scholarly journals Study on relationship between stroke and kidney dysfunction based on estimated glomerular filtration rate (eGFR)

2014 ◽  
Vol 29 (1-2) ◽  
pp. 12-16
Author(s):  
Sharmin Jahan ◽  
Rokeya Begum ◽  
Qazi Shamima Akhter
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Control Group ◽  
Normal Person ◽  
Stroke Patients ◽  
Kidney Dysfunction ◽  
Group A ◽  
Group B

Background: Stroke is one of the commonest causes of severe disability and accounts for a large proportion of health care resources. Kidney diseases are related to stroke and reduced estimated glomerular filtration rate (eGFR) appears to be a significant independent prognostic factor for short as well as long term mortality in stroke patients. Objective: The present study has been designed to assess the relationship between stroke and kidney dysfunction based on eGFR. Methods: The present study was a case control study. The study was conducted in the Department of Physiology, Dhaka Medical College and Hospital (DMCH), Dhaka from 1st July 2010 to 30th June 2011. A total of 200 subjects were included with the age limit of 35–85 years. Out of them 100 apparently healthy subjects were selected as control(Group A) for comparison and 100 diagnosed stroke patients were selected as study group (Group B). On the basis of age, group A and group B were further subdivided into group A1(age 35-59 years) consisting of 47 normal persons and group A2(age 60-85 years) consisting of 53 normal person, group B1(age35-59 years) was consisting of 42 stroke patients and group B2(60-85 years) consisting of 58 stroke patients .The study subjects were selected from admitted patients in Department of Medicine, DMCH, Dhaka. Estimated GFR (eGFR) were measured by MDRD equation. The data was analyzed by computer based statistical software (SPSS version 12). Results: The result was expressed as Mean (+SD). The test of significance was calculated and p values <0.05 was accepted as level of significance. The mean(±SD)of eGFR level was significantly(p<0.001) lower in group B1 and B2 than that of group A1 and A2 respectively.Conclusion: From this study it can be concluded that, stroke patients suffers from kidney dysfunction than that of normal control group on the basis of measuring eGFR.http://dx.doi.org/10.3329/bjpp.v29i1-2.20062 Bangladesh J Physiol Pharmacol 2013; 29(1&2) : 12-16 

scholarly journals Radiofrequency renal denervation with different device for treatment in patient with uncontrolled hypertension

2018 ◽  
Vol 15 (4) ◽  
pp. 34-38 ◽  
Author(s):  
R A Agaeva ◽  
N M Danilov ◽  
G V Shelkova ◽  
O V Sagaydak ◽  
V A Grigin ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Arterial Hypertension ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Renal Denervation ◽  
Renal Arteries ◽  
General Group ◽  
Radiofrequency Denervation ◽  
Group A ◽  
Group B

Objective. To study the efficacy and safety of radiofrequency renal denervation with mono-electrode and multi-electrode devices in patients with uncontrolled arterial hypertension during follow-up period. Materials and methods. The study included 42 patients with uncontrolled arterial hypertension (mean age 51±12 years), while receiving multicomponent antihypertensive therapy, including diuretic. All patients underwent radiofrequency denervation of the renal arteries with a mono-electrode (n=27; group A) and multi-electrode devices (n=15; group B). The safety of the procedure was assessed using creatinine and glomerular filtration rate (MDRD equation), as well as according to ultrasound of the kidneys and renal arteries. The effectiveness of the procedure was study according to office blood pressure (BP) and ambulatory BP monitoring (ABPM). Results. In the general group, according to office BP after 6 months, there decreased in systolic (SBP)/diastolic BP (DBP) by 28/13 mm Hg (p=0.000001). According to ABPM, there was a decrease in the average daily SBP by 9 mm Hg (p=0.007) and DBP by 6 mm Hg (p=0.03). No significant changes in creatinine and glomerular filtration rate were detected in the general group. According to ABPM, after 6 months in group B, there was a decrease in the average daily SBP/DBP by 13 and 6 mm Hg (p=0.1). In group A, according to the ABPM, after 6 months, there was a decrease in the average daily SBP and DBP by 7 mm Hg (p=0.001) and 4 mm Hg (p=0.03). After 1 year, according to the office BP, there was a decrease in SBP/DBP by 14/11 mm Hg (p=0.002), and after 3 years at 15/17 mm Hg (p=0.3). Conclusion. The results confirm the safety and efficacy of radiofrequency renal denervation. Renal denervation in combination with drug therapy leads to decreasing of BP after 6 months and in the long-term

