scholarly journals Renalase and Biomarkers of Contrast-Induced Acute Kidney Injury

2015 ◽  
Vol 6 (1) ◽  
pp. 25-36 ◽  
Author(s):  
Maciej T. Wybraniec ◽  
Katarzyna Mizia-Stec
Keyword(s):  
Acute Kidney Injury ◽  
Renal Injury ◽  
Amine Oxidase ◽  
Kidney Injury ◽  
Cardiorenal Syndrome ◽  
Creatinine Concentration ◽  
Invasive Cardiology ◽  
Proximal Tubular ◽  
Novel Biomarkers

Background: Contrast-induced acute kidney injury (CI-AKI) remains one of the crucial issues related to the development of invasive cardiology. The massive use of contrast media exposes patients to a great risk of contrast-induced nephropathy and chronic kidney disease development, and increases morbidity and mortality rates. The serum creatinine concentration does not allow for a timely and accurate CI-AKI diagnosis; hence numerous other biomarkers of renal injury have been proposed. Renalase, a novel catecholamine-metabolizing amine oxidase, is synthesized mainly in proximal tubular cells and secreted into urine and blood. It is primarily engaged in the degradation of circulating catecholamines. Notwithstanding its key role in blood pressure regulation, renalase remains a potential CI-AKI biomarker, which was shown to be markedly downregulated in the aftermath of renal injury. In this sense, renalase appears to be the first CI-AKI marker revealing an actual loss of renal function and indicating disease severity. Summary: The purpose of this review is to summarize the contemporary knowledge about the application of novel biomarkers of CI-AKI and to highlight the potential role of renalase as a functional marker of contrast-induced renal injury. Key Messages: Renalase may constitute a missing biochemical link in the mutual interplay between kidney and cardiac pathology known as the cardiorenal syndrome.

scholarly journals Perioperative Acute Kidney Injury

2020 ◽  
Vol 132 (1) ◽  
pp. 180-204 ◽  
Author(s):  
Sam D. Gumbert ◽  
Felix Kork ◽  
Maisie L. Jackson ◽  
Naveen Vanga ◽  
Semhar J. Ghebremichael ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Fluid Replacement ◽  
Organ Injury ◽  
Surgical Patients ◽  
Creatinine Concentration ◽  
Ongoing Research ◽  
Different Types ◽  
Novel Biomarkers ◽  
Goal Directed Fluid Therapy

Abstract Perioperative organ injury is among the leading causes of morbidity and mortality of surgical patients. Among different types of perioperative organ injury, acute kidney injury occurs particularly frequently and has an exceptionally detrimental effect on surgical outcomes. Currently, acute kidney injury is most commonly diagnosed by assessing increases in serum creatinine concentration or decreased urine output. Recently, novel biomarkers have become a focus of translational research for improving timely detection and prognosis for acute kidney injury. However, specificity and timing of biomarker release continue to present challenges to their integration into existing diagnostic regimens. Despite many clinical trials using various pharmacologic or nonpharmacologic interventions, reliable means to prevent or reverse acute kidney injury are still lacking. Nevertheless, several recent randomized multicenter trials provide new insights into renal replacement strategies, composition of intravenous fluid replacement, goal-directed fluid therapy, or remote ischemic preconditioning in their impact on perioperative acute kidney injury. This review provides an update on the latest progress toward the understanding of disease mechanism, diagnosis, and managing perioperative acute kidney injury, as well as highlights areas of ongoing research efforts for preventing and treating acute kidney injury in surgical patients.

scholarly journals Potential role of imaging for assessing acute pancreatitis-induced acute kidney injury

2020 ◽  
pp. 20200802
Author(s):  
Yi Wang ◽  
Kaixiang Liu ◽  
Xisheng Xie ◽  
Bin Song
Keyword(s):  
Acute Kidney Injury ◽  
Acute Pancreatitis ◽  
Early Stage ◽  
Kidney Injury ◽  
Current Evidence ◽  
Advanced Imaging ◽  
Creatinine Concentration ◽  
New Techniques ◽  
Magnetic Resonance Imaging Mri

