scholarly journals Cognitive Impairment in Opium Use Disorder

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Hossein Sanjari Moghaddam ◽  
Behrang Shadloo ◽  
Helen Shahkhah ◽  
Abbas Tafakhori ◽  
Maryam Haghshomar ◽  
...  
Keyword(s):  
Working Memory ◽  
Information Processing ◽  
Processing Speed ◽  
Verbal Learning ◽  
Cross Sectional Study ◽  
Digit Symbol Substitution Test ◽  
Information Processing Speed ◽  
Cross Sectional ◽  
Significant Difference ◽  
Opium Use

This cross-sectional study is aimed at assessing the effects of opium use disorder (OUD) on attention, working memory, and information-processing speed. Thirty outpatients with OUD and 20 healthy controls (HCs) were assessed using a neuropsychological battery consisted of Auditory Verbal Learning Test-Revised (AVLT-R), Brief Visuospatial Memory Test-Revised (BVMT-R), Digit Forward and Backward Tests (DFT and DBT), and WAIS-R Digit Symbol Substitution Test (DSST). The most affected cognitive functions in patients with OUD were detected by DBT and DSST. However, we found no significant difference between patients according to the route of administration. Within patients with OUD, DBT score was associated with opium use quantity (OUQ) ( r = − 0.385 ), and DBT ( r = 0.483 ) and DSST ( r = 0.542 ) scores were correlated with duration of use. Our findings indicated that working memory and information-processing speed are the most affected domains of cognitive functioning. DBT and DSST could be used as brief assessments in clinical settings to screen for cognitive deficits in patients with OUD.

scholarly journals Cognitive dysfunction in adolescents with chronic fatigue: a cross-sectional study

2015 ◽  
Vol 100 (9) ◽  
pp. 838-844 ◽  
Author(s):  
Dag Sulheim ◽  
Even Fagermoen ◽  
Øyvind Stople Sivertsen ◽  
Anette Winger ◽  
Vegard Bruun Wyller ◽  
...  
Keyword(s):  
Working Memory ◽  
Cognitive Function ◽  
Processing Speed ◽  
Sleep Problems ◽  
Verbal Learning ◽  
Chronic Fatigue ◽  
Cross Sectional Study ◽  
Cognitive Inhibition ◽  
Sectional Study ◽  
Cross Sectional

ObjectiveTo compare cognitive function in adolescents with chronic fatigue with cognitive function in healthy controls (HC).Study designCross-sectional study.SettingPaediatric department at Oslo University Hospital, Norway.Participants120 adolescents with chronic fatigue (average age 15.4 years; range 12–18) and 39 HC (average age 15.2 years; range 12–18).MethodsThe adolescents completed a neurocognitive test battery measuring processing speed, working memory, cognitive inhibition, cognitive flexibility, verbal learning and verbal memory, and questionnaires addressing demographic data, depression symptoms, anxiety traits, fatigue and sleep problems. Parents completed the Behaviour Rating Inventory of Executive Function (BRIEF), which measures the everyday executive functions of children.ResultsAdolescents with chronic fatigue had impaired cognitive function compared to HC regarding processing speed (mean difference 3.3, 95% CI 1.1 to 5.5, p=0.003), working memory (−2.4, −3.7 to −1.1, p<0.001), cognitive inhibition response time (6.2, 0.8 to 11.7, p=0.025) and verbal learning (−1.7, −3.2 to −0.3, p=0.022). The BRIEF results indicated that everyday executive functions were significantly worse in the chronic fatigue group compared to the HC (11.2, 8.2 to 14.3, p<0.001). Group differences remained largely unaffected when adjusted for symptoms of depression, anxiety traits and sleep problems.ConclusionsAdolescents with chronic fatigue had impaired cognitive function of clinical relevance, measured by objective cognitive tests, in comparison to HC. Working memory and processing speed may represent core difficulties.

scholarly journals Cannabis and cognitive performance in psychosis: a cross-sectional study in patients with non-affective psychotic illness and their unaffected siblings

2011 ◽  
Vol 42 (4) ◽  
pp. 705-716 ◽  
Author(s):  
J. H. Meijer ◽  
N. Dekker ◽  
M. W. Koeter ◽  
P. J. Quee ◽  
N. J. M. van Beveren ◽  
...  
Keyword(s):  
Working Memory ◽  
Cognitive Functioning ◽  
Processing Speed ◽  
Verbal Learning ◽  
Cross Sectional Study ◽  
Cannabis Use ◽  
Cognitive Test ◽  
Sectional Study ◽  
Cross Sectional ◽  
Knowledge Reasoning

