scholarly journals Intralymphatic Injections as a New Administration Route for Allergen-Specific Immunotherapy

2009 ◽  
Vol 150 (1) ◽  
pp. 59-65 ◽  
Author(s):  
Julia M. Martínez-Gómez ◽  
Pål Johansen ◽  
Iris Erdmann ◽  
Gabriela Senti ◽  
Reto Crameri ◽  
...  
Keyword(s):  
Specific Immunotherapy ◽  
Administration Route ◽  
Allergen Specific Immunotherapy

scholarly journals Diverse Mechanisms of Allergen Specific Immunotherapy

2019 ◽  
Vol 23 (3) ◽  
pp. 233-249 ◽  
Author(s):  
Lacin Cevhertas ◽  
Mübeccel Akdis
Keyword(s):  
Immune Response ◽  
Molecular Mechanisms ◽  
Allergen Immunotherapy ◽  
Specific Immunotherapy ◽  
Prognostic Markers ◽  
Recent Literature ◽  
Administration Route ◽  
Allergen Specific Immunotherapy ◽  
Disease Modifying ◽  
Disease Modifying Treatment

Allergen immunotherapy (AIT) is widely used to establish a tolerant immune response and it is currently the only disease modifying treatment. There are different routes to administer the allergen, including subcutaneous, sublingual, intralymphatic, epicutaneous, intradermal, and oral and local nasal allergen immunotherapy. Although the optimal administration route depends on the type of allergen, some patients remain unresponsive and so it is important to predict the outcome before and during treatment. Therefore, there is a need to identify candidate prognostic markers for allergen immunotherapy. Herein, we discuss the recent literature on the molecular mechanisms of AIT.

Immunotheraphy in Allergic Diseases

2018 ◽  
Vol 24 (11) ◽  
pp. 1174-1194
Author(s):  
Albert Roger ◽  
Maria Basagana ◽  
Aina Teniente-Serra ◽  
Nathalie Depreux ◽  
Yanina Jurgens ◽  
...  
Keyword(s):  
Specific Immunotherapy ◽  
Allergic Diseases ◽  
Specific Ige ◽  
World Population ◽  
Allergen Specific Immunotherapy ◽  
Routes Of Administration ◽  
Disease Modifying Therapy ◽  
History Of ◽  
Ige Mediated ◽  
Special Case

The prevalence of allergic diseases is increasing worldwide. It is estimated that more than 30% of the world population is now affected by one or more allergic conditions and a high proportion of this increase is in young people. The diagnosis of allergy is dependent on a history of symptoms on exposure to an allergen together with the detection of allergen-specific IgE. Accurate diagnosis of allergies opens up therapeutic options. Allergen specific immunotherapy is the only successful disease-modifying therapy for IgE-mediated allergic diseases. New therapeutic strategies have been developed or are currently under clinical trials. Besides new routes of administration, new types of allergens are being developed. The use of adjuvants may amplify the immune response towards tolerance to the antigens. In this review, we analyze different antigen-specific immunotherapies according to administration route, type of antigens and adjuvants, and we address the special case of food allergy.

Planning and approach to allergen-specific immunotherapy in polyallergic patients

Immunotherapy ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 577-585
Author(s):  
Nerin N Bahceciler ◽  
Ozel Yuruker
Keyword(s):  
Clinical Management ◽  
Respiratory Diseases ◽  
Specific Immunotherapy ◽  
Clinical Symptoms ◽  
Allergen Specific Immunotherapy ◽  
Stepwise Approach ◽  
Future Studies ◽  
Disease Modifying ◽  
Management Recommendations ◽  
Disease Modifying Treatment

Allergy immunotherapy (AIT) is currently the only disease-modifying treatment for allergic-respiratory diseases. Polysensitization may increase the severity of current disease resulting in subsequent asthma development in patients with allergic rhinitis. Due to the absence of general recommendations for the practical approach to polysensitized patients, clinical management is not standardized. The correlation between sensitizations and clinical symptoms, elimination of possible pollen cross-reactivities and principles of homologous allergen groups will guide the allergists to deduce the most relevant allergens for AIT. In the highlight of the previously proposed approach strategies to polyallergic patients, hereby we propose a revised practical stepwise approach based on the current European Medicine Agency (EMA) guidelines. However, more supporting data from well-designed, controlled, future studies are needed to improve clinical management recommendations for AIT in polyallergic patients.

scholarly journals Distinct modulation of allergic T cell responses by subcutaneous vs. sublingual allergen-specific immunotherapy

2016 ◽  
Vol 46 (3) ◽  
pp. 439-448 ◽  
Author(s):  
V. Schulten ◽  
V. Tripple ◽  
K. Aasbjerg ◽  
V. Backer ◽  
G. Lund ◽  
...  
Keyword(s):  
T Cell ◽  
Specific Immunotherapy ◽  
T Cell Responses ◽  
Allergen Specific Immunotherapy ◽  
Cell Responses
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