scholarly journals Morphological and Metabolic Alteration of Cerebellum in Patients with Post-Stroke Depression

2016 ◽  
Vol 40 (3-4) ◽  
pp. 420-430 ◽  
Author(s):  
Ling Zhang ◽  
Rubo Sui ◽  
Lei Zhang ◽  
Zhuang Zhang
Keyword(s):  
Magnetic Resonance ◽  
Depression Scale ◽  
Resonance Spectroscopy ◽  
Hamilton Depression Scale ◽  
Stroke Patients ◽  
1H Mrs ◽  
Post Stroke ◽  
Cont Group ◽  
Post Stroke Depression ◽  
Norm Group

Background: To study morphological and metabolic changes of cerebellum with multimodality magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H-MRS), respective, to explore correlation between cerebellum alteration and severity of depression in patients with post-stroke depression. Methods: 60 subjects, including 40 stroke patients and 20 healthy volunteers were enrolled. Depression of stroke patients was tested by Self-rating Depression Scale (SDS) and Hamilton Depression Scale (HAMD), based on which stroke-patients were grouped into post-stroke depression (PSD group) and without post-stroke depression (CONT group). Results: Volume of cerebellum decreased in PSD group and CONT group compared with healthy volunteer (NORM) group. White matter of cerebellum in PSD group and CONT group was disrupted; such disruption was significantly in PSD group. In addition, there was correlation between cerebellum volume and FA and HDRS scores (P<00.01). The Cho/Cr and Cho/NAA ratios in cerebellum contralateral to stroke lesion in PSD were higher than those in NORM group (P<0.05). Cho/Cr and Cho/NAA ratios in contralateral cerebellum and ratio difference of Cho/Cr in bilateral cerebellum were positively correlated with HAMD scales (P<0.05). Conclusion: Morphologic and metabolic alterations are evident in patients with post-stroke depression, indicating possible involvement of cerebellum in post-stroke-depression occurrence.

scholarly journals Proton Magnetic Resonance Spectroscopy Study on the Metabolism Changes of Cerebellum in Patients with Post-Stroke Depression

2017 ◽  
Vol 41 (4) ◽  
pp. 1393-1402 ◽  
Author(s):  
Lei Zhang ◽  
Ru-Bo Sui
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
1H Mrs ◽  
Statistical Significant Difference ◽  
Post Stroke ◽  
Significant Difference ◽  
Post Stroke Depression

Objective: To study the metabolic changes of cerebellum by proton magnetic resonance Spectroscopy (1H-MRS) and discuss the relationships between the cerebellar changes and depression severity in patients with post-stroke depression. Methods and Results: Data of demographic characteristics, individual history and life style of all subjects were collected. 40 patients with stroke and 20 controls were enrolled. All groups received T1WI, T2WI, DWI and 1H-MRS examination. The cerebral infarction volume and the distribution and severity of leukoaraiosis were evaluated. The ratios of NAA/Cr, Cho/Cr and Cho/NAA in the cerebellum were calculated. There were no statistical significant difference in the NAA/Cr, Cho/Cr and Cho/NAA ratios in bilateral cerebellum between CONT group and NORM group. The Cho/Cr and Cho/NAA ratios in the cerebellum contralateral to the stroke region were higher in PSD group than those in NORM and CONT groups, and the Cho/Cr and Cho/NAA ratios in the cerebellum ipsilateral to the stroke region were similar with those in NORM and CONT groups. However, there were no statistical significant difference in the NAA/Cr ratios in bilateral cerebellum among three groups. Conclusion: The result shows preliminarily that the cerebellum involves in the development of post-stroke depression.

scholarly journals Depressed Mood after Stroke: Predictive Factors at Six Months Follow-Up

2020 ◽  
Vol 17 (24) ◽  
pp. 9542
Author(s):  
Fidel López-Espuela ◽  
Raúl Roncero-Martín ◽  
Maria de la Luz Canal-Macías ◽  
Jose M. Moran ◽  
Vicente Vera ◽  
...  
Keyword(s):  
Rating Scale ◽  
Depression Scale ◽  
Length Of Hospital Stay ◽  
Hamilton Depression Scale ◽  
Modified Rankin Scale ◽  
Cross Sectional ◽  
Post Stroke ◽  
Depression Assessment ◽  
Degree Of Disability ◽  
Post Stroke Depression

