scholarly journals Multifocal Electroretinogram Can Detect the Abnormal Retinal Change in Early Stage of type2 DM Patients without Apparent Diabetic Retinopathy

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Jiang Huang ◽  
Yi Li ◽  
Yao Chen ◽  
Yuhong You ◽  
Tongtong Niu ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Early Stage ◽  
Multifocal Electroretinogram ◽  
Implicit Time ◽  
Diabetic Patients ◽  
Healthy Controls ◽  
Type 2 Diabetic Patients ◽  
Type 2 Dm ◽  
Retinal Change

Purpose. To study retinal function defects in type 2 diabetic patients without clinically apparent retinopathy using a multifocal electroretinogram (mf-ERG). Methods. Seventy-six eyes of thirty-eight type 2 diabetes mellitus(DM) patients without clinically apparent retinopathy and sixty-four normal eyes of thirty-two healthy control (HC) participants were examined using mf-ERG. Results. Patients with type 2 DM without apparent diabetic retinopathy demonstrated an obvious implicit time delay of P1 in ring 1, ring 3, and ring 5 compared with healthy controls ( t = 5.184 , p ≤ 0.001 ; t = 8.077 , p ≤ 0.001 ; t = 2.000 , p = 0.047 , respectively). The implicit time (IT) in ring 4 of N1wave was significantly delayed in the DM group ( t = 2.327 , p = 0.021 ). Compared with the HC group, the implicit time of the P1 and N1 waves in the temporal retina zone was significantly prolonged ( t = 3.66 , p ≤ 0.001 ; t = 2.187 , p = 0.03 , respectively). And the amplitude of P1 in the temporal retina decreased in the DM group, which had a significantly statistical difference with the healthy controls ( t = − 6.963 , p ≤ 0.001 ). However, there were no differences in either the amplitude of the response or the implicit time of the nasal retina zone between DM and HC. The AUC of multiparameters of mf-ERG was higher in the diagnosis of DR patients. Conclusions. Patients with type 2 DM without clinically apparent retinopathy had a delayed implicit time of P1 wave in temporal regions of the postpole of the retina compared with HC subjects. It demonstrates that mf-ERG can detect the abnormal retinal change in the early stage of type2 DM patients without apparent diabetic retinopathy. Multiparameters of mf-ERG can improve the diagnostic efficacy of DR, and it may be a potential clinical biomarker for early diagnosis of DR.

scholarly journals Association of hypertension and diabetic retinopathy in type 2 DM patients.

2020 ◽  
Vol 27 (10) ◽  
pp. 2056-2061
Author(s):  
Ali Saqib ◽  
Muhammad Sarfraz ◽  
Touseef Anwar ◽  
Muhammad Absar Alam ◽  
Rizwan Rasul Khan ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diabetic Retinopathy ◽  
Strong Association ◽  
Mean Value ◽  
University Hospital ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Dm ◽  
Group B

Objectives: To evaluate the association of hypertension and diabetic retinopathy in type 2 DM patients. Study Design: Case Control study. Setting: Diabetic Clinic Department of Medicine, Independent University Hospital, Faisalabad. Period: From January 2019 to June 2019. Material & Methods: One Hundred Type 2 diabetic patients of either sex were reviewed and these patients were screened for diabetic retinopathy using welchallyn ophthalmoscope. The patients with diabetic retinopathy fulfilling the inclusion criteria were placed in group A (cases) and patients without diabetic retinopathy were placed in group B (control). After resting the patient in supine position for 5 minutes, blood pressure (BP) measurements were taken in all these patients using mercury sphygmomanometer in two successive out-patient department visits, and mean value of B.P. was taken. All patients were asked for duration of diabetes, hypertension and visual problems specifically. These patients were advised following investigations: - FBS. - RBS. - HbAlc. Relevant statistics, mean & standard deviation were computed for variables. T-test was applied on hypertension (independent) and DM retinopathy (dependent) variables. Results: Systolic and diastolic blood pressure were significantly higher in the patients with retinopathy (mean systolic B.P 153.4± 17.13 and mean diastolic B.P. 84.1±9.26) than in those without retinopathy (mean systolic B.P. 130.65±11.94 and mean diastolic B.P 77.3 ±6.64). There was significant correlation of diabetic retinopathy with systolic hypertension (P<0.05) and diastolic hypertension (P<0.001). Conclusion: There is strong association between diabetic retinopathy and hypertension. So early detection and treatment of hypertension can retard the development and progression of diabetic retinopathy.

