Serum Levels of Calcitonin in Uremic Patients in the Predialytic Phase and on Regular Dialytic Treatment

2015 ◽  
pp. 101-106 ◽  
Author(s):  
D. Di Landro ◽  
G. Luisetto ◽  
L. Tizian ◽  
C. Pennetta ◽  
M. Urso ◽  
...  
Keyword(s):  
Serum Levels ◽  
Uremic Patients ◽  
Dialytic Treatment

Elevated Serum Levels of 3-Deoxyglucosone, a Potent Protein-Cross-Linking Intermediate of the Maillard Reaction, in Uremic Patients

Nephron ◽  
1995 ◽  
Vol 69 (4) ◽  
pp. 438-443 ◽  
Author(s):  
Toshimitsu Niwa ◽  
Naohito Takeda ◽  
Takashi Miyazaki ◽  
Hideo Yoshizumi ◽  
Akira Tatematsu ◽  
...  
Keyword(s):  
Maillard Reaction ◽  
Elevated Serum ◽  
Serum Levels ◽  
Cross Linking ◽  
Uremic Patients ◽  
Protein Cross Linking

Does Immunodeficiency in Uremic Patients Promote Dialysis-Related Amyloidosis?

1988 ◽  
Vol 11 (2) ◽  
pp. 102-106 ◽  
Author(s):  
P. Simon ◽  
K.S. Ang ◽  
Y. Cavarle ◽  
G. Cam ◽  
M. Catheline ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
T Cell ◽  
Lymphocyte Subsets ◽  
Serum Levels ◽  
Hemodialysis Patients ◽  
Peripheral Lymphocyte ◽  
Skin Tests ◽  
Healthy Controls ◽  
Uremic Patients ◽  
T Cell Help

The present study was undertaken to evaluate the immune function of 5 hemodialysis patients with dialysis-related amyloidosis as compared to 6 without, both groups having a dialytic age from 7 to 21 years, and 5 healthy controls. We investigated serum levels of immunoglobulins (IgG, IgA, IgM), made skin tests and measured peripheral lymphocyte subsets using monoclonal antibodies. 1) The absolute numbers of T3, T4 and T8 cells were significantly lower in hemodialysis patients than controls and T3, T4 cells were lower in patients with amyloidosis than in those without: T3 (m ± SD/μl), 387 ± 253 vs 744 ± 207 (p = 0.03); T4, 262 ± 115 vs 589 ± 297 (p = 0.04). 2) Serum levels of IgG and IgM were significantly lower in patients with amyloidosis than in the others: IgG (m ± SD, g/l), 10.2 ± 1.4 vs 15.4 ± 3.2 (p < 0.001); IgM, 0.65 ± 0.28 vs 1.65 ± 0.37 (p < 0.001). 3) Delayed hypersensitivity studied by skin tests showed less than 3 positive antigens in 4/5 patients with amyloidosis against 1/6 patients without. These data suggest there is a marked defect of T-cell help in uremic patients with dialysis-related amyloidosis.

Gastric Acid Secretion, Calcitonin and Secondary Hyperparathyroidism in Uremic Patients Undergoing Regular Dialysis Therapy (RDT)

1978 ◽  
Vol 1 (6) ◽  
pp. 260-265 ◽  
Author(s):  
F. Antonucci ◽  
P. Vezzadini ◽  
M. Cecchettin ◽  
G. Bonora ◽  
A. Adami ◽  
...  
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Protective Factor ◽  
Serum Levels ◽  
Significant Negative Correlation ◽  
Inhibitory Effect ◽  
Negative Influence ◽  
Positive Influence ◽  
Uremic Patients

