Abstract 2043: Deregulated Cdc7/Dbf4 expression promotes DNA repair and checkpoint recovery to enhance survival and associates with poor prognosis in OSCC

2012 ◽  
Author(s):  
An Ning Cheng ◽  
Yu-Kang Lo ◽  
Shih Sheng Jiang ◽  
Alan Yueh-Luen Lee
Keyword(s):  
Dna Repair ◽  
Poor Prognosis ◽  
Checkpoint Recovery

scholarly journals Chromatin regulators and their impact on DNA repair and G2 checkpoint recovery

Cell Cycle ◽  
2020 ◽  
Vol 19 (17) ◽  
pp. 2083-2093
Author(s):  
Veronique A. J. Smits ◽  
Ignacio Alonso-de Vega ◽  
Daniël O. Warmerdam
Keyword(s):  
Dna Repair ◽  
G2 Checkpoint ◽  
Chromatin Regulators ◽  
Checkpoint Recovery

scholarly journals Overexpression of karyopherin-α2 in cholangiocarcinoma correlates with poor prognosis and gemcitabine sensitivity via nuclear translocation of DNA repair proteins

Oncotarget ◽  
2017 ◽  
Vol 8 (26) ◽  
pp. 42159-42172 ◽  
Author(s):  
Mariko Tsukagoshi ◽  
Kenichiro Araki ◽  
Takehiko Yokobori ◽  
Bolag Altan ◽  
Hideki Suzuki ◽  
...  
Keyword(s):  
Dna Repair ◽  
Poor Prognosis ◽  
Nuclear Translocation ◽  
Dna Repair Proteins

scholarly journals Up-regulated Wnt1-inducible signaling pathway protein 1 correlates with poor prognosis and drug resistance by reducing DNA repair in gastric cancer

2019 ◽  
Vol 25 (38) ◽  
pp. 5814-5825 ◽  
Author(s):  
Li-Hua Zhang ◽  
Yan Wang ◽  
Qian-Qian Fan ◽  
Yan-Kui Liu ◽  
Long-Hai Li ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Drug Resistance ◽  
Dna Repair ◽  
Signaling Pathway ◽  
Poor Prognosis

scholarly journals Low expression of MSH2 DNA repair protein is associated with poor prognosis in head and neck squamous cell carcinoma

2013 ◽  
Vol 21 (5) ◽  
pp. 416-421 ◽  
Author(s):  
Camila Santos Pereira ◽  
Marcos Vinicius Macedo de Oliveira ◽  
Lucas Oliveira Barros ◽  
Gabriela Alencar Bandeira ◽  
Sergio Henrique Sousa Santos ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Dna Repair ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Neck Squamous Cell Carcinoma ◽  
Repair Protein ◽  
Dna Repair Protein ◽  
Low Expression

Insulinoma-associated protein 1 controls nasopharyngeal carcinoma to radiotherapy by modulating cyclin D1-dependent DNA repair machinery

2019 ◽  
Vol 41 (3) ◽  
pp. 326-333 ◽  
Author(s):  
Ruibiao Song ◽  
Xing Wei ◽  
You Wang ◽  
Shousen Hu ◽  
Yunpeng Ba ◽  
...  
Keyword(s):  
Dna Repair ◽  
Nasopharyngeal Carcinoma ◽  
Cell Survival ◽  
Cyclin D1 ◽  
Poor Prognosis ◽  
Genetic Manipulation ◽  
Molecular Target ◽  
Transcriptional Factor ◽  
Xenograft Mice

AbstractInsulinoma-associated protein 1 (INSM1), a zinc finger transcriptional factor, is proven to be deregulated in several types of cancers. However, comprehension of the molecular mechanism of INSM1-mediated tumor progression remains poor. Here, we show that the radioresistant nasopharyngeal carcinoma (NPC) patients have higher expressions of INSM1 that correlated with poor prognosis. Genetic manipulation of INSM1 expression sufficiently controls the response of NPC cells to irradiation (IR). Mechanistically, cells exposed to IR, increased intracellular INSM1 competitively disrupts the interaction of cyclin D1 and CDK4 resulting in cell survival by the cyclin D1-dependent DNA repair machinery. Moreover, knockdown of INSM1 sensitives NPC cells to IR in vivo and protects xenograft mice from mortality. Taken together, these results indicate that INSM1 modulates NPC to radiotherapy by controlling cyclin D1-dependent DNA repair machinery that could be manipulated as a novel molecular target for NPC therapy.

scholarly journals A Novel Mechanism Driving Poor-Prognosis Prostate Cancer: Overexpression of the DNA Repair Gene, Ribonucleotide Reductase Small Subunit M2 (RRM2)

2019 ◽  
Vol 25 (14) ◽  
pp. 4480-4492 ◽  
Author(s):  
Ying Z. Mazzu ◽  
Joshua Armenia ◽  
Goutam Chakraborty ◽  
Yuki Yoshikawa ◽  
Si'Ana A. Coggins ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Repair ◽  
Ribonucleotide Reductase ◽  
Poor Prognosis ◽  
Small Subunit ◽  
Repair Gene ◽  
Dna Repair Gene

scholarly journals LncRNA ST7-AS1 is a Potential Novel Biomarker and Correlated With Immune Infiltrates for Breast Cancer

2021 ◽  
Vol 8 ◽  
Author(s):  
Ziwen Zhang ◽  
Han Zhang ◽  
Dongbo Li ◽  
Xiaoping Zhou ◽  
Jinlu Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Dna Repair ◽  
Noncoding Rna ◽  
Poor Prognosis ◽  
Enrichment Analysis ◽  
Gene Set Enrichment Analysis ◽  
The Cancer Genome Atlas ◽  
Functional Enrichment ◽  
Her2 Status

Background: Long noncoding RNA (lncRNA) ST7-AS1 can be observed in various cancers, but its role in breast cancer (BRC) remains unclear. Our aim is to, on the basis of The Cancer Genome Atlas (TCGA) database, prove the correlation between lncRNA ST7-AS1 and BRC.Methods: The lncRNA ST7-AS1 expression and its roles in the prognosis of BRC were explored using data from the TCGA database. The expression level of lncRNA ST7-AS1 in BRC samples was detected using RT-PCR. The 1-, 3-, or 5-year survival rate was predicted using a nomogram established through Cox proportional hazard regression. At last, the biological function was explored through gene ontology (GO) analysis and gene set enrichment analysis (GSEA). The hallmark pathways significantly involved in hub genes were described through functional enrichment analysis. The correlation between lncRNA ST7-AS1 expression and immune infiltration was analyzed through single-sample GSEA (ssGSEA).Results: LncRNA ST7-AS1 expression was downregulated in BRC. Decreased lncRNA ST7-AS1 expression in BRC was correlated with advanced clinical pathologic characteristics (high grade, histological type, age, menopause status, and HER2 status), survival time, and poor prognosis. The nomogram was established for using lncRNA ST7-AS1 to predict 1-, 3-, or 5-year survival in patients with BRC. In addition, GO and pathway analyses suggested the involvement of lncRNA ST7-AS1 in cell cycle, DNA repair, and immune cell infiltration in the BRC immune microenvironment. We found the correlation of lncRNA ST7-AS1 with T helper cells and DC cells.Conclusion: Low expression of lncRNA ST7-AS1 indicates poor prognosis and has an impact on cell cycle, DNA repair, and proportion of infiltrating immune cells in the BRC microenvironment. Therefore, lncRNA ST7-AS1 can be used as a protective prognostic marker and a potential treatment target for BRC.

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