BackgroundThe relationship between cannabis use and cognitive functioning in patients with psychosis has yielded contradictory findings. In individuals at genetic high risk for psychosis, information is sparse. The aim of this study was to assess the association between recency and frequency of cannabis use and cognitive functioning in patients with psychosis and their unaffected siblings.MethodWe conducted a cross-sectional study in 956 patients with non-affective psychosis, 953 unaffected siblings, and 554 control subjects. Participants completed a cognitive test battery including assessments of verbal learning, set shifting, sustained attention, processing speed, working memory, acquired knowledge, reasoning and problem solving and social cognition. Cannabis use was assessed by urinalysis and by the Composite International Diagnostic Interview. Using random-effect regression models the main effects of cannabis (recency and frequency) and the interaction with status (patient, sibling, control) on cognitive functioning were assessed.ResultsCurrent cannabis use was associated with poorer performance on immediate verbal learning, processing speed and working memory (Cohen's d −0.20 to −0.33, p<0.005). Lifetime cannabis use was associated with better performance on acquired knowledge, facial affect recognition and face identity recognition (Cohen's d+0.17 to +0.33, p<0.005). There was no significant interaction between cannabis and status on cognitive functioning.ConclusionsLifetime cannabis-using individuals might constitute a subgroup with a higher cognitive potential. The residual effects of cannabis may impair short-term memory and processing speed.

scholarly journals Swimming as a Positive Moderator of Cognitive Aging: A Cross-Sectional Study with a Multitask Approach

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Amira Abou-Dest ◽  
Cédric T. Albinet ◽  
Geoffroy Boucard ◽  
Michel Audiffren
Keyword(s):  
Older Adults ◽  
Young Adults ◽  
Information Processing ◽  
Processing Speed ◽  
Cognitive Aging ◽  
Cross Sectional Study ◽  
Information Processing Speed ◽  
Cross Sectional ◽  
Positive Effects ◽  
Potential Benefits

This study examined whether regular swimming in older adults was related to better cognitive functioning and whether there were any global or selective positive effects of this physical activity (PA) on cognition. The cognitive performances of three groups of sixteen volunteer participants (young adults, sedentary older adults, and older adults who regularly practice swimming) were evaluated using a multitask approach. All participants performed a battery of ten tasks: two reaction time tasks assessing information processing speed and eight experimental tasks assessing three executive functions (EFs), (behavioral inhibition, working memory updating, and cognitive flexibility). The results showed that young adults performed significantly better than older adults on all examined cognitive functions. However, in older adults, regular swimming was related to better performance on the three EFs, but not on information processing speed. More precisely, five experimental tasks out of the eight tapping EFs were shown to be sensitive to positive effects from swimming practice. Finally, the demonstrated benefits of swimming on EFs were not necessarily linked to better cardiorespiratory fitness. The present findings illustrate the validity of using a multitask approach in examining the potential benefits of regular PA on cognitive aging.

scholarly journals Predicting Academic Achievement with Cognitive Abilities: Cross-Sectional Study across School Education

2020 ◽  
Vol 10 (10) ◽  
pp. 158
Author(s):  
Tatiana Tikhomirova ◽  
Artem Malykh ◽  
Sergey Malykh
Keyword(s):  
Academic Achievement ◽  
Working Memory ◽  
Information Processing ◽  
Processing Speed ◽  
Cognitive Abilities ◽  
Fluid Intelligence ◽  
Number Sense ◽  
Information Processing Speed ◽  
Cross Sectional ◽  
The Relationship

The relationship between cognitive abilities and academic achievement across schooling from the first to the eleventh grade was analyzed. Information processing speed, visuospatial working memory, number sense, and fluid intelligence were considered predictors of general academic achievement, which was derived from grades in mathematics, language, and biology. This cross-sectional study involved 1560 pupils who were in grades 1–11 at general education schools and were aged from 6.8 to 19.1 years (50.4% were boys). Information processing speed, visuospatial working memory, and number sense were measured using the Choice Reaction Time, Corsi Block-Tapping, and Number Sense computerized tests, respectively. Fluid intelligence was measured using the paper-and-pencil version of the Standard Progressive Matrices test. Correlation analysis and structural equation modeling were carried out. It was shown that it is possible to describe the structure of the relationship between cognitive abilities and academic achievement for all levels of schooling with a single model. In this model, information processing speed is the key predictor of fluid intelligence, working memory, and number sense, which in turn contribute to individual differences in academic success. Additionally, the specificity of the relationship between individual indicators of cognitive abilities and academic achievement at each level of schooling was revealed.

