scholarly journals Optic Coherence Tomography Angiography Findings of Bilateral Choroidal Neovascularization Associated with Optic Disc Drusen Treated with Intravitreal Aflibercept Injection

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Melih Akıdan ◽  
Mehmet Bulut ◽  
Lütfiye Yaprak ◽  
Muhammet Kazım Erol ◽  
Elcin Suren
Keyword(s):  
Optic Disc ◽  
Choroidal Neovascularization ◽  
Fundus Photography ◽  
Vascular Density ◽  
Optic Coherence Tomography ◽  
Main Trunk ◽  
Optic Disc Drusen ◽  
Intravitreal Aflibercept ◽  
The Right ◽  
Sd Oct

Purpose. The purpose of this case report is to present the findings of optical coherence tomography angiography (OCTA) of a patient with bilateral choroidal neovascularization (CNV) associated with optic disc drusen (ODD), who was treated with intravitreal aflibercept injection. Case presentation. A 14-year-old girl presented with a complaint of visual loss and metamorphopsia in her both eyes. Best-corrected visual acuity (BCVA) was 20/32 and 20/25, respectively, in the right and left eyes. Intraocular pressure and anterior segment examination were normal. Dilated fundus examination revealed elevated optic discs with blurred margins in both eyes. In addition, slightly elevated yellow lesion extending from optic nerve head to the macula was observed bilaterally. The patient underwent imaging with colour fundus photography, fundus autofluorescence (FAF), fundus fluorescein angiography (FFA), spectral-domain optic coherence tomography (SD-OCT), OCTA, orbital ultrasonography (USG), and computed tomography (CT). In particular, OCTA demonstrated clearly the large circular CNV complex in the right eye and the CNV structure in the left eye containing slightly activated main trunk and minimal vessel loops in the papillomacular region. CNV secondary to bilateral ODD was suspected. Intravitreal aflibercept injections were performed in 3 doses to the right eye and a single dose to the left eye. After the injections, BCVA reached its complete level in both eyes. SD-OCT revealed irregularity of RPE in the temporal region of the optic disc and complete regression of the subretinal fluid. Interestingly, the entire CNV complex including the main trunk completely disappeared in OCTA. CNV complex was not observed in OCTA during 1-year follow-up, and peripapillary and macular vascular density measurements did not show any significant change. BCVA was preserved, and no additional injections were needed. Conclusion. It is possible that OCTA can be used for detailed evaluation of CNV associated with ODD, response to anti-VEGF treatment, and peripapillary and macular vascular density. There is a need for further studies to confirm the changes such as disappearance of CNV in OCTA after injection as we observed in our patient.

scholarly journals Paediatric case of peripapillary choroidal neovascularisation associated with optic disc drusen treated with aflibercept

2019 ◽  
Vol 12 (1) ◽  
pp. bcr-2018-228134 ◽  
Author(s):  
Weh Loong Gan ◽  
Vernon W Long
Keyword(s):  
Visual Acuity ◽  
Optic Disc ◽  
Rare Complication ◽  
Fundus Autofluorescence ◽  
Choroidal Neovascularisation ◽  
First Case ◽  
Optic Disc Drusen ◽  
Intravitreal Aflibercept ◽  
The Right ◽  
Subfoveal Fluid

Peripapillary choroidal neovascularisation (PPCNV) associated with optic disc drusen is a rare complication that can result in severe vision impairment in children. We report the first case of paediatric PPCNV secondary to optic disc drusen successfully treated with intravitreal aflibercept. A 6-year-old girl presented with a one week history of reduced vision in her right eye with best-corrected visual acuity of 20/500. Fundus examination revealed bilateral elevated discs with a peripapillary pigmentary lesion in the right eye. Optical coherence tomography of the right eye showed marked subfoveal fluid. Both B-scan ultrasonography and fundus autofluorescence demonstrated findings consistent with optic disc drusen. Diagnosis of PPCNV was further confirmed on fluorescein fundus angiography. The child received three intravitreal aflibercept injections with complete resolution of the subfoveal fluid. Her visual acuity improved to 20/25 with no recurrence at a 16-month follow-up. No adverse side effects were reported.

scholarly journals Vision Loss in Optic Disc Drusen Correlates With Increased Macular Vessel Diameter and Flux and Reduced Peripapillary Vascular Density

2020 ◽  
Vol 218 ◽  
pp. 214-224 ◽  
Author(s):  
Yan Yan ◽  
Xiao Zhou ◽  
Zhongdi Chu ◽  
Laurel Stell ◽  
Mohammad Ali Shariati ◽  
...  
Keyword(s):  
Optic Disc ◽  
Vision Loss ◽  
Vessel Diameter ◽  
Vascular Density ◽  
Optic Disc Drusen

scholarly journals Fundus changes in high myopic Kashmiri population

2021 ◽  
Vol 12 (1) ◽  
pp. 47-49
Author(s):  
Nazia Anjum ◽  
Numrah Muqsit ◽  
Junaid S Wani
Keyword(s):  
Optic Disc ◽  
Choroidal Neovascularization ◽  
High Myopia ◽  
Structural Changes ◽  
Head Tilt ◽  
Fundus Photography ◽  
Posterior Staphyloma ◽  
Chorioretinal Atrophy ◽  
Kashmiri Population ◽  
Tilted Disc

