scholarly journals Analysis of Clinical Characteristics, Radiological Predictors, Pathological Features, and Perioperative Outcomes Associated with Perinephric Fat Adhesion Degree

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Junqiang Liu ◽  
Yiheng Jiang ◽  
Hongwei Huang ◽  
Zheng Zhu ◽  
Jing Chen ◽  
...  
Keyword(s):  
Immune Cells ◽  
Clinical Characteristics ◽  
Renal Cortex ◽  
Multivariate Analyses ◽  
Perioperative Outcomes ◽  
Pathological Features ◽  
Fat Thickness ◽  
The Impact ◽  
Perinephric Fat ◽  
Masson Staining

Background. To assess the clinical characteristics, radiological predictors, and pathological features of perinephric fat adhesion degree (PFAD) graded based on fixed criteria and to determine the impact of adherent perinephric fat (APF) on retroperitoneal laparoscopic partial nephrectomy (RLPN) outcomes. Methods. 84 patients undergoing RLPN were included and graded into 4 groups based on PFAD. Univariate and multivariate analyses were performed for clinical characteristics and radiological predictors of PFAD. Perioperative data were compared between APF groups and non-APF groups. Masson staining determined collagen fibers. Immunohistochemistry detected CD45 immune cells and CD34 vessels. Results. 20, 28, 18, and 18 patients were graded as normal perinephric fat (NPF), mild adherent perinephric fat (MiPF), moderate adherent perinephric fat (MoPF), and severe adherent perinephric fat (SPF), respectively. Multivariate analysis revealed that gender ( p  < 0.001), age ( p  = 0.003), and hypertension ( p  = 0.006) were significant clinical risk factors of PFAD, while radiological predictors included perinephric stranding ( p  = 0.001), posterior perinephric fat thickness ( p  = 0.009), and perinephric fat density ( p  = 0.02). APF was associated with drain output ( p  = 0.012) and accompanied by immune cells gathering in renal cortex near thickened renal capsule with many vessels. Conclusions. Clinical characteristics and radiological predictors can evaluate PFAD and may assist to guide preoperative surgical option. Pathological features of APF reflect decapsulation and bleeding during kidney mobilization at RLPN.

scholarly journals Analysis of Clinical Characteristics, Radiological Predictors, Pathological Features and Perioperative Outcomes Associated with Perinephric Fat Adhesion Degree

2021 ◽  
Author(s):  
Junqiang Liu ◽  
Hongwei Huang ◽  
Yiheng Jiang ◽  
Zheng Zhu ◽  
Jing Chen ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Immune Cells ◽  
Clinical Characteristics ◽  
Renal Cortex ◽  
Perioperative Outcomes ◽  
Pathological Features ◽  
Fat Thickness ◽  
The Impact ◽  
Perinephric Fat ◽  
Masson Staining

Abstract Background To assess the clinical characteristics, radiological predictors and pathological features of perinephric fat adhesion degree (PFAD) graded based on fixed criteria and to determine the impact of adherent perinephric fat (APF) on retroperitoneal laparoscopic partial nephrectomy (RLPN) outcomes. Methods 84 patients undergoing RLPN were included and graded into 4 groups based on PFAD. Univariate and multivariate analysis were performed for clinical characteristics and radiological predictors of PFAD. Perioperative data was compared between APF groups and non-APF groups. Masson staining determined collagen fibers. Immunohistochemistry detected CD45 immune cells and CD34 vessels. Results: 20, 28, 18 and 18 patients were graded as normal perinephric fat (NPF), mild adherent perinephric fat (MiPF), moderate adherent perinephric fat (MoPF) and severe adherent perinephric fat (SPF), respectively. Multivariate analysis revealed that gender (p < 0.001), age (p = 0.003) and hypertension (p = 0.006) were significant clinical risk factors of PFAD, while radiological predictors included perinephric stranding (p = 0.001), posterior perinephric fat thickness (p = 0.009) and perinephric fat density (p = 0.02). APF was associated with drain output (P = 0.012) and accompanied by immune cells gathering in renal cortex near thickened renal capsule with many vessels. Conclusions Clinical characteristics and radiological predictors can evaluate PFAD and may assist guide preoperative surgical option. Pathological features of APF reflect decapsulation and bleeding during kidney mobilization at RLPN.

scholarly journals Analysis of clinical characteristics, radiological predictors, pathological features and perioperative outcomes associated with perinephric fat adhesion degree

2020 ◽  
Author(s):  
Junqiang Liu ◽  
Hongwei Huang ◽  
Tianyu Cao ◽  
Dikuan Liu ◽  
Zheng Zhu ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Immune Cells ◽  
Clinical Characteristics ◽  
Renal Cortex ◽  
Perioperative Outcomes ◽  
Pathological Features ◽  
Fat Thickness ◽  
The Impact ◽  
Perinephric Fat ◽  
Masson Staining

