Pregnancy and Neonatal Outcomes in Gestational Diabetes Treated with Regular Insulin or Fast-Acting Insulin Analogues

2015 ◽  
Vol 81 (3) ◽  
pp. 232-237 ◽  
Author(s):  
Ji Yeon You ◽  
Suk-Joo Choi ◽  
Cheong-Rae Roh ◽  
Jong-Hwa Kim ◽  
Soo-young Oh
Keyword(s):  
Gestational Diabetes ◽  
Regular Insulin ◽  
Insulin Analogues ◽  
Neonatal Outcomes ◽  
Acting Insulin ◽  
Fast Acting

scholarly journals Physico-chemical properties of co-formulation of insulin with pramlintide

2017 ◽  
Author(s):  
Dayana Cabral da Silva ◽  
Luís Maurício T. R. Lima
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Insulin Analogues ◽  
Amyloid Aggregation ◽  
Solution Ph ◽  
Lispro Insulin ◽  
Acting Insulin ◽  
Fast Acting

ABSTRACTSince the discovery of amylin its use has been discouraged by the inadequacy of the protocol involving multiple injections in addition to insulin. While a combined fixed-dose formulation is thus highly desirable, it has long been limited due to incompatibility as historically documented. We have investigated the compatibility of regular and fast-acting insulin analogues (Aspart, AspB28, and LisPro, LysB28ProB29) with the amylin analogue pramlintide. Insulin interacts with pramlintide, forming heterodimers as probed by electrospray ionization - ion mobility spectrometry-mass spectrometry. While their interaction is likely to delay the amyloid aggregation of pramlintide in phosphate-buffered solution pH 7.0, they do not prevent aggregation at this condition. At acidic sodium acetate solution pH 5.0, combination of pramlintide and the fast-acting insulin analogues become stable against amyloid aggregation. The co-formulated product at high concentration of both pramlintide (600 μg/mL,150 μM) and LisPro insulin (50 IU/mL, 300 μM) showed also stability against amyloid aggregation. These data indicate a potential for the development of a co-formulation of fast-acting LisPro insulin with pramlintide, which could bring benefits for the combined therapy.AbbreviationsIAPP,islet amyloid polypeptide;ESI-IMS-MS,Electrospray Ionization–Ion Mobility Spectrometry–Mass Spectrometry.

scholarly journals Three-Year Health Care Expenditures in Diabetic Patients Receiving Rapid-Acting Insulin Analogues Versus Those on Human Regular Insulin

2013 ◽  
Vol 16 (7) ◽  
pp. A451
Author(s):  
S. Cammarota ◽  
D. Bruzzese ◽  
A.L. Catapano ◽  
A. Citarella ◽  
L. De Luca ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Expenditures ◽  
Regular Insulin ◽  
Insulin Analogues ◽  
Diabetic Patients ◽  
Acting Insulin
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