scholarly journals Effect of Electromyographic Biofeedback Therapy on Muscle Strength Recovery in Children with Guillain–Barré Syndrome

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Qianqian Liu ◽  
Jianhua Xue ◽  
Pingping Zhao ◽  
Yue Ling ◽  
Suzhe Liu ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Guillain Barre Syndrome ◽  
Control Group ◽  
Biofeedback Therapy ◽  
Electromyographic Biofeedback ◽  
Strength Recovery ◽  
Guillain Barré Syndrome ◽  
Guillain Barré ◽  
Experimental Group ◽  
Better Than

GBS, as an immune-mediated acute inflammatory peripheral neuropathy (Tan and Halpin et al.), with the characteristics of acute onset and rapid progression, is mainly manifested with damages in nerve root and peripheral nerve. The purpose of the study was to investigate the effect of electromyographic biofeedback therapy on muscle strength recovery in children with Guillain–Barré syndrome (GBS). A total of 62 GBS children patients admitted to our hospital from June 2014 to December 2018 were selected and divided into control group (n = 30) and experimental group (n = 32) according to the order of admission. The children patients in the control group received physical therapy combined with occupational therapy (PT + OT), while based on the treatment in the control group, the experimental group children patients were treated with electromyographic biofeedback therapy. After that, the recovery of nerve and muscle at different time points, muscle strength score, gross motor function measure (GMFM) score, and Barthel index (BI) score of the children patients before and after treatment were compared between the two groups. There were no significant differences in the recovery of nerve and muscle of the children patients between the two groups at T0 and T1 ( P  > 0.05), and the recovery of nerve and muscle of the children patients in the experimental group was significantly better than that in the control group at T2, T3, and T4 (P < 0.001); the muscle strength score, GMFM score, and BI score of the children patients in the experimental group were significantly better than those in the control group after treatment ( P  < 0.001). The application of electromyographic biofeedback therapy for the treatment of GBS can effectively relieve clinical symptoms, promote rapid recovery, and improve treatment efficacy in children patients, which is worthy of application and promotion.

scholarly journals Efficacy of therapies in the treatment of Guillain-Barre Syndrome: a network meta-analysis

2020 ◽  
Author(s):  
Jingfeng Lin ◽  
Qiang Gao ◽  
Kang Xiao ◽  
Danfeng Tian ◽  
Wenyue Hu ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Indirect Evidence ◽  
Guillain Barre Syndrome ◽  
Cochrane Library ◽  
Control Group ◽  
Human Beings ◽  
R Software ◽  
Significant Difference ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Abstract Background Guillain-Barre syndrome (GBS) is an acute, paralyzing, inflammatory peripheral nerve disease. For treatments of the Guillain-Barre Syndrome, there are many kinds of therapies for this diseases. For comparing all of the therapies, such as immunoglobulin, plasma exchanging, etc. in the treatment of Guillain-Barre Syndrome(GBS) to better inform clinical practice, we use Network meta analysis to get the outcome of the Guillain-Barre Syndrome. The protocol has been submitted to PROSPERO:CRD: 42019119178. Methods Web of Science, PubMed, Embase, and the Cochrane library were searched for related articles. We identified citations of these and included 26 trials comprising 2434 patients and control group human beings. Network meta-analysis (NMA) was performed with two kinds of outcomes. We carried on R software with gemtc package and JAGS software to calculate results for different therapies. The consistency of direct and indirect evidence was also assessed by R software. Results Concerning for two outcomes, there were no improvement observed in MTP and Pred compared with placebo. PE and IVIg were illustrated to be effective over Placebo. There was no significant difference between different doses and times of PE and IVIg. On consistency examination between direct and indirect evidences, there were no obvious heterogeneity between all of therapies. Funnel plots indicates the possibility of publication bias in this study are small. Conclusion PE or IVIg had a significant efficency for GBS patients. The effects of some combination treatments should be further explored. Corticosteroids had no significant effects on GBS.

