Clinical significance of expression of murine double minute 2 and ribosomal protein L23 in gastric cancer

2016 ◽  
Vol 24 (4) ◽  
pp. 513
Author(s):  
Yu-Wei Jiang
Keyword(s):  
Gastric Cancer ◽  
Ribosomal Protein ◽  
Clinical Significance ◽  
Double Minute ◽  
Murine Double Minute

scholarly journals The Expression of Murine Double Minute 2 (MDM2) on Helicobacter pylori-Infected Intestinal Metaplasia and Gastric Cancer

2009 ◽  
Vol 44 (2) ◽  
pp. 196-202 ◽  
Author(s):  
Noriko Nakajima ◽  
Yoko Ito ◽  
Kiyoshi Yokoyama ◽  
Akitake Uno ◽  
Noriko Kinukawa ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Intestinal Metaplasia ◽  
Double Minute ◽  
Murine Double Minute

scholarly journals Association of Murine Double Minute 2 polymorphisms with gastric cancer: A systematic review with meta‑analysis

2021 ◽  
Vol 15 (2) ◽  
Author(s):  
Mafalda Timóteo ◽  
Ana Tavares ◽  
Sara Cruz ◽  
Carla Campos ◽  
Rui Medeiros ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Systematic Review ◽  
Meta Analysis ◽  
Double Minute ◽  
Murine Double Minute

miR-17-5p/20a are important markers for gastric cancer and murine double minute 2 participates in their functional regulation

2013 ◽  
Vol 49 (8) ◽  
pp. 2010-2021 ◽  
Author(s):  
Mei Wang ◽  
Hongbing Gu ◽  
Hui Qian ◽  
Wei Zhu ◽  
Chonghui Zhao ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Double Minute ◽  
Functional Regulation ◽  
Murine Double Minute

scholarly journals MDM2 Amplified Sarcomas: A Literature Review

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 496
Author(s):  
Raf Sciot
Keyword(s):  
Suppressor Gene ◽  
Negative Regulator ◽  
Low Grade ◽  
P53 Mutations ◽  
Lipomatous Tumor ◽  
Double Minute ◽  
Genetic Features ◽  
Murine Double Minute ◽  
Well Differentiated ◽  
Mdm2 Amplification

Murine Double Minute Clone 2, located at 12q15, is an oncogene that codes for an oncoprotein of which the association with p53 was discovered 30 years ago. The most important function of MDM2 is to control p53 activity; it is in fact the best documented negative regulator of p53. Mutations of the tumor suppressor gene p53 represent the most frequent genetic change in human cancers. By overexpressing MDM2, cancer cells have another means to block p53. The sarcomas in which MDM2 amplification is a hallmark are well-differentiated liposarcoma/atypical lipomatous tumor, dedifferentiated liposarcoma, intimal sarcoma, and low-grade osteosarcoma. The purpose of this review is to summarize the typical clinical, histopathological, immunohistochemical, and genetic features of these tumors.

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