Ratio of Transmitral E-Wave Velocity to Early Diastole Mitral Annulus Velocity with Cardiovascular and Renal Outcomes in Chronic Kidney Disease

2013 ◽  
Vol 123 (1-2) ◽  
pp. 52-60 ◽  
Author(s):  
Szu-Chia Chen ◽  
Jer-Ming Chang ◽  
Yi-Chun Tsai ◽  
Jiun-Chi Huang ◽  
Ling-I Chen ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Wave Velocity ◽  
Mitral Annulus ◽  
Renal Outcomes ◽  
Early Diastole ◽  
Mitral Annulus Velocity

scholarly journals Correlation Between Thyroid Autoantibodies and Cardiovascular Disease in Patients With Stages 3-5 Chronic Kidney Disease

2021 ◽  
Author(s):  
Weicheng Xu ◽  
Shiyi Liang ◽  
Ge qian ◽  
Chijian Li ◽  
Yuxiang Huang ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Mitral Valve ◽  
Kidney Disease ◽  
Flow Velocity ◽  
Mitral Annulus ◽  
Thyroid Autoantibodies ◽  
Female Patients ◽  
Early Diastole ◽  
Mitral Annulus Velocity

Abstract Background: Chronic kidney disease (CKD) interacts with thyroid disease and cardiovascular disease (CVD). Our research aimed to analyze the correlation between echocardiographic parameters E / A, E / E ', E' / A ', LVEF and thyroid autoantibodies, and evaluate the role of thyroid autoimmunity in the development of CVD in patients with stages 3-5 CKD.Methods: The patients who were diagnosed as stages 3-5 CKD in our department from January 2015 to May 2019 were recruited. We collected the routine medical history, general clinical data, and laboratory test index of patients. Echocardiography is performed by a trained echocardiographer to measure mitral valve blood flow velocity (E) in early diastole and Mitral valve flow velocity (A), E / A ratio, mitral annulus velocity (E ') in early diastole, mitral annulus velocity (A') in end-diastole, E / E 'ratio, and E' / A ' ratio. The SPSS 22.0 statistical software was used to analyze the data.Results: A total of 1164 patients with stages 3-5 CKD were included. Thyroglobulin antibody (TGAb) was negatively correlated with eGFR (r = -0.287, P <0.05). Thyrotropin receptor antibody (TRAb) was significantly positively correlated with CRP (r = 0.206, P <0.001). The titers of TPOAb and TGAb in male diabetic patients were higher (r = 0.137, P = 0.023; r = 0.159, P = 0.011). In female patients, both TPOAb and TGAb are significantly negatively correlated with HGB (r = -0.213, P = 0.018; r = -0.188, P = 0.019). The E / E’ of patients with TPOAb positive was higher (r = 0.181, P ＜ 0.001). The LVEF in patients with TPOAb positive were higher (r = 0.159, P = 0.007). In addition, LVEF was significantly negatively correlated with TRAb (r = -0.112, P = 0.026).Conclusion: The prevalence of AITD in stages 3-5 CKD gradually increases with the decline of renal function, and the titers of TPOAb and TGAb also gradually increase. In patients with stages 3-5 CKD, AITD may accelerate the incidence of CVD in CKD patients by affecting TG levels, accelerating the occurrence of anemia, and promoting the micro-inflammation. Female patients with high titers of TPOAb and TGAb should be paid more attention. The average E/E' of patients with stage 5 CKD was 16. Women with low FT3 and TPOAb positive maybe more likely to develop diastolic heart failure.

scholarly journals Brachial-ankle pulse wave velocity and brachial pre-ejection period to ejection time ratio with renal outcomes in chronic kidney disease

2012 ◽  
Vol 35 (12) ◽  
pp. 1159-1163 ◽  
Author(s):  
Szu-Chia Chen ◽  
Jer-Ming Chang ◽  
Yi-Chun Tsai ◽  
Ho-Ming Su ◽  
Hung-Chun Chen
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Ejection Time ◽  
Renal Outcomes ◽  
Time Ratio

scholarly journals P246 Exercise E/e refines diagnosis of diastolic impairment in patients with chronic kidney disease

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
G Gan ◽  
K Kadappu ◽  
A Bhat ◽  
F Fernandez ◽  
H Chen ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Exercise Capacity ◽  
Mitral Annulus ◽  
Left Ventricular ◽  
Exercise Stress ◽  
Total N ◽  
Metabolic Equivalents ◽  
Mitral Annulus Velocity ◽  
The Relationship