Acute kidney injury (AKI) is a common complication of acute pancreatitis (AP) that is associated with increased mortality. Conventional assessment of AKI is based on changes in serum creatinine concentration and urinary output. However, these examinations have limited accuracy and sensitivity for the diagnosis of early-stage AKI. This review summarizes current evidence on the use of advanced imaging approaches and artificial intelligence (AI) for the early prediction and diagnosis of AKI in patients with AP. CT scores, CT post-processing technology, Doppler ultrasound, and AI technology provide increasingly valuable information for the diagnosis of AP-induced AKI. Magnetic resonance imaging (MRI) also has potential for the evaluation of AP-induced AKI. For the accurate diagnosis of early-stage AP-induced AKI, more studies are needed that use these new techniques and that use AI in combination with advanced imaging technologies.

P6358Novel biomarkers for prediction of acute cardiorenal syndrome

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
M Dankova ◽  
Z Minarikova ◽  
J Danko ◽  
J Gergel ◽  
P Pontuch ◽  
...  
Keyword(s):  
Renal Injury ◽  
Diagnostic Yield ◽  
Kidney Injury ◽  
Cardiorenal Syndrome ◽  
Urine Concentration ◽  
Reduced Ejection Fraction ◽  
Frequent Event ◽  
Novel Biomarkers ◽  
New Biomarkers ◽  
Time Of Admission

Abstract Objectives Acute kidney injury (AKI) is frequent event in patients with acute heart failure (AHF) and is associated with poor short and longterm outcome. Aim of the study was to decribe diagnostic yield of selected novel biomarkers in prediction of AKI in patients addmitted for AHF. Methods We performed a prospective cohort study of 72 consecutive patients (46/26 M/F) aged 69±10,3 years admitted for AHF. Renal damage was defined according to KDIGO guidelines. Patients were divided into two groups: AKI- (without renal injury, n=52) and AKI+ (with renal injury, n=20). Urine samples for AKI biomarkers measurements (NGAL, TIMP2, IGFBP7) were collected at admission. The ROC and linear logistic regression of new biomarkers and selected clinical variables was performed for evaluation of the AKI prediction. Results Patients with AKI + were older (median age: 75 vs. 64 years, p=0,01), had lower BMI (median: 28 vs. 29,5 kg/m2, p=0,04), were with higher proportion of patients with HF with reduced ejection fraction (55% vs 23,1%, p=0,01) and higher level of serum NTproBNP. Urinary NGAL at admission was significantly higher in the AKI+ compared to AKI – group (152 vs. 19,5 ng/ml, p <.0001); also median of u-TIMP-2 and u-IGFBP-7 in the AKI+ patients were significantly higher: 194,1 versus 42,5 ng/ml (p<0.0001) and 379 versus 92,4 pg/ml (p<0.0001) resp. Age, u-NGAL, u-TIMP2, u-IGFBP7, s-hemoglobin, NTproBNP and LVEF were associated with the development of AKI. Urine concentration IGFBP-7 performs the best for the prediction AKI (AUC 0,94). Conclusion Urine concentrations of NGAL, TIMP2, IGFBP7 at the time of admission for AHF predict developement of AKI. Age, NTproBNP, LVEF and s-hemoglobin are also associated with AKI in AHF patients. Acknowledgement/Funding Project was supported by Slovak Society of Cardiology research grant 2015-2018.

scholarly journals FP266PBI-4050 REDUCES SYSTEMIC INFLAMMATION, ELECTROLYTE DISTURBANCES, AND RENAL INJURY IN MICE WITH SEPSIS-INDUCED ACUTE KIDNEY INJURY; ROLE OF GPR84

2019 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
Lyne Gagnon ◽  
Jean-Francois Thibodeau ◽  
Chet Holterman ◽  
Marie-Pier Cloutier ◽  
Jean-Christophe Simard ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Systemic Inflammation ◽  
Renal Injury ◽  
Kidney Injury ◽  
Electrolyte Disturbances