Fortyseven uremic patients on RDT underwent a gastric secretion study and a contemporary evaluation of serum levels of Calcium (Ca), Phosphate (iP), Magnesium (Mg), Alkaline Phosphatase (AP), immunoreactive gastrin (Gas), parathyroid hormone (PTH), calcitonin (CT). Secretory test (pentagastrin 6 μg/kg) was performed in the morning, after 12 hours of fasting, in the interdialytic interval. Female patients, male patients on RDT from less 1 year and hyposecretor patients were excluded from the study. On the basis of these criteria 25 normal or hyper-secretor males between 20 and 55 years old were selected. A significant positive correlation was found between PTH and CT, while a negative significant correlation was found between CT and BAO and CT and PAO. Similarly, a significant negative correlation was found between PTH and BAO and PTH and PAO. Multiple regression study showed that the negative influence of CT on BAO and PAO is more relevant than the positive influence of PTH. These data suggest that PTH and CT are involved in gastric acid secretion in uremia. Since the inhibitory effect of CT is prevailing on the stimulating effect of PTH, patients with higher levels of PTH and CT have a lower gastric acid secretion. CT might therefore be considered as a protective factor against hypersecretion in uremia.

scholarly journals Imbalance of Th22/Treg cells causes microinflammation in uremic patients undergoing hemodialysis

2019 ◽  
Vol 39 (10) ◽  
Author(s):  
Tingting Ren ◽  
Jingyuan Xiong ◽  
Guangliang Liu ◽  
Shaoyong Wang ◽  
Zhongqi Tan ◽  
...  
Keyword(s):  
Mononuclear Cells ◽  
Serum Levels ◽  
Treg Cells ◽  
Inflammatory Factors ◽  
Enzyme Linked Immunosorbent Assay ◽  
Dialysis Adequacy ◽  
Th22 Cells ◽  
Tnf Α ◽  
Uremic Patients ◽  
Dialysis Time

Abstract Background: Regulatory T (Treg) cells are of critical functionality in immune activation and inflammation in uremic patients undergoing hemodialysis (HD). A disruption in balance of Treg cells has potency to elicit infectious disease progression. Here, we examined possible association between ratio imbalance of Th22/Treg cells and microinflammation in uremic patients undergoing HD. Methods: Peripheral blood mononuclear cells (PBMCs) were isolated to allow measurement of the percentage of Th22 cells and Treg cells using flow cytometry. Subsequently, serum levels of related cytokines, interleukin (IL) 22 (IL-22) and IL-10 and inflammatory factors, C-reactive protein (CRP), (TNF-α), IL-6 were determined via enzyme-linked immunosorbent assay (ELISA). Then relationships among dialysis time, microinflammation status (CRP) and dialysis adequacy (immunoreactive parathyroid hormone (iPTH), urea clearance index (Kt/V), β2-MG, serum calcium, and serum phosphorus) were evaluated. Finally, correlation between microinflammation status and dialysis adequacy was analyzed with Pearson’s correlation coefficient. Results: An increased percentage of Th22 and a decreased percentage of Treg cells were evident in uremic patients undergoing HD. Serum levels of IL-22, CRP, TNF-α, and IL-6 were increased, while IL-10 serum level was reduced. An imbalance of Th22/Treg cells was associated with microinflammation status in uremic patients undergoing HD. Furthermore, prolongation of the dialysis time, the microinflammation status and dialysis adequacy were changed. Increased dialysis adequacy was observed to correlate with alleviated microinflammation of uremic patients undergoing HD. Conclusions: Conjointly, an imbalance of Th22/Treg cells may be a potential cause responsible for uremia occurrence, which in turn indicates that uremia could be effectively alleviated by altering the ratio of Th22/Treg cells.

