Qatari Genotype May Contribute to Complications in Type 2 Diabetes

Objective. There is increasing evidence of a strong genetic component in type 2 diabetes (T2DM) that may contribute to diabetes complications. Given the high prevalence of diabetes with its associated complications in the Middle East, we sought to determine if the genotype within a Middle East population may be contributory. Therefore, three genotype-based Qatari ancestral groups, Q1 Arab Bedouin, Q2 Asian/Persian, and Q3 sub-Saharan African, with a fourth admixed group were correlated with T2DM prevalence and its complications to determine if they differed between the 4 Qatari ancestries, particularly for the SLMAP allele-associated diabetic retinopathy. Methods. In this cross-sectional study, 398 Qatari subjects, 220 with and 178 without T2DM, were genotyped by Affymetrix 500k SNP arrays. Ancestry was correlated with diabetes complications. Results. 398 subjects were included, the mean age was 49.8 years, and 56.8% were male. The genotype-based ancestry and T2DM prevalence were as follows: 164 (41.2%) with ancestry Q1, 60.4% with T2DM; 149 (37.4%) with ancestry Q2, 49.7% with T2DM; 31 (7.8%) with ancestry Q3, 61.3% with T2DM; and 54 (13.6%) with “admixed” ancestry, 51.9% with T2DM. For patients with diabetes, hypertension (p<0.035) and retinopathy (p<0.016) were greater in the Q3 ancestry. Conclusion. These data suggest that the genotype may contribute to complication risk, as exemplified by the increase in hypertension and retinopathy in the Q3 ancestry, though the SLMAP allele was not implicated; however, diabetes prevalence did not differ between the four Qatari ancestries.

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Association between obesity and depression in patients with diabetes mellitus type 2; a study protocol

F1000Research ◽

10.12688/f1000research.5995.1 ◽

2015 ◽

Vol 4 ◽

pp. 7 ◽

Cited By ~ 4

Author(s):

Eduardo De la Cruz-Cano ◽

Carlos Alfonso Tovilla-Zarate ◽

Emilio Reyes-Ramos ◽

Thelma Beatriz Gonzalez-Castro ◽

Isela Juarez-Castro ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Diabetes Mellitus Type 2 ◽

Cross Sectional Study ◽

Diabetes Mellitus Type ◽

Sectional Study ◽

Cross Sectional ◽

The World ◽

Patients With Diabetes

Background: Diabetes mellitus and depression are highly prevalent conditions throughout the world and have significant impact on health outcomes. It has been estimated that diabetes mellitus type 2 affects about 246 million people in the world; nevertheless, incidence varies among countries. There is evidence that depression is associated with a poor metabolic control in patients with type 2 diabetes mellitus that present other health problems (such as hypertension and obesity). The aim of this study protocol is to determine if obesity increases the risk for depression in patient with diabetes type 2.Methods: The analysis will be reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).The studies suitable for inclusion will be assessed by the Newcastle-Ottawa Scale (NOS) to determine their methodological quality. To identify the studies of interest, we will search on PubMed and EBSCO databases. We will use the following keyword combinations: "Diabetes Mellitus type 2 AND obesity AND depression", "depression AND Diabetes Mellitus type 2", "Diabetes Mellitus type 2 AND body mass index cross sectional study", "depression AND obesity cross-sectional study". Causes for exclusion will be publications that studied patients diagnosed with diabetes mellitus type 1; articles that focused on the treatment and complications of diabetes mellitus type 2; publications that have studied other clinical or psychiatric conditions (for instance, seizure disorder or history of schizophrenia, bipolar disorder, psychotic symptoms or dementia).Conclusion: The results of this study will form the basis for a better understanding of the association between obesity and depression in patients with diabetes mellitus type 2, and will allow development of prediction tools and better interventions. It is evident that several modifiable and non-modifiable risk factors play an important role in the pathogenesis of diabetes among population. Currently, evidence for the deleterious effects of diabetes mellitus type 2 are based on cross-sectional or other observational designs. Therefore, this study will have important implications for future research and public health guidance.

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Effect of Type 2 Diabetes Mellitus on the Hypoxia-Inducible Factor 1-Alpha Expression. Is There a Relationship with the Clock Genes?

