scholarly journals A Scary Onset of a Rare and Aggressive Type of Primary Breast Sarcoma: A Case Report

2016 ◽  
Vol 9 (3) ◽  
pp. 796-801 ◽  
Author(s):  
Inês Ramalho ◽  
Sara Campos ◽  
Teresa Rebelo ◽  
Margarida Figueiredo Dias
Keyword(s):  
Poor Prognosis ◽  
Case Reports ◽  
Relevant Literature ◽  
Phyllodes Tumor ◽  
Left Breast ◽  
Breast Sarcoma ◽  
Systemic Dissemination ◽  
High Grade Sarcoma ◽  
Histological Characteristics

Primary breast sarcoma, arising from connective tissue within the breast, is extremely rare, accounting for less than 1% of all primary breast malignancies and no more than 5% of all sarcomas. The rarity of this pathology limits most studies to case reports and small retrospective studies, which has led to a lack of consensus on the clinical management. We report a clinical case of a 52-year-old woman, perimenopausal, previously healthy, with regular breast surveillance, who presented with a large (>20 cm) and rapidly expanding hypervascularized tumor of the left breast developed over 10 days, with a very thin preulcerative skin over the last 4 days. There was no systemic dissemination. The patient was submitted to total mastectomy and excision of axillary adenopathy. The tumor was diagnosed histologically as malignant phyllodes tumor associated with areas of high-grade sarcoma. Due to rapid growth and aggressive histological characteristics, adjuvant chemotherapy and radiotherapy were performed. There is a lot of evidence that tumors larger than 5 cm are associated with a poor prognosis. Despite the poor prognosis associated with this aggressive entity, the patient had no recurrence during 5 years of follow-up. We review the relevant literature about primary breast sarcomas.

scholarly journals Recurrent giant fibroadenomas with transformation to cystosarcoma phyllodes in a 17-year-old girl: a rare case report from Syria

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Sawsan Ismail ◽  
Sara Alaidi ◽  
Sarah Jouni ◽  
Yahya Kassab ◽  
Zuheir Al-Shehabi
Keyword(s):  
Premenopausal Women ◽  
Phyllodes Tumor ◽  
Left Breast ◽  
Cystosarcoma Phyllodes ◽  
Rare Case Report ◽  
Long Term Follow Up ◽  
Multiple Recurrences ◽  
High Possibility

Abstract Background Fibroadenoma is the most prevalent benign breast lesion that generally affects middle-aged women; it is rare in adolescents and younger children. The transformation into malignancy is not common. However, multiple recurrences of rapidly enlarging fibroadenomas suggest a high possibility of transforming into phyllodes tumors, which are uncommon fibroepithelial lesions that account for 0.3–0.5% of female breast tumors and typically present in premenopausal women. Case presentation We report a case of a 17-year-old Syrian girl who previously had three episodes of recurrence of multiple rapidly enlarging fibroadenomas in her left breast and underwent three operations for complete resection of the lesions. However, a few months later, she was readmitted with multiple large masses in the same breast, and pathological findings confirmed a surprising combination of multiple fibroadenomas for the fourth time with a malignant phyllodes tumor (cystosarcoma phyllodes). The patient underwent lumpectomies followed by adjuvant radiotherapy. Long-term follow-up was recommended. Conclusion Our patient had an extraordinary number of episodes of recurrence at a young age and a rare combination of malignant and benign lesions in the same breast with multiple recurrences. We present her unique, very challenging case with the aim of highlighting the importance of clinical correlation, detailed diagnosis, and careful follow-up.

scholarly journals Phyllodes tumor presented as fungating mass on right breast and fibroadenoma on contralateral breast: a case report

2020 ◽  
Vol 7 (2) ◽  
pp. 596
Author(s):  
Sribatsa Kumar Mahapatra ◽  
Pramit Ballav Panigrahi ◽  
Abinash Mahapatra ◽  
Srimanta Mahapatra
Keyword(s):  
Case Report ◽  
Wide Local Excision ◽  
Phyllodes Tumor ◽  
Left Breast ◽  
Contralateral Breast ◽  
Histopathological Diagnosis ◽  
Ki 67 ◽  
Tumor Margin ◽  
Proliferative Markers

