scholarly journals Gastric Plexiform Fibromyxoma Arising in the Cardia in an Adolescent Male: A Rare Tumor with an Unusual Location

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Awrad Nasralla ◽  
Mufeed Alwabari ◽  
Osama Alsaif ◽  
Samir S. Amr
Keyword(s):  
Abdominal Pain ◽  
North America ◽  
Gastrointestinal Stromal Tumor ◽  
Histopathological Examination ◽  
Correct Diagnosis ◽  
Clinical Manifestations ◽  
Adolescent Male ◽  
Rare Tumor ◽  
Review Of The Literature ◽  
Unique Case

Plexiform fibromyxoma of the stomach, also known as plexiform angiomyxoid myofibroblastic tumor, is a rare benign gastric mesenchymal tumor, first described in 2007, which usually arises in the gastric antrum and affects adults. Few cases have been reported in children and adolescents. It can present with different clinical manifestations including abdominal pain, dyspepsia, hematemesis, and vomiting. Preoperatively, this tumor is usually diagnosed as gastrointestinal stromal tumor (GIST), and the correct diagnosis is made only after histopathological examination following surgical resection. Most cases were reported from East Asia (China, Japan, and Korea), North America, and Europe. We report herein a unique case of plexiform fibromyxoma, the first to be reported from the Middle East, arising in the cardia of the stomach in a 16-year-old adolescent male, with a brief review of the literature.

scholarly journals Grover’s disease in a patient with atopic dermatitis - a case report

2021 ◽  
Vol 74 (1-2) ◽  
pp. 33-37
Author(s):  
Sanja Jakovljevic ◽  
Ljuba Vujanovic ◽  
Dejan Ogorelica ◽  
Aleksandra Fejsa-Levakov ◽  
Jasmina Sekulic
Keyword(s):  
Case Report ◽  
Immunoglobulin E ◽  
Histopathological Examination ◽  
Correct Diagnosis ◽  
Elevated Serum ◽  
Clinical Manifestations ◽  
Skin Lesions ◽  
Complete Regression ◽  
Laboratory Findings ◽  
Topical Corticosteroids

Introduction. Grover?s disease is characterized by pruriginous polymorphic rash with a variable course and duration. Although the etiology is still unknown, the disease is often associated with other dermatoses, malignant diseases, use of certain medications, as well as immunosuppression. Case Report. We report a case of a 70-year-old male patient who was referred for examination to the Clinic of Dermatovenereology Diseases, Clinical Center of Vojvodina, due to a rash that lasted for nine months. The first lesions on the skin appeared around the nipples as exudative eczematous plaques. A few months later, identical lesions appeared on the lower legs. During treatment with systemic antihistamines and topical corticosteroids, there were episodes of transient improvements and re-exacerbations. In the meantime, erythematous brownish, round and oval papules appeared on the abdomen and the back, accompanied by intense itch. Laboratory findings revealed eosinophilia and elevated serum immunoglobulin E levels. A skin biopsy of the back lesion was performed and the histopathological examination confirmed the diagnosis of Grover?s disease. After the systemic treatment using corticosteroids and antihistamines, with gradual dose reduction and application of topical corticosteroids and emollients, complete regression of the skin lesions was achieved. Conclusion. Since the clinical manifestations of the disease may be nonspecific and discrete, dermatopathological analysis is of crucial importance in making the correct diagnosis. In patients with atopy, the treatment with systemic corticosteroids, antihistamines and topical agents may lead to regression of skin lesions with a significant improvement in the quality of life.

scholarly journals Numerous gastrointestinal tumors

2021 ◽  
Vol 18 (4) ◽  
pp. 328-330
Author(s):  
Piotr Przyczyna ◽  
◽  
Elżbieta Trojnar ◽  
Dorota Bartusik-Aebisher ◽  
David Aebisher ◽  
...  
Keyword(s):  
Small Intestine ◽  
High Risk ◽  
Gastrointestinal Stromal Tumor ◽  
Histopathological Examination ◽  
Clinical Manifestations ◽  
Proximal Part ◽  
Interstitial Cells ◽  
Stromal Tumor ◽  
Gastrointestinal Tumors ◽  
Multiple Neoplasms

Introduction. Gastrointestinal stromal tumor (GIST) is most often locate in the region of the stomach and the proximal part of the small intestine. Aim. The multiple histopathological examination is described. Description of the case. Multiple GISTs are rare neoplasms that originate from the interstitial cells are described. Conclussion. GIST can occur in any part of the gut, they are most common in the stomach and small intestine, and less frequent in the colorectum and esophagus. Although their pathogenesis and clinical manifestations are different, these tumor syndromes confer a high risk for developing multiple neoplasms.