Journal of Clinical Medicine ◽

10.3390/jcm9082632 ◽

2020 ◽

Vol 9 (8) ◽

pp. 2632

Author(s):

Carolina López-Cano ◽

Liliana Gutiérrez-Carrasquilla ◽

Ferran Barbé ◽

Enric Sánchez ◽

Marta Hernández ◽

...

Keyword(s):

Type 2 Diabetes ◽

Clock Genes ◽

Univariate Analysis ◽

Hypoxia Inducible Factor ◽

Multivariate Regression Analysis ◽

Cross Sectional Study ◽

Orphan Receptor ◽

Cross Sectional ◽

Patients With Diabetes

Limited reports exist on the relationships between regulation of oxygen homeostasis and circadian clock genes in type 2 diabetes. We examined whether the expression of Hypoxia-Inducible Factor-1α (HIF-1α) and HIF-2α relates to changes in the expression of clock genes (Period homolog proteins (PER)1, PER2, PER3, Retinoid-related orphan receptor alpha (RORA), Aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL), Circadian locomotor output cycles kaput (CLOCK), and Cryptochrome proteins (CRY) 1 and CRY2) in patients with type 2 diabetes. A total of 129 subjects were evaluated in this cross-sectional study (48% with diabetes). The gene expression was measured by polymerase chain reaction. The lactate and pyruvate levels were used as surrogate of the hypoxia induced anaerobic glycolysis activity. Patients with diabetes showed an increased plasma concentration of both lactate (2102.1 ± 688.2 vs. 1730.4 ± 694.4 uM/L, p = 0.013) and pyruvate (61.9 ± 25.6 vs. 50.3 ± 23.1 uM/L, p = 0.026) in comparison to controls. However, this finding was accompanied by a blunted HIF-1α expression (1.1 (0.2 to 5.0) vs. 1.7 (0.4 to 9.2) arbitrary units (AU), p ≤ 0.001). Patients with diabetes also showed a significant reduction of all assessed clock genes’ expression. Univariate analysis showed that HIF-1α and almost all clock genes were significantly and negatively correlated with HbA1c concentration. In addition, positive correlations between HIF-1α and the clock genes were observed. The stepwise multivariate regression analysis showed that HbA1c and clock genes independently predicted the expression of HIF-1α. Type 2 diabetes modifies the expression of HIF-1α and clock genes, which correlates with the degree of metabolic control.

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Dietary Attitude of Adults with Type 2 Diabetes Mellitus in the Kingdom of Saudi Arabia: A Cross-Sectional Study

Medicina ◽

10.3390/medicina56020091 ◽

2020 ◽

Vol 56 (2) ◽

pp. 91 ◽

Cited By ~ 1

Author(s):

Waqas Sami ◽

Khalid M Alabdulwahhab ◽

Mohd Rashid Ab Hamid ◽

Tariq A. Alasbali ◽

Fahd Al Alwadani ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Saudi Arabia ◽

Dietary Behavior ◽

Cross Sectional Study ◽

Sectional Study ◽

Kingdom Of Saudi Arabia ◽

Cross Sectional ◽

Patients With Diabetes

Background and Objectives: There is a paucity of literature on the dietary attitude (DA) of patients with type 2 diabetes in the Kingdom of Saudi Arabia (KSA). Although the prevalence of diabetes mellitus (DM) is high in Gulf countries, there remains a lack of understanding of the importance of dietary behavior in diabetes management among patients. Understanding the behavior of patients with diabetes towards the disease requires knowledge of their DA. Therefore, this study aimed to assess and evaluate the DA of type 2 diabetes patients, and it is the first of its kind in the KSA. Material and Methods: An analytical cross-sectional study was conducted among 350 patients with type 2 diabetes. A self-administered DA questionnaire was used to collect the data. Psychometric properties of the questionnaire were assessed by face validity, content validity, exploratory factor analysis, and internal consistency reliability. The data were collected using a systematic random sampling technique. Results: The overall DA of the patients was inappropriate (p = 0.014). Patients had an inappropriate DA towards food selection (p = 0.003), healthy choices (p = 0.005), food restraint (p < 0.001), health impact (p < 0.001), and food categorization (p = 0.033). A poor DA was also observed in relation to the consumption of red meat (p <0.001), rice (p < 0.001), soup and sauces (p = 0.040), dairy products (p = 0.015), and junk food (p < 0.001). Conclusions: It is highly recommended that patients with diabetes receive counseling with an empowerment approach, as this can bring about changes in their dietary behavior, which is deeply rooted in their daily routine. Healthcare providers should also be well-informed about patients’ attitudes and beliefs towards diabetes to design tailored educational and salutary programs for this specific community. Diabetes self-management educational programs should also be provided on a regular basis with a special emphasis on diet and its related components.

