2011. A total of 200 subjects were included with the age limit of 3585 years. Out of them 100 apparently healthy subjects were selected as control(Group A) for comparison and 100 diagnosed stroke patients were selected as study group (Group B). On the basis of age, group A and group B were further subdivided into group A1(age 35-59 years) consisting of 47 normal persons and group A2(age 60-85 years) consisting of 53 normal person, group B1(age35-59 years) was consisting of 42 stroke patients and group B2(60-85 years) consisting of 58 stroke patients .The study subjects were selected from admitted patients in Department of Medicine, DMCH, Dhaka. Estimated GFR (eGFR) were measured by MDRD equation. The data was analyzed by computer based statistical software (SPSS version 12). Results: The result was expressed as Mean (+SD). The test of significance was calculated and p values <0.05 was accepted as level of significance. The mean(±SD)of eGFR level was significantly(p<0.001) lower in group B1 and B2 than that of group A1 and A2 respectively.Conclusion: From this study it can be concluded that, stroke patients suffers from kidney dysfunction than that of normal control group on the basis of measuring eGFR.http://dx.doi.org/10.3329/bjpp.v29i1-2.20062 Bangladesh J Physiol Pharmacol 2013; 29(1&2) : 12-16

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