Population-Based Screening for Family History of End-Stage Renal Disease among Incident Dialysis Patients

2005 ◽  
Vol 25 (6) ◽  
pp. 529-535 ◽  
Author(s):  
Barry I. Freedman ◽  
Nataliya V. Volkova ◽  
Scott G. Satko ◽  
Jenna Krisher ◽  
Claudine Jurkovitz ◽  
...  
Keyword(s):  
Family History ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Population Based ◽  
Dialysis Patients ◽  
History Of ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Family history of end-stage renal disease among incident dialysis patients.

1997 ◽  
Vol 8 (12) ◽  
pp. 1942-1945 ◽  
Author(s):  
B I Freedman ◽  
J M Soucie ◽  
W M McClellan
Keyword(s):  
Renal Failure ◽  
African American ◽  
Family History ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Dialysis Patients ◽  
History Of ◽  
Stage Renal Disease ◽  
End Stage ◽  
Second Degree

As part of a larger study of genetic risk factors for the occurrence of renal failure, the prevalence of a family history of end-stage renal disease (ESRD) in first- and second-degree relatives of all incident dialysis patients treated in Georgia, North Carolina, and South Carolina (ESRD Network 6) in 1994 was ascertained. Family histories were obtained from 4365 dialysis patients (83% of those eligible), and 856 (20%) reported having a family history of ESRD. Among race-sex groups, 14.1% of Caucasian men, 14.6% of Caucasian women, 22.9% of African-American men, and 23.9% of African-American women reported a first- or second-degree relative with ESRD (P = 0.001). The prevalence of relatives with ESRD varied by the reported etiology: 22.2% in diabetes mellitus; 18.9% in hypertension, 22.7% in glomerulonephritis; and 13.0% of other etiologies (P = 0.001). Patient characteristics independently associated with family history of ESRD included race, younger age, higher levels of education, and etiology of ESRD. In this report, it is concluded that a large proportion of incident ESRD cases have close relatives with ESRD in whom preventive actions might be directed. Genetic analyses in multiply affected families may identify the inherited factors contributing to progressive renal failure.

scholarly journals Risk of End-Stage Renal Disease in Psoriatic Patients: Real-World Data from a Nationwide Population-Based Cohort Study

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Eun Lee ◽  
Ju Hee Han ◽  
Chul Hwan Bang ◽  
Seung Ah Yoo ◽  
Kyung Do Han ◽  
...  
Keyword(s):  
Cohort Study ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Treated Group ◽  
Population Based ◽  
Control Group ◽  
Real World Data ◽  
History Of ◽  
Stage Renal Disease ◽  
End Stage

Abstract Psoriasis is a chronic inflammatory skin disorder mediated by the T-cell–related immune response. Psoriatic patients may have a variety of comorbidities, but their risk of end-stage renal disease (ESRD), particularly according to the subtype of psoriasis, is unclear. We investigated the risk of ESRD in patients with psoriasis according to the subtype of psoriasis and history of systemic therapy for psoriasis. A total of 2,121,228 adults (1,590,921 in the control group and 530,307 in the psoriasis group) were enrolled in this nationwide population-based cohort study until 2015. During follow-up, 1,434 of the subjects in the psoriasis group developed ESRD. After adjusting for confounding factors, psoriasis was associated with the risk of ESRD (hazard ratio (HR) 1.58, 95% confidence interval [95% CI] 1.47–1.68). The psoriatic arthritis group (HR 7.60, 95% CI 1.90–30.41) had a higher risk of ESRD than the control group. Interestingly, no such association was detected in the systemically treated group (HR 1.07, 95% CI 0.80–1.41). Moreover, the acitretin-treated group had a lower risk of ESRD (HR 0.658, 95% CI, 0.494–0.875) than the non-systemically treated group. In conclusion, the risk of developing ESRD in patients with psoriasis differed according to the type of treatment and the presence of arthritis.