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Evaluation of the Predictive Power of the Health Belief Model on the Care of Kidney in Type 2 Patients With Diabetes: a Cross-sectional Study

10.21203/rs.3.rs-757538/v1 ◽

2021 ◽

Author(s):

mallihe faramarzi ◽

mohsen shamsi ◽

mahboobeh khorsandi ◽

amir hashyani almasi

Keyword(s):

Type 2 Diabetes ◽

Health Belief Model ◽

Kidney Failure ◽

Health Belief ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Patients With Diabetes ◽

Belief Model

Abstract Background: Kidney failure is one of the most important late complication in type 2 patients with diabetes, so more of half-people are wait to graft kidney are people that caused to diabetes. The purpose of this study, was predict to care of kidney in type 2 diabetes patients based on Health Belief Model (HBM).Methods: In this analytical cross-sectional study, 242 patients with type 2 diabetes select with simple sampling of health centers in Arak ( a city in Iran) in 2020 and health behaviors of kidneys collected based on HBM with reliable and validity of questionaries’ and analyses by linear regression logistic.Results: The mean age of patients was 47.51 ±7.86 years. FBS average was 159.65 ± 55.01 mi/dc and average of performance of patients about care of kidney was 30/31± 6/42. Among HBM construct predicted about %38 perceived severity, %67.6 knowledge, %31.8 self-efficacy and %16.4 internal cues to action, these cases have the most power for prediction and total of construct predict health behavior of kidneys that are about %49. Conclusion: This study showed that increasing patients information in field of recognizing kidney failure, emphasis on role of cues to action and finally increasing self-efficacy in patients with type 2 diabetes about care of kidney should be emphasis in education programs for preventing of kidney failure.

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High prevalence of peripheral neuropathy in type 2 diabetes: a hospital based cross sectional study from South India

10.26226/morressier.59d51849d462b80296ca30c0 ◽

2017 ◽

Author(s):

Sankar Prasanth

Keyword(s):

Type 2 Diabetes ◽

Peripheral Neuropathy ◽

South India ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

High Prevalence

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Frequency and Determinants of Erectile Dysfunction among Type 2 Diabetes Patients in a Tertiary Health Institution in Nigeria

Journal of Advances in Medicine and Medical Research ◽

10.9734/jammr/2020/v32i2330726 ◽

2020 ◽

pp. 139-147

Author(s):

Michael A. Olamoyegun ◽

Oluwabukola A. Ala ◽

Emmanuel Y. Fagbemiro

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Erectile Dysfunction ◽

Cross Sectional Study ◽

Diabetes Clinic ◽

Cross Sectional ◽

Health Institution ◽

High Prevalence ◽

Diabetes And Obesity

Background: Sexual dysfunction of which erectile dysfunction is one of the complications usually occurred in men with diabetes mellitus. Hence this study aimed to assess the prevalence and analyze risk factors for erectile dysfunction (ED) in patients with type 2 diabetes mellitus (DM). Materials and Methods: This is a cross-sectional study of 147 men with type 2 DM recruited from the diabetes clinic of a tertiary health institution in Nigeria. ED was assessed using an abridged version of international index of erectile function (IIEF–5). Sociodemographic data that included age, education, occupation, marital status were assessed and medical history including diabetes duration, smoking, alcohol intake, frequency and style of sexual intercourse obtained. Results: The mean age of the study sample was 68.22±12.15 years. The prevalence of ED was 69.5%, of which 14.3%, 14.3%, 10.5% and 29.9% had mild, mild-moderate, moderate and severe dysfunctions respectively. The prevalence of ED increased with age, duration of diabetes and obesity but not with glycaemic control, consumption of alcohol or smoking. Conclusions: ED was highly prevalent among men with DM in South-West Nigeria. Hence, efforts must be made to reduce the high prevalence by managing the factors responsible for its development. Also, health care practitioners must regularly inquire about this specifically as patients may not readily volunteer this information.

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