scholarly journals Ovarian Hemangioma: a rare entity

2018 ◽  
Vol 7 (6) ◽  
pp. 2490
Author(s):  
Mona Dahal ◽  
Paricha Upadhyaya ◽  
Purbesh Adhikari ◽  
Diksha Karki ◽  
Niraj Regmi
Keyword(s):  
Abdominal Pain ◽  
Cavernous Hemangioma ◽  
Cystic Lesion ◽  
Radical Surgery ◽  
Histopathological Examination ◽  
Correct Diagnosis ◽  
Lower Abdominal Pain ◽  
Surgical Excision ◽  
Vascular Tumors ◽  
Rare Entity

Ovarian hemangiomas are uncommon benign vascular tumors of ovary. Most of them are asymptomatic and detected incidentally during surgery. Authors report a case of 41 years female, parity 2; with complain of lower abdominal pain for 6 months. Ultrasonography showed a cystic lesion at right adnexa with a heterogeneously echogenic component within and devoid of internal vascularity. Laparoscopic right adnexal cystectomy was done, which on histopathological examination demonstrated features of cavernous hemangioma replacing the ovarian parenchyma. As surgical excision is treatment of choice, correct diagnosis is essential to avoid unnecessary radical surgery and treatment.

scholarly journals A High Urinary Urobilinogen / Serum Total Bilirubin Ratio Reported in Abdominal Pain Patients Can Indicate Acute Hepatic Porphyria

2021 ◽  
Author(s):  
Chengyuan Song ◽  
Shaowei Sang ◽  
Yuan Liu
Keyword(s):  
Abdominal Pain ◽  
Roc Curve ◽  
Total Bilirubin ◽  
Correct Diagnosis ◽  
Clinical Manifestations ◽  
Total Bilirubin Level ◽  
Serum Total Bilirubin ◽  
Control Groups ◽  
Diagnostic Dilemma ◽  
Laboratory Test Results

Abstract Background: Due to its variable symptoms and nonspecific laboratory test results during routine examinations, acute hepatic porphyria (AHP) has always been a diagnostic dilemma for physicians. Correct diagnosis mainly depends on the elevated urinary porphobilinogen (PBG) level, which is not a routine test performed in the emergency department. Therefore, identifying a more convenient indicator during routine examinations is important to improve the diagnosis of AHP.Methods: In this retrospective study, we enrolled 12 AHP patients and 100 patients with abdominal pain of other causes as the control groups in Qilu hospital of Shandong University between 2015 and 2021. The clinical manifestations and laboratory result data including urinary urobilinogen/serum total bilirubin ratio were compared between these two groups. The diagnostic performance of urinary urobilinogen/serum total bilirubin ratio was measured as sensitivity, specificity, and accuracy. The cut-off for optimal clinical performance was determined by the receiver operator characteristic (ROC) curve. Results were considered significant at a P < 0.05.Results: Compared with the control groups, AHP patients showed a significantly higher urinary urobilinogen level (P < 0.05). However, we showed that the higher urobilinogen level was caused by a false-positive result due to elevated urine PBG. Hence, we used serum total bilirubin, an upstream substance of urinary urobilinogen synthesis, for calibration. A remarkable increase in the urinary urobilinogen/serum total bilirubin ratio was observed in AHP patients. The area under the ROC curve of this ratio for AHP was 1.000 (95% confidence interval, 1.000–1.000, P < 0.01). A cutoff value of 3.22 for the urinary urobilinogen/serum total bilirubin ratio yielded a sensitivity of 100% and a specificity of 100% to distinguish AHP patients from the controls.Conclusion: A reported high urinary urobilinogen level that was adjusted by the serum total bilirubin level (urinary urobilinogen/serum total bilirubin ratio) could be used as a sensitive and specific indicator for AHP in patients with abdominal pain.

scholarly journals Cutaneous Hyperpigmentation and Familial Gastrointestinal Stromal Tumor Associated With Germline KIT Mutation Treated With Imatinib: A Chinese Case Report

2020 ◽  
Author(s):  
Wei Yuan ◽  
Wen Huang ◽  
Lei Ren ◽  
Jinghuan Lv ◽  
Chen Xu ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Gastrointestinal Stromal Tumor ◽  
Mutational Analysis ◽  
Direct Sequencing ◽  
Correct Diagnosis ◽  
Stromal Tumor ◽  
Kit Mutation ◽  
History Of ◽  
Exon 11 ◽  
Cells Of Cajal