This is an article reporting a large phyllodes tumor with fibroadenoma. A 25 years female presented with a fungating mass of size 20×15 cms in right breast since last 1 year and amass of size 3×3 cms in left breast since 6 month. Biopsy from right side and left side breast mass proven to be Cystosarcomaphyllodes and fibroadenoma respectively. Wide local excision with 1cm normal tumor margin on right side and   excision of mass on left side done. Proliferative markers like Ki-67 and P53 were in range of 1-2% and 3-4% respectively. Histopathological diagnosis of tumor was borderline phyllodes tumor (right side) and fibroadenoma (left side). Patient had an uneventful post-operative course and is presently on three monthly follow up since 1 year.

scholarly journals Neuroendocrine tumors producing calcitonin: characteristics, prognosis and potential interest of calcitonin monitoring during follow-up

2016 ◽  
Vol 174 (3) ◽  
pp. 335-341 ◽  
Author(s):  
Cécile Nozières ◽  
Laurence Chardon ◽  
Bernard Goichot ◽  
Françoise Borson-Chazot ◽  
Valérie Hervieu ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Poor Prognosis ◽  
Carcinoid Syndrome ◽  
Medullary Thyroid Cancer ◽  
High Grade ◽  
Poor Differentiation ◽  
Histological Characteristics ◽  
Grade 3 ◽  
Pancreatic Origin

ObjectivesInappropriate calcitonin (CT) release, a major feature of medullary thyroid cancer (MTC), may occur in neuroendocrine tumors (NETs). The aims of this retrospective study were to assess i) the characteristics and prognosis of CT-producing NETs, and ii) the value of CT monitoring during follow-up.MethodsAll patients with NETs in whom serum CT was assayed between 2010 and 2012 were included. MTCs were excluded. Clinical, biological, and histological characteristics were studied.ResultsTwenty-one (12%) of 176 patients in whom serum CT was systematically assayed had concentrations >100 ng/l, with tumours predominantly of bronchial or pancreatic origin (P<0.0001), and of high grade (P=0.0006). Poor prognosis was linked to high CT levels, poor differentiation, and grade 3. In a total group of 24 patients with serum CT >100 ng/l, symptoms potentially attributable to CT were recorded in eight, with occasional overlap with the carcinoid syndrome among other secretory syndromes. Immunohistochemistry could be performed in six tumor specimens, CT being detected in five. In 11 patients with five or more successive CT assays, hormone levels were fairly well correlated with clinical courses.ConclusionSerum CT levels may be raised in some patients with NETs, especially from foregut origin, and of high grade. The suggested value of CT monitoring during follow-up must be confirmed in further studies.

scholarly journals A case of recurrent malignant phyllodes tumor undergoing nipple-sparing mastectomy with immediate breast reconstruction

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Emi Morioka ◽  
Masakuni Noguchi ◽  
Miki Noguchi ◽  
Masafumi Inokuchi ◽  
Ken-ichi Shimada ◽  
...  
Keyword(s):  
Breast Reconstruction ◽  
Radiation Treatment ◽  
Tissue Expander ◽  
Phyllodes Tumor ◽  
Left Breast ◽  
Immediate Breast Reconstruction ◽  
Malignant Phyllodes Tumor ◽  
Nipple Sparing Mastectomy ◽  
Nipple Sparing

Abstract Background Although the primary treatment for malignant phyllodes tumor (PT) is complete surgical excision with either breast-conserving surgery or total mastectomy, recent technical advances have led to the adoption of nipple-sparing mastectomy (NSM) with immediate breast reconstruction (IBR). Case presentation A 28-year-old woman noticed a mass in her left breast that was rapidly increasing in size. She underwent tumor excision and a histological diagnosis of marked degenerative and necrotic induration suggested benign PT. One year later, however, she was found to have recurrent masses in the left breast on follow-up mammography and sonography. Needle biopsy was performed and the tumor was diagnosed as borderline or malignant PT. She underwent NSM and sentinel lymph-node biopsy with IBR using a tissue expander. Histological examination of the mastectomy specimen showed multiple fibroepithelial tumors with marked stromal overgrowth, focal necrosis, and hemorrhage. Stromal cells showed pleomorphism and a maximal mitotic rate of approximately 25 per 10 high-power fields. The tumor was diagnosed as malignant PT. She did not receive adjuvant chemotherapy or radiation treatment. At 3-year follow-up, the patient remains free of disease and highly satisfied with the cosmetic results. Conclusions NSM with IBR is not a contraindication for malignant PT. It is both curative and can offer an appealing cosmetic option for localized malignant PT.