Change in Glomerular Filtration Rate with Febuxostat in Patients with Advanced Chronic Renal Failure

2021 ◽  
Vol 15 (11) ◽  
pp. 3293-3295
Author(s):  
Ishtiaq Alam ◽  
Faheem Usman Sulehri ◽  
Muhammad Abdul Azim Baig ◽  
Maira Bhatti ◽  
Fouzia Perveen ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Kidney Disease ◽  
Serum Creatinine ◽  
Serum Creatinine Level ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Mean Value ◽  
Kidney Dysfunction ◽  
The Mean

Background: Chronic kidney disease (CKD), is defined as progressive loss in kidney function. The study evaluated the mean change in estimated glomerular filtration rate (eGFR) with febuxostat in patients of advanced chronic kidney dysfunction with hyperuricemia. Methodology: A prospective observational study was conducted at the department of Nephrology, Sheikh Zayed Hospital, Lahore for 6 months, from January 2019 to October 2019. At baselines, the blood sample was obtained and sent to the laboratory for assessment of serum creatinine level. The eGFR was calculated by using the MDRD formula. Patients were then advised to take one oral Febuxostat 40 mg daily for 6 months. After 6 months, the blood sample was obtained for assessment of serum creatinine level. Results: The mean age of the patients was 40.72±14.90 years, male to female ratio was 1:1. The mean value of eGFR at baseline was 23.53±11.09 and its mean value at 6th month was 34.28+12.31, which was significant (p<0.001). Conclusion: Febuxostat effectively improved estimated glomerular filtration rate (eGFR) in patients presenting with advanced chronic kidney dysfunction with hyperuricemia. Keywords: Hyperuricemia, Kidney, Disease, Febuxostat, Dysfunction, Glomerular, Filtration

scholarly journals Edaravone in contrast-induced acute kidney injury prophelaxis

2020 ◽  
Vol 27 (1) ◽  
pp. 39-44
Author(s):  
D. D. Ivanov ◽  
M. D. Ivanova ◽  
I. I. Burlachenko
Keyword(s):  
Acute Kidney Injury ◽  
Glomerular Filtration Rate ◽  
Contrast Media ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Kidney Injury ◽  
Controlled Study ◽  
Ckd Stage ◽  
Group A ◽  
Group B

The aim – to evaluate the effectiveness of edaravon in preventing the development of contrast-induced acute kidney injury. Materials and methods. We have conducted a multicenter open prospective randomized controlled study to evaluate the efficacy of edaravone in preventing contrast-induced acute kidney injury in patients with chronic kidney disease (CKD) 3b–4 stages. The study included 2 groups of patients aged 46 to 68 (55±3): group A (n=16) with CKD stage 3b or 4 (еstimated glomerular filtration rate (formula СКD-EPI) 32±4 ml/min) that received intravenous edaravone 30 mg bid on 0, 1, 2 day of contrast media infusion and control group B (n=20) with CKD stage 3b or 4 (еstimated glomerular filtration rate 33±3 ml/min) with no edaravone intervention during CT coronarography. Patients of both groups received intravenous hydration with 0.9 % sodium before CT. Primary endpoint: contrast-induced acute kidney injury onset in 48 hours after contrast media infusion and need for RRT. Secondary endpoint: serum potassium level above 5.5 mmol/l. Results. Contrast-induced acute kidney injury onset was obtained in 4 patients of group A and 12 patients of group B (p≤0.05, RR 0.417, RRR 0.583, RD 0.350, NNT 2.857). The results shows statistical significance both of endpoints which demonstrates the promising possibilities for contrast-induced acute kidney injury prophylaxis with edaravone in CKD 3b–4. Individual data analyses shows that edaravone was more effective in CKD 3b (3 cases of contrast-induced acute kidney injury of 10) instead of CKD 4 (1 of 2). Conclusions. Edaravone is promising solution for contrast-induced acute kidney injury prevention in patients with CKD 3b–4 who urgently undergo CT coronarography

scholarly journals Reduced glomerular filtration rate and prior cardiovascular event entail similar risk for coronary atherosclerotic burden

