Do we have Markers for the Metastatic Potential of Malignant Melanomas?

The purpose of this study was to demonstrate by ISH the presence of IL-8 mRNA, and by immunohistochemistry (IHC) the presence of the chemokine IL-8 and the distribution of infiltrating macrophages in subcutaneous melanomas in the same tumor. IL-8 is a multifunctional cytokine produced by melanoma cells, activated macrophages and monocytes and it has been shown to be a growth and angiogenic factor for tumor cells. More recently it was shown that constitutive expression of IL-8 correlated directly with metastatic potential of human melanoma cells in nude mice. IL-8 content of a solid tumor as determined by Western blot analysis does not take into account the contribution of macrophages. Previous studies showed that murine tumors contain many infiltrating cells interspersed among tumor cells whereas human tumors growing in nude mice exhibit macrophages at the periphery or between tumor islands. In this study we demonstrate the expression of IL-8 and the distribution of macrophages by immunoperoxidase assay and IL-8 mRNA by ISH.

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Letter: Malignant melanomas

Archives of Dermatology ◽

10.1001/archderm.111.10.1365b ◽

1975 ◽

Vol 111 (10) ◽

pp. 1365b-1366

Author(s):

H. Gartmann

Keyword(s):

Malignant Melanomas

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CD44 splice variants expression correlates with in vitro metastatic potential in ovarian cancer cell lines

Journal of the Society for Gynecologic Investigation ◽

10.1016/s1071-5576(97)86250-8 ◽

1998 ◽

Vol 5 (1) ◽

pp. 82A-82A

Author(s):

D GIBBONS ◽

I SANCHOTORRES ◽

C MESONERO ◽

P LEAKEY ◽

J LUDLOW ◽

...

Keyword(s):

Ovarian Cancer ◽

Cell Lines ◽

Cancer Cell ◽

Ovarian Cancer Cell ◽

Splice Variants ◽

Metastatic Potential ◽

Cancer Cell Lines ◽

Ovarian Cancer Cell Lines

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Osteoblast-derived factors increased metastatic potential in human prostate cancer cells

Bone Abstracts ◽

10.1530/boneabs.5.p132 ◽

2016 ◽

Author(s):

Terese Karlsson ◽

Reshma Sundar ◽

Anders Widmark ◽

Marene Landstrom ◽

Emma Persson

Keyword(s):

Prostate Cancer ◽

Cancer Cells ◽

Metastatic Potential ◽

Human Prostate ◽

Human Prostate Cancer ◽

Prostate Cancer Cells

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Down-regulation of the Ataxia Telangiectasia Mutated Gene (ATM) is associated with increased metastatic potential and decreased overal survival in patients diagnosed with gastroenteropancreatic neuroendocrine tumors (GEP-NETs)

Endocrine Abstracts ◽

10.1530/endoabs.63.p447 ◽

2019 ◽

Author(s):

Darko Katalinic ◽

Ivan Aleric ◽

Aleksandar Vcev ◽

Jure Mirat ◽

Lilly Soerensen ◽

...

Keyword(s):

Neuroendocrine Tumors ◽

Ataxia Telangiectasia ◽

Metastatic Potential ◽

Ataxia Telangiectasia Mutated ◽

Down Regulation ◽

Gastroenteropancreatic Neuroendocrine Tumors ◽

Overal Survival

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Rare localization of renal cell carcinoma metastases in the paranasal sinuses and breast: a case report

Medical Visualization ◽

10.24835/1607-0763-2018-6-13-22 ◽

2019 ◽

Vol 22 (6) ◽

pp. 13-22

Author(s):

E. V. Kryaneva ◽

N. A. Rubtsova ◽

A. V. Levshakova ◽

A. I. Khalimon ◽

A. V. Leontyev ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Paranasal Sinuses ◽

Renal Cell ◽

Clinical Case ◽

Clear Cell ◽

Malignant Tumors ◽

Metastatic Potential ◽

Cell Renal Cell Carcinoma ◽

Metastatic Lesions

This article presents a clinical case demonsratinga high metastatic potential of clear cell renal cell carcinoma combined with atypical metastases to breast and paranasal sinuses. The prevalence of metastatic lesions to the breast and paranasal sinuses in various malignant tumors depending on their morphological forms is analyzed. The authors present an analysis of data published for the last 30 years. The optimal diagnostic algorithms to detect the progression of renal cell carcinoma and to evaluate the effectiveness of the treatment are considered.

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