Abstract BackgroundFamilial gastrointestinal stromal tumor (GIST) has been identified with multiple GISTs harboring the mutations in germline KIT and PDGFRA. There are only 35 kindreds with germline KIT and 6 with PDGFRA mutations have been reported to date. Familial GIST is often characterized by a series of manifestations, such as multiple lesions, hyperpigmentation, mastocytosis, and dysphagia. Only some kindreds have response to imatinib treatment.Materials and MethodsA 25-year-old Chinese woman presented to the hospital with abdominal pain, and computed tomography (CT) scan showed multiple tumors in the small intestine. Her father had a history of multifocal GISTs, and referred to the hospital with abdominal pain and tumor recurrences last year. Immuhistochemical analysis of CD117 and DOG-1 were performed on tumor samples from the two patients, while KIT mutational analysis was carried out by direct sequencing on DNA from paraffin-embedded specimens and saliva sample.ResultsMultiple GISTs associated with diffuse interstitial cells of Cajal (ICC) hyperplasia were illustrated in these two patients. These tumors were positive for CD117 and DOG-1. The germline mutation at codon 560 of exon 11 (p.V560G) of the KIT gene were found. Treatment with imatinib resulted in favorable responses in both tumor and cutaneous hyperpigmentation.ConclusionsIt is difficult to make a correct diagnosis of familial GIST at first time due to its rarity. This case was finally diagnosed as familial GIST depending on the combination of diffuse ICC hyperplasia, germline KIT mutation, hyperpigmentation and its family history.

scholarly journals Cutaneous Hyperpigmentation and Familial Gastrointestinal Stromal Tumor Associated with Germline KIT Mutation Treated with Imatinib

2020 ◽  
Author(s):  
Wei Yuan ◽  
Wen Huang ◽  
Lei Ren ◽  
Chen Xu ◽  
Lijuan Luan ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Gastrointestinal Stromal Tumor ◽  
Mutational Analysis ◽  
Direct Sequencing ◽  
Correct Diagnosis ◽  
Saliva Sample ◽  
Stromal Tumor ◽  
Imatinib Treatment ◽  
Kit Mutation ◽  
Exon 11

Abstract Background: Familial gastrointestinal stromal tumor (GIST) has been identified with multiple GISTs containing the mutations in germline KIT and PDGFRA. There are only 35 kindreds with germline KIT and 6 with PDGFRA mutations have been reported so far. Familial GIST is often characterized by a series of manifestations, such as multiple lesions, hyperpigmentation, mastocytosis, and dysphagia. Only some kindreds have response to imatinib treatment.Materials and Methods: A 25-year-old Chinese woman went to hospital because of the abdominal pain, and through the computed tomography (CT) scan showed us the multiple tumors in the small intestine. Her father had a history of multifocal GISTs, and referred to the hospital with abdominal pain and tumor recurrences last year. Immuhistochemical analysis of CD117 and DOG-1 were performed on tumor samples from the two patients, while KIT mutational analysis was carried out by direct sequencing on DNA from paraffin-embedded specimens and saliva sample.Results: Multiple GISTs associated with diffuse interstitial cells of Cajal (ICC) hyperplasia were illustrated in these two patients. These tumors were positive for CD117 and DOG-1. The germline mutation at codon 560 of exon 11 (p.V560G) of the KIT gene were found. The treatment with imatinib resulted in favorable responses in both tumor and cutaneous hyperpigmentation.Conclusions: It is difficult to make a correct diagnosis of familial GIST at first time for its rarity. This case was finally diagnosed as familial GIST depending on the combination of diffuse ICC hyperplasia, germline KIT mutation, hyperpigmentation and its family history.

scholarly journals Seborrheic keratosis evolution into squamous cell carcinoma: A truly modified sun-related tumor? A case report and review of the literature

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Ioana Cimpean ◽  
Ivan Theate ◽  
Olivier Vanhooteghem
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Malignant Transformation ◽  
Histopathological Examination ◽  
Clinical Manifestations ◽  
Immunocompromised Patients ◽  
Review Of The Literature ◽  
Seborrheic Keratosis ◽  
Increased Risk

The incidence of seborrheic keratosis (SK) generally increases with age and are mostly localized on the trunk, face and neck, especially on sun-exposed areas. The association between SK and skin malignancies appears to be accidental, but in situ transformation occurs more frequently in sun-exposed areas. Histopathological examination of all SK cases should be considered, especially when SK lesions exhibit atypical clinical manifestations, such as ulceration and cresting, as they may herald malignant transformation. In addition, other features associated with malignant transformation include excoriations or hemorrhages identified on the lesion, modification and evolution of the macroscopic characteristics, and the presence of local erythema or pruritus. Immunocompromised patients exhibit an increased risk of malignant transformation, even when radiation is involved.

scholarly journals Cartilaginous melanoma: case report and review of the literature

2013 ◽  
Vol 88 (3) ◽  
pp. 403-407 ◽  
Author(s):  
Parente Joana Devesa ◽  
Jose Manuel Pereira da Silva Labareda ◽  
Elvira Augusta Felgueira Leonardo Fernandes Bartolo ◽  
Maria Fernanda Sachse Pinto Fonseca Santos ◽  
Esmeralda Maria Seco do Vale
Keyword(s):  
Differential Diagnosis ◽  
Malignant Melanoma ◽  
Histopathological Examination ◽  
Correct Diagnosis ◽  
Careful Examination ◽  
Review Of The Literature ◽  
Great Toe ◽  
Wide Range ◽  
Melanoma Case

