Development and evaluation of a cancer risk educational tool (CREdIT) for women with a family history of breast and ovarian cancer.

2009 ◽  
Author(s):  
C Wilcox ◽  
R Lee ◽  
M Beattie ◽  
J Luce ◽  
G Joseph ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Family History ◽  
Cancer Risk ◽  
Educational Tool ◽  
Breast And Ovarian Cancer ◽  
History Of

Screening RAD51C nucleotide alterations in patients with a family history of breast and ovarian cancer

2010 ◽  
Vol 124 (3) ◽  
pp. 857-861 ◽  
Author(s):  
Yonglan Zheng ◽  
Jing Zhang ◽  
Kisha Hope ◽  
Qun Niu ◽  
Dezheng Huo ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Family History ◽  
Breast And Ovarian Cancer ◽  
History Of

Identification of Women at Risk for Hereditary Breast and Ovarian Cancer in A Sample of 1000 Slovenian Women: A Comparison of Guidelines

2020 ◽  
Author(s):  
Urška Kotnik ◽  
Borut Peterlin ◽  
Luca Lovrecic
Keyword(s):  
Ovarian Cancer ◽  
At Risk ◽  
Family History ◽  
High Risk ◽  
Breast And Ovarian Cancer ◽  
Nccn Guidelines ◽  
Family History Of Cancer ◽  
Slovenian Population ◽  
History Of ◽  
History Of Cancer

Abstract Background: An important number of breast and ovarian cancer cases is due to a strong genetic predisposition. The main tool for identifying individuals at risk is recognizing a suggestive family history of cancer. We present a prospective study on applying three selected clinical guidelines to a cohort of 1000 Slovenian women to determine the prevalence of at-risk women according to each of the guidelines and analyze the differences amongst the guidelines.Methods: Personal and family history of cancer was collected for 1000 Slovenian women. Guidelines by three organizations: National Comprehensive Cancer Network (NCCN), American College of Medical Genetics in cooperation with National Society of Genetic Counselors (ACMG/NSGC), and Society of Gynecologic Oncology (SGO) were applied to the cohort. The number of women identified, the characteristics of the high-risk population, and the agreement between the guidelines were explored. Results: NCCN guidelines identify 16.7 % of women, ACMG/NSGC guidelines identify 7.1 % of women, and SGO guidelines identify 7.0 % of women from the Slovenian population, while 6.2 % of women are identified by all three guidelines as having high-risk for hereditary breast and ovarian cancer.Conclusions: We identified 17.4 % of women from the Slovenian population as being at an increased risk for breast and ovarian cancer based on their personal and family history of cancer using all of the guidelines. There are important differences between the guidelines. NCCN guidelines are the most inclusive, identifying more than twice the amount of women as high-risk for hereditary breast and ovarian cancer as compared to the AGMG/NSCG and SGO guidelines in the Slovenian population.

Internet use is associated with utilization of genetic counseling for BRCA 1/2 mutations in women with a family history of breast or ovarian cancer

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 10654-10654 ◽  
Author(s):  
K. Armstrong ◽  
S. Gray ◽  
S. Domchek
Keyword(s):  
Ovarian Cancer ◽  
Genetic Counseling ◽  
Family History ◽  
Cancer Risk ◽  
Health Information ◽  
Internet Use ◽  
The Internet ◽  
Frequent Use ◽  
Brca 1 ◽  
History Of

10654 Background: Women obtain breast cancer risk information from a variety of sources including mass media, the internet and personal and professional sources. Little is know about how internet use for health information influences choices about breast cancer risk evaluation and decision making. Methods: Case control study of 408 women with a family history of breast or ovarian cancer, of whom 217 underwent genetic counseling for BRCA 1/2 testing (cases) and 191 women who did not (controls). Participants received primary care within a large health system in greater Philadelphia, PA. Results: Women with a family history of breast or ovarian cancer who reported frequent use of the internet for health information (>1–2 times a month) were significantly more likely to undergo genetic counseling for BRCA 1/2 testing than women that rarely used the internet to obtain health information (<2 times a year) (odds ratio 2.6; 95% CI 1.7–4.0). This association persisted after adjustment for age, race, education and Gail risk (adjusted odds ratio 2.1; 95% CI 1.05–4.2) Conclusions: Frequent use of the internet for health care information is associated with higher use of genetic counseling for BRCA 1/2 mutations in women with a family history of breast or ovarian cancer. The association can not be explained by differences in education, cancer risk, age or race. A possible hypothesis for this association is that internet use exposes women to more information about genetic testing, BRCA testing opportunities and the experiences of other women who have utilized BRCA counseling services. No significant financial relationships to disclose.