Plasma Exchange in Five Patients with Acute Guillain Barré syndrome

1981 ◽  
Vol 4 (5) ◽  
pp. 230-233 ◽  
Author(s):  
A.E.J. de Jager ◽  
T.H. The ◽  
C. Th. Smit Sibinga ◽  
P.C. Das
Keyword(s):  
Motor Activity ◽  
Plasma Exchange ◽  
Recovery Phase ◽  
Guillain Barre Syndrome ◽  
Respiratory Care ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Guillain Barré Syndrome ◽  
Group A ◽  
Guillain Barré

During the last 3 years plasma exchanges were undertaken in 5 patients with acute Guillain Barré syndrome (G.B.S.). All the patients were admitted in the intensive respiratory care unit and had received six plasma exchange procedures over two weeks (each procedure consists of 2–3 L exchange). The first patient improved dramatically after the second exchange. Moderate success was obtained in two patients. One patient did not show any effect. The fifth patient received plasma exchange one day after her recovery phase had begun but the course of recovery remained uneffected. The effect of plasma exchange was analysed as the patients’ response to motor activity, and compaired with a historical control group consisting of 50 acute G.B.S. patients admitted in the intensive respiratory care area over the last 25 years. Plasma exchange does not seem to have excerted any significant effect although at any given time the plasma exchange group had higher motor activity than that of the control group. A controlled clinical trial especially in the early phase of the disease is emphasized.

scholarly journals CSF Neurofilament-H Levels as a Potential Prognostic Marker in Patients of Guillain- Barré Syndrome- A Cohort Study

2021 ◽  
Author(s):  
Tanveer Hassan ◽  
Rayees Ahmad Tarray ◽  
Tanzeel Ahmad Wani ◽  
Mushtaq Ahmad Wani ◽  
Zaffar Amin Shah ◽  
...  
Keyword(s):  
Cohort Study ◽  
Guillain Barre Syndrome ◽  
Control Group ◽  
P Value ◽  
Moderate Degree ◽  
Good Outcome ◽  
Poor Outcome ◽  
Outcome Group ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Introduction: The prognosis of Guillain-Barré Syndrome (GBS) at an early stage with explicit biomarkers is critical to distinguish patients with possibility of poor recovery. Cerebrospinal Fluid (CSF) serves as an impending source for biomarkers that portrays the exact biochemical changes. Aim: To find out if there is any prognostic value of high CSF phosphorylated Neurofilament Heavy subunit (pNf-H) levels, measured during first two weeks of onset of GBS, as assessed by the level of disability at six months after the onset of GBS. Materials and Methods: The cohort study was conducted in the Department of Neurology and Department of Immunology and Molecular Medicine, at the Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India, over a period of two years from August 2015 to August 2017. Sixty two patients who satisfied the required diagnostic standards for GBS (study group) and 35 patients with tension-type headache (control group) were selected for the study. After clinical and electrophysiological assessment, CSF samples were collected. A commercially available sandwich enzyme immunoassay kit, manufactured by BioVendor-Laboratorní medicína (Czech Republic), was used for measuring human pNf-H quantitatively. Results: Mean CSF pNf-H level in patients with good outcome was 325.3 pg/mL whereas, in patients with poor outcome it was 3655.2 pg/mL. CSF pNf-H levels were found to be suggestively higher in GBS patients with poor outcome as compared to those with good outcome. Only eight patients in good outcome group had pathologically high CSF Nf-H levels whereas 10 patients in poor outcome group had CSF Nf-H levels ≤730 pg/mL. The odds ratio was 17.1 (95% Confidence Interval (CI) 3.83-76.29). Thus, high CSF Nf-H levels on admission predicted poor outcome in GBS (p-value <0.001). Moderate degree of positive correlation was found between CSF Nf-H levels and outcome (F score) at six months (R=0.684; p-value <0.001). Conclusion: It can be determined that higher values of CSF pNf-H in GBS (acute stage), could serve as a predictive marker indicative of poor prognosis.

scholarly journals Guillain-Barre Syndrome in a patient with SARS-CoV-2 infection: Case Report

2021 ◽  
Author(s):  
Louis Fernando Marques de Almeida ◽  
Déborah Inayara Mendes Tenório de Albuquerque ◽  
Érico Induzzi Borges ◽  
Marcele Schettini ◽  
Herval Ribeiro Soares Neto ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Case Report ◽  
Muscle Strength ◽  
Neurological Complication ◽  
Laboratory Diagnosis ◽  
Lower Limbs ◽  
Guillain Barre Syndrome ◽  
Strength Grade ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Introduction: Guillain-Barré syndrome is an acute/subacute set of clinical features of immune mediated polyradiculoneuropathy, typically after respiratory or gastrointestinal viral infection. In this scenario, we described a case of the syndrome mentioned after infection by sars-cov-2 virus. Objectives and Methods: Description of a clinical case after analysis of medical history and complementary exams, in addition to literature review. Design and Setting: Case report, type of descriptive study, developed in the Institute of Medical Assistance to the State Public Servant of São Paulo. Results: A 68-year-old female patient with clinical and laboratory diagnosis of coronavirus infection, hospitalized in need of oxygen supplementation, which evolved after twelve days of symptoms with hypoesthesia on legs and feet and progressively ascending and symmetrical flaccid paraparesis that led to tetraparesis. Neurological examination showed tetraparesis (muscle strength: grade III in MMSS and grade II in MMII), hyporeflexia in MMSS and reflexes abolished in the lower limbs, plantar skin reflex in flexion in both feet, preserved facial mimicry. About complementary tests, it presented cerebrospinal fluid with albuminocytologic dissociation (cell: 1, protein: 89, glucose: 86), RT-PCR for sars-cov-2 research in cerebrospinal fluid, inconclusive, in addition to four-limb electroneuromyography performed after 19 days of onset of neurological condition, indicated polyradiculoneuropathy with involvement of sensory and motor fibers, primarily demyering. Treatment with human immunoglobulin 400 mg/kg/day for 05 days was started. The reported patient was dismissed from the hospital with significant improvement, presenting muscle strength: grade V in MMSS and grade IV in MMII and already with the ability to walk. Conclusions: the case describes a classic neurological complication associated with a virus that was once non-circulating, but currently with a big clinical relevance.

