scholarly journals The Clinical Features of Graves’ Orbitopathy with Elevated Intraocular Pressure

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Shu-Xian Fan ◽  
Peng Zeng ◽  
Zi-Jing Li ◽  
Jing Wang ◽  
Jia-Qi Liang ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Optic Nerve ◽  
Thyroid Disease ◽  
Visual Fields ◽  
Nerve Damage ◽  
Visual Field Defects ◽  
Optic Nerve Damage ◽  
Significant Difference ◽  
Elevated Intraocular Pressure ◽  
Graves Orbitopathy

Background. To investigate the clinical characteristics of Graves’ orbitopathy (GO) with elevated intraocular pressure (IOP) using the European Group of Graves’ Orbitopathy (EUGOGO) system. Methods. In this retrospective study, the clinical data of GO patients with elevated IOP (≥21 mmHg) were collected in Sun Yat-sen Memorial Hospital from January 2010 to June 2016. The demographic characteristics, clinical history of thyroid disease and GO, and ocular examination data were evaluated, and the activity and severity of GO were classified. Results. Data were collected from 58 eyes of 39 patients. The durations of thyroid disease and GO were 15.9 ± 18.9 months and 7.5 ± 6.2 months, respectively. The average IOP was 24.8 ± 5.3 mmHg (range: 21–55 mmHg). No significant difference in IOP was observed between active and inactive eyes. Eight eyes (13.8%), 29 eyes (50.0%), and 21 eyes (36.2%) were graded as mild, moderate-severe, and sight-threatening disease, respectively, according to the EUGOGO classification. The IOP was not significantly different among the three EUGOGO grades. No glaucomatous optic nerve damage or visual field defects were found. Conclusion. Increased IOP was evident for every grade of GO severity and activity of the EUGOGO system. IOP, glaucomatous optic nerve damage, and visual fields must be evaluated regularly during follow-up evaluations, regardless of the degree of activity and severity of GO.

Treatment with Bifemelane for Optic Nerve Damage following High Intraocular Pressure in Rat Eyes

1996 ◽  
Vol 6 (4) ◽  
pp. 415-420
Author(s):  
M. Adachi ◽  
K. Takahashi ◽  
K. Yuge ◽  
M. Nishikawa ◽  
H. Miki ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Optic Nerve ◽  
Nerve Damage ◽  
Optic Nerve Damage

Neurofilament light chain as biomarker in idiopathic intracranial hypertension

Cephalalgia ◽  
2020 ◽  
Vol 40 (12) ◽  
pp. 1346-1354
Author(s):  
Dagmar Beier ◽  
Johanne Juhl Korsbæk ◽  
Jonna Skov Madsen ◽  
Dorte Aalund Olsen ◽  
Laleh Dehghani Molander ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Optic Nerve ◽  
Visual Field ◽  
Intracranial Hypertension ◽  
Idiopathic Intracranial Hypertension ◽  
Nerve Damage ◽  
Visual Field Defects ◽  
Neurofilament Light Chain ◽  
Optic Nerve Damage ◽  
Field Defects

Background Damage of the optic nerve is the major complication of idiopathic intracranial hypertension. A biomarker indicative for optic nerve damage would help identifying high-risk patients requiring surgical procedures. Here, we studied the potential of cerebrospinal fluid neurofilament to predict idiopathic intracranial hypertension-induced optic nerve damage. Methods In two centers, serum and cerebrospinal fluid of 61 patients with clinically suspected idiopathic intracranial hypertension were prospectively collected. Neurofilament concentrations were measured and related to ophthalmological assessment. Results The average cerebrospinal fluid neurofilament concentration in patients with moderate and severe papilledema was increased compared to patients with minor and no papilledema (1755 ± 3507 pg/ml vs. 244 ± 102 pg/ml; p < 0.001). Cerebrospinal fluid neurofilament concentrations correlated with the maximal lumbar puncture opening pressure (r = 0.67, p < 0.001). In patients fulfilling the Friedman criteria for idiopathic intracranial hypertension with or without papilledema (n = 35), development of bilateral visual field defects and bilateral atrophy of the optic nerve were associated with increased average age-adjusted cerebrospinal fluid neurofilament concentrations. At last follow-up (n = 30), 8/13 of patients with increased, but only 3/17 with normal, cerebrospinal fluid neurofilament had developed bilateral visual field defects and/or bilateral optic nerve atrophy resulting in a sensitivity of 72.7% and a specificity of 73.7% of cerebrospinal fluid neurofilament to detect permanent optic nerve damage. Conclusions Cerebrospinal fluid neurofilament is a putative biomarker for optical nerve damage in idiopathic intracranial hypertension.