scholarly journals Family history of breast and ovarian cancer and triple negative subtype in hispanic/latina women

SpringerPlus ◽  
2014 ◽  
Vol 3 (1) ◽  
pp. 727 ◽  
Author(s):  
Kristin Anderson ◽  
Patricia A Thompson ◽  
Betsy C Wertheim ◽  
Lorena Martin ◽  
Ian K Komenaka ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Family History ◽  
Triple Negative ◽  
Latina Women ◽  
Breast And Ovarian Cancer ◽  
History Of ◽  
Triple Negative Subtype

scholarly journals The incidence of PALB2 c.3113G>A in women with a strong family history of breast and ovarian cancer attending familial cancer centres in Australia

2013 ◽  
Vol 12 (4) ◽  
pp. 587-595 ◽  
Author(s):  
Zhi L. Teo ◽  
Sarah D. Sawyer ◽  
Paul A. James ◽  
Gillian Mitchell ◽  
Alison H. Trainer ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Family History ◽  
Familial Cancer ◽  
Strong Family History ◽  
Breast And Ovarian Cancer ◽  
History Of

Adiposity post prophylactic oophorectomy in young women at high risk for breast and ovarian cancer.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 1572-1572
Author(s):  
Kala Visvanathan ◽  
Minh-Huy Huynh ◽  
Rawan Al-Lozi ◽  
Jessica Oidtman ◽  
Betty J May ◽  
...  
Keyword(s):  
Physical Activity ◽  
Ovarian Cancer ◽  
Family History ◽  
Hormone Therapy ◽  
Body Fat ◽  
Young Women ◽  
Age Distribution ◽  
Abdominal Circumference ◽  
Breast And Ovarian Cancer ◽  
History Of

1572 Background: Bilateral prophylactic salpingo-oophorectomy (BPSO) is the current standard of care for BRCA1/2 mutation carriers and women with a strong family history of ovarian cancer. We have previously demonstrated an association between early oophorectomy, adiposity and mortality in the general population. Methods: A cross sectional study was conducted between November 2009 and January 2013 in 87 women with a family history of breast and ovarian cancer and/or BRCA1/2 mutation to identify the effect of early BPSO on multiple health outcomes. Twenty-two women who underwent BPSO within 1 to 5 years of enrollment while premenopausal and not on hormone therapy were compared to 44 premenopausal women with intact ovaries and the same age distribution and 21 postmenopausal women with intact ovaries and not on hormone therapy. Multiple anthropometric measures were taken and % body fat assessed by DEXA scan. Linear regression was used to estimate differences in these measures between the three groups. Results: The mean ages were 47, 47, and 54 years in the BPSO, premenopausal and postmenopausal groups respectively. Parity, alcohol intake, smoking and race did not significantly differ between groups. Fewer BPSO women had ever used oral contraceptives (OCP) compared to the premenopausal group (p =0.05). The BPSO group had lower mean physical activity (p = 0.05) compared to the two other groups. BMI was increased in the BPSO group but was not statistically different across groups. However, mean waist and abdominal circumference and trunk % body fat were significantly higher among women who underwent BPSO compared to both groups. In multivariate analyses adjusting for age, physical activity, and OCP use, the average waist circumference was 7.92 cm (95% CI 1.46, 14.37) higher and 8.98 cm (95% CI 0.40, 17.46) higher in the BPSO group compared to the postmenopausal and premenopausal groups, respectively. A similar pattern was seen for abdominal circumference. Association with % body fat were not statistically significant. Conclusions: This pilot study suggests that increased central adiposity, is a sequelae of BPSO in young women. Longitudinal studies are needed to confirm results and evaluate the efficacy of interventions.

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