scholarly journals Mortality among HIV-1– and Human Herpesvirus Type 8–Affected Mother-Infant Pairs in Zambia

2008 ◽  
Vol 17 (9) ◽  
pp. 2238-2243 ◽  
Author(s):  
Janet Wojcicki ◽  
Mulindi Mwanahamuntu ◽  
Veenu Minhas ◽  
Boris Djokic ◽  
Chipepo Kankasa ◽  
...  
1992 ◽  
Vol 54 (3) ◽  
pp. 354-371 ◽  
Author(s):  
B A Esterling ◽  
M H Antoni ◽  
N Schneiderman ◽  
C S Carver ◽  
A LaPerriere ◽  
...  

1996 ◽  
Vol 7 (3) ◽  
pp. 142-152 ◽  
Author(s):  
D. Reymen ◽  
M. Witvrouw ◽  
J. A. Esté ◽  
J. Neyts ◽  
D. Schols ◽  
...  

Various new aurintricarboxylic acid (ATA) polymer analogues have been evaluated for their antiviral activity against a wide array of DNA and RNA viruses, and their mechanism of action against human cytomegalovirus (HCMV) and human immunodeficiency virus type 1 (HIV-1). Most of the polymers exhibited marked antiviral activity against a variety of enveloped viruses, but not against non-enveloped viruses. The ATA polymers displayed the most pronounced activity against HIV-1, HCMV and human herpesvirus type 6 (HHV-6). Their action against HCMV and HIV could be ascribed to inhibition of the initial attachment of virus particles to the cells. Using radiolabelled virus, we proved that the polymers inhibit the binding of HCMV to HEL fibroblasts. By flow cytometric analysis, we demonstrated that these new polymers interfere with (i) the binding of OKT4A monoclonal antibody (mAb) to the cellular CD4 receptor, (ii) the binding of anti-gp120 mAb to HIV-1 glycoprotein (gp) 120, and (iii) the adsorption of HIV-1 virions and recombinant HIV-1gp120 (rgp120) to MT-4 cells. The presence of a salicylic acid substituent on the central bridging carbon in the parent compound ATA seems to play an important role in the anti-HIV activity of these ATA related polymer analogues.


AIDS ◽  
2000 ◽  
Vol 14 (8) ◽  
pp. 913-919 ◽  
Author(s):  
Marina Núñez ◽  
Ana Machuca ◽  
Vincent Soriano ◽  
Daniel Podzamczer ◽  
Juan González-Lahoz

2016 ◽  
Vol 89 (3) ◽  
pp. 518-527 ◽  
Author(s):  
María Laura Hulaniuk ◽  
Oscar Torres ◽  
Sonia Bartoli ◽  
Lisandro Fortuny ◽  
Leandro Burgos Pratx ◽  
...  

2013 ◽  
Vol 88 (2) ◽  
pp. 243-246 ◽  
Author(s):  
Patricia Fonseca Pereira ◽  
Tullia Cuzzi ◽  
Maria Clara Gutierrez Galhardo

Kaposi's sarcoma is the most common neoplasia diagnosed in AIDS patients and the expression of the human herpesvirus-8 (HHV-8) latent nuclear antigen-1 has been useful for its histological diagnosis. The aim of this study is to confirm that immunohistochemistry is a valuable tool for differentiating KS from its simulators in skin biopsies of HIV patients. Immunohistochemical and histological analyses were performed in 49 Kaposi's sarcoma skin biopsies and 60 of its histological simulators. Positivity was present in the 49 Kaposi's sarcoma skin biopsies and no staining was observed in the 60 simulators analyzed, resulting in sensibility and specificity of 100%. HHV-8 immunohistochemical detection is an effective tool for diagnosing Kaposi's sarcoma, especially in early lesions in which neoplastic features are not evident. It also contributes to its histological differential diagnosis.


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