[PP.17.32] THE ROLE OF BIOMARKERS IN EARLY DIAGNOSTIC OF ACUTE KIDNEY INJURY IN PATIENTS WITH ACUTE CARDIORENAL SYNDROME

2017 ◽  
Vol 35 ◽  
pp. e231
Author(s):  
M. Kurmanov ◽  
M. Efremovtseva ◽  
S. Avdoshina ◽  
S. Villevalde ◽  
Z. Kobalava
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Cardiorenal Syndrome ◽  
Early Diagnostic

scholarly journals Acute Kidney Injury in COVID-19

2021 ◽  
Vol 22 (15) ◽  
pp. 8081
Author(s):  
Marta Głowacka ◽  
Sara Lipka ◽  
Ewelina Młynarska ◽  
Beata Franczyk ◽  
Jacek Rysz
Keyword(s):  
Acute Kidney Injury ◽  
Strong Association ◽  
Kidney Injury ◽  
Respiratory Illness ◽  
Angiotensin Converting Enzyme 2 ◽  
Tubular Cells ◽  
Collapsing Glomerulopathy ◽  
Proximal Tubular ◽  
Insight Into

COVID-19 is mainly considered a respiratory illness, but since SARS-CoV-2 uses the angiotensin converting enzyme 2 receptor (ACE2) to enter human cells, the kidney is also a target of the viral infection. Acute kidney injury (AKI) is the most alarming condition in COVID-19 patients. Recent studies have confirmed the direct entry of SARS-CoV-2 into the renal cells, namely podocytes and proximal tubular cells, but this is not the only pathomechanism of kidney damage. Hypovolemia, cytokine storm and collapsing glomerulopathy also play an important role. An increasing number of papers suggest a strong association between AKI development and higher mortality in COVID-19 patients, hence our interest in the matter. Although knowledge about the role of kidneys in SARS-CoV-2 infection is changing dynamically and is yet to be fully investigated, we present an insight into the possible pathomechanisms of AKI in COVID-19, its clinical features, risk factors, impact on hospitalization and possible ways for its management via renal replacement therapy.

scholarly journals Role of intratubular pressure during the ischemic phase in acute kidney injury

2017 ◽  
Vol 312 (6) ◽  
pp. F1158-F1165 ◽  
Author(s):  
Jin Wei ◽  
Jiangping Song ◽  
Shan Jiang ◽  
Gensheng Zhang ◽  
Donald Wheeler ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Renal Artery ◽  
Kidney Injury ◽  
Renal Ischemia ◽  
Plasma Creatinine ◽  
Renal Veins ◽  
Artery Pressure ◽  
Intratubular Pressure ◽  
Proximal Tubular

Acute kidney injury (AKI) induced by clamping of renal vein or pedicle is more severe than clamping of artery, but the mechanism has not been clarified. In the present study, we tested our hypothesis that increased proximal tubular pressure (Pt) during the ischemic phase exacerbates kidney injury and promotes the development of AKI. We induced AKI by bilateral clamping of renal arteries, pedicles, or veins for 18 min at 37°C, respectively. Pt during the ischemic phase was measured with micropuncture. We found that higher Pt was associated with more severe AKI. To determine the role of Pt during the ischemic phase on the development of AKI, we adjusted the Pt by altering renal artery pressure. We induced AKI by bilateral clamping of renal veins, and the Pt was changed by adjusting the renal artery pressure during the ischemic phase by constriction of aorta and mesenteric artery. When we decreased renal artery pressure from 85 ± 5 to 65 ± 8 mmHg, Pt decreased from 53.3 ± 2.7 to 44.7 ± 2.0 mmHg. Plasma creatinine decreased from 2.48 ± 0.23 to 1.91 ± 0.21 mg/dl at 24 h after renal ischemia. When we raised renal artery pressure to 103 ± 7 mmHg, Pt increased to 67.2 ± 5.1 mmHg. Plasma creatinine elevated to 3.17 ± 0.14 mg·dl·24 h after renal ischemia. Changes in KIM-1, NGAL, and histology were in the similar pattern as plasma creatinine. In summary, we found that higher Pt during the ischemic phase promoted the development of AKI, while lower Pt protected from kidney injury. Pt may be a potential target for treatment of AKI.

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