Behavior of Beta 2-microglobulin (B2-m) serum levels in uremic patients

1994 ◽  
Vol 17 (11) ◽  
pp. 576-580 ◽  
Author(s):  
V.A. Mioli ◽  
E. Balestra ◽  
L. Bibiano ◽  
S. Dellabella ◽  
E. Fanciulli ◽  
...  
Keyword(s):  
Carpal Tunnel Syndrome ◽  
Carpal Tunnel ◽  
Serum Levels ◽  
Hemodialysis Patients ◽  
Study Data ◽  
Synthetic Membranes ◽  
Tunnel Syndrome ◽  
Beta 2 ◽  
Uremic Patients ◽  
Beta 2 Microglobulin

This Study Was Performed In 97 Hemodialysis Patients (85 On Hd And 12 On Capd) To Investigate The Possible Correlation Between B2-M And Hemodialysis-Related Amyloidosis Syndromes (Hra-S); Differences In B2-M And Hra Behavior Between Patients Hemodialysed With Cellulose And Synthetic Membranes Were Also Included In The Present Study. Data Indicate That B2-M Levels Are Not Correlated With Dialysis Length Or With The Type Of Membrane Used For The Dialysis. On The Contrary, In 16 Patients With The Carpal Tunnel Syndrome, A Significant Correlation Was Found Between The Cts, The Dialysis Length And The Type Of Membrane (Greater Incidence With Cellulosic Membranes).

Oxidative stress biomarkers and chromogranin A in uremic patients: Effects of dialytic treatment

2010 ◽  
Vol 43 (18) ◽  
pp. 1387-1392 ◽  
Author(s):  
Giovanna Castoldi ◽  
Laura Antolini ◽  
Camila Bombardi ◽  
Lucia Perego ◽  
Paola Mariani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chromogranin A ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
Uremic Patients ◽  
Dialytic Treatment

A Case of Liver Failure Due to Dabigatran Treated with Venovenous Hemodiafiltration and Idarucizumab

2020 ◽  
Vol 15 (3) ◽  
pp. 227-230
Author(s):  
Nicola Guglielmo ◽  
Daniele Orso ◽  
Rosalba Mestroni ◽  
Giulia Montanari
Keyword(s):  
Liver Toxicity ◽  
Dabigatran Etexilate ◽  
Serum Levels ◽  
Direct Thrombin Inhibitor ◽  
Thrombin Inhibitor ◽  
Clinical Use ◽  
Vein Thrombosis ◽  
Co Morbidity ◽  
Deep Vein ◽  
Dialytic Treatment

Dabigatran etexilate, a direct thrombin inhibitor, was recently introduced in clinical use to prevent thromboembolic events in patients with risk factors (such as non-valvular atrial fibrillation or deep vein thrombosis). Dabigatran is not recommended in patients with creatinine clearance below 30 mL/min. More than 85% of the drug is eliminated by the renal route while the remaining part via the enteral route. Acute renal failure can result in an unexpected increase in serum levels of Dabigatran. In elderly, renal dysfunction, co-morbidity, and concomitant intake of different drugs could make the dosage of Dabigatran challenging. We present a case of an elderly man who suffered a severe accidental dabigatran intoxication with acute liver toxicity recovered after dialytic treatment and Idarucizumab.

Sexual Influence on Bone Metabolism in Uremic Patients on Regular Dialytic Treatment

Nephron ◽  
1994 ◽  
Vol 67 (2) ◽  
pp. 150-157 ◽  
Author(s):  
Giovanni Luisetto ◽  
Massimo Bertoli
Keyword(s):  
Bone Metabolism ◽  
Uremic Patients ◽  
Dialytic Treatment

Three-year follow-up after withdrawal of iron therapy in uremic patients on regular dialytic treatment

1986 ◽  
Vol 16 (4) ◽  
pp. 517-522
Author(s):  
Alessandra Thea ◽  
Caterina Canavese ◽  
Giovanni Mangiarotti ◽  
Alfonso Pacitti ◽  
Mario Salomone ◽  
...  
Keyword(s):  
Iron Therapy ◽  
Uremic Patients ◽  
Dialytic Treatment

Thoracic complications in uremic patients and in patients undergoing dialytic treatment: state of the art

1997 ◽  
Vol 7 (5) ◽  
pp. 708-717 ◽  
Author(s):  
G. Gavelli ◽  
M. Zompatori
Keyword(s):  
State Of The Art ◽  
Uremic Patients ◽  
Dialytic Treatment
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