Malignant melanoma can present a variety of histopathological patterns. Cartilaginous change in the absence of osteogenic differentiation is extremely rare in malignant melanoma, being among the least frequent of the wide range of melanoma histologic patterns. We report a case of a 47-year-old woman with a subungual nodule on her right great toe for many years. Histopathological examination of the lesion led to a diagnosis of malignant melanoma with cartilaginous differentiation devoid of concomitant osseous areas. It would appear that this unusual form of melanoma has a predilection for acral location, particularly the subungual region. Malignant melanoma with chondroid stroma should therefore be considered in the differential diagnosis of cartilaginous lesions of the toes and fingers. Careful examination of the overlying epidermis and identification of an in situ component of melanoma may be necessary in order to establish the correct diagnosis.

scholarly journals Clinical and morphological characteristics of lichen planus and lichenoid drug eruption of the skin

2020 ◽  
Vol 23 (3) ◽  
pp. 157-164
Author(s):  
Denis V. Zaslavsky ◽  
A. A. Sidikov ◽  
A. I. Sadykov ◽  
I. N. Chuprov ◽  
D. V. Kozlova ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Histological Study ◽  
Correct Diagnosis ◽  
Clinical Manifestations ◽  
Morphological Characteristics ◽  
Final Diagnosis ◽  
Response To Therapy ◽  
Lichen Ruber Planus ◽  
Microscopic Features ◽  
Classic Form

Background: Lichen ruber planus (LP) and lichenoid skin reaction (LSR) are clinically and histologically similar. The performance of histological diagnosis in these diseases remains controversial. Materials and methods: We prospectively studied 33 patients with clinical manifestations and histological signs of the classic form of LP and LSR to assess the accuracy of an isolated histological LP and LSR examinations and to identify a variety of microscopic features. Each histological study was conducted by a pathomorphologist, who was blinded to the patients clinical characteristics and diagnosis. Results: Isolated histopathological examination made it possible to make a correct diagnosis in 25 (75%) of 33 patients: in particular, the diagnosis of LRC was established in 10 (30%), CPL-in 15 (45%) cases. Based on a combined assessment of histological and clinical data and response to therapy, the final diagnosis was established in 30 (91%) of the 33 patients who were divided into two groups. The first group comprised 18 patients diagnosed with LSR, and the second group comprised 12 patients diagnosed with the classic form of LP. Conclusions: Through this investigation, some differences in these diseases based on their clinical and pathomorphological features were identified. The diseases were characterized by different typical localizations and lesion sizes. The pathomorphology of both diseases is represented by lichenoid type of interface dermatitis.

scholarly journals Spontaneous regression of infantile dural-based non-Langerhans cell histiocytosis after surgery: case report

2015 ◽  
Vol 15 (4) ◽  
pp. 372-379 ◽  
Author(s):  
Yohei Miyake ◽  
Susumu Ito ◽  
Mio Tanaka ◽  
Yukichi Tanaka
Keyword(s):  
Langerhans Cell Histiocytosis ◽  
Spontaneous Regression ◽  
Histopathological Examination ◽  
Residual Tumor ◽  
Giant Cells ◽  
Langerhans Cell ◽  
Juvenile Xanthogranuloma ◽  
Review Of The Literature ◽  
Unique Case ◽  
Postoperative Course

The authors report the case of a large left occipital mass lesion in an 8-month-old boy who presented with seizure. Neuroimaging demonstrated an approximately 5-cm extraaxial tumor, and the patient underwent partial resection. The tumor was strongly attached to the tentorium and falx. In the postoperative course the residual lesion regressed spontaneously, and after 5 years only a slight residual tumor remained along the tentorium. Histopathological examination of the tumor revealed non-Langerhans cell histiocytosis (non-LCH). However, the tumor was not diagnosed as juvenile xanthogranuloma (JXG) because it lacked Touton giant cells. Hence, the authors described this lesion as a fibroxanthogranuloma. Most intracraniospinal non-LCHs have been reported as JXG; however, several cases of xanthomatous tumors with histopathological features resembling those of JXG have been described as fibrous xanthoma, xanthoma, fibroxanthoma, and xanthogranuloma. Among JXG and the xanthomatous tumors, a review of the literature revealed several cases of dural-based tumors; these dural-based tumors have had favorable courses, including the case described in this report. In addition, the patient in the present case experienced spontaneous regression of the residual tumor. The authors report this unique case and review the literature on isolated intracraniospinal non-LCHs, especially in cases of dural-based lesion.

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