scholarly journals Phyllodes Tumor in a Lactating Breast

2016 ◽  
Vol 9 ◽  
pp. CPath.S38476 ◽  
Author(s):  
Sudha S. Murthy ◽  
K. V. V. N. Raju ◽  
Haripreetha G. Nair
Keyword(s):  
Needle Biopsy ◽  
Phyllodes Tumor ◽  
Left Breast ◽  
Diagnostic Challenge ◽  
Primary Tumors ◽  
Pregnancy And Lactation ◽  
Lactating Breast ◽  
Mitotic Figures ◽  
Microscopic Findings

Phyllodes tumor is attributed to a small fraction of primary tumors of the breast. Such tumors occur rarely in pregnancy and lactation. We report a case of a 25-year-old lactating mother presenting with a lump in the left breast. Core needle biopsy was opined as phyllodes tumor with lactational changes, and subsequent wide local excision confirmed the diagnosis of benign phyllodes tumor with lactational changes. The characteristic gross and microscopic findings of a well-circumscribed lesion with leaf-like fibroepithelial growth pattern and typical nonuniform or diffuse stromal proliferation with periductal accentuation even in the absence of mitotic figures can help clinch the diagnosis. Benign phyllodes is known for its recurrence and requires wide excision and close follow-up. It is vital to identify these lesions even on limited biopsies as therapeutic options differ. This case is presented for its rarity and the diagnostic challenge it poses in limited biopsy.

scholarly journals Creeping Attachment Involving Dental Implants: Two Case Reports with a Two-Year Follow-Up from an Ongoing Clinical Study

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Armando R. Lopes Pereira Neto ◽  
Bernardo Born Passoni ◽  
José Moisés de Souza ◽  
João Gustavo Oliveira de Souza ◽  
César Augusto Magalhães Benfatti ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Case Reports ◽  
Relevant Literature ◽  
Connective Tissue Graft ◽  
Tissue Graft ◽  
Soft Tissue Graft ◽  
Subepithelial Connective Tissue Graft ◽  
Titanium Surfaces ◽  
Gingival Graft

Introduction. This paper describes case reports where coronal growth of soft tissue on implant threads was observed after surgery for soft tissue graft. This phenomenon is known as “creeping attachment.”Methods. Two patients were submitted to gingival graft procedure including subepithelial connective tissue graft and masticatory mucosal graft. A two-year follow-up appointment was performed.Results. After a two-year follow-up gingival growth over titanium surfaces characterizing the “creeping attachment” phenomenon was observed. This gingival growth happened over abutment and threads surfaces.Conclusion. The creeping attachment phenomenon is possible over titanium surfaces and has not yet been reported in the relevant literature over this kind of structure.

Primary Osteosarcoma of the Breast: Report of 2 Cases

2007 ◽  
Vol 131 (5) ◽  
pp. 792-795
Author(s):  
Armita Bahrami ◽  
Erika Resetkova ◽  
Jae Y. Ro ◽  
Joe D. Ibañez ◽  
Alberto G. Ayala
Keyword(s):  
Elderly Women ◽  
Treatment Approach ◽  
Sarcomatoid Carcinoma ◽  
Phyllodes Tumor ◽  
Left Breast ◽  
Biological Behavior ◽  
Hematogenous Spread ◽  
Simple Mastectomy ◽  
Slow Growing

Abstract Two distinct histologic variants of primary breast osteosarcoma in 2 elderly women are described. The first patient was an 88-year-old woman with a long-standing, slow-growing, 18-cm mass in her right breast. The second patient was a 96-year-old woman with a recently self-detected, painless, 7.5-cm lump in her left breast. Clinically, there was no evidence of metastasis, and both women underwent simple mastectomy. Histologic features of both specimens were those of high-grade primary breast osteosarcoma. The first patient's tumor was classified as a chondroblastic variant, and the second as an osteoblastic variant of osteosarcoma. The patients were alive without evidence of local recurrence or hematogenous spread at a 16- and 4-month follow-up, respectively. Primary mammary osteosarcoma should be distinguished from metaplastic/ sarcomatoid carcinoma with heterologous osseous/cartilaginous differentiation or malignant phyllodes tumor because it has a different biological behavior and requires a different treatment approach.