Family history of end-stage renal disease does not predict dialytic survival

2001 ◽  
Vol 38 (3) ◽  
pp. 547-552 ◽  
Author(s):  
Barry I. Freedman ◽  
J.Michael Soucie ◽  
Barbara Kenderes ◽  
Jenna Krisher ◽  
Leland E. Garrett ◽  
...  
Keyword(s):  
Family History ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
History Of ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Risk factors for foot ulceration in adults with end-stage renal disease on dialysis: a prospective observational cohort study

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Michelle R. Kaminski ◽  
Katrina A. Lambert ◽  
Anita Raspovic ◽  
Lawrence P. McMahon ◽  
Bircan Erbas ◽  
...  
Keyword(s):  
Risk Factors ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Arterial Disease ◽  
Multinomial Regression ◽  
Dialysis Patients ◽  
Foot Ulceration ◽  
History Of ◽  
Stage Renal Disease ◽  
End Stage

Abstract Background Dialysis patients experience high rates of foot ulceration. Although risk factors for ulceration have been extensively studied in patients with diabetes, there is limited high-quality, longitudinal evidence in the dialysis population. Therefore, this study investigated risk factors for foot ulceration in a stable dialysis cohort. Methods We prospectively collected clinical, demographic, health status, and foot examination information on 450 adults with end-stage renal disease from satellite and home-therapy dialysis units in Melbourne, Australia over 12 months. The primary outcome was foot ulceration. Cox proportional hazard modelling and multinomial regression were used to investigate risk factors. Results Among 450 dialysis patients (mean age, 67.5 years; 64.7% male; 94% hemodialysis; 50.2% diabetes), new cases of foot ulceration were identified in 81 (18%) participants. Overall, risk factors for foot ulceration were neuropathy (HR 3.02; 95% CI 1.48 to 6.15) and previous ulceration (HR 2.86; CI 1.53 to 5.34). In those without history of ulceration, nail pathology (RR 3.85; CI 1.08 to 13.75) and neuropathy (RR 2.66; CI 1.04 to 6.82) were risk factors. In those with history of ulceration, neuropathy (RR 11.23; CI 3.16 to 39.87), peripheral arterial disease (RR 7.15; CI 2.24 to 22.82) and cerebrovascular disease (RR 2.08; CI 1.04 to 4.16) were risk factors. There were 12 (2.7%) new amputations, 96 (21.3%) infections, 24 (5.3%) revascularizations, 42 (9.3%) foot-related hospitalizations, and 52 (11.6%) deaths. Conclusions Neuropathy and previous ulceration are major risk factors for foot ulceration in dialysis patients. Risk factors differ between those with and without prior ulceration. The risk factors identified will help to reduce the incidence of ulceration and its associated complications.

scholarly journals Patterns of Cardiac Arrhythmia in Haemodialysis Patients

2017 ◽  
Vol 7 (1) ◽  
pp. 28-33
Author(s):  
Nazneen Mahmood ◽  
AM Mujibul Haq ◽  
ASM Giasuddin ◽  
Khadija Akther Jhuma ◽  
Md Mahbubul Hoque ◽  
...  
Keyword(s):  
Renal Disease ◽  
Cardiac Arrhythmia ◽  
End Stage Renal Disease ◽  
Left Ventricular ◽  
Dialysis Patients ◽  
Female Ratio ◽  
Medical College ◽  
History Of ◽  
Stage Renal Disease ◽  
End Stage

