scholarly journals Prognostic Value and Therapeutic Potential of TREM-1 in Streptococcus pyogenes-Induced Sepsis

2013 ◽  
Vol 5 (6) ◽  
pp. 581-590 ◽  
Author(s):  
Sarah A. Horst ◽  
Anna Linnér ◽  
Andreas Beineke ◽  
Sabine Lehne ◽  
Claudia Höltje ◽  
...  
Keyword(s):  
Streptococcus Pyogenes ◽  
Prognostic Value ◽  
Therapeutic Potential

scholarly journals Clinical relevance of CD70 expression in resected pancreatic cancer: Prognostic value and therapeutic potential

Pancreatology ◽  
2021 ◽  
Author(s):  
Kota Nakamura ◽  
Masayuki Sho ◽  
Takahiro Akahori ◽  
Satoshi Nishiwada ◽  
Tomohiro Kunishige ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Clinical Relevance ◽  
Prognostic Value ◽  
Therapeutic Potential

Leptin Involvement in Primary Brain and Pituitary Tumors: Therapeutic Potential, Prognostic Value, and Proposed Diagnostic Application

2018 ◽  
Vol 9 (3) ◽  
pp. 144-155 ◽  
Author(s):  
Christos Bikis ◽  
Theodora Tzanavari ◽  
Krystallenia I. Alexandraki ◽  
Stamatios Theocharis
Keyword(s):  
Prognostic Value ◽  
Therapeutic Potential ◽  
Pituitary Tumors ◽  
Diagnostic Application

Can antioxidant nutraceuticals benefit the menopause?

2002 ◽  
Vol 8 (3) ◽  
pp. 98-101
Author(s):  
Erick Valencia ◽  
Angela Marin ◽  
Gil Hardy
Keyword(s):  
Breast Cancer ◽  
Chronic Diseases ◽  
Prognostic Value ◽  
Literature Search ◽  
Therapeutic Potential ◽  
Nutritional Supplements ◽  
Ageing Population ◽  
Physiological Changes ◽  
Menopausal Women

The antioxidants glutathione, selenium and vitamins C and E meet the criteria for nutraceuticals and their in vivo concentrations can undoubtedly influence and improve many disease processes. In an attempt to quantify and correlate their individual roles as nutritional supplements with their therapeutic potential to improve symptoms and lifestyle during the menopause, we conducted a literature search covering the 15 years up to 2001. Few publications were found dealing specifically with menopausal women. Approximately 90% reported research with vitamins and/or selenium and only one paper investigated a possible correlation between glutathione and breast cancer. This relatively low level of research interest in nutritional or antioxidant aspects of the menopause may just reflect a preoccupation with the more general chronic diseases of an ageing population, without necessarily acknowledging the important physiological changes that occur in women. The little encouraging data in the literature should stimulate more research into the prognostic value, mechanisms and efficacy of nutraceutical supplementation that specifically relate to menopausal women.

scholarly journals Prognostic and Therapeutic Value of Apolipoprotein A and a New Risk Scoring System Based on Apolipoprotein A and Adenosine Deaminase in Chronic Lymphocytic Leukemia

2021 ◽  
Vol 11 ◽  
Author(s):  
Xiaoya Yun ◽  
Xiang Sun ◽  
Xinting Hu ◽  
Huimin Zhang ◽  
Zixun Yin ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Adenosine Deaminase ◽  
Scoring System ◽  
Prognostic Value ◽  
Therapeutic Potential ◽  
Lymphocytic Leukemia ◽  
Major Protein ◽  
Apolipoprotein A ◽  
Risk Scoring ◽  
Risk Scoring System

Lipid metabolism is related to lymphomagenesis, and is a novel therapeutic target in some hematologic tumors. Apolipoprotein A (ApoA), the major protein of high-density lipoprotein (HDL), plays a crucial role in lipid transportation and protecting against cardiovascular disease, and takes effect on anti-inflammation and anti-oxidation. It is correlated with the prognosis of some solid tumors. Yet, there is no investigation involving the role of ApoA plays in chronic lymphocytic leukemia (CLL). Our retrospective study focuses on the prognostic value of ApoA in CLL and its therapeutic potential for CLL patients. Herein, ApoA is a favorable independent prognostic factor for both overall survival (OS) and progression-free survival (PFS) of CLL patients. ApoA is negatively associated with β2-microglobulin (β2-MG) and advanced stage, which are poor prognostic factors in CLL. Age, Rai stage, ApoA, and adenosine deaminase (ADA) are included in a new risk scoring system named ARAA-score. It is capable of assessing OS and PFS of CLL patients. Furthermore, cell proliferation assays show that the ApoA-I mimetic L-4F can inhibit the proliferation of CLL cell lines and primary cells. In conclusion, ApoA is of prognostic value in CLL, and is a potential therapy for CLL patients. The ARAA-score may optimize the risk stratification of CLL patients.

scholarly journals Exploring the prognostic value of SCARF1 in non-small cell lung cancers

2021 ◽  
Author(s):  
Daniel A. Patten ◽  
Shishir Shetty
Keyword(s):  
Endothelial Cells ◽  
Prognostic Value ◽  
Therapeutic Potential ◽  
Small Cell Lung Carcinoma ◽  
Lung Squamous Cell Carcinoma ◽  
Small Cell ◽  
The Cancer Genome Atlas ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Lung Cancers