scholarly journals Efficacy of therapies in the treatment of Guillain-Barre Syndrome: a network meta-analysis

2020 ◽  
Author(s):  
Jingfeng Lin ◽  
Qiang Gao ◽  
Kang Xiao ◽  
Wenyue Hu ◽  
Danfeng Tian ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Indirect Evidence ◽  
Guillain Barre Syndrome ◽  
Cochrane Library ◽  
Control Group ◽  
Human Beings ◽  
R Software ◽  
Significant Difference ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Objective: For comparing all of the therapies, such as immunoglobulin, plasma exchanging, etc. in the treatment of Guillain-Barre Syndrome(GBS) to better inform clinical practice, we used Network meta analysis to get the outcome of the Guillain-Barre Syndrome. The protocol had been submitted to PROSPERO:CRD: 42019119178. Methods: Web of Science, PubMed, Embase, and the Cochrane library were searched for related articles. We identified citations and of these included 28 trials comprising 2474 patients and control group human beings. Network meta-analysis (NMA) was performed with two kinds of outcomes. We carried on R software with gemtc package and JAGS software to calculate results for different therapies. The consistency of direct and indirect evidence was also assessed by R software. Results: Concerning for two outcomes, there were no improvement observed in methylprednisolone and prednisolone compared with placebo. PE and IVIg were illustrated to be effective over Placebo. There was no significant difference between different doses and times of PE and IVIg. On consistency examination between direct and indirect evidences, there were no obvious heterogeneity between all of therapies. Funnel plots indicates the possibility of publication bias in this study is small. Conclusion: PE or IVIg have a significant efficiency for GBS patients. The effect of some combination treatments should be further explored. Corticosteroids have no significant effects on GBS.

scholarly journals Integrated Chinese and western medicine for acute guillain-barré syndrome treatment

2020 ◽  
Vol 11 (1) ◽  
pp. 38-47
Author(s):  
Liu Yang ◽  
Xiumin Zhao
Keyword(s):  
Conduction Velocity ◽  
Western Medicine ◽  
Nerve Conduction ◽  
Motor Nerve ◽  
Sensory Nerve ◽  
Guillain Barre Syndrome ◽  
Functional Score ◽  
Control Group ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

AbstractIntroductionGuillain-Barré syndrome (GBS) is a worldwide demyelinating polyradiculopathy and polyneuropathy. Currently, there is no specific drug for GBS, and established treatment is generally based on immune-modulating treatment with plasma exchange or intravenous immunoglobulin in combination with supportive care. This study aimed to investigate the efficiency of integrated Chinese and Western medicine for acute GBS treatment.MethodsWe enrolled 73 subjects, and randomly divided them into two groups: 35 cases in the traditional Chinese medicine (TCM) group, and 28 in the Control group. The Control group was treated with the common Western medicine for one month; and the TCM group was administrated with one month of common treatment combined with TCM medication.ResultsCompared to the controls, TCM significantly enhanced the treatment efficiency in symptom expression, including the TCM syndrome score, the activity of daily living score, Hughes functional score and sensory dysfunction assessment. The total effective rate of the TCM group was 94.29%, significantly better than controls (78.59%). Moreover, TCM provide better improvement in motor nerve conduction functions (distal motor latency and motor conduction velocity) and sensory nerve conduction functions (sensory conduction velocity and sensory nerve action potential) in median nerve, ulnar nerve, and common fibular nerve.ConclusionWhen combined with TCM administration, the GBS treatment could acquire better outcomes.