Reduced information processing speed as primum movens for cognitive decline in MS

2014 ◽  
Vol 21 (1) ◽  
pp. 83-91 ◽  
Author(s):  
Jeroen Van Schependom ◽  
Marie B D’hooghe ◽  
Krista Cleynhens ◽  
Mieke D’hooge ◽  
Marie-Claire Haelewyck ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Information Processing ◽  
Processing Speed ◽  
Time Course ◽  
Age At Onset ◽  
Memory Task ◽  
Cognitive Domain ◽  
Information Processing Speed ◽  
Survival Curves ◽  
Cross Sectional

Background: Cognitive impairment affects half of the multiple sclerosis (MS) patient population and is an important contributor to patients’ daily activities. Most cognitive impairment studies in MS are, however, cross-sectional or/and focused on the early disease stages. Objective: We aim to assess the time course of decline of different cognitive domains. Methods: We collected neuropsychological data on 514 MS patients to construct Kaplan-Meier survival curves of the tests included in the Neuropsychological Screening Battery for MS (NSBMS) and the Symbol Digit Modalities Test (SDMT). Cox-proportional hazard models were constructed to examine the influence of MS onset type, age at onset, gender, depression and level of education on the time course, expressed as age or disease. Results: Survival curves of tests focusing on information processing speed (IPS) declined significantly faster than tests with less specific demands of IPS. Median age for pathological decline was 56.2 years (95% CI: 54.4–58.2) on the SDMT and 63.9 years (95% CI: 60–66.9) on the CLTR, a memory task. Conclusion: In conclusion, IPS is the cognitive domain not only most widely affected by MS but it is also the first cognitive deficit to emerge in MS.

Abstract NS10: Patients with Mild and Moderate Stroke Have Frequent, Severe, and Persistent Impairment in Information Processing Speed

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Susan Alderman ◽  
Terri Armstrong ◽  
Geri Wood ◽  
Sean Savitz ◽  
Joshua Breier
Keyword(s):  
Information Processing ◽  
Processing Speed ◽  
Memory Impairment ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Stroke Recovery ◽  
Stroke Severity ◽  
Information Processing Speed ◽  
Significant Difference ◽  
Mild Stroke

Background: One year after stroke 50-70% of survivors have information processing speed (IPS) impairment. IPS is a complex, elemental cognitive function with close but separate relationships with memory, attention, executive function, reading, and writing. IPS impairment can be devastating, even without physical deficits. Hypothesis: The frequency and severity of IPS impairment in patients with acute stroke is unrelated to stroke severity. Methods: In a longitudinal study, 30 adults with acute mild (NIHSS <5) versus moderate stroke (NIHSS 5-12) were assessed for IPS and memory impairments at three time points (< 72 hours, Week 3, and Week 12). The Symbol Digit Modalities Test (SDMT) was the primary IPS instrument, scores below the norm (51-62 points) indicate impairment. Results: Using linear mixed model regression, no significant difference was noted between patients with mild and moderate stroke in frequency and severity of IPS impairment (p=0.2). All patients had baseline abnormal SDMT scores, improving 21% by Week 12 (p=.005) with one patient scoring as unimpaired (51 points). Patients with mild stroke (n=18) had baseline scores on average 53% lower than SDMT norm (mean score 24 (12), [95% CI] 6 [18, 30], Standard Error (SEM) 3) and 32% lower at Week 12 (mean 34 (11), [95% CI] 5 [29, 40], SEM 3). Patients with moderate stroke (n=12) had baseline SDMT scores 60% lower than norm (mean 21 (11), [95% CI] 6 [15, 27], SEM 3) and 39% lower by Week 12 (mean 31 (12), [95% CI] 7 [25, 38], SEM 3). Memory impairment at enrollment (<72 hours post stroke) was noted in 100% of patients with moderate stroke and 78% of patients with mild stroke; at Week 12 the frequency of memory impairment was equal in both groups (67%). Conclusion: IPS were critically impaired, in both mild and moderate stroke, with minimal spontaneous recovery at Week 12. IPS impairment is clinically significant during stroke recovery. IPS impairment should be considered in the planning of healthcare of stroke victims even with mild stroke.