Background: High myopia (defined as myopia of -6D or more) is one of the main causes of visual impairment worldwide. High myopia is always accompanied by pathological structural changes such as axial elongation, posterior staphyloma, lacquer crack formation, thinning of the retina and choroid, and choroidal neovascularization. Aims and Objectives: The purpose of this study was to examine the fundus changes in eyes with high myopia. Materials and Methods: All study participants underwent dilated fundus examination and fundus photography. Myopia-related macular (posterior staphyloma, lacquer cracks, Fuchs spot, myopic chorioretinal atrophy, and myopic choroidal neovascularization)and optic disc (optic nerve head tilt,optic disc dimensions, and peripapillary atrophy) changes were evaluated. Results: Statistical analysis was performed to evaluate fundus changes in eyes with high myopia. Data analysis included 107 eyes of 57 patients.Mean ± SE was 12.07 ± 3.184D in eyes with high myopia. Mean ± AL was 26.68± 1.577mm in eyes with high myopia. The mean age was 28.54 ± 9.44 years(14-50 years). Fundus changes were: Temporal crescent in 56 (52.33%) eyes, tessellated fundus appearance in 52(48.59%) eyes, lacquer cracks in 40 (37.38%) eyes, tilted disc in 30 (28%) eyes, lattice degeneration in 20(18.69%) eyes, posterior staphyloma in 20(18.69%) eyes, focal chorioretinal atrophy in 3 (2.8%) eyes. CNV in 2 (1.86%)eyes and retinal hole in 1(1%) eye. Conclusions: Tessellated fundus and temporal crescent were the most common fundus findings among Kashmiri population with high myopia. In this population, lacquer cracks and tilted disc were also common, while CNV and retinal holes were rare.

scholarly journals Management of Choroidal Neovascularization Associated with Optic Disc Melanocytoma with Intravitreal Aflibercept: A Case Report and Review of the Literature

2019 ◽  
Vol 2019 ◽  
pp. 1-3
Author(s):  
Hany S. Hamza ◽  
Magdy Moussa ◽  
Abdelrahman M. Elhusseiny
Keyword(s):  
Optic Disc ◽  
Choroidal Neovascularization ◽  
Rare Case ◽  
Review Of Literature ◽  
Review Of The Literature ◽  
Choroidal Neovascular Membrane ◽  
Rare Association ◽  
Melanocytic Tumor ◽  
Intravitreal Aflibercept ◽  
Methods Of Treatment

Purpose. To report a rare case of melanocytoma associated choroidal neovascularization (CNV) treated with intravitreal aflibercept. Methods. We reviewed the literature for the previous reports and different methods of treatment. Results. Optic disc melanocytoma has been considered as a benign melanocytic tumor that rarely affects vision. There is evidence in the literature of association between choroidal neovascular membrane and disc melanocytoma. Conclusions. In conclusion, our article provides a review of literature of such a rare association in which the ophthalmologists must be aware of its occurrence and possible ways of management.

scholarly journals Differentiation between optic disc drusen and optic disc oedema using fundus photography

2017 ◽  
Vol 95 (4) ◽  
pp. e329-e335 ◽  
Author(s):  
Kyoung Min Lee ◽  
Se Joon Woo ◽  
Jeong-Min Hwang
Keyword(s):  
Optic Disc ◽  
Fundus Photography ◽  
Optic Disc Oedema ◽  
Disc Oedema ◽  
Optic Disc Drusen

scholarly journals Choroidal Neovascularization in Congenital Disorders of the Optic Nerve

2007 ◽  
pp. 303-307
Keyword(s):  
Optic Nerve ◽  
Optic Disc ◽  
Choroidal Neovascularization ◽  
Young Age ◽  
Age Related Macular Degeneration ◽  
Age Group ◽  
Important Place ◽  
Optic Nerve Diseases ◽  
Age Related ◽  
Optic Disc Drusen

Choroidal neovascularization is one of the most important visual losses seen in developed countries and is usually associated with age-related macular degeneration in the older age group. Choroidal neovascular membranes seen at a young age may be associated with pathologic myopia and ocular histoplasmosis; the idiopathic group also has an important place. Congenital optic nerve diseases are an important but rare disease group that makes peripapillary choroidal neovascularization in the young age group. Under these headings, besides isolated congenital optic nerve anomalies such as tilted disc, optic disc drusen, optic pit, and myelinated nerve fiber; anomalies showing serious neurological deficits such as optic disc coloboma, morning glory anomaly, optic nerve hypoplasia can also be counted. In this review, pathophysiology and treatment of the togetherness of optic nerve diseases and the neovascular membrane will be evaluated.

scholarly journals Diagnostic Value of Systematic Imaging Examination in Embedded Optic Disc Drusen in Adolescents with Mild Visual Impairment