Background: Cardiovascular disorders are one of the most serious problems in chronic haemodialysis patients. According to the records of last 15 years, 50% of these patients died from cardiovascular complications every year, without a marked reduction in the annual frequency of deaths. Cardiac arrhythmias are frequently associated with haemodialysis and have been reported to be seen in some series in up to 76% of patients.Materials & Methods: They appear to occur mostly after the first 3 hours of dialysis. In this study we have evaluated the arrhythmias that occured before and during dialysis to reduce the burden of morbidity and mortality of the patients. This is a cross sectional descriptive type of observational study on haemodialysis patients in Medical College for Women and Hospital (MCWH). Duration of study was 2 years, from July 2011 to June 2013.All the patients of end stage renal disease (ESRD) on maintenance haemodialysis (MHD) were included in the study. 81 patients were included to the study. One patient had permanent pacemaker and was excluded. Four patients had died during the study and four patients did not co-operated and left the study. Holter monitoring of a patient was unreadable because of artifact. Finally 71 patients were studied.Results: Out of 71 patients 38 were males and 33 were females with male to female ratio of 1.5:1. The mean age of the patient was 50.81 12.45 ( Range-22-75 ) year. Among 71 patients 19 had both DM and HTN and 42 patients had only HTN and 10 patients had other causes of chronic kidney disease (CKD).Premature atrial contraction(PAC) 27(40.30%) and Premature ventricular contraction(PVC) 40(59.70%)were the most common arrhythmia in dialysis patients before and during dialysis in our study. We found no significant effect of heamodialysis (HD) on cardiac arrhythmia. There was no correlation between arrhythmia and changes in Hb%, HbA1C, S. Albumin, S Creatinine, ions changes(Na+, K+, Ca++, Mg++)before and during haemodialysis (HD). QT intervals had no significant increase in dialysis patients. The prevalence of Atrial fibrillation (AF) rhythm was 5.63%.A high prevalence of cardiovascular disease is observed in end stage renal disease(ESRD) patients receiving dialysis therapy.Conclusion: The number of arrhythmias did not increase during dialysis in patients with no history of cardiac diseases, so the dialysis itself is not a leading risk factor for arrhythmias. But if a patient has history of arrhythmia, ischemia or left ventricular hypertrophy(LVH), he should be monitored during haemodialysis or undergo peritoneal dialysis in order to reduce the arrhythmia risk.Anwer Khan Modern Medical College Journal Vol. 7, No. 1: Jan 2016, P 28-33

scholarly journals Investigation of the Impact of Endodontic Therapy on Survival among Dialysis Patients in Taiwan: A Nationwide Population-Based Cohort Study

2021 ◽  
Vol 18 (1) ◽  
pp. 326
Author(s):  
Chih-Chien Chiu ◽  
Ya-Chieh Chang ◽  
Ren-Yeong Huang ◽  
Jenq-Shyong Chan ◽  
Chi-Hsiang Chung ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Root Canal ◽  
Dialysis Patients ◽  
Root Canal Therapy ◽  
Risk Of Death ◽  
Stage Renal Disease ◽  
End Stage

Objectives Dental problems occur widely in patients with chronic kidney disease (CKD) and may increase comorbidities. Root canal therapy (RCT) is a common procedure for advanced decayed caries with pulp inflammation and root canals. However, end-stage renal disease (ESRD) patients are considered to have a higher risk of potentially life-threatening infections after treatment and might fail to receive satisfactory dental care such as RCT. We investigated whether appropriate intervention for dental problems had a potential impact among dialysis patients. Design Men and women who began maintenance dialysis (hemodialysis or peritoneal dialysis) between January 1, 2000, and December 31, 2015, in Taiwan (total 12,454 patients) were enrolled in this study. Participants were followed up from the first reported dialysis date to the date of death or end of dialysis by December 31, 2015. Setting Data collection was conducted in Taiwan. Results A total of 2633 and 9821 patients were classified into the RCT and non-RCT groups, respectively. From the data of Taiwan’s National Health Insurance, a total of 5,092,734 teeth received RCT from 2000 to 2015. Then, a total of 12,454 patients were followed within the 16 years, and 4030 patients passed away. The results showed that members of the non-RCT group (34.93%) had a higher mortality rate than those of the RCT group (22.79%; p = 0.001). The multivariate-adjusted hazard ratio for the risk of death was 0.69 (RCT vs. non-RCT; p = 0.001). Conclusions This study suggested that patients who had received RCT had a relatively lower risk of death among dialysis patients. Infectious diseases had a significant role in mortality among dialysis patients with non-RCT. Appropriate interventions for dental problems may increase survival among dialysis patients. Abbreviations: CKD = chronic kidney disease, ESRD = end-stage renal disease, RCT = root canal therapy.

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