scholarly journals Renal Epithelioid Angiomyolipoma in Children

2021 ◽  
Vol 8 (2) ◽  
pp. 20-26
Author(s):  
Dhruv Mahajan ◽  
Vishesh Jain ◽  
Sandeep Agarwala ◽  
Manisha Jana ◽  
Prashant P Ramteke
Keyword(s):  
Tuberous Sclerosis ◽  
Poor Prognosis ◽  
Tumor Metastasis ◽  
Renal Mass ◽  
Renal Tumor ◽  
Case Reports ◽  
Renal Angiomyolipoma ◽  
Epithelioid Angiomyolipoma ◽  
Left Flank

Renal angiomyolipoma is a rare cause of renal tumor in children. Most are associated with tuberous sclerosis, and the classic type is observed more commonly. Epithelioid angiomyolipoma is even rarer with only limited case reports and series published in literature, most of which are of adult patients. We describe a 12-year-old boy, a diagnosed patient of tuberous sclerosis, who presented with pain in the left flank. On evaluation, it was found to have a left renal mass with the clinical picture suggestive of renal cell carcinoma. Partial nephrectomy was performed and histopathology revealed epithelioid angiomyolipoma. The child was asymptomatic at follow-up after 3 months. Only a few such cases in children are found in literature, which are discussed alongside. Differential diagnosis of this rare tumor must be kept in mind in a renal tumor as surgery is generally curative in this possibly malignant tumor. Metastasis confers a poor prognosis. Chemotherapy is generally not effective, although various regimens have been tried. Tumor recurrence must be kept in mind and a follow-up after apparent complete remission is of paramount importance.

scholarly journals Skin-Reducing Mastectomy and Immediate Reconstruction for a Large Recurrent Borderline Phyllodes Tumor

2021 ◽  
Vol 11 (3) ◽  
pp. 1224
Author(s):  
Daciana Grujic ◽  
Horia Cristian ◽  
Teodora Hoinoiu ◽  
Codruta Diana Miclauș ◽  
Simona Cerbu ◽  
...  
Keyword(s):  
Phyllodes Tumor ◽  
Left Breast ◽  
Breast Hypertrophy ◽  
Immediate Reconstruction ◽  
Case Presentation ◽  
Surgical Decision ◽  
Simple Mastectomy ◽  
Resection Specimen ◽  
The Right

Background: Large recurrent phyllodes breast tumors are often malignant. Therefore, when taking the surgical decision, a simple mastectomy and immediate reconstruction must be considered. Case presentation: The patient, aged 40 years, with a benign phyllodes tumor in the left breast, having a recurrence 2 years after, with 4–7 cm conglomerate tumor masses, was subjected to skin-reducing mastectomy, breast reconstruction with a silicone mammary implant in the left breast, and symmetrization of the right breast. Discussion and conclusions: In the case of patients with breast hypertrophy and gigantomastia (cup size D–F), skin-reducing mastectomy and immediate reconstruction with an implant can be the option. It is important for the resection specimen to include the skin tissue above the tumor. After 14 months of follow-up, there was no recurrence of the lesions on a clinical examination, ultrasonography, or MRI.

Severe Head Injury linked to Subsequent Development of Malignant Brain Tumour within a Short Period- A Case Report

2018 ◽  
Vol 3 (2) ◽  
Keyword(s):  
Head Injury ◽  
Brain Tumour ◽  
Severe Head Injury ◽  
Case Reports ◽  
Subsequent Development ◽  
Malignant Brain Tumour ◽  
Tumour Development ◽  
Short Period ◽  
The Brain

There have been a few case reports of head injury leading to brain tumour development in the same region as the brain injury. Here we report a case where the patient suffered a severe head injury with contusion. He recovered clinically with conservative management. Follow up Computed Tomography scan of the brain a month later showed complete resolution of the lesion. He subsequently developed malignant brain tumour in the same region as the original contusion within a very short period of 15 months. Head injury patients need close follow up especially when severe. The link between severity of head injury and malignant brain tumour development needs further evaluation. Role of anti-inflammatory agents for prevention of post traumatic brain tumours needs further exploration.

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