scholarly journals A review of pharmacological therapy for glaucoma

2005 ◽  
Vol 64 (3) ◽  
Author(s):  
S.D. Mathebula
Keyword(s):  
Intraocular Pressure ◽  
Optic Nerve ◽  
Open Angle Glaucoma ◽  
Pharmacological Therapy ◽  
Nerve Damage ◽  
Causative Role ◽  
Optic Nerve Damage ◽  
Low Tension Glaucoma ◽  
Standard Devia ◽  
Low Tension

Glaucoma is a chronic or acute disease in which optic nerve damage occurs in a characteristic way. In  primary  open  angle  glaucoma  (POAG),  the manifestations of the optic nerve damage include visible excavation that develops in the optic nerve head and regions of the retina lose ability to detect all the elements that go into the total sensory prod-uct called vision.1, 2  When these regions worsen and enlarge to coalesce, the result is blindness.The intraocular pressure (IOP) has a causative role in producing the damage. All eyes have an in-ternal pressure to keep them inflated, perhaps 17 mmHg on the average, ± 5 mmHg standard devia-tion. In at least two thirds of the eyes that suffer glaucomatous damage, the intraocular pressure is high, at least a bit above the pressure found in 95% of the non-glaucomatous population. The cut-off is in the region of 20 to 22 mmHg used by most definitions.2 However, a normal or even low intra-ocular pressure can be harmful to some eyes, and when it is, the person has normal or low tension glaucoma. The traditional treatment of glaucoma has logically been to lower the intraocular pres-sure, to prevent further damage to the optic nerve, though previous damage is not undone.

Optic Nerve Damage in Alzheimer's Disease

Ophthalmology ◽  
1990 ◽  
Vol 97 (1) ◽  
pp. 9-17 ◽  
Author(s):  
Alfredo A. Sadun ◽  
Carl J. Bassi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Optic Nerve ◽  
Nerve Damage ◽  
Optic Nerve Damage

scholarly journals Taurine protects against retinal and optic nerve damage induced by endothelin-1 in rats via antioxidant effects

2018 ◽  
Vol 13 (11) ◽  
pp. 2014 ◽  
Author(s):  
Renu Agarwal ◽  
NatashaNajwa Nor Arfuzir ◽  
Igor Iezhitsa ◽  
Puneet Agarwal ◽  
Sabrilhakim Sidek ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Nerve Damage ◽  
Endothelin 1 ◽  
Optic Nerve Damage ◽  
Antioxidant Effects

scholarly journals Evidence of Post Trabeculectomy Optic Nerve Reperfusion by OCT Angiography

2020 ◽  
pp. 35-39
Author(s):  
Jigyasa Sahu
Keyword(s):  
Intraocular Pressure ◽  
Optic Nerve ◽  
Nerve Fiber ◽  
Structural Parameters ◽  
Visual Fields ◽  
Vessel Density ◽  
Oct Angiography ◽  
Prognostic Indicators ◽  
Fiber Layer ◽  
Nerve Fiber Layer

Aim: To describe a case of glaucoma which showed increase in optical coherence tomography (OCT) angiographic vessel densities after intraocular pressure reduction suggesting reperfusion of optic nerve. Presentation of Case: A 55 year old female with primary open angle glaucoma was taken up for trabeculectomy in view of inadequate control of intraocular pressure (IOP) despite maximal medical therapy. In addition to routine glaucoma assessment by visual fields and nerve fiber layer assessment by OCT, OCT angiographic evaluation of peripapillary vessel density was done preoperatively. Three months after trabeculectomy, her intraocular pressure decreased from 35mmHg to 14mmHg. Compared with the preoperative baseline value, the vessel density increased significantly in all quadrants after three months from surgery as demonstrated by OCT angiography. Discussion: This case report suggests that decreased optic nerve head perfusion due to high IOP can be reversed by reduction of IOP. Conclusion: Vascular parameters like angiographic vessel density can show reversible changes as decreased blood flow reinstates and thus can be better prognostic indicators than structural parameters like OCT retinal nerve fiber layer (RNFL) in glaucoma patients.

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