Abstract Background To assess the clinical characteristics, radiological predictors and pathological features of perinephric fat adhesion degree (PFAD) graded based on fixed criteria and to determine the impact of adherent perinephric fat (APF) on retroperitoneal laparoscopic partial nephrectomy (RLPN) outcomes. Methods 84 patients undergoing RLPN were included and graded into 4 groups based on PFAD. Univariate and multivariate analysis were performed for clinical characteristics and radiological predictors of PFAD. Perioperative data was compared between APF groups and non-APF groups. Masson staining determined collagen fibers. Immunohistochemistry detected CD45 immune cells and CD34 vessels. Results 20, 28, 18 and 18 patients were graded as normal perinephric fat (NPF), mild adherent perinephric fat (MiPF), moderate adherent perinephric fat (MoPF) and severe adherent perinephric fat (SPF), respectively. Multivariate analysis revealed that gender (p < 0.001), age (p = 0.003) and hypertension (p = 0.006) were significant clinical risk factors of PFAD, while radiological predictors included perinephric stranding (p = 0.001), posterior perinephric fat thickness (p = 0.009) and perinephric fat density (p = 0.02). APF was associated with drain output (P = 0.012) and accompanied by immune cells gathering in renal cortex near thickened renal capsule with many vessels. Conclusions Clinical characteristics and radiological predictors can evaluate PFAD and may assist guide preoperative surgical option. Pathological features of APF reflect decapsulation and bleeding during kidney mobilization at RLPN.

scholarly journals Analysis of Clinical Characteristics, Radiological Predictors, Pathological Features and Perioperative Outcomes Associated With Perinephric Fat Adhesion Degree

2021 ◽  
Author(s):  
Junqiang Liu ◽  
Hongwei Huang ◽  
Yiheng Jiang ◽  
Dikuan Liu ◽  
Zheng Zhu ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Immune Cells ◽  
Clinical Characteristics ◽  
Renal Cortex ◽  
Perioperative Outcomes ◽  
Pathological Features ◽  
Fat Thickness ◽  
The Impact ◽  
Perinephric Fat ◽  
Masson Staining

Abstract Background: To assess the clinical characteristics, radiological predictors and pathological features of perinephric fat adhesion degree (PFAD) graded based on fixed criteria and to determine the impact of adherent perinephric fat (APF) on retroperitoneal laparoscopic partial nephrectomy (RLPN) outcomes. Methods: 84 patients undergoing RLPN were included and graded into 4 groups based on PFAD. Univariate and multivariate analysis were performed for clinical characteristics and radiological predictors of PFAD. Perioperative data was compared between APF groups and non-APF groups. Masson staining determined collagen fibers. Immunohistochemistry detected CD45 immune cells and CD34 vessels.Results: 20, 28, 18 and 18 patients were graded as normal perinephric fat (NPF), mild adherent perinephric fat (MiPF), moderate adherent perinephric fat (MoPF) and severe adherent perinephric fat (SPF), respectively. Multivariate analysis revealed that gender (p<0.001), age (p=0.003) and hypertension (p=0.006) were significant clinical risk factors of PFAD, while radiological predictors included perinephric stranding (p=0.001), posterior perinephric fat thickness (p=0.009) and perinephric fat density (p=0.02). APF was associated with drain output (P = 0.012) and accompanied by immune cells gathering in renal cortex near thickened renal capsule with many vessels.Conclusions: Clinical characteristics and radiological predictors can evaluate PFAD and may assist guide preoperative surgical option. Pathological features of APF reflect decapsulation and bleeding during kidney mobilization at RLPN.

scholarly journals Analysis of clinical characteristics, radiological predictors, pathological features and perioperative outcomes associated with perinephric fat adhesion degree

2020 ◽  
Author(s):  
Junqiang Liu ◽  
Hongwei Huang ◽  
Tianyu Cao ◽  
Dikuan Liu ◽  
Zheng Zhu ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Immune Cells ◽  
Clinical Characteristics ◽  
Renal Cortex ◽  
Perioperative Outcomes ◽  
Pathological Features ◽  
Fat Thickness ◽  
The Impact ◽  
Perinephric Fat ◽  
Masson Staining