We aimed to know the prevalence of post-stroke depression (PSD) in our context, identify the variables that could predict post-stroke depression, by using the Hamilton Depression Rating Scale, occurring within six months after stroke, and identify patients at high risk for PSD. Methods: descriptive, cross-sectional and observational study. We included 173 patients with stroke (transient ischemic attack (TIA) included) and collected sociodemographic and clinical variables. We used the Hamilton Depression Scale (HDS) for depression assessment and Barthel Index and modified Rankin Scale (mRS) for functional assessment. The neurological severity was evaluated by the National Institutes of Health Stroke Scale (NIHSS). Results: 35.5% were women, aged 71.16 (±12.3). Depression was present in 42.2% patients (n = 73) at six months after stroke. The following variables were significantly associated with PSD: diagnosis of previous depression (p = 0.005), the modified Rankin Scale at discharge (p = 0.032) and length of hospital stay (p = 0.012). Conclusion: PSD is highly prevalent after stroke and is associated with the severity, left location of the stroke, and the degree of disability at discharge. Its impact justifies the evaluation and early treatment that still continues to be a challenge today.

scholarly journals Assessment of Quality of Life and Incidence of Depression in Post Stroke Patients

2020 ◽  
Vol 11 (4) ◽  
pp. 7146-7150
Author(s):  
Aditya Dharman ◽  
Chandrina Loungchot ◽  
Ven Davis ◽  
Mahshid Delavari ◽  
Binai K Sankar ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Depression Scale ◽  
Severe Depression ◽  
The Elderly ◽  
Hamilton Depression Scale ◽  
Early Assessment ◽  
Stroke Patients ◽  
Post Stroke

Depression is a common illness worldwide. Social, psychological and biological factors can lead to depression. Chronic illness among the elderly is a significant reason affecting mental health. Often it is not diagnosed correctly. An observational study was conducted to assess the quality of life and the incidence of depression in post-stroke patients. Subjects were recruited to the study by investigations during ward/OP visits. The subjects were briefed about the study, and informed consent was obtained. Data were collected using various study tools and analyzed statistically by computing proportion for all qualitative data and mean, standard deviation, median, the interquartile range for quantitative data. A total of 50 subjects were enrolled in the study based on inclusion and exclusion criteria. Severe cognitive impairment was revealed in 14% of the patients. The burden of depression and severity was evaluated using Patient health questionnaire-9 and Hamilton depression scale, respectively. It was found that 22 subjects (44%) had moderate depression, while 2 (4%) had severe depression. The functionality of the subjects was measured and found that 18% of subjects were 'dependent' on their caregiver. SSQOL assessment showed the lowest score in the domains 'work & productivity' and 'energy". As much as treating the etiological factors of stroke, dealing with the mental aspect of stroke is necessary. Assessing and treating post-stroke depression is essential to reduce the morbidity and mortality of patients. Hence, early assessment and management of mental health after stroke is necessary to prevent a chance of developing another stroke.

Single voxel proton magnetic resonance spectroscopy in post-stroke depression

2006 ◽  
Vol 148 (2-3) ◽  
pp. 111-120 ◽  
Author(s):  
Lidia Glodzik-Sobanska ◽  
Agnieszka Slowik ◽  
Pauline McHugh ◽  
Barbara Sobiecka ◽  
Justyna Kozub ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Post Stroke ◽  
Single Voxel ◽  
Post Stroke Depression

The Sensitivity and Specificity of the Center for Epidemiologic Studies Depression Scale in Screening for Post-Stroke Depression

1989 ◽  
Vol 18 (2) ◽  
pp. 169-181 ◽  
Author(s):  
Rajesh M. Parikh ◽  
Dianne T. Eden ◽  
Thomas R. Price ◽  
Robert G. Robinson
Keyword(s):  
Sensitivity And Specificity ◽  
Depression Scale ◽  
Screening Instrument ◽  
Epidemiologic Studies ◽  
Stroke Patients ◽  
Post Stroke ◽  
Standardized Interview ◽  
Post Stroke Depression ◽  
One Year

The present study examines the sensitivity and specificity of the Center for Epidemiologic Studies Depression Scale (CES-D) as a screening instrument for post-stroke depression. Eighty stroke patients were evaluated by a research nurse over a two-year period using the CES-D and also by a trained psychiatrist using a standardized interview for affective, cognitive, physical and social functioning. CES-D scores correlated significantly with DSM-III diagnoses of depression in-hospital and at three months, six months, and one year follow-up but not at two years follow-up, reflecting the natural course of these depressions, as well as the predictive validity of the CES-D. Furthermore, at a cut-off point of 16, the CES-D was found to have a specificity of 90 percent, a sensitivity of 86 percent and a positive predictive value of 80 percent and thus may be a potentially useful screening instrument for post-stroke depression.