2019 ◽  
Author(s):  
Pamela Angela Piscitelli ◽  
Antonio Mangiacotti ◽  
Nicola Marchese ◽  
Eulalia Valentina Greco ◽  
Maria Maddalena D'Errico ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Cardiovascular Event ◽  
Filtration Rate ◽  
Large Population ◽  
Vessel Disease ◽  
Atherosclerotic Burden ◽  
Group A ◽  
Group B ◽  
Group D

Abstract Background: Prior cardiovascular event and kidney dysfunction are both strong risk factor for coronary artery disease. Aim of this study is to assess coronary atherosclerotic burden in a large population of patients undergoing coronary angiography, according to the prior cardiovascular event or chronic kidney disease. Methods: We evaluated 700 consecutive patients who underwent CA. Serum creatinine to estimate glomerular filtration rate (eGFR) was measured. Clinically significant CAD was defined by the presence of a coronary lesion resulting in a luminal stenosis >50%. For the purpose of the study, the whole population was divided into 4 subgroups according to the presence/absence of eGFR <60 ml/min/1.73 m2 or prior cardiovascular event: eGFR≥60/no event (Group A), eGFR≥60/yes event (Group B), eGFR<60/no event (Group C), eGFR<60/yes event (Group D). Results: As expected, patients in group D had the worst clinical and biochemical profile. These patients also showed the highest values of ACR (p<0.001) and the lowest values of eGFR (p<0.01). One-hundred-ninety-six patients had three vessel disease. Considering group A as reference, the risk of having three-vessel disease was increased in group B (OR= 2.09; 95% CI 1.37-3.19), in group C, (OR= 1.80; 95% CI 1.04-3.14) and finally in group D (OR= 3.35; 95% CI 2.01-5.58). The risk carried by group C was not significantly different from that carried by Group B: OR= 0.86; 95% CI 0.5-1.5. Conclusions: In our study low eGFR seems to have the same excess risk of prior CV event.

scholarly journals Relationship between Plasma Proprotein Convertase Subtilisin/Kexin Type 9 and Estimated Glomerular Filtration Rate in the General Chinese Population

2018 ◽  
Vol 8 (4) ◽  
pp. 311-320 ◽  
Author(s):  
Hui-Wen Zhang ◽  
Xi Zhao ◽  
Rui-Xia Xu ◽  
Yuan-Lin Guo ◽  
Cheng-Gang Zhu ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Linear Regression ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Lipid Lowering ◽  
Proprotein Convertase ◽  
Kidney Dysfunction ◽  
Significant Difference ◽  
Spearman’S Correlation

Background: Elevated levels of proprotein convertase subtilisin/kexin type 9 (PCSK9) have been reported to be related to dyslipidemia, including patients with kidney dysfunction. However, its association with estimated glomerular filtration rate (eGFR) in individuals with normal serum creatinine (SCr) has not been determined. Methods: A total of 2,089 subjects with normal SCr and without lipid-lowering treatment were consecutively enrolled in this study. Plasma PCSK9 levels were measured by ELISA kit and eGFR was evaluated by the Chronic Kidney Disease Epidemiology Collaboration equation. Subjects were divided into a normal eGFR group (n = 1,205, ≥90 mL/min/1.73 m2) and a decreased eGFR group (n = 884, < 90 mL/min/1.73 m2). Baseline characteristics and laboratory findings were compared between the two groups. Spearman’s correlation and linear regression were performed to determine the association between PCSK9 and eGFR. Results: No significant difference in PCSK9 levels was found between the normal eGFR group and the decreased eGFR group (236.84 ± 67.87 vs. 239.98 ± 68.72 ng/mL, p = 0.303). In Spearman’s correlation and multivariable linear regression analysis, no association of PCSK9 levels with eGFR was detected in the total cohort (r = –0.039, p = 0.079; adjusted β = –0.013, p = 0.630). This result remained the same in the subgroups of normal eGFR (r = –0.038, p = 0.190; adjusted β = –0.031, p = 0.367) and decreased eGFR (r = –0.054, p = 0.109; adjusted β = –0.034, p = 0.319). Conclusion: In this single-center study with moderate sample size, the data showed no relationship of PCSK9 levels with normal or decreased eGFR in untreated patients with normal SCr, suggesting that further studies may be needed to understand the relationship between PCSK9 and lipid disorder in different stage of kidney dysfunction.