Paranoidism and memory deficits: An epidemiological study

2017 ◽  
Vol 41 (S1) ◽  
pp. S569-S569
Author(s):  
C.M. Calahorro ◽  
M. Guerrero Jiménez ◽  
B.M. Girela Serrano ◽  
J.E. Muñoz Negro
Keyword(s):  
Cognitive Abilities ◽  
Wide Spectrum ◽  
Verbal Learning ◽  
Multidisciplinary Treatment ◽  
Cross Sectional Study ◽  
Clinical Population ◽  
Psychotic Symptoms ◽  
Attention And Memory ◽  
Cross Sectional ◽  
Significant Difference

BackgroundThe Green et al. Paranoid Thought Scales (GPTS) was developed to fulfill a need for a tool that was adapted to the current dimensional definition of paranoia, capable to assess dimensions of preoccupation, conviction, and distress, valid and reliable for the assessment of both clinical and healthy populations, and precise enough to detect subtle clinical change. It has recently been validated for the Spanish population (S-GPTS) with very good psychometric properties. Numerous studies suggest that patients with severe psychiatric disorders have impaired sustained attention and memory. A wide spectrum of executive deficits have also been described (goal-oriented tasks, recognizing priority patterns, planning, etc.) Very few studies have attempted to identify whether these same relationships between neuropsychological deficits and psychotic symptoms also occur in general population.MethodsThis is a cross-sectional study. We undertook a multistage sampling using different standard stratification levels and out of the 5496 eligible participants finally approached, 4507 (83.7%) agreed to take part in the study, completed the interview and were finally included in the study (n = 4507).ResultsIndividuals with high cut off S-GPTS scores showed lower scores in working memory subtest verbal statistically significant(P > .05). While no significant difference was found among for immediate verbal learning subtest and high S-GPTS scores (P > .05654).DiscussionThis information can improve the clinician's understanding of patient's cognitive strength and weaknesses, put patients’ cognitive abilities into perspective for their diagnosis, and facilitate multidisciplinary treatment decisions as we improve our ability to distinguish clinical cases from non-clinical population.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals The Reliability and Validity of the Action Fluency Test in Healthy College Students

2019 ◽  
Vol 34 (7) ◽  
pp. 1175-1191 ◽  
Author(s):  
Thomas P Ross ◽  
Sydne O’Connor ◽  
Graham Holmes ◽  
Brittany Fuller ◽  
Megan Henrich
Keyword(s):  
College Students ◽  
Working Memory ◽  
Information Processing ◽  
Executive Functioning ◽  
Processing Speed ◽  
Convergent Validity ◽  
Reliability And Validity ◽  
Information Processing Speed ◽  
Perceptual Reasoning ◽  
Fluency Test

Abstract Objective This study examined the test–retest reliability and construct validity of the Action Fluency Test (AFT) as a measure of executive functioning. Method Using a correlational design, 128 healthy college students (M Age = 19.24, SD = 2.01; M education = 13.29 years, SD = 0.81) completed the AFT, and measures of verbal and figural fluency, executive functioning and other relevant constructs (e.g., vocabulary, working memory, and attention). Results Coefficients of stability were acceptable for AFT correct words (r = .76; p &lt; .01), but not for errors (r = .41) or perseverations (r = .14). No practice effects were observed upon repeat testing (M interval = 39.21 days). Divergent validity evidence was mixed. AFT scores were unrelated to working memory and perceptual-reasoning abilities; however, correlations with vocabulary (r = .32; p &lt; .01) and information-processing speed (r = .30; p &lt; .01) were greater than associations between AFT scores and executive measures. Regarding convergent validity, AFT scores correlated with other fluency tasks (r = .4 range), but correlations with measures of executive functioning were absent or small. Action and letter fluency correlated with measures of attentional control and inhibition; however, these associations were no longer significant after controlling for shared variance with information-processing speed. Conclusions Findings are consistent with previous research suggesting vocabulary and information-processing speed underlie effective fluency performance to a greater extent than executive functioning. The AFT measures unique variance not accounted for by semantic and letter fluency tasks, and therefore may be used for a variety of research and clinical purposes.

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