Abstract Background To assess the clinical characteristics, radiological predictors and pathological features of perinephric fat adhesion degree (PFAD) graded based on fixed criteria and to determine the impact of adherent perinephric fat (APF) on retroperitoneal laparoscopic partial nephrectomy (RLPN) outcomes.Methods 84 patients undergoing RLPN were included and graded into 4 groups based on PFAD. Univariate and multivariate analysis were performed for clinical characteristics and radiological predictors of PFAD. Perioperative data was compared between APF groups and non-APF groups. Masson staining determined collagen fibers. Immunohistochemistry detected CD45 immune cells and CD34 vessels.Results 20, 28, 18 and 18 patients were graded as normal perinephric fat (NPF), mild adherent perinephric fat (MiPF), moderate adherent perinephric fat (MoPF) and severe adherent perinephric fat (SPF), respectively. Multivariate analysis revealed that gender (p<0.001), age (p=0.003) and hypertension (p=0.006) were significant clinical risk factors of PFAD, while radiological predictors included perinephric stranding (p=0.001), posterior perinephric fat thickness (p=0.009) and perinephric fat density (p=0.02). APF was associated with drain output (P = 0.012) and accompanied by immune cells gathering in renal cortex near thickened renal capsule with many vessels.Conclusions Clinical characteristics and radiological predictors can evaluate PFAD and may assist guide preoperative surgical option. Pathological features of APF reflect decapsulation and bleeding during kidney mobilization at RLPN.

scholarly journals Analysis of clinical characteristics, radiological predictors, pathological features and perioperative outcomes associated with perinephric fat adhesion degree

2020 ◽  
Author(s):  
Junqiang Liu ◽  
Hongwei Huang ◽  
Tianyu Cao ◽  
Dikuan Liu ◽  
Zheng Zhu ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Immune Cells ◽  
Clinical Characteristics ◽  
Renal Cortex ◽  
Perioperative Outcomes ◽  
Pathological Features ◽  
Fat Thickness ◽  
The Impact ◽  
Perinephric Fat ◽  
Masson Staining

Abstract Background To assess the clinical characteristics, radiological predictors and pathological features of perinephric fat adhesion degree (PFAD) graded based on fixed criteria and to determine the impact of adherent perinephric fat (APF) on retroperitoneal laparoscopic partial nephrectomy (RLPN) outcomes. Methods 84 patients undergoing RLPN were included and graded into 4 groups based on PFAD. Univariate and multivariate analysis were performed for clinical characteristics and radiological predictors of PFAD. Perioperative data was compared between APF groups and non-APF groups. Masson staining determined collagen fibers. Immunohistochemistry detected CD45 immune cells and CD34 vessels. Results 20, 28, 18 and 18 patients were graded as normal perinephric fat (NPF), mild adherent perinephric fat (MiPF), moderate adherent perinephric fat (MoPF) and severe adherent perinephric fat (SPF), respectively. Multivariate analysis revealed that gender (p < 0.001), age (p = 0.003) and hypertension (p = 0.006) were significant clinical risk factors of PFAD, while radiological predictors included perinephric stranding (p = 0.001), posterior perinephric fat thickness (p = 0.009) and perinephric fat density (p = 0.02). APF was associated with drain output (P = 0.012) and accompanied by immune cells gathering in renal cortex near thickened renal capsule with many vessels. Conclusions Clinical characteristics and radiological predictors can evaluate PFAD and may assist guide preoperative surgical option. Pathological features of APF reflect decapsulation and bleeding during kidney mobilization at RLPN.

scholarly journals Significant impact of three-dimensional volumetry of perinephric fat on the console time during robot-assisted partial nephrectomy

BMC Urology ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Daisuke Motoyama ◽  
Yuto Matsushita ◽  
Hiromitsu Watanabe ◽  
Keita Tamura ◽  
Toshiki Ito ◽  
...  
Keyword(s):  
Partial Nephrectomy ◽  
Three Dimensional ◽  
The Body ◽  
Renal Tumors ◽  
Perioperative Outcomes ◽  
Robot Assisted ◽  
Computed Tomography Images ◽  
Significant Difference ◽  
The Impact ◽  
Perinephric Fat

Abstract Background To assess the impact of volumetry of perinephric fat (PNF) on the perioperative outcomes of robot-assisted partial nephrectomy (RAPN). Methods Between 2016 and 2019, a single surgeon performed RAPN for 128 patients with clinical T1a-b renal tumors at our institution, and the 70 most recent patients were included in this study to minimize the effects of surgical experience. PNF was defined as a fatty area around the kidney within the anatomical structures, including the lateroconal fascia, fusion fascia, psoas muscle, lumbar quadrate muscle and diaphragm, and its volume was calculated based on reconstructed three-dimensional computed tomography images using the SYNAPSE VINCENT system. Results In this series, the trifecta and MIC (margin, ischemia and complications) score system outcomes were achieved in 69 (98.6%) and 64 patients (91.4%), respectively. The median PNF volume in the 70 patients was 166.05 cm3, which was significantly correlated with both the body mass index (BMI) and Mayo adhesive probability (MAP) score (correlation coefficient = 0.68 and 0.74, respectively). There was no significant difference in the R.E.N.A.L. nephrometry score, PNF volume or console time during RAPN among 5 groups consisting of 14 consecutive patients. Of several factors examined, the console time was significantly affected by the sex, MAP score and PNF volume, and only the PNF volume was independently associated with the console time. Conclusion Even if performed by an experienced robotic surgeon beyond the initial learning curve, the PNF volume may influence the console time during RAPN.