scholarly journals Association of Cytomegalovirus (CMV) Infection with Guillain- Barré Syndrome (GBS) In Tertiary Care Hospital (BSMMU) of Bangladesh

2013 ◽  
Vol 29 (2) ◽  
pp. 88-97
Author(s):  
Nuruddin Mohammad Eusuf ◽  
Md Rezaul Karim Khan ◽  
Abu Nasir Rizvi ◽  
Sheikh Abdul Kader ◽  
Abu Jafor Md Salahuddin ◽  
...  
Keyword(s):  
Guillain Barre Syndrome ◽  
Control Group ◽  
Case Group ◽  
Care Hospital ◽  
Cmv Infection ◽  
Hepatic Diseases ◽  
Guillain Barré Syndrome ◽  
History Of ◽  
Guillain Barré ◽  
Inpatient Department

Background: Guillain-Barré syndrome (GBS) usually preceded by infections, in particular cytomegalovirus (CMV). It may occur by primary infection, reinfection or by reactivation of CMV. Objective: The aim of the present study was to evaluate the association of Guillain-Barré syndrome (GBS) with Cytomegalovirus (CMV) infection. Methodology: This case control study was carried out in the indoor and outpatient Department of Neurology at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from 1st January 2010 to 31st December 2011 for the duration of two years. All patients with GBS, who attended in neurology OPD or inpatient department at BSMMU during the study period, fulfilling the inclusion and exclusion criterias were included in this study. Age & sex matched volunteers, patients attendants, patients other than GBS who were nondiabetic, had no renal or hepatic diseases or family history of polyneuropathy were included in control group. Results: A total number of 78 respondents of which 39 patients were taken as cases and rest 39 were taken as controls who appeared in neurology OPD or inpatient department at BSMMU during the study period, fulfilling the inclusion and exclusion criterias were included in this study. The mean age ± SD of case and control groups were 30.82 ± 12.56 and 31.00 ± 12.77 years respectively (p=0.950). In case group the history of respiratory tract infection was present in 46.2% cases and absent in control group (p=0.001). In case group the history of gastroenteritis was present in 28.2% cases and absent in control group (p=0.001). In case group the history of fever was present in 30.8% cases and absent in control group (p=0.001). Anti-CMV IgM antibody was positive in 5.1% cases. Four fold rise of IgG in case group was present in 10.3% cases and absent in control group (p=0.040). Confirmed CMV infected GBS cases were 15.4% and absent in control group (p=0.011). Conclusion: The findings of this study permit to conclude that there is a significant association of Guillain-Barré syndrome (GBS) with Cytomegalovirus (CMV) infection. Bangladesh Journal of Neuroscience 2013; Vol. 29 (2) : 88-97

scholarly journals Efficacy of Intravenous Immunoglobulin in the Management of Guillain Barre Syndrome

1970 ◽  
Vol 28 (2) ◽  
pp. 81-85
Author(s):  
Md Mahbubur Rahman ◽  
Kafiluddin Ahmed
Keyword(s):  
Muscle Power ◽  
Muscle Tone ◽  
Guillain Barre Syndrome ◽  
Control Group ◽  
Control Groups ◽  
Female Ratio ◽  
Sensory Features ◽  
Guillain Barré Syndrome ◽  
Guillain Barré ◽  
And Control

A total number of 40 respondents consisting of 20 subjectsof Guillain barre syndrome in each group treated withintravenous immunoglobulin (case) and without IVIg wereselected during the study period. Out of 20 cases, 12 (60%)were male and 8 (40%) were females, ratio 1.5:1. Majorityof the cases were presented at second or third decade oflife. In control group, 11 (55%) were male and 9 (45%)female, ratio 1.22:1. Majority of the patients had history ofupper respiratory tract infection or acute gastroenteritis 14 weeks preceding illness. All the patients had flaccidparalysis in all four limbs with some sensory features withoutbowel and bladder involvement. Thirteen patients from thecase and control groups developed respiratory failure requiring ICU support. Cerebrospinal fluid study showedalbumin cytological dissociation. Nerve conduction studyshowed features of demyelination, axonal loss or both.There was significant improvement of GBS patientstreated with IVIg in respect of respiratory function,muscle tone, muscle power, jerks and autonomicfunction. ICU stay of patients treated with IVIg wassignificantly shorter. Final outcome of patients treatedwith IVIg showed one death. There was no death incontrol group. The patient died probably due to severityof disease and/or comorbid disease.Key words: Intravenous Ig; Guillain barre syndromeDOI: 10.3329/jbcps.v28i2.5368J Bangladesh Coll Phys Surg 2010; 28: 81-85

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