scholarly journals Treatment of Radiation-Induced Brain Necrosis

2021 ◽  
Vol 2021 ◽  
pp. 1-15
Author(s):  
Xiaojing Yang ◽  
Hanru Ren ◽  
Jie Fu
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Effective Treatment ◽  
Skull Base ◽  
Skull Base Tumors ◽  
Treatment Methods ◽  
The Past ◽  
Brain Necrosis ◽  
Radiation Induced ◽  
New Treatment

Radiation-induced brain necrosis (RBN) is a serious complication of intracranial as well as skull base tumors after radiotherapy. In the past, due to the lack of effective treatment, radiation brain necrosis was considered to be progressive and irreversible. With better understanding in histopathology and neuroimaging, the occurrence and development of RBN have been gradually clarified, and new treatment methods are constantly emerging. In recent years, some scholars have tried to treat RBN with bevacizumab, nerve growth factor, and gangliosides and have achieved similar results. Some cases of brain necrosis can be repairable and reversible. We aimed to summarize the incidence, pathogenesis, and treatment of RBN.

Radiation-Induced Middle Ear and Mastoid Opacification in Skull Base Tumors Treated With Radiotherapy

2011 ◽  
Vol 81 (5) ◽  
pp. e819-e823 ◽  
Author(s):  
Gary V. Walker ◽  
Salmaan Ahmed ◽  
Pamela Allen ◽  
Paul W. Gidley ◽  
Shiao Y. Woo ◽  
...  
Keyword(s):  
Skull Base ◽  
Middle Ear ◽  
Skull Base Tumors ◽  
Radiation Induced

Successful Treatment of Radiation-Induced Temporal Lobe Necrosis With Mouse Nerve Growth Factor

2011 ◽  
Vol 29 (7) ◽  
pp. e166-e168 ◽  
Author(s):  
XiaoShen Wang ◽  
HongMei Ying ◽  
ZhengRong Zhou ◽  
ChaoSu Hu ◽  
Avraham Eisbruch
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Temporal Lobe ◽  
Successful Treatment ◽  
Nerve Growth ◽  
Temporal Lobe Necrosis ◽  
Radiation Induced

2103 Heavy ion therapy in the treatment of skull base tumors: Acute radiation induced toxicity

1999 ◽  
Vol 45 (3) ◽  
pp. 329-330 ◽  
Author(s):  
D. Schulz-Ertner ◽  
J. Debus ◽  
T. Haberer ◽  
O. Jäkel ◽  
F. Wenz ◽  
...  
Keyword(s):  
Skull Base ◽  
Heavy Ion ◽  
Acute Radiation ◽  
Skull Base Tumors ◽  
Heavy Ion Therapy ◽  
Ion Therapy ◽  
Radiation Induced

Radiation-Induced Middle Ear and Mastoid Opacification in Skull Base Tumors

Skull Base ◽  
2009 ◽  
Vol 19 (03) ◽  
Author(s):  
Gary Walker ◽  
Salmaan Ahmed ◽  
Paul Gidley ◽  
Shiao Woo ◽  
Franco DeMonte ◽  
...  
Keyword(s):  
Skull Base ◽  
Middle Ear ◽  
Skull Base Tumors ◽  
Radiation Induced

scholarly journals Endoscopic-assisted Craniofacial Resection

2011 ◽  
Vol 3 (3) ◽  
pp. 156-160
Author(s):  
Aliasgar Moiyadi ◽  
Deepa Nair ◽  
Prathamesh S Pai
Keyword(s):  
Skull Base ◽  
Tumor Resection ◽  
Additional Treatment ◽  
Anterior Skull Base ◽  
Skull Base Tumors ◽  
Craniofacial Resection ◽  
Endoscopic Endonasal ◽  
The Past ◽  
Select Group ◽  
Sinonasal Tumor

ABSTRACT Management of anterior skull base tumors has progressed steadily since AS Ketcham popularized the craniofacial surgical technique in the seventies with good results. In the past two decades, endoscopic sinonasal tumor resection has been established as an additional treatment option. For tumors that cross the anterior skull base, a cranial access is vital to encompass the tumor all around. For a select group of these transcranial lesions, the sinonasal component is suitable for an endoscopic endonasal oncologically safe resection along with a traditional transcranial access to complete the resection. This article endeavors to describe the endoscopicassisted craniofacial combining the advantages of a transnasal minimal access to reduce facial morbidity and the transcranial access for superior control of tumors with adequate margins.

scholarly journals Study of relationship between dose, LET and the risk of brain necrosis after proton therapy for skull base tumors

2021 ◽  
Author(s):  
Magdalena Garbacz ◽  
Francesco Giuseppe Cordoni ◽  
Marco Durante ◽  
Jan Gajewski ◽  
Kamil Kisielewicz ◽  
...  
Keyword(s):  
Skull Base ◽  
Proton Therapy ◽  
Skull Base Tumors ◽  
Brain Necrosis

Human recombinant nerve growth factor (Cenegermin) in a patient affected by primary congenital glaucoma with neurotrophic keratopathy

2021 ◽  
pp. 112067212199934
Author(s):  
Ivano Riva ◽  
Eleonora Micheletti ◽  
Riccardo Fausto ◽  
Carlo Bruttini ◽  
Giovanni De Angelis ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Congenital Glaucoma ◽  
Eye Drops ◽  
Nerve Growth ◽  
Primary Congenital Glaucoma ◽  
Complete Restoration ◽  
New Treatment ◽  
The Right ◽  
Neurotrophic Keratopathy

Purpose: To report a case of neurotrophic keratopathy (NK) in a patient affected by primary congenital glaucoma (PCG) who undergone glaucoma drainage implant surgery. NK was successfully treated with human recombinant Nerve Growth Factor (Cenegermin) eye drops. Case report description: A 46-years-old patient affected by primary congenital glaucoma underwent Ahmed glaucoma valve implantation in the right eye, after several unsuccessful surgeries to control intraocular pressure (IOP) since the age of three. Surgical intervention was performed without complications, and IOP was well-controlled post-operatively. However, 1 month after surgery, he developed NK with stromal ulceration, initially treated with a topical combination of preservative-free artificial tears and antibiotic ointment. As NK did not resolve, a new treatment with Cenegermin 20 µg/ml eye drops, 6 times daily, was started. Outcome: NK completely resolved after 8 weeks of Cenegermin treatment, with complete restoration of corneal integrity and improvement of corneal sensitivity and transparency. Visual acuity in the operated eye reverted to the pre-operative value. Conclusion: Cenegermin was extremely effective in restoring corneal integrity in this PCG patient with NK.

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