scholarly journals Membranous Expression of Secreted Frizzled-Related Protein 4 Predicts for Good Prognosis in Localized Prostate Cancer and Inhibits PC3 Cellular Proliferation in Vitro

2004 ◽  
Vol 10 (2) ◽  
pp. 615-625 ◽  
Author(s):  
Lisa G. Horvath ◽  
Susan M. Henshall ◽  
James G. Kench ◽  
Darren N. Saunders ◽  
C.-Soon Lee ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cellular Proliferation ◽  
Good Prognosis ◽  
Localized Prostate Cancer ◽  
Related Protein ◽  
Proliferation In Vitro

932 Targeting the 19S Proteasomal Subunit, Rpt4, in Colon Cancer Cells Induces Cell Death and Reduces Cellular Proliferation In Vitro and In Vivo

2013 ◽  
Vol 144 (5) ◽  
pp. S-166-S-167
Author(s):  
Karen Boland ◽  
Caoimhin Concannon ◽  
Niamh McCawley ◽  
Elaine W. Kay ◽  
Deborah McNamara ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Cellular Proliferation ◽  
Colon Cancer Cells ◽  
Proliferation In Vitro

scholarly journals HNRNPA2B1 promotes multiple myeloma progression by increasing AKT3 expression via m6A-dependent stabilization of ILF3 mRNA

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Fengjie Jiang ◽  
Xiaozhu Tang ◽  
Chao Tang ◽  
Zhen Hua ◽  
Mengying Ke ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Cell Proliferation ◽  
Cellular Proliferation ◽  
Aberrant Expression ◽  
The Stability ◽  
Induced Apoptosis ◽  
Proliferation In Vitro

AbstractN6-methyladenosine (m6A) modification is the most prevalent modification in eukaryotic RNAs while accumulating studies suggest that m6A aberrant expression plays an important role in cancer. HNRNPA2B1 is a m6A reader which binds to nascent RNA and thus affects a perplexing array of RNA metabolism exquisitely. Despite unveiled facets that HNRNPA2B1 is deregulated in several tumors and facilitates tumor growth, a clear role of HNRNPA2B1 in multiple myeloma (MM) remains elusive. Herein, we analyzed the function and the regulatory mechanism of HNRNPA2B1 in MM. We found that HNRNPA2B1 was elevated in MM patients and negatively correlated with favorable prognosis. The depletion of HNRNPA2B1 in MM cells inhibited cell proliferation and induced apoptosis. On the contrary, the overexpression of HNRNPA2B1 promoted cell proliferation in vitro and in vivo. Mechanistic studies revealed that HNRNPA2B1 recognized the m6A sites of ILF3 and enhanced the stability of ILF3 mRNA transcripts, while AKT3 downregulation by siRNA abrogated the cellular proliferation induced by HNRNPA2B1 overexpression. Additionally, the expression of HNRNPA2B1, ILF3 and AKT3 was positively associated with each other in MM tissues tested by immunohistochemistry. In summary, our study highlights that HNRNPA2B1 potentially acts as a therapeutic target of MM through regulating AKT3 expression mediated by ILF3-dependent pattern.

Anomalous cellular proliferation in vitro associated with Huntington's disease

1977 ◽  
Vol 36 (2) ◽  
pp. 143-154 ◽  
Author(s):  
David Kirk ◽  
Jennifer M. Parrington ◽  
Gerald Corney ◽  
Jean M. W. Bolt
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Cellular Proliferation ◽  
Proliferation In Vitro

scholarly journals Prostate Cancer Cell Proliferation In vitro Is Modulated by Antibodies against Glucose-Regulated Protein 78 Isolated from Patient Serum

2006 ◽  
Vol 66 (23) ◽  
pp. 11424-11431 ◽  
Author(s):  
Mario Gonzalez-Gronow ◽  
Miguel Cuchacovich ◽  
Carolina Llanos ◽  
Cristian Urzua ◽  
Govind Gawdi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Proliferation In Vitro ◽  
Glucose Regulated Protein

Mechanistic association of Notch 3 protein with the chemotherapy response of localized prostate cancer

2017 ◽  
Vol 5 (2) ◽  
pp. 161-175
Author(s):  
ones Lorenzoni ◽  
Lutz Hartsell
Keyword(s):  
Prostate Cancer ◽  
Notch Signaling Pathway ◽  
Localized Prostate Cancer ◽  
Chemotherapy Response ◽  
Cancer Specific Survival ◽  
Free Survival ◽  
Notch 3 ◽  
Kaplan Meier

Prostate cancer is one of the most common cancers in American men. Genetics and age play a role in its development. Notch signaling pathway proteins are known to play critical roles in maintaining the balance between cell proliferation, differentiation and apoptosis, and thus it has been suggested that Notch may be responsible for the development and progression of human malignancies. The aim of this study is investigated the mechanistic role of Notch 3 with the chemotherapy response of patients with localized prostate cancer (PCa). A total of 772 patients with clinically localized PCa, confirmed by biopsy. Biochemical recurrence-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS) were assessed with Kaplan-Meier curves. Various histopathological parameters were analyzed by univariate and multivariate analysis. Our results demonstrate that a high Notch 3 expression in prostate tumor represented a significantly higher possibility of being resistant to chemotherapy and reduced OS. Also, patients with high Notch 3 expression had a poorer prognosis than those with low Notch 3 expression. Further, in vitro studies showed that Notch 3 inhibition the proliferation, migration of invasiveness of prostate cancer. Consequently, we propose that Notch 3 protein is an important event that enhances tumor angiogenesis in human prostate cancer cells.

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