Effect of Nebulized Ipratropium Bromide on Lung Function in Nonallergic Bronchial Asthma

Respiration ◽  
1987 ◽  
Vol 52 (1) ◽  
pp. 1-6 ◽  
Author(s):  
T. Wegener ◽  
H. Hedenström
Keyword(s):  
Lung Function ◽  
Bronchial Asthma ◽  
Ipratropium Bromide

scholarly journals A relationship between lung function and arterial wall stiffness in patients with bronchial asthma

2011 ◽  
pp. 61-64 ◽  
Author(s):  
E. A. Sobko ◽  
A. Yu. Kraposhina ◽  
I. V. Demko ◽  
N. G. Ryazanova ◽  
O. P. Ishchenko ◽  
...  
Keyword(s):  
Lung Function ◽  
Bronchial Asthma ◽  
Arterial Wall ◽  
Wall Stiffness

Regulation of the IL-33/ST2 Pathway Contributes to the Anti-Inflammatory Effect of Acupuncture in the Ovalbumin-Induced Murine Asthma Model

2018 ◽  
Vol 36 (5) ◽  
pp. 319-326 ◽  
Author(s):  
Ming Dong ◽  
Cheng Ma ◽  
Wen-Qian Wang ◽  
Juan Chen ◽  
Ying Wei
Keyword(s):  
Lung Function ◽  
Mouse Model ◽  
Chronic Inflammation ◽  
Bronchial Asthma ◽  
Acupuncture Treatment ◽  
Dynamic Compliance ◽  
Mucus Secretion ◽  
Asthma Model ◽  
Tnf Α ◽  
Murine Asthma Model

Background Bronchial asthma is a chronic airway inflammatory disease which has three main pathological features: airway hyperresponsiveness (AHR), airway remodelling, and chronic inflammation. Acupuncture is known to be an effective integrative medical therapy that has been used in the treatment of several chronic diseases, including bronchial asthma. The aim of the current study was to evaluate the effects of acupuncture on inflammation and regulation of the IL-33/ST2 pathway in a mouse model of asthma. Methods The murine asthma model was established by both injection and inhalation of ovalbumin (OVA). Within 24 hours of the last OVA challenge, lung function was assessed by measurement of the airway resistance (RL) and lung dynamic compliance (Cdyn). Pulmonary tissues were collected for the detection of pathological changes and mucus secretion. Serum levels of tumour necrosis factor α (TNF-α), interleukin (IL)-1β, IL-33 and sST2 (secreted ST2) were detected by ELISA. Th17 cell proportions and counts in bronchoalveolar lavage fluid (BALF) were analysed by flow cytometry. Results The results showed that AHR, chronic inflammation and mucus secretion were significantly suppressed by acupuncture treatment. RL decreased while Cdyn increased after acupuncture treatment. There was an apparent decrease in the serum concentrations of certain pro-inflammatory cytokines, such as TNF-α, IL-1β and IL-33, and an increase in sST2 level compared with untreated asthmatic mice. Acupuncture also reduced the CD4 +IL-17A+ cell proportion and counts in BALF. Conclusion Acupuncture effectively protects lung function and attenuates airway inflammation in the OVA-induced mouse model of asthma, which supports the role of acupuncture as a potential therapy in asthma treatment.

scholarly journals Is platelet activating factor (PAF) an important mediator in bronchial asthma?

1992 ◽  
Vol 1 (6) ◽  
pp. 367-369 ◽  
Author(s):  
R. H. Gundel ◽  
H. O. Heuer ◽  
L. G. Letts
Keyword(s):  
Lung Function ◽  
Bronchial Asthma ◽  
Platelet Activating Factor ◽  
Receptor Antagonists ◽  
Primate Model ◽  
Novel Approach ◽  
Paf Receptor ◽  
Airway Responses ◽  
Preclinical Animal Models ◽  
Induced Changes

The development of selective PAF receptor antagonists may provide a novel approach to the treatment of human bronchial asthma. In preclinical animal models of human asthma, PAF receptor antagonists have been found to be efficacious in blocking antigen-induced changes in lung function. However, the majority of these models involve acute inflammatory events and transient changes in lung function and, therefore, their relevance to human asthma is questionable. In a recent study with a primate model of chronic airway inflammation and hyperresponsiveness, we have shown that treatment with a PAF receptor antagonist had no effect on reducing chronic inflammation and hyperresponsiveness. Similarly, recent studies in human asthmatics with PAF receptor antagonists have failed to show efficacy in blocking allergen-induced airway responses or to have any steroid sparing effects in patients with ongoing asthma. Thus, it seems that PAF may not be a key mediator which can be blocked and thereby provide therapy for bronchial asthma.

scholarly journals Association between tuberculosis and bronchial asthma

2017 ◽  
Vol 5 (8) ◽  
pp. 3566
Author(s):  
Kranti Garg ◽  
Jai Kishan Karahyla
Keyword(s):  
Family History ◽  
Lung Function ◽  
Bronchial Asthma ◽  
Positive Family History ◽  
Government Medical College ◽  
Medical College ◽  
Asthma Patients ◽  
History Of

Background: Everything that wheezes is not asthma. In patients of tuberculosis (TB), wheezing can be because of bronchial asthma, or many other causes. Asthma and other causes of wheezing need to be differentiated, as the treatment should be planned accordingly.Methods: Patients of active/quiescent tuberculosis who presented to Department of Tuberculosis and Chest Diseases, Government Medical College, Patiala, Punjab, India, with complaints of breathlessness and had rhonchi on examination were subjected to bronchodilator reversibility testing to prove if they were suffering from concomitant asthma. Patients thus found to have tuberculosis along with asthma were analyzed with respect to age, sex, rural urban differences and timing of diagnosis of either disease. Patients who developed asthma after tuberculosis were further analyzed for duration between completion of anti-tubercular treatment (ATT) and onset of asthma, family history of asthma and correlation of radiological manifestations and lung function measurements. Aim was to find association, if any, between tuberculosis and asthma.Results: Over 6 months, 69 patients of tuberculosis along with asthma were found. Only 21/69 (30.4%) patients developed tuberculosis after asthma. 48/69 (69.6%) patients developed asthma after tuberculosis. Majority (25/48=52.1%) of them developed asthma within 5 years of completion of ATT (p=0.020). Only 2/48 (2.9%) patients had a positive family history for asthma. Lung function abnormalities correlated with the extent of radiological involvement in these patients who developed asthma after tuberculosis (p ≤0.0001).Conclusions: Patients of active/quiescent tuberculosis who present with breathlessness and have rhonchi on examination should be treated for asthma only after confirmation of the diagnosis, as there can be other reasons for the same.

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