scholarly journals Synthesis andin vitroAntitumor Potency of (Cyclohexane-1,2-Diamine)Platinum(II) Complexes with Aminotris(Methylenephosphonic Acid) as Bone-Seeking Ligand

2005 ◽  
Vol 3 (3-4) ◽  
pp. 179-190 ◽  
Author(s):  
Markus Galanski ◽  
Susanna Slaby ◽  
Michael A. Jakupec ◽  
Bernhard K. Keppler
Keyword(s):  
Dna Adducts ◽  
Coordination Mode ◽  
Carcinoma Cell ◽  
Platinum Complexes ◽  
Ovarian Carcinoma Cell Line ◽  
Aminoacetic Acid ◽  
Structure Activity ◽  
Cellular Processing ◽  
Diamine Ligands

In order to develop platinum complexes with selective activity in primary and secondary bone malignancies and with the aim to optimize antitumor activity, platinum(II) complexes with aminotris(methylenephosphonic acid) as bone-seeking (osteotropic) ligand have been synthesized, characterized and tested in the cisplatin-sensitive ovarian carcinoma cell line CH1. As non-leaving diamine ligands, which are decisive for the cellular processing of DNA adducts,cis-R,S-cyclohexane-1,2-diamine,trans-S,S-cyclohexane-1,2-diamine andtrans-R,R-cyclohexane-1,2-diamine have been used, resulting in complexes 1, 2, and 3, respectively. The cytotoxicity of the complexes under investigation decreases in the order 3>2>1 which is in accord with structure-activity relationships with other (cyclohexane-1,2- diamine)platinum(II) and platinum(IV) complexes: Bothtranscomplexes (2 and 3) display a higherin vitropotency than the correspondingcisisomer (I), with thetrans-R,Risomer (3) being the most active in this series. In comparison to the analogous (cyclohexane-1,2-diamine)platinum(II) complexes with bis(phosphonomethyl)aminoacetic acid as osteotropic carrier ligand, the cytotoxicity of 1-3 was found to be 1.5 – 2 fold higher, which is explainable by a different coordination mode of the phosphonic acid ligands (acetato versus phosphonato).

Inhibitory Effects of Natural Food Dyes Genistein on Invasion of SKOV3 Human Ovarian Carcinoma Cells In Vivo and In Vitro

2013 ◽  
Vol 781-784 ◽  
pp. 1152-1155
Author(s):  
Tang Li ◽  
Li Yu
Keyword(s):  
Ovarian Carcinoma ◽  
Carcinoma Cell ◽  
Treated Group ◽  
Ovarian Cancer Cells ◽  
Natural Food ◽  
Ovarian Carcinoma Cell Line ◽  
Skov3 Cells ◽  
Human Ovarian Carcinoma

The invasion behavior of tumor cells is important in the metastasis process of ovarian cancer cells. In this study we investigated the effects of Genistein on invasion inhibition in ovarian carcinoma cell line SKOV3 in vivo and in vitro. The abilities of the Genistein-treated SKOV3 cells to invade through reconstitute matrigel in transwell chambers were investigated in vitro and the invasion effect in vivo was determined by using the xenograft models of SKOV3 in nude mice. The ability of the 20μmol/L Genistein-treated cells to invade the reconstitute basement membrane was decreased significantly at 72h. This inhibition was dose-dependent. 40μmol/L Genistein had the strongest effect. The in vivo result suggested that the grade of invasion in control SKOV3 cells was time-dependent and Genistein-treated group could apparently inhibit the progress of invasion, localizing the tumor in invasion Grade 0 or Grade I and decreasing the proportion of Grade II, III and IV. The results suggested that Genistein possessed inhibitory effect on invasion in human ovarian carcinoma cell lines SKOV3 in vivo and in vitro.

Betulinic acid and its spray dried microparticle formulation: In vitro PDT effect against ovarian carcinoma cell line and in vivo plasma and tumor disposition

2021 ◽  
Vol 224 ◽  
pp. 112328
Author(s):  
Alessandra F. Serain ◽  
Lavinia Morosi ◽  
Tommaso Ceruti ◽  
Cristina Matteo ◽  
Marina Meroni ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Cell Line ◽  
Betulinic Acid ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Ovarian Carcinoma Cell Line ◽  
Spray Dried

In vitro cytotoxicity and structure-activity relationship approaches of ent-kaurenoic acid derivatives against human breast carcinoma cell line

2018 ◽  
Vol 156 ◽  
pp. 214-223 ◽  
Author(s):  
Ricardo M. da Costa ◽  
Jairo K. Bastos ◽  
Maria C.A. Costa ◽  
Márcia M.C. Ferreira ◽  
Cássia S. Mizuno ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Cell Line ◽  
Carcinoma Cell ◽  
In Vitro Cytotoxicity ◽  
Activity Relationship ◽  
Breast Carcinoma Cell Line ◽  
Human Breast ◽  
Human Breast Carcinoma Cell ◽  
Structure Activity

scholarly journals Biological properties of ten human ovarian carcinoma cell lines: calibration in vitro against four platinum complexes

1989 ◽  
Vol 59 (4) ◽  
pp. 527-534 ◽  
Author(s):  
CA Hills ◽  
LR Kelland ◽  
G Abel ◽  
J Siracky ◽  
AP Wilson ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Platinum Complexes ◽  
Biological Properties ◽  
Human Ovarian Carcinoma Cell ◽  
Carcinoma Cell Lines ◽  
Human Ovarian Carcinoma

Effect of interleukin-7 gene transfection into ovarian carcinoma cell line SKOV3 in vitro and in vivo

2004 ◽  
Vol 92 (2) ◽  
pp. 578-585 ◽  
Author(s):  
Xing Xie ◽  
Da-Feng Ye ◽  
Huai-Zeng Chen ◽  
Wei-Guo Lu ◽  
Yun-Feng Fu ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Cell Line ◽  
Carcinoma Cell ◽  
Gene Transfection ◽  
Carcinoma Cell Line ◽  
Ovarian Carcinoma Cell Line ◽  
Interleukin 7

Structure-activity-relationship (SAR) for in vitro antileishmanial activity of maesabalide (PX-6518) analogue natural products

Planta Medica ◽  
2006 ◽  
Vol 72 (11) ◽  
Author(s):  
L Maes ◽  
K Kuypers ◽  
M Vermeersch ◽  
P Cos ◽  
L Pieters ◽  
...  
Keyword(s):  
Natural Products ◽  
Structure Activity Relationship ◽  
Antileishmanial Activity ◽  
Activity Relationship ◽  
Structure Activity

STRUCTURE-ACTIVITY RELATIONSHIP OF VARIOUS ANALOGUES OF β-CORTICOTRROPHIN DETERMINED BY REFERENCE TO VARIOUS PARAMETERS IN VITRO AND IN VIVO

1969 ◽  
Vol 61 (1_Suppl) ◽  
pp. S29
Author(s):  
Pierre A. Desaulles ◽  
René Maier ◽  
Matthys Staehelin
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of
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