scholarly journals SUN-686 Diabetic Retinopathy in Latinos with Type 2 Diabetes: Temperance Is Protective

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Alex Fukunaga ◽  
Pauline Genter ◽  
Eli Ipp
Keyword(s):  
Diabetic Retinopathy ◽  
Alcohol Consumption ◽  
Alcohol Intake ◽  
Retinal Images ◽  
Diabetic Patients ◽  
Renal Protection ◽  
Type 2 Diabetic Patients ◽  
Type 2 Dm ◽  
Lower Alcohol

Abstract Diabetic retinopathy (DR) is a duration-dependent complication of diabetes (DM). Yet some people with DM do not develop DR despite long disease duration. We evaluated such a group in search of novel factors that might signal protection from DR, using a large cohort of Latinos with type 2 DM and readable retinal images in the GOLDR study (n=614). Participants were phenotyped and 7-field retinal images were evaluated using Airlie House criteria. We identified 90 participants with DM&gt;10y without evidence for DR (NoDR). We compared this group of patients with another group more susceptible to DR with evidence for earlier onset DR, in DM &lt;10y duration (EoDR, n=103). Duration of diabetes in NoDR was [x+SEM] 14.2+ 0.6y, and in EoDR, 4.3+ 2.9 y (p&lt;0.001), a 10-y spread. We found that most of the typical DR-associated risk factors could not explain DR protection in NoDR, including age, sex, age at DM onset, systolic blood pressure (SBP), percent insulin users, duration of hypertension, fasting plasma glucose, A1C, urine albumin/creatinine ratio and estimate glomerular filtration rate; these parameters were not significantly different in the two groups. Protective factors that did emerge were female sex (p=0.02), lower diastolic BP 69.1+0.9 vs. 72.5+0.9 (p&lt;0.01) and lower alcohol intake 3.1+0.8 vs. 7.8+2 de/w (14g drink equivalents/week; p=0.025). In a sensitivity analysis to determine whether sex accounted for the apparent effect of alcohol on DR, we evaluated the men in the study, who were more likely to be drinkers. Alcohol consumption was compared in men with DR who reported drinking alcohol (n=93) compared to men without DR who also reported drinking (n=53). Men without DR reported significantly less alcohol intake, 14.8+2.4 vs. 25.9 +3.3 de/w in those with DR (P&lt;0.01), suggesting that a possible protective benefit of lower alcohol consumption observed in NoDR was not likely to be mediated by the presence of fewer men in that cohort. In summary, type 2 diabetic patients with no evidence of DR after 10y were more likely to be women, have a lower diastolic BP, and who imbibed less alcohol when compared with a more accelerated DR subgroup with &lt;10yrs duration of DM. We conclude that in type 2 DM Latino patients, a focus on alcohol intake may be a useful management strategy in addition to traditional medication-based BP control and renal protection, as well as a pathophysiological pathway for DR worthy of investigation.

scholarly journals Copper, Zinc levels of newly diagnosed type 2 Diabetic patients are better marker in RBC than in Plasma

2019 ◽  
Vol 4 (6) ◽  
Keyword(s):  
Diabetic Patients ◽  
Healthy Controls ◽  
Newly Diagnosed ◽  
Type 2 Diabetic Patients ◽  
Medical Problems ◽  
Type 2 Dm ◽  
Zinc Levels ◽  
Type 2 Diabetic ◽  
Cu And Zn