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Xiuhua Jia ◽  
Tiancheng Bao ◽  
Shasha Wang ◽  
Ting Jiang ◽  
Zhijian Zhong ◽  
...  
Keyword(s):  
Visual Field ◽  
Visual Impairment ◽  
Optic Disc ◽  
Diagnostic Value ◽  
Fundus Photography ◽  
Mri Findings ◽  
Fundus Fluorescein Angiography ◽  
Fiber Layer ◽  
Imaging Examination ◽  
Optic Disc Drusen

Aim. To evaluate the diagnostic value of systematic ophthalmologic imaging examination in the diagnosis of embedded optic disc drusen (ODD) in adolescents with mild visual impairment. Methods. Eleven patients were evaluated through optometric examination, fundus photography, visual field inspection, optical coherence tomography (OCT), ultrasonography (US), and fundus fluorescein angiography (FFA). Of the 11 patients, three also underwent cranial and orbital magnetic resonance imaging (MRI). Results. All 11 patients had either no apparent abnormality or only mild refractive abnormalities. In all patients, fundus inspection revealed flushing the optic disc with varying degrees of limited boundary ambiguity and optic disc congestion with disappearance of the fovea. One patient had a visual field defect during the period of edema of ODD, but the visual field returned to normal after the optic disc edema subsided. US revealed discoid acousto-optic masses in front of the optic disc in six patients. OCT showed a slight elevation and thinning of the retinal nerve fiber layer (RNFL) of the optic disc in all patients. Quasicircular, hyperreflex signals of different sizes could be observed below the RNFL. Late-stage FFA revealed focal staining at the edge of the optic disc without fluorescence leakage in all patients. Orbital and cranial MRI findings were normal in the three patients. Conclusion. A systematic ophthalmologic imaging examination can not only improve the detection rate of embedded ODD but also avoid excessive examinations and treatments.

scholarly journals Multimodal imaging of small hard retinal drusen in young healthy adults

2017 ◽  
Vol 102 (1) ◽  
pp. 146-152 ◽  
Author(s):  
Hilde R Pedersen ◽  
Stuart J Gilson ◽  
Alfredo Dubra ◽  
Inger Christine Munch ◽  
Michael Larsen ◽  
...  
Keyword(s):  
Retinal Pigment ◽  
Adaptive Optic ◽  
Healthy Adults ◽  
Age Related Macular Degeneration ◽  
Fundus Photography ◽  
Optic Coherence Tomography ◽  
Age Related ◽  
Prospective Longitudinal ◽  
Retinal Drusen ◽  
Sd Oct

BackgroundSmall hard macular drusen can be observed in the retina of adults as young as 18 years of age. Here, we seek to describe the in vivo topography and geometry of these drusen.MethodsRetinal images were acquired in young, healthy adults using colour fundus photography, spectral domain optic coherence tomography (SD-OCT), reflectance flood-illuminated adaptive optic ophthalmoscopy (AO flood) and reflectance adaptive optic scanning light ophthalmoscopy (AOSLO) in both confocal and non-confocal split-detection modalities. Small bright yellow hard drusen within a 10 degree radius from the foveal centre were characterised.ResultsSmall hard drusen were seen on colour photographs in 21 out of 97 participants and 26 drusen in 12 eyes in 11 participants were imaged using the full protocol. Drusen were easily identifiable in all modalities, except a few very small ones, which were not visible on SD-OCT. On AOSLO images, these drusen appeared as round, oval or lobular areas (up to three lobules) of diameter 22–61 µm where cone photoreceptor reflectivity and density was decreased (p=0.049). This was usually associated with discrete thickening of the retinal pigment epithelium (RPE) complex.ConclusionHigh lateral resolution imaging of small lobular hard retinal drusen suggests formation through the confluence of two or more smaller round lesions. The outline and size of these smaller lesions corresponds to 1–4 RPE cells. Prospective longitudinal studies are needed to determine the ultimate fate of small hard drusen and their potential relation to age-related macular degeneration.

scholarly journals A hybrid coloboma and optic disc pit associated with macular retinoschisis

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Ricardo Yuji Abe ◽  
Camila Ishii Iguma ◽  
Lorena Campos Wen
Keyword(s):  
Optic Disc ◽  
Unusual Case ◽  
Optic Disc Pit ◽  
Case Presentation ◽  
Macular Retinoschisis ◽  
Optic Disc Coloboma ◽  
Oct Imaging ◽  
The Right ◽  
Sd Oct

Abstract Background To report and describe an unusual case of a patient with optic disc pit in one eye and optic disc coloboma with a focal pit associated with macular retinoschisis in the other eye. Case presentation A 21-year-old woman presented with optic disc pit in the right eye and optic disc coloboma with a focal pit like excavation in the left eye. Macular spectral domain optical coherence tomography (SD-OCT) of the left eye revealed macular retinoschisis, without serous detachment. Conclusions Proper monitoring of patients with disc anomalies associated with maculopathy is mandatory. The use of OCT imaging during follow-up can help to identify involvement of the fovea or enlargement of the retinoschisis area.

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