AbstractScavenger receptor class F member 1 (SCARF1) has previously been shown to be highly expressed within the human liver, hold prognostic value in hepatocellular carcinoma and mediate the specific recruitment of leukocytes to liver sinusoidal endothelial cells; however, to date, the liver remains the only major organ in which SCARF1 has been explored in any detail. Here, we utilised publically-available RNA-sequencing data from The Cancer Genome Atlas (TGCA) to identify the lungs as a site of significant SCARF1 expression and attribute the majority of its expression to endothelial cell populations. Next, we show that SCARF1 expression is significantly reduced in two histologically distinct types of non-small cell lung carcinoma cancers (NSCLCs), lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC), compared to non-tumoural tissues. Interestingly, loss of SCARF1 expression was associated with aggressive tumour biology in LUAD tissues, but not in LUSC. Furthermore, increased SCARF1 expression was highly prognostic of better overall survival in LUAD tumour tissues, but this was again in contrast to LUSC tumours, in which SCARF1 held no prognostic value. Finally, we showed that SCARF1 is widely expressed in tumour endothelial cells of non-small cell lung cancers and that its total expression in LUAD tumour tissues correlated with immune score and CD4+ T cell infiltration. This study represents the first detailed exploration of SCARF1 expression in normal and diseased human lung tissues and further highlights the prognostic value and therapeutic potential of SCARF1 in immunologically active cancers.

HSP90 as a regulator of extracellular matrix dynamics

2021 ◽  
Author(s):  
Abir Chakraborty ◽  
Adrienne Lesley Edkins
Keyword(s):  
Extracellular Matrix ◽  
Molecular Chaperone ◽  
Prognostic Value ◽  
Therapeutic Potential ◽  
Tissue Homeostasis ◽  
Protein Homeostasis ◽  
Matrix Dynamics

The extracellular matrix (ECM) is a dynamic and organised extracellular network assembled from proteins and carbohydrates exported from the cell. The ECM is critical for multicellular life, providing spatial and temporal cellular cues to maintain tissue homeostasis. Consequently, ECM production must be carefully balanced with turnover to ensure homeostasis; ECM dysfunction culminates in disease. Hsp90 is a molecular chaperone central to protein homeostasis, including in the ECM. Intracellular and extracellular Hsp90 isoforms collaborate to regulate the levels and status of proteins in the ECM via multiple mechanisms. In so doing, Hsp90 regulates ECM dynamics, and changes in Hsp90 levels or activity support the development of ECM-related diseases, like cancer and fibrosis. Consequently, Hsp90 levels may have prognostic value, while inhibition of Hsp90 may have therapeutic potential in conditions characterised by ECM dysfunction.

scholarly journals The Streptococcus pyogenes signaling peptide SpoV regulates streptolysin O and enhances survival in murine blood

2021 ◽  
Author(s):  
Andrea L. Herrera ◽  
Eduardo A. Callegari ◽  
Michael S. Chaussee
Keyword(s):  
Gene Expression ◽  
Streptococcus Pyogenes ◽  
Regulatory Networks ◽  
Environmental Changes ◽  
Therapeutic Potential ◽  
Transcript Abundance ◽  
Bacterial Survival ◽  
Streptolysin O ◽  
Wide Range ◽  
Peptide Derivatives

Streptococcus pyogenes (Group A Streptococcus, GAS) is a human pathogen that causes a wide range of diseases. For successful colonization within a variety of host niches, GAS must sense and respond to environmental changes. Intercellular communication mediated by peptides is one way GAS coordinates gene expression in response to diverse environmental stressors, which enhances bacterial survival and contributes to virulence. Using peptidomics we identified SpoV (Streptococcal peptide controlling virulence) in culture supernatant fluids. SpoV is a secreted peptide encoded near the gene encoding the extracellular cholesterol-dependent cytolysin streptolysin O (slo). The addition of synthetic SpoV peptide derivatives, but not control peptides, increased slo transcript abundance in an M49 isolate but not in an M3 isolate. Deletion of spoV decreased slo transcript abundance, extracellular SLO protein levels, and SLO-specific hemolytic activity. Complementation of the spoV mutant increased slo transcript abundance. Lastly, a spoV mutant was deficient in the ability to survive in murine blood compared to the parental strain. Moreover, pre-incubation of the spoV mutant with synthetic SpoV peptide derivatives increased GAS survival. Our findings show that slo expression is regulated, in part, by the GAS-specific signaling peptide SpoV. IMPORTANCE GAS secretes signaling peptides that can alter gene expression and impact virulence. We used peptidomics to identify a signaling peptide designated SpoV. Further, we showed that SpoV altered the expression of the cholesterol-dependent cytolysin SLO. Peptide signaling plays an important regulatory role during disease progression among several bacterial pathogens, including GAS. The therapeutic potential of manipulating peptide-controlled regulatory networks is an attractive option for the development of novel therapeutic strategies that disrupt virulence gene expression.

scholarly journals Signaling Peptide SpoV Is Essential for Streptococcus pyogenes Virulence, and Prophylaxis with Anti-SpoV Decreases Disease Severity

2021 ◽  
Vol 9 (11) ◽  
pp. 2321
Author(s):  
Andrea L. Herrera ◽  
Michael S. Chaussee
Keyword(s):  
Streptococcus Pyogenes ◽  
Therapeutic Potential ◽  
Group A Streptococcus ◽  
Ex Vivo ◽  
Invasive Disease ◽  
Human Model ◽  
Streptolysin S ◽  
Streptolysin O ◽  
Group A ◽  
Specific Peptide

Streptococcal peptide of virulence (SpoV) is a Streptococcus pyogenes (group A streptococcus (GAS))-specific peptide that is important for GAS survival in murine blood, and the expression of the virulence factors streptolysin O (slo) and streptolysin S (sagA). We used a spoV mutant in isolate MGAS315 to assess the contribution of the SpoV peptide to virulence by using a murine model of invasive disease and an ex vivo human model (Lancefield assay). We then used antibodies to SpoV in both models to evaluate their ability to decrease morbidity and mortality. Results showed that SpoV is essential for GAS virulence, and targeting the peptide has therapeutic potential.

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