Galectin-3 Targeted Therapy with a Small Molecule Inhibitor Activates Apoptosis and Enhances Both Chemosensitivity and Radiosensitivity in Papillary Thyroid Cancer

Abstract Purpose Prevalence of papillary thyroid cancer (PTC) is increased in patients with acromegaly. We aimed to determine the protein expression of BRAF, RAS, RET, insulin like growth factor 1(IGF1), Galectine 3, CD56 in patients with PTC related acromegaly and to compare the extensity of these expressions with normal PTC patients and benign thyroid nodules. Methods We studied 313 patients with acromegaly followed in Cerrahpasa Medical Faculty, Endocrinology and Metabolism Clinic between 1998 and 2015. On the basis of availability of pathological specimen of thyroid tissues, thyroid samples of 13 patients from 19 with acromegaly related PTC (APTC), 20 normal PTC and 20 patients with multinodulary goiter (MNG) were histopathologically evaluated. Protein expressions were determined via immunohistochemical staining in ex-vivo tumor samples and benign nodules. Results The incidence of PTC in acromegaly patients were 6% (n=19). Among patients with PTC, APTC and MNG, all the immunohistochemical protein expressions we have studied were higher in papillary thyroid cancer groups (p<0.01, for all). Between PTC group without acromegaly and APTC, galectin 3 and IGF1 expression was significantly higher in acromegalic patients (p<0.01 for all) while RAS was predominantly higher in PTC patients without acromegaly (p<0.01). Conclusion BRAF expression was not higher in PTC with acromegaly patients compared to PTC patients without acromegaly. Galectine 3 and IGF1 were expressed more intensively in APTC. These positive protein expressions may have more influence on determining malign nodules among acromegaly patients.

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FAK inhibition with small molecule inhibitor Y15 decreases viability, clonogenicity, and cell attachment in thyroid cancer cell lines and synergizes with targeted therapeutics

Oncotarget ◽

10.18632/oncotarget.2381 ◽

2014 ◽

Vol 5 (17) ◽

pp. 7945-7959 ◽

Cited By ~ 19

Author(s):

Shalana O’Brien ◽

Vita M. Golubovskaya ◽

Jeffrey Conroy ◽

Song Liu ◽

Dan Wang ◽

...

Keyword(s):

Thyroid Cancer ◽

Cell Lines ◽

Cancer Cell ◽

Small Molecule ◽

Cell Attachment ◽

Small Molecule Inhibitor ◽

Targeted Therapeutics ◽

Thyroid Cancer Cell ◽

Molecule Inhibitor ◽

Thyroid Cancer Cell Lines

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Copper Chelation as Targeted Therapy in a Mouse Model of Oncogenic BRAF-Driven Papillary Thyroid Cancer

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-17-3705 ◽

2018 ◽

Vol 24 (17) ◽

pp. 4271-4281 ◽

Cited By ~ 16

Author(s):

MengMeng Xu ◽

Michael Casio ◽

Danielle E. Range ◽

Julie A. Sosa ◽

Christopher M. Counter

Keyword(s):

Thyroid Cancer ◽

Targeted Therapy ◽

Mouse Model ◽

Papillary Thyroid Cancer ◽

Papillary Thyroid ◽

Copper Chelation

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Galectin-3 Inhibition by a Small-Molecule Inhibitor Reduces Both Pathological Corneal Neovascularization and Fibrosis

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.16-20009 ◽

2017 ◽

Vol 58 (1) ◽

pp. 9 ◽

Cited By ~ 29

Author(s):

Wei-Sheng Chen* ◽

Zhiyi Cao ◽

Hakon Leffler ◽

Ulf J. Nilsson ◽

Noorjahan Panjwani

Keyword(s):

Small Molecule ◽

Corneal Neovascularization ◽

Small Molecule Inhibitor ◽

Molecule Inhibitor ◽

Galectin 3

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The Immunocytochemistry Is a Valuable Tool in the Diagnosis of Papillary Thyroid Cancer in FNA's Using Liquid-Based Cytology

Journal of Oncology ◽

10.1155/2010/963926 ◽

2010 ◽

Vol 2010 ◽

pp. 1-5 ◽

Cited By ~ 15

Author(s):

Kalliopi Pazaitou-Panayiotou ◽

Nikolas Mygdakos ◽

Kyriaki Boglou ◽

Anastasia kiziridou ◽

Alexandra Chrisoulidou ◽

...

Keyword(s):

Thyroid Cancer ◽

Diagnostic Accuracy ◽

Thin Layer ◽

Papillary Thyroid Cancer ◽

Cytokeratin 19 ◽

Papillary Thyroid ◽

Cervical Lymph Nodes ◽

Galectin 3 ◽

Cytological Features ◽

E Cadherin

Introduction. Papillary thyroid carcinoma (PTC) is the most common malignancy of the thyroid. An accurate cytological diagnosis is based on distinctive cytological features in combination with immunocytochemistry.Methods. A number of 83 fine needle aspirations, positive for papillary thyroid cancer (44 from thyroid nodules and 39 from cervical lymph nodes), were studied using Thin Layer Cytology. A panel of the immunomarkers Cytokeratin-19, Galectin-3, HBME1, CD-44, CD-56, and E-Cadherin was performed.Results. Positive expression of CK-19 was observed in 77 cases (92.7%), of Galectin-3 in 74 cases (89.1%), of HBME1 in 65 (78.3%), and of CD-44 in 72 cases (86.7%). Loss of expression of CD-56 was observed in 80 cases (96.4%) and of E-cadherin in 78 (93.9%).Conclusions. Our data suggest that Thin Layer Cytology increases the diagnostic accuracy in papillary carcinoma and seems to be a promising technique for further investigation of thyroid lesions permitting the possibility to use archive material. Positive immunoexpression of CK-19, Galectin-3, HBME-1, and CD-44 improves the diagnostic accuracy of papillary thyroid cancer. Furthermore, loss of E-cadherin and of CD-56 expression is a feature of malignancy.

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