scholarly journals Virtual Reality Alleviates Post-Stroke Depression by Regulating FGF21

2021 ◽  
Author(s):  
Yihui Zhang ◽  
Zekun Xing ◽  
Zhanxiang Xie ◽  
Yuzheng Zhou ◽  
Shengjie Wan ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Virtual Reality ◽  
Depression Scale ◽  
Trial Registration ◽  
Fibroblast Growth Factor 21 ◽  
Control Group ◽  
Hamilton Depression Scale ◽  
Post Stroke ◽  
Post Stroke Depression ◽  
Experimental Group

Abstract Background: Post-stroke depression(PSD) lacks timely and effective treatment and virtual reality (VR) technology can create a lifelike experience and simulate users' physical presence in an immersive environment. It has been confirmed to have a positive effect on stroke and depression. Data about the efficacy VR on PSD are limited. The intensification of fibroblast growth factor 21(FGF21) can improve depression and other emotional symptoms, but there is no study on its role in PSD.Methods: We enlisted 76 PSD patients (6 lost) and divided into the experimental group and control group randomly. The patient underwent psychological rehabilitation once a week for 50 minutes each time for a total of 12 weeks. The patients in the experimental group received psychological counseling and VR rehabilitation while patients in the control group also took the same pattern but without VR rehabilitation. The Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) were evaluated before rehabilitation, in the 4th week and at the end of rehabilitation respectively in two groups for the sake of observing changes in the patients' depression. Then 8 people in each group did functional near-infrared spectroscopy (fNIRS), and blood samples were taken for detection with brain-derived neurotrophic factor (BDNF), IL-6, TNF-α and FGF21 by ELISA.Results: The result of fNIRS showed the hemodynamic activation in the prefrontal region of the experimental group was significantly increased. Both groups of FGF21 increased and compared with the control group, the experimental group has a greater upsurge and a faster increase rate.Conclusions: VR alleviates PSD. FGF21 is closely related to PSD，and it is likely to be a potential pathological mechanism of PSD. It suggests that VR is possible to improve PSD by increasing FGF21.Trial registration: We registered in Chinese Clinical Trial Registry which is the first level registration organization of WHO international clinical trial registration platform. The registration number is ChiCTR1900027987, the date of registration December 7, 2019.

scholarly journals Early-Onset Depression in Stroke Patients: Effects on Unfavorable Outcome 5 Years Post-stroke

2021 ◽  
Vol 12 ◽  
Author(s):  
Ya-Ying Zeng ◽  
Meng-Xuan Wu ◽  
Dan-Dan Geng ◽  
Lin Cheng ◽  
Sheng-Nan Zhou ◽  
...  
Keyword(s):  
Early Onset ◽  
Depression Scale ◽  
Unfavorable Outcome ◽  
Chinese Patients ◽  
Hamilton Depression Scale ◽  
Post Stroke ◽  
Potential Risk Factors ◽  
Post Stroke Depression ◽  
State Examination

Background: Post-stroke depression (PSD) constitutes an essential complication of stroke and is associated with high-risk unfavorable outcome after stroke. The main objective of this prospective study was to determine the relationship between early-onset PSD (1 month after stroke) and functional outcomes 5 years after baseline enrollment.Methods: Four hundred thirty-six patients who met the criteria were included in this study from October 2013 to February 2015. The follow-up time for each patient was ~5 years, with follow-up every 3 months. Patients received questionnaires including the 17-item Hamilton Depression Scale (HAMD), the Mini-Mental State Examination (MMSE), the National Institutes of Health Stroke Scale (NIHSS), the modified Rankin Scale (mRS), and the Barthel Index (BI).Results: Of the 436 patients, 154 (35.3%) patients with the prevalence of PSD status at baseline, 26 (7.2%) patients with the prevalence of PSD status, and 73 (20.1%) had an unfavorable outcome 5 years after stroke. The odds ratio (OR) for unfavorable outcome at 5 years in the PSD group was ~2.2 relative to the non-PSD group after adjusting for potential risk factors [OR = 2.217, 95% confidence interval (CI) = 1.179–4.421, P = 0.015]. In the early-onset PSD group, HAMD scores were independently associated with 5-year unfavorable outcome rates (OR = 1.168, 95% CI = 1.015–1.345, P = 0.031).Conclusions: Our findings indicate that early-onset PSD status in Chinese patients is an independent risk factor for unfavorable outcome 5 years after stroke, and that the severity of PSD is also related to unfavorable outcome.

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