scholarly journals Unusual Fundus Autofluorescence Appearance in a Patient with Hydroxychloroquine Retinal Toxicity

2015 ◽  
Vol 6 (2) ◽  
pp. 186-190 ◽  
Author(s):  
Sleiman Abou-Ltaif
Keyword(s):  
Cumulative Dose ◽  
Colour Vision ◽  
Fundus Autofluorescence ◽  
Retinal Toxicity ◽  
Night Vision ◽  
Central Vision ◽  
Colour Perception ◽  
History Of ◽  
Caucasian Female

Purpose: To report an unusual fundus autofluorescence aspect in a patient with suspected hydroxychloroquine retinal toxicity. Method: Case report of an unusual presentation of a patient treated for 9 consecutive years with a therapeutically recommended dose of hydroxychloroquine. Result: We report the case of a 53-year-old Caucasian female treated with 400 mg hydroxychloroquine for rheumatoid arthritis over 9 years, currently on methotrexate and folinic acid, who stopped treatment 3 years ago. The cumulative dose is estimated at 1.314 kg. She recently noticed a reduction of vision in both eyes to 0.34 logMAR, with colour vision problems and major distortion in central vision. Fundus autofluorescence revealed minimal foveal pigmentary changes and more pronounced changes in the retina elsewhere. Foveal changes were confirmed by optical coherence tomography in both eyes. The patient did not report any colour perception difficulties or night vision problems and has no family history of any eye condition. Her visual field tested by an optician was full, with some central changes. Conclusion: Retinal toxicity from hydroxychloroquine can present in a different aspect than the commonly known retinal toxicity, and it happens even after years of cessation of the drug. The role of cumulative dose in toxicity is supported in this paper.

Didanosine-Associated Retinal Toxicity in a Patient With a Mutation in the CRB1 Gene

2021 ◽  
pp. 247412642110445
Author(s):  
Tamara L. Lenis ◽  
Benjamin W. Botsford ◽  
David Sarraf ◽  
Thanos D. Papakostas
Keyword(s):  
Cell Polarity ◽  
Genetic Risk ◽  
Potential Role ◽  
Retinal Toxicity ◽  
Pathogenic Variant ◽  
Aged Patient ◽  
Drug Induced ◽  
History Of ◽  
Haart Therapy

Purpose: This article describes a case of didanosine (DDI)-associated retinal toxicity in a patient with a heterozygous pathogenic variant in the CRB1 gene. Methods: Case report. Results: A middle-aged patient with HIV controlled on HAART therapy, and a remote 10-year year history of treatment with DDI and tenofivir, presented with external ophthalmoplegia and well-circumscribed, midperipheral patterns of bilateral pigmentary retinopathy and chorioretinal atrophy in both eyes. Genetic testing revealed a heterozygous pathogenic variant in the CRB1 gene that encodes a protein (Crumbs homolog 1) involved in regulation of cell polarity and junctions and is localized adjacent to mitochondria in the ellipsoid and myoid area. Conclusions: This case highlights a potential role for genetic susceptibility to retinal toxicity in DDI-associated retinal toxicity. Large, prospective pharmacogenomics studies may be informative to further elucidate the role of genetic risk factors in drug-induced retinal toxicity.

scholarly journals Migraine with aura is associated with impaired colour vision: Results from the cross-sectional German DMKG headache study

Cephalalgia ◽  
2014 ◽  
Vol 35 (6) ◽  
pp. 508-515
Author(s):  
TP Jürgens ◽  
K Berger ◽  
A Straube ◽  
L Khil
Keyword(s):  
Colour Vision ◽  
Cortical Excitability ◽  
Smoking Status ◽  
Head Injuries ◽  
Population Based ◽  
Sensory Testing ◽  
Cross Sectional ◽  
Colour Perception ◽  
Population Based Study ◽  
History Of