scholarly journals Urine cytokine profile and nephroprotective effect of lercanidipine in patients with urolithiasis with obstructive uropathy before and after nephrostomy

2018 ◽  
Vol 8 (3) ◽  
pp. 20-27
Author(s):  
Vladimir M. Popkov ◽  
Natalia B. Zakharova ◽  
Alexander B. Polozov ◽  
Anastasiia I. Khotko ◽  
Dmitrii N. Khotko ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Kidney Stones ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Solid Phase ◽  
Obstructive Uropathy ◽  
Control Group ◽  
Gm Csf ◽  
Nephroprotective Effect

Objective. To study the nephroprotective effect of lercanidipine and its influence on creatinine clearance and cytokine damage in patients with urolithiasis with obstructive uropathy. Material and methods. Of 96 patients evaluated, 66 were diagnosed with kidney stones in the ureteropelvic segment and obstructive uropathy, which was then treated with percutaneous nephrostomy. All 66 patients were given antibacterial and anti-inflammatory therapy to prevent postoperative infections, but in addition, 33 were treated with lercanidipine, 10 mg per day. IL-8, VEGF, MCP-1, G-CSF, and GM-CSF concentrations in the urine were determined by solid-phase ELISA. The estimated glomerular filtration rate was calculated using the CKD-EPI formula. All studies were done preoperatively and on days 7, 14, 21, and 28 after nephrostomy. A control group consisted of 30 people with kidney stones without sings of obstruction. Results. In the patients with obstructive uropathy, a correlation was found between VEGF, IL-8, and MCP-1 concentrations in the urine and the serum creatinine and estimated glomerular filtration rate. Patients in the lercanidipine group had a faster decrease in IL-8, VEGF, MCP-1, and GM-CSF concentrations in the urine and improved renal function compared with patients who did not receive lercanidipine. By day 21 after nephrostomy, the lercanidipine group had values comparable with the control group, whereas the group not treated with lercanidipine did not achieve similar values until day 28. Conclusion. The third generation calcium channel blocker lercanidipine is nephroprotective in patients with obstructive uropathy.

Association between estimated glomerular filtration rate, ankle-brachial index, and recurrent ischemic stroke in a Chinese population of ischemic stroke patients

VASA ◽  
2013 ◽  
Vol 42 (3) ◽  
pp. 177-183 ◽  
Author(s):  
Yong L. Wang ◽  
Heng Ma ◽  
Jun Yang ◽  
Jue Li ◽  
Xiaochen Hao ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Chinese Population ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Ankle Brachial Index ◽  
Stroke Patients ◽  
Study Results

Background: Very few studies have examined combined association of estimated glomerular filtration rate (eGFR) and ankle-brachial index (ABI) on recurrent ischemic stroke in patients with ischemic stroke in Chinese populations. Patients and methods: A Chinese population of 1219 ischemic stroke patients was followed up in this six-year prospective study. Results: 1080 ischemic stroke patients with complete follow-up data were included in the statistical analysis. A total of 245 ischemic stroke patients (22.7 %) had recurrent ischemic stroke during follow-up. The Incidence of recurrent ischemic stroke was significantly increased with decreasing eGFR levels and that of patients with eGFR < 30 ml/min/1.73m2 was the highest. Hazard ratio (HR) of eGFR < 30 ml/min/1.73m2 to recurrent ischemic stroke was 2.633 (95 % CI: 1.653 - 4.194) compared with that of eGFR ≥ 60 ml/min/1.73m2 after adjusting for other potential confounders using Cox regression analysis. Incidence of recurrent ischemic stroke was significantly increased with simultaneously decreasing eGFR and ABI. The highest percentage (71.4 %) of patients with eGFR < 30 ml/min/1.73m2 and ABI ≤ 0.4 simultaneously had recurrent ischemic stroke during follow-up. HR of eGFR < 30 ml/min/1.73m2 and ABI ≤ 0.4 simultaneously with recurrent ischemic stroke was 9.415 (95 % CI: 3.479 - 25.483) compared with that of eGFR ≥ 60 ml/min/1.73m2 and ABI > 1.0 to ≤ 1.4 respectively Conclusions: Low ABI and low eGFR together had synergistic effects on increasing recurrent ischemic stroke of ischemic stroke patients during a long-term follow-up.

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