Abstract Background Diastolic dysfunction is common in chronic kidney disease (CKD) patients and is associated with reduced exercise capacity. The ratio of early diastolic mitral inflow velocity to early diastolic mitral annulus velocity (E/e’) correlates with invasively measured left ventricular pressures, both at rest and during exercise. The aim of our study was to evaluate the relationship of resting and exercise E/e’ to exercise capacity in patients with stage 3 and 4 CKD. Methods CKD patients were prospectively recruited. All patients were required to be in sinus rhythm, without previous cardiac disease and with normal LVEF. The E/e’ ratio was assessed at rest and patients were stratified into 3 groups based on conventional clinical classifications (normal: ≤8, indeterminate: 8-14, raised: &gt;14). Patients then underwent a symptom limited exercise stress echocardiogram whereby patients with resting E/e’ &lt;14 additionally had post exercise E/e’ measured. Exercise capacity was assessed as metabolic equivalents (METs). A raised exercise E/e’ was defined as exercise E/e’ of ≥13. Lastly, we grouped patients based on abnormalities of baseline and exercise E/e’ (resting E/e’&lt;14 & exercise E/e’&lt;13, resting E/e’&lt;14 & exercise E/e ≥13, resting E/e’ ≥14) and the relationship to METs achieved was evaluated. Results The cohort consisted of 156 CKD patients (62.8 ± 10.6 yrs, male 62%). 85% had hypertension and 39% had diabetes mellitus. 52/156 (34%) CKD patients had resting E/e’ of ≥14. Of the 104/156 (66%) CKD patients with normal/indeterminate resting E/e’, 66/104(63%) had normal exercise E/e’ &lt;13 whilst 38/104(37%) had exercise E/e’ ≥13. Patients with resting E/e" & raised exercise E/e’ ≥13 achieved significantly lower METs compared to CKD patients with resting E/e’ &lt;14 & exercise E/e’ &lt;13 (5.0 ± 2.2 vs 8.8 ± 2.5, p&lt; 0.01). Of note, METs achieved in this group were comparable to that achieved by CKD patients with raised resting E/e’ ≥ 14 (5.0 ± 2.2 METs vs 5.3 ± 2.6 METs, p = 0.55). Conclusion In CKD patients with normal/indeterminate resting E/e’, there is utility in performing exercise E/e’, which was increased in 37% of patients. Raised exercise E/e’ is associated with poorer exercise capacity and is a potential tool to refine diastolic abnormalities in patients with CKD. Group Total (n,%) METs Achieved Exercise Duration (minutes) Resting E/e’ ≤ 14 & Exercise E/e’ ≤ 13 66/156 (42%) 8.8 ± 2.5 8.4 ± 3.1 Resting E/e’ ≤ 14 & Exercise E/e’ ≥ 13 38/156 (24%) 5.0 ± 2.2 6.0 ± 3.1 Resting E/e’ ≥ 14 52/156 (34%) 5.3 ± 2.6 5.6 ± 2.2

scholarly journals Low serum calcium is associated with poor renal outcomes in chronic kidney disease stages 3–4 patients

2014 ◽  
Vol 15 (1) ◽  
Author(s):  
Lee-Moay Lim ◽  
Hung-Tien Kuo ◽  
Mei-Chuan Kuo ◽  
Yi-Wen Chiu ◽  
Jia-Jung Lee ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Serum Calcium ◽  
Renal Outcomes ◽  
Disease Stages ◽  
Low Serum

scholarly journals Left Atrial Diameter and Albumin with Renal Outcomes in Chronic Kidney Disease

2013 ◽  
Vol 10 (5) ◽  
pp. 575-584 ◽  
Author(s):  
Szu-Chia Chen ◽  
Jer-Ming Chang ◽  
Yi-Chun Tsai ◽  
Jiun-Chi Huang ◽  
Ho-Ming Su ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Left Atrial ◽  
Left Atrial Diameter ◽  
Renal Outcomes

Prospective associations between environmental heavy metal exposure and renal outcomes in adults with chronic kidney disease

Nephrology ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 830-836 ◽  
Author(s):  
Chun-Chieh Tsai ◽  
Chia-Lin Wu ◽  
Chew-Teng Kor ◽  
Ie-Bin Lian ◽  
Chin-Hua Chang ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Heavy Metal ◽  
Kidney Disease ◽  
Metal Exposure ◽  
Heavy Metal Exposure ◽  
Renal Outcomes

Association of serum bilirubin with renal outcomes in Han Chinese patients with chronic kidney disease

2018 ◽  
Vol 480 ◽  
pp. 9-16 ◽  
Author(s):  
Yan Liu ◽  
Mengyuan Li ◽  
Yaxiang Song ◽  
Xinying Liu ◽  
Jian Zhao ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Serum Bilirubin ◽  
Han Chinese ◽  
Chinese Patients ◽  
Renal Outcomes

Relationship between renal biopsy and renal survival in elderly patients with chronic kidney disease: A propensity score matching approach

2020 ◽  
Author(s):  
Xiaowei Lou ◽  
Shizhu Yuan ◽  
Wei Shen ◽  
Yueming Liu ◽  
Juan Jin ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Elderly Patients ◽  
Renal Biopsy ◽  
Cox Regression ◽  
Renal Survival ◽  
Aged Patients ◽  
Renal Outcomes ◽  
Propensity Matching

Abstract Background The effect of renal biopsy on the prognosis of elderly patients with chronic kidney disease remains unclear. Thus, in this study, we aimed to evaluate the relationship between renal biopsy and renal survival in this population.Methods In this multi-centre retrospective study, the baseline characteristics among three groups were balanced by propensity matching. All patients were divided into three groups according to age and renal biopsy. The clinicopathological features at biopsy and renal outcomes during the follow-up were collected and analysed. Renal outcomes were defined as estimated glomerular filtration rate < 15 mL/min/1.73 m2, dialysis, renal transplantation, or death. The prognostic effects of renal biopsy were evaluated using Cox regression models. Results A total of 1313 patients were identified. After propensity matching, 390 patients were selected and divided into three groups. After a total follow-up period of 55 months, 20 (13.3%) patients (47.6% group 1 vs 7.41% group 2 vs 39.1% group 3) reached renal outcomes. No significant differences were found in renal outcomes among aged patients whether they underwent renal biopsy or not. Cox regression analysis revealed risk factors in aged patients including low albumin and high levels of proteinuria and serum creatinine (P < 0.05). Platelet count was significant only in aged patients who underwent renal biopsy (hazard ratio: 0.642, P < 0.05). Conclusion In conclusion, renal biopsy in the elderly has not shown benefits in terms of renal survival, conservative treatment appears to be a viable therapeutic option in the management of those people.

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