One of the greatest medical problems threatening the world today is Diabetes Mellitus. Aims of this study were to compare plasma, RBC Cu and Zn between healthy and newly diagnosed type 2 diabetic patients, also association of hyperglycaemia, dyslipidaemia with plasma and RBC Cu, Zn. Study was carried out in departments of Biochemistry jointly with Endocrine Medicine of Bangabandhu Sheikh Mujib Medical University. Thirty three newly diagnosed type 2 DM, thirty one age and sex matched healthy controls were included. Both Cu and Zn were measured by atomic absorption spectrophotometer. The median value of plasma Cu in healthy controls was 942.00 ppb (ranging 846-1393.50 ppb), in newly diagnosed type 2 diabetic patients, 2739.00 ppb (ranging 1400- 5743.50ppb). Significantly higher level of plasma Cu was observed in cases (p<.001). Median value of RBC Cu of healthy controls was 1067.50 (ranging 423-2810.5 ppb) whereas that of diabetic patient was 773.50 ppb (ranging 52.50-2765.00 ppb). RBC Cu was significantly lower (p<.05) than the healthy controls. Median values of plasma Zn of healthy controls and type 2 diabetic patients were 777.50 ppb (ranging 621.50- 1018.00 ppb) and 703.00 ppb (ranging 472-930 ppb), whereas that of RBC Zn of both groups were 6984.00 ppb (ranging 5693.50-7796.00 ppb) and 5155.50 ppb (ranging 2820- 6153 ppb) respectively. The plasma and RBC Zn were significantly lowered (p<.001) in diabetic group. There was significant positive correlation (p<.05) between fasting plasma Cu and glucose, significant negative (p<.05) correlation between fasting RBC Zn and triglyceride in type 2 DM. RBC is a better marker to see the trace element status than plasma.

MO052BIOPSY PROVEN KIDEY DISEASES IN TYPE 2 DIABETIC PATIENTS WITH IMPAIRED RENAL FUNCTION

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Jin Hyuk Paek ◽  
Ohyun Kwon ◽  
Yaerim Kim ◽  
Woo Yeong Park ◽  
Seungyeup Han ◽  
...  
Keyword(s):  
Renal Function ◽  
Diabetic Retinopathy ◽  
Kidney Disease ◽  
Renal Disease ◽  
Impaired Renal Function ◽  
Kidney Biopsy ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Dm

Abstract Background and Aims Diabetic nephropathy (DN) is a major microvascular complication of diabetes mellitus (DM) and the most common cause of end stage of renal disease worldwide. The nature of kidney disease in type 2 DM is more complex than type 1 DM. However, the usefulness of kidney biopsy in type 2 DM is still controversial and there are few reports about the biopsy proven kidney disease, especially in patients with impaired renal function. Method We retrospectively reviewed 1454 patients who received native kidney biopsy at Keimyung university Dongsan medical center between 2005 and 2018. Among 1454 patients, 92 patients were diagnosed with type 2 DM before kidney biopsy. Fifty-three patients with impaired renal function (estimated glomerular filtration rate &lt; 60 mL/min/1.73 m2 using Modification of Diet in Renal Disease formula) were finally enrolled in this study. We categorized the pathologic diagnoses as DN, non-diabetic renal disease (NDRD), and NDRD mixed with DN (Mixed). Results The mean age at kidney biopsy was 58.4 ± 11.2 and mean eGFR was 28.6 ± 14.6 mL/min/1.73 m2. Nineteen patients (35.8%) had diabetic retinopathy and mean duration of DM before kidney biopsy was 102.1 ± 82.2 months. Of the 53 patients, there were 28 NDRD (52.8%), 18 DN (34.0%), and 7 Mixed (13.2%). Diabetic retinopathy was more common in DN, following Mixed and NDRD (72.2%, 42.9%, and 10.7%, respectively, p &lt; 0.001). Multivariable logistic regression analysis revealed that diabetic retinopathy was significantly associated with DN (OR, 23.672; 95% CI, 4.290-130.609; p &lt; 0.001). In multivariable cox proportional hazard models, creatinine level (HR, 1.779; 95% CI, 1.404-2.255; p &lt; 0.001) and dipstick albuminuria ≥ 2+ (HR, 22.721; 95% CI, 4.670-110.542; p &lt; 0.001) were identified as independent prognostic factors for renal survival. Conclusion Kidney disease of type 2 diabetic patients were various and clinical parameters could not completely predict. Kidney biopsy is an important tool for the definite diagnosis and the proper treatment of kidney disease in diabetic patients with impaired renal function.