Background Hypersensitivity to light, noise and odour are pivotal clinical characteristics of migraine associated with enhanced cortical excitability and dysfunctional habituation. However, little is known about the integrity of basic sensory functioning in migraine on a population-based level. Methods A total of 129 participants with migraine (105 without aura, MwoA, 24 with aura, MA) and 522 healthy controls without headache 12 months prior to baseline were included from a sample of the DMKG study and underwent standardised clinical sensory testing of smell, taste, hearing and vision. Results After adjustment for age, sex, smoking status and history of head injuries, the chance of impaired colour perception was significantly higher in MA compared to controls (odds ratio, OR = 3.20; 95% CI = 1.20–8.53) and MwoA (OR = 3.62; 95% CI = 1.31–9.97). Compared to MwoA, MA also had an increased chance of smell (OR = 3.20; 95% CI = 0.98–10.42) and taste (OR = 2.58; 95% CI = 0.90–7.40) impairment. Conclusions In this cross-sectional, population-based study on sensory functioning in migraine participants, colour vision was impaired interictally in MA compared to MwoA and controls.

scholarly journals Use of En Face Optical Coherence Tomography in a Case of Hydroxychloroquine Retinal Toxicity

2017 ◽  
Vol 2 (1) ◽  
pp. 51-57
Author(s):  
Maria D. Garcia ◽  
Camila V. Ventura ◽  
Steven J. Ryder ◽  
João R. de Oliveira Dias ◽  
Audina M. Berrocal
Keyword(s):  
Optical Coherence Tomography ◽  
Fundus Autofluorescence ◽  
Multifocal Electroretinogram ◽  
Visual Fields ◽  
Retinal Toxicity ◽  
Optical Coherence ◽  
En Face ◽  
History Of ◽  
Funduscopic Examination ◽  
Sd Oct

Purpose: To describe the case of 49-year-old woman with a history of rheumatoid arthritis on hydroxychloroquine (HCQ) therapy, who presented with findings of HCQ retinopathy on optical coherence tomography (OCT). Methods: Evaluation included clinical examination with multimodal imaging findings on spectral domain (SD)-OCT, en face OCT, and multifocal electroretinogram (mfERG). Results: The patient had nonspecific visual symptoms and an unremarkable funduscopic examination. Humphrey visual fields, fundus autofluorescence, mfERG, SD-OCT, and en face structural OCT, however, suggested HCQ retinal toxicity. Conclusions: This case demonstrates that the findings of HCQ retinopathy on en face structural OCT are analogous to those identified by current imaging modalities used for the screening and diagnosis of HCQ toxicity. En face structural OCT may be useful in the detection of HCQ-induced retinal toxicity.

scholarly journals A Rare Case of Adult-onset Best Disease

2020 ◽  
Author(s):  
Siddharam S Janti ◽  
Shinisha Damodaran Paul ◽  
Stephen Sudhakar Karunakaran
Keyword(s):  
Rare Case ◽  
Previous History ◽  
Macular Dystrophy ◽  
Adult Onset ◽  
Normal Vision ◽  
Central Vision ◽  
Colour Perception ◽  
Vitelliform Macular Dystrophy ◽  
History Of ◽  
Best Disease

Best Disease also known as Vitelliform Macular Dystrophy (VMD), classically presents with defective central vision. Macula which is responsible for the central vision and colour perception is affected. Individuals affected by Best disease, initially have normal vision followed by decrease in central visual acuity as well as metamorphopsia. The case presented a 49-years-old female with complaints of progressive and painless defective Vision of her Left Eye (LE) with previous history of diabetes. A well-circumscribed single greyish lesion of size 0.5DD was noted in the macula, which was conformed to be Best disease.

Elaborating the role of reflection and individual differences in the study of folk-economic beliefs

2018 ◽  
Vol 41 ◽  
Author(s):  
Kevin Arceneaux
Keyword(s):  
Decision Making ◽  
Individual Differences ◽  
Cognitive Processes ◽  
Evolutionary History ◽  
Behavioral Responses ◽  
History Of ◽  
Economic Beliefs

AbstractIntuitions guide decision-making, and looking to the evolutionary history of humans illuminates why some behavioral responses are more intuitive than others. Yet a place remains for cognitive processes to second-guess intuitive responses – that is, to be reflective – and individual differences abound in automatic, intuitive processing as well.

