Discoidin Domain Receptor 1 Receptor Tyrosine Kinase Induces Cyclooxygenase-2 and Promotes Chemoresistance through Nuclear Factor-κB Pathway Activation

2006 ◽  
Vol 66 (16) ◽  
pp. 8123-8130 ◽  
Author(s):  
Sanjeev Das ◽  
Pat P. Ongusaha ◽  
Yoon Sun Yang ◽  
Jin-Mo Park ◽  
Stuart A. Aaronson ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Receptor Tyrosine Kinase ◽  
Nuclear Factor Κb ◽  
Cyclooxygenase 2 ◽  
Nuclear Factor ◽  
Discoidin Domain Receptor ◽  
Pathway Activation ◽  
Discoidin Domain Receptor 1

Role of nuclear factor-κB in gastric ulcer healing in rats

2001 ◽  
Vol 280 (6) ◽  
pp. G1296-G1304 ◽  
Author(s):  
Satoru Takahashi ◽  
Takuya Fujita ◽  
Akira Yamamoto
Keyword(s):  
Gastric Ulcer ◽  
Mrna Expression ◽  
Ulcer Healing ◽  
Nuclear Factor Κb ◽  
Normal Mucosa ◽  
Cyclooxygenase 2 ◽  
Interleukin 1Β ◽  
Nuclear Factor ◽  
Gastric Ulcer Healing

We investigated the role of nuclear factor-κB (NF-κB) in gastric ulcer healing in rats. NF-κB was activated in ulcerated tissue but not in normal mucosa, and the level of the activation was decreased with ulcer healing. NF-κB activation was observed in fibroblasts, monocytes/macrophages, and neutrophils. Treatment of gastric fibroblasts, isolated from the ulcer base, with interleukin-1β activated NF-κB and the subsequently induced cyclooxygenase-2 and cytokine-induced neutrophil chemoattractant-1 (CINC-1) mRNA expression. Inhibition of activated NF-κB action resulted in suppression of both their mRNA expression and increases in PGE2 and CINC-1 levels induced by interleukin-1β. Persistent prevention of NF-κB activation caused an impairment of ulcer healing in rats. Gene expression of interleukin-1β, CINC-1, cyclooxygenase-2, and inducible nitric oxide synthase in ulcerated tissue had been inhibited before the delay in ulcer healing became manifest. The increased levels of cyclooxygenase-2 protein and PGE2 production were also reduced. These results demonstrate that NF-κB, activated in ulcerated tissue, might upregulate the expression of healing-promoting factors responsible for gastric ulcer healing in rats.

Nuclear factor-κB mediates over-expression of cyclooxygenase-2 during activation of RAW 264.7 macrophages in selenium deficiency

2002 ◽  
Vol 32 (9) ◽  
pp. 890-897 ◽  
Author(s):  
Faith Zamamiri-Davis ◽  
Ying Lu ◽  
Jerry T Thompson ◽  
K.Sandeep Prabhu ◽  
Padala V Reddy ◽  
...  
Keyword(s):  
Selenium Deficiency ◽  
Nuclear Factor Κb ◽  
Cyclooxygenase 2 ◽  
Raw 264.7 ◽  
Nuclear Factor ◽  
Raw 264.7 Macrophages ◽  
Over Expression

scholarly journals Erratum to: Hyperglycemia Exacerbates Burn-Induced Liver Inflammation via Noncanonical Nuclear Factor-κB Pathway Activation

2012 ◽  
Vol 18 (6) ◽  
pp. 1042-1042
Author(s):  
Gabriela A Kulp ◽  
Ronald G. Tilton ◽  
David N Herndon ◽  
Marc G Jeschke
Keyword(s):  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Liver Inflammation ◽  
Pathway Activation

scholarly journals Induction of Cyclooxygenase-2 and Activation of Nuclear Factor-κB in Myocardium of Patients With Congestive Heart Failure

Circulation ◽  
1998 ◽  
Vol 98 (2) ◽  
pp. 100-103 ◽  
Author(s):  
Samuel C. Y. Wong ◽  
Mitsumasa Fukuchi ◽  
Peter Melnyk ◽  
Ian Rodger ◽  
Adel Giaid
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Nuclear Factor Κb ◽  
Cyclooxygenase 2 ◽  
Nuclear Factor
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