The Impact of Proinflammatory Cytokynes of Rheumatoid Polyarthritis on the Generalized Loss of Bone Mass

2018 ◽  
Vol 69 (9) ◽  
pp. 2541-2545
Author(s):  
Raluca Barzoi ◽  
Elena Rezus ◽  
Codruta Badescu ◽  
Razan Al Namat ◽  
Manuela Ciocoiu
Keyword(s):  
Rheumatoid Arthritis ◽  
Immune Cells ◽  
Osteoclast Differentiation ◽  
Bone Destruction ◽  
Nuclear Factor ◽  
Receptor Activator ◽  
Level Function ◽  
Rheumatoid Polyarthritis ◽  
The Impact ◽  
Nuclear Factor Kb

There is a bidirectional interaction between most immune cells and osteoblasts, osteoclasts and their precursor cells. The receptor activator of nuclear factor-kB ligand (RANKL)/RANK/osteoprotegerin (OPG) system plays an essential role in the formation of osteoblasts, but it also has implications in osteoclast biology and implicitly on the diseases characterized by bone loss. Proinflammatory cytokines existing at synovial level function as direct or indirect stimulators of osteoclast differentiation, but also of its survival or activity, although some cytokines may also play an antiosteocastogenic role. The fate of bone destruction is determined by the balance between osteoclastogenic and antiosteoclastogenic mediators. Our study has shown that the early initiation of the therapy with anti-TNF and anti-IL6 biological agents, in patients with rheumatoid arthritis, inhibits bone destruction, regardless of the anti-inflammatory activity in patients with rheumatoid arthritis.

scholarly journals Clinical Characteristics and Outcomes of Patients with High Ankle-Brachial Index from the IMPACT-ABI Study

PLoS ONE ◽  
2016 ◽  
Vol 11 (11) ◽  
pp. e0167150 ◽  
Author(s):  
Hitoshi Nishimura ◽  
Takashi Miura ◽  
Masatoshi Minamisawa ◽  
Yasushi Ueki ◽  
Naoyuki Abe ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Ankle Brachial Index ◽  
The Impact

scholarly journals Ethnic comparison in takotsubo syndrome: novel insights from the International Takotsubo Registry

2021 ◽  
Author(s):  
Yoichi Imori ◽  
Ken Kato ◽  
Victoria L. Cammann ◽  
Konrad A. Szawan ◽  
Manfred Wischnewsky ◽  
...  
Keyword(s):  
Hospital Mortality ◽  
Clinical Characteristics ◽  
Ethnic Disparities ◽  
Japanese Patients ◽  
Learning Approach ◽  
Takotsubo Syndrome ◽  
Unique Identifier ◽  
Hospital Outcomes ◽  
Machine Learning Approach ◽  
The Impact

Abstract Background Ethnic disparities have been reported in cardiovascular disease. However, ethnic disparities in takotsubo syndrome (TTS) remain elusive. This study assessed differences in clinical characteristics between Japanese and European TTS patients and determined the impact of ethnicity on in-hospital outcomes. Methods TTS patients in Japan were enrolled from 10 hospitals and TTS patients in Europe were enrolled from 32 hospitals participating in the International Takotsubo Registry. Clinical characteristics and in-hospital outcomes were compared between Japanese and European patients. Results A total of 503 Japanese and 1670 European patients were included. Japanese patients were older (72.6 ± 11.4 years vs. 68.0 ± 12.0 years; p < 0.001) and more likely to be male (18.5 vs. 8.4%; p < 0.001) than European TTS patients. Physical triggering factors were more common (45.5 vs. 32.0%; p < 0.001), and emotional triggers less common (17.5 vs. 31.5%; p < 0.001), in Japanese patients than in European patients. Japanese patients were more likely to experience cardiogenic shock during the acute phase (15.5 vs. 9.0%; p < 0.001) and had a higher in-hospital mortality (8.2 vs. 3.2%; p < 0.001). However, ethnicity itself did not appear to have an impact on in-hospital mortality. Machine learning approach revealed that the presence of physical stressors was the most important prognostic factor in both Japanese and European TTS patients. Conclusion Differences in clinical characteristics and in-hospital outcomes between Japanese and European TTS patients exist. Ethnicity does not impact the outcome in TTS patients. The worse in-hospital outcome in Japanese patients, is mainly driven by the higher prevalence of physical triggers. Trial Registration URL: https://www.clinicaltrials.gov; Unique Identifier: NCT01947621.

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