The role of a family history of adenocarcinomas in patients with Barrett oesophagus

2001 ◽  
Vol 120 (5) ◽  
pp. A442-A442
Author(s):  
P TSIBOURIS ◽  
M HENDRICKSE ◽  
P ISAACS
Keyword(s):  
Family History ◽  
History Of ◽  
Barrett Oesophagus

Protective Factors and Suicidality in Members of Arab Kindred

Crisis ◽  
2012 ◽  
Vol 33 (2) ◽  
pp. 80-86 ◽  
Author(s):  
Sami Hamdan ◽  
Nadine Melhem ◽  
Israel Orbach ◽  
Ilana Farbstein ◽  
Mohammad El-Haib ◽  
...  
Keyword(s):  
Risk Factors ◽  
Protective Factors ◽  
Suicidal Behavior ◽  
Composite International Diagnostic Interview ◽  
Diagnostic Interview ◽  
Suicidal Risk ◽  
Arab Population ◽  
Psychiatric Interview ◽  
History Of

Background: Relatively little is known about the role of protective factors in an Arab population in the presence of suicidal risk factors. Aims: To examine the role of protective factors in a subsample of in large Arab Kindred participants in the presence of suicidal risk factors. Methods: We assessed protective and risk factors in a sample of 64 participants (16 suicidal and 48 nonsuicidal) between 15 and 55 years of age, using a comprehensive structured psychiatric interview, the Composite International Diagnostic Interview (CIDI), self-reported depression, anxiety, hopelessness, impulsivity, hostility, and suicidal behavior in first-degree and second-relatives. We also used the Religiosity Questionnaire and suicide attitude (SUIATT) and multidimensional perceived support scale. Results: Suicidal as opposed to nonsuicidal participants were more likely to have a lifetime history of major depressive disorder (MDD) (68.8% vs. 22.9% χ2 = 11.17, p = .001), an anxiety disorder (87.5% vs. 22.9, χ2 = 21.02, p < .001), or posttraumatic stress disorder (PTSD) (25% vs. 0.0%, Fisher’s, p = .003). Individuals who are otherwise at high risk for suicidality have a much lower risk when they experience higher perceived social support (3.31 ± 1.36 vs. 4.96 ± 1.40, t = 4.10, df = 62, p < .001), and they have the view that suicide is somehow unacceptable (1.83 ± .10 vs. 1.89 ± .07, t = 2.76, df = 60, p = .008). Conclusions: Taken together with other studies, these data suggest that the augmentation of protective factors could play a very important role in the prevention of incidental and recurrent suicidal behavior in Arab populations, where suicidal behavior in increasing rapidly.

THE ROLE OF RECTAL EUS-FNA/B IN PRE-SACRAL UNDEFINED LESIONS IN PATIENTS WITH HISTORY OF LOWER GI NEOPLASIA

2020 ◽  
Author(s):  
B Mangiavillano ◽  
S Carrara ◽  
E Dabizzi ◽  
F Auriemma ◽  
V Cennamo ◽  
...  
Keyword(s):  
History Of

The problem of periodization of the history of religion

1997 ◽  
pp. 3-8
Author(s):  
Borys Lobovyk
Keyword(s):  
Religious Studies ◽  
Human Being ◽  
Religious Development ◽  
History Of Religion ◽  
The Social ◽  
The World ◽  
History Of ◽  
Role Of Religion

An important problem of religious studies, the history of religion as a branch of knowledge is the periodization process of the development of religious phenomenon. It is precisely here, as in focus, that the question of the essence and meaning of the religious development of the human being of the world, the origin of beliefs and cult, the reasons for the changes in them, the place and role of religion in the social and spiritual process, etc., are converging.

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