Abstract 5357: Inhibition of collagen receptor discoidin domain receptor-1 (DDR1) tyrosine kinase enhances cytotoxicity of anti-mesothelin immunotoxin for cancer therapy

2015 ◽  
Author(s):  
Fatima G. Ali-Rahmani ◽  
David Fitzgerald ◽  
Scott Martin ◽  
Paresma Patel ◽  
Craig Thomas ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Tyrosine Kinase ◽  
Discoidin Domain Receptor ◽  
Collagen Receptor ◽  
Discoidin Domain Receptor 1

scholarly journals Discoidin Domain Receptor 1 Protein Is a Novel Modulator of Megakaryocyte-Collagen Interactions

2013 ◽  
Vol 288 (23) ◽  
pp. 16738-16746 ◽  
Author(s):  
Vittorio Abbonante ◽  
Cristian Gruppi ◽  
Diana Rubel ◽  
Oliver Gross ◽  
Remigio Moratti ◽  
...  
Keyword(s):  
Type I Collagen ◽  
Type I ◽  
Discoidin Domain Receptor ◽  
Glycoprotein Vi ◽  
Protein Levels ◽  
Collagen Receptors ◽  
And Function ◽  
Extracellular Matrix Receptors ◽  
Collagen Receptor ◽  
Discoidin Domain Receptor 1

Growing evidence demonstrates that extracellular matrices regulate many aspects of megakaryocyte (MK) development; however, among the different extracellular matrix receptors, integrin α2β1 and glycoprotein VI are the only collagen receptors studied in platelets and MKs. In this study, we demonstrate the expression of the novel collagen receptor discoidin domain receptor 1 (DDR1) by human MKs at both mRNA and protein levels and provide evidence of DDR1 involvement in the regulation of MK motility on type I collagen through a mechanism based on the activity of SHP1 phosphatase and spleen tyrosine kinase (Syk). Specifically, we demonstrated that inhibition of DDR1 binding to type I collagen, preserving the engagement of the other collagen receptors, glycoprotein VI, α2β1, and LAIR-1, determines a decrease in MK migration due to the reduction in SHP1 phosphatase activity and consequent increase in the phosphorylation level of its main substrate Syk. Consistently, inhibition of Syk activity restored MK migration on type I collagen. In conclusion, we report the expression and function of a novel collagen receptor on human MKs, and we point out that an increasing level of complexity is necessary to better understand MK-collagen interactions in the bone marrow environment.

scholarly journals Inhibition of Collagen Receptor Discoidin Domain Receptor-1 (DDR1) Reduces Cell Survival, Homing, and Colonization in Lung Cancer Bone Metastasis

2012 ◽  
Vol 18 (4) ◽  
pp. 969-980 ◽  
Author(s):  
Karmele Valencia ◽  
Cristina Ormazábal ◽  
Carolina Zandueta ◽  
Diego Luis-Ravelo ◽  
Iker Antón ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Bone Metastasis ◽  
Cell Survival ◽  
Discoidin Domain Receptor ◽  
Collagen Receptor ◽  
Discoidin Domain Receptor 1

Consistent and Selective Expression of the Discoidin Domain Receptor-1 Tyrosine Kinase in Human Brain Tumors

Neurosurgery ◽  
2000 ◽  
Vol 47 (6) ◽  
pp. 1400-1409 ◽  
Author(s):  
Howard L. Weiner ◽  
Hongyun Huang ◽  
David Zagzag ◽  
Hayden Boyce ◽  
Roger Lichtenbaum ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Tyrosine Kinase ◽  
Human Brain ◽  
Human Brain Tumors ◽  
Discoidin Domain Receptor ◽  
Selective Expression ◽  
Discoidin Domain Receptor 1

Expression of the tyrosine kinase discoidin domain receptor 1 (DDR1) in human central nervous system myelin

2010 ◽  
Vol 1336 ◽  
pp. 22-29 ◽  
Author(s):  
Bàrbara Roig ◽  
Neus Franco-Pons ◽  
Lourdes Martorell ◽  
Jordi Tomàs ◽  
Wolfgang F. Vogel ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Tyrosine Kinase ◽  
Human Central Nervous System ◽  
Discoidin Domain Receptor ◽  
Discoidin Domain Receptor 1
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