scholarly journals The Importance of Close Follow-Up in Patients with Early-Grade Diabetic Retinopathy: A Taiwan Population-Based Study Grading via Deep Learning Model

2021 ◽  
Vol 18 (18) ◽  
pp. 9768
Author(s):  
Chia-Cheng Lee ◽  
Shi-Chue Hsing ◽  
Yu-Ting Lin ◽  
Chin Lin ◽  
Jiann-Torng Chen ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Rapid Development ◽  
Population Based ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Dm ◽  
Early Grade ◽  
Current Guidelines

(1) Background: Diabetic retinopathy (DR) can cause blindness. Current guidelines on diabetic eye care recommend more frequent eye examinations for more severe DR to prevent deterioration. However, close follow-up and early intervention at earlier stages are important for the prevention of disease progression of other diabetes mellitus (DM) complications. The study was designed to investigate the association between different stages of DR in type 2 DM patients and the progression of DR; (2) Methods: A total of 2623 type 2 DM patients were included in this study. In these patients, a total of 14,409 fundus color photographs was obtained. The primary outcome was the progression of DR; (3) Results: The progression of DR was highly associated with the initial grade of DR (p < 0.001). Severe nonproliferative diabetic retinopathy (NPDR) was the most likely to progress to proliferative diabetic retinopathy (PDR), followed by moderate NPDR, mild NPDR, and no retinopathy. However, progression to the next stage of DR showed a different trend. We used no retinopathy as a reference. Mild NPDR showed the highest risk for progression to the next stage [hazard ratio (HR): 2.00 (95% conference interval (CI): 1.72–2.32)] relative to higher initial grades [HR (moderate NPDR): 1.82 (95% CI: 1.58–2.09) and HR (severe NPDR): 0.87 (95% CI: 0.69–1.09)]. The same trend was observed in the multivariate analysis, in which mild NPDR presented the highest risk for progression to the next stage (adjusted HR (mild NPDR): 1.95 (95% CI: 1.68–2.27), adjusted HR (moderate NPDR): 1.73 (95% CI: 1.50–1.99), and adjusted HR (severe NPDR): 0.82 (95% CI: 0.65–1.03)); (4) Conclusions: Type 2 diabetic patients with earlier-grade DR appeared to exhibit more rapid development to the next grade in our study. As these findings show, more frequent fundus color photography follow-up in earlier-grade DR patients is important to slow DR progression and awaken self-perception.

Male Type 2 Diabetic Patients Have Higher Diabetic Retinopathy Prevalence

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 599-P ◽  
Author(s):  
SARA CHERCHI ◽  
ALFONSO GIGANTE ◽  
PIERPAOLO CONTINI ◽  
DANILA PISTIS ◽  
ROSANGELA M. PILOSU ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Male Type ◽  
Type 2 Diabetic

scholarly journals Diabetic retinopathy is associated with diastolic dysfunction in type 2 diabetic patients with non-ischemic dilated cardiomyopathy

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Yoo-Ri Chung ◽  
Se-Jun Park ◽  
Ka Young Moon ◽  
Seoyoung Annie Choi ◽  
Hong-Seok Lim ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Dilated Cardiomyopathy ◽  
Diastolic Dysfunction ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Non Ischemic Dilated Cardiomyopathy ◽  
Type 2 Diabetic

Familial clustering of diabetic retinopathy in type 2 diabetic patients

2000 ◽  
Vol 50 ◽  
pp. 252
Author(s):  
M Rema ◽  
G Saravanan ◽  
R Deepa ◽  
V Mohan
Keyword(s):  
Diabetic Retinopathy ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Familial Clustering ◽  
Type 2 Diabetic
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