Inverse Correlation of Venous Brain Natriuretic Peptide Levels with Body Mass Index Is due to Decreased Production

Objective: The aim of this paper was to study the association between body mass index (BMI) and coronary sinus (CS) brain natriuretic peptide (BNP) levels in patients with heart failure and reduced systolic function (HFrEF). Background: There is an inverse relationship between systemic venous BNP (V-BNP) levels and BMI in patients with HFrEF. It is unclear whether this finding is due to decreased production or due to an increased metabolism of BNP. Since CS-BNP levels reflect BNP production, we hypothesized that assessing the correlation of CS-BNP levels with BMI would provide insight into the mechanism of this inverse relationship of V-BNP and BMI. Methods: We prospectively enrolled 54 subjects with HFrEF who were to undergo cardiac resynchronization device implantation. CS-BNP, V-BNP, and arterial BNP (A-BNP) levels were measured during the implant procedure. Subjects were divided into 2 groups based on their BMI (group 1: BMI <30 and group 2: BMI ≥30). Results: The mean age of the overall study group was 64 ± 10 years. Average BMI for group 1 was 25.8 ± 2.8 and 36.8 ± 4.6 for group 2 (p < 0.03). A history of hypertension was present in 55% (n = 26) of the subjects, while diabetes was reported in 31% (n = 15). Serum creatinine was 1.0 ± 0.2 mg/dL and TSH 2.1 ± 1.4 mIU/L. 79% of the subjects were receiving β-blockers, while 94% were receiving angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. The mean CS-BNP, V-BNP, and A-BNP levels in group 2 were significantly lower than in group 1 (286.2 ± 170.5 vs. 417.5 ± 247.5 pg/mL, p = 0.04; 126.6 ± 32.5 vs. 228 ± 96.4 pg/mL, p = 0.01; and 151.9 ± 28.6 vs. 242 ± 88.8 pg/mL, p = 0.04, respectively). Univariate analysis and multivariate regression adjusted for age, diabetes mellitus, sex, glomerular filtration rate, and left atrial size confirmed BMI as an independent predictor of CS-BNP levels (β = -0.372, p = 0. 03) in our study. Conclusions: In this study, we demonstrate an inverse relationship between CS-BNP levels and BMI in patients with HFrEF. These findings suggest that the previously established inverse relationship between V-BNP and BMI is due to a decreased cardiac production of BNP in obese patients rather than from increased peripheral metabolism.

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Can Body Mass Index Affect Height Growth at Menarche among Girls Receiving Treatment for Early Puberty? A Retrospective Study in Korean Girls

Children ◽

10.3390/children9010110 ◽

2022 ◽

Vol 9 (1) ◽

pp. 110

Author(s):

Sun-Jin Lee ◽

Sun-Young Kim ◽

Minsun Kim

Keyword(s):

Body Mass Index ◽

Body Weight ◽

Body Mass ◽

Central Precocious Puberty ◽

Early Puberty ◽

Time Points ◽

Height Gain ◽

The Mean ◽

Group 2 ◽

Group 1

Gonadotropin-releasing hormone agonist (GnRHa) therapy is used to control puberty progression and it preserves height potential in patients with idiopathic central precocious puberty (ICPP). This study evaluated the correlation between weight and height gain at menarche following GnRHa treatment among girls with ICPP and relatively central early puberty (EP). We investigated height/weight trends and changes in height from diagnosis to menarche in girls with ICPP and EP treated with GnRHa. The mean difference in height (Δheight) from treatment cessation to menarche was 9.79 ± 3.53 cm. Girls were divided into girls with Δheight ≥ 9.79 cm (Group 1) and girls with Δheight < 9.79 cm (Group 2). Although near adult height was significantly higher in Group 1, the mean body mass index (BMI) and weight were significantly lower at diagnosis, treatment discontinuation, and menarche. The BMI and weight at the three time points were negatively correlated with height. Girls with higher BMI at all three time points had slower growth rates during the study period. Considering that BMI and body weight were closely related to Δheight, proper management of BMI and body weight of girls receiving early puberty treatment might contribute to growth during and after GnRHa treatment.

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The Benefits of Good Nutrition in Preventing Post-Surgical Ileostomy Complications

Romanian Journal of Diabetes Nutrition and Metabolic Diseases ◽

10.1515/rjdnmd-2015-0051 ◽

2015 ◽

Vol 22 (4) ◽

pp. 433-437

Author(s):

Tiberius Viorel Mogos ◽

Claudia Valeria Chelan ◽

Carmen Ionela Dondoi ◽

Andra Evelin Iacobini ◽

Mihaela Buzea

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Surgical Procedures ◽

Surgical Intervention ◽

Nutrition Therapy ◽

Good Nutrition ◽

The Mean ◽

Group 2 ◽

Specialist Group ◽

Group 1

Abstract Background and Aims: Ileostomy induces important local and general complications. The present study evaluates if nutrition therapy can influence the development of these complications. Methods: We evaluated a group of 43 patients with ileostomy, without general complications after the surgical intervention, starting from the second day following surgery, for a period of 8 weeks. The mean age was 58.2 ±8.7 years and body mass index (BMI) of 28.2 ±6.5 kg/m2. The patients were divided into 2 groups: one following a diet prescribed by a nutrition specialist (group 1), and another with scarce notions of nutrition given by the attending surgeon (group 2). Results: When comparing group 1 with group 2, we observed: obstruction of the ileostomy in 1% vs. 49% (p<0.01); skin abrasions around the ileostomy in 21% vs. 97% (p<0.01); unpleasant odors at the site of the stoma in 16% vs. 99% (p<0.01); mean BMI 26.2 ± 4.3 kg/m2 vs. 19.4 ± 3.3 kg/m2 (p<0.01); natremia 138.1 ± 2.1 mEq/l vs. 129.2 ± 3.3 mEq/l (p<0.01); kalemia 4.2 ± 0.2 mEq/l vs. 3.1 ± 0.3 mEq/l (p<0.01). Conclusion: A correct nutrition of patients with ileostomy reduces the rate of local and general complications related to surgical procedures.

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In hemodialysis, adiponectin, and pro-brain natriuretic peptide levels may be subjected to variations in body mass index

Hemodialysis International ◽

10.1111/j.1542-4758.2011.00562.x ◽

2011 ◽

Vol 15 (4) ◽

pp. 477-484 ◽

Cited By ~ 7

Author(s):

Hernan TRIMARCHI ◽

Alexis MURYAN ◽

Mariana DICUGNO ◽

Mariano FORRESTER ◽

Fernando LOMBI ◽

...

Keyword(s):

Body Mass Index ◽

Brain Natriuretic Peptide ◽

Natriuretic Peptide ◽

Body Mass

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Effect of Body Mass Index on Diagnostic and Prognostic Usefulness of Amino-Terminal Pro–Brain Natriuretic Peptide in Patients With Acute Dyspnea

Archives of Internal Medicine ◽

10.1001/archinte.167.4.400 ◽

2007 ◽

Vol 167 (4) ◽

pp. 400 ◽

Cited By ~ 96

Author(s):

Antoni Bayes-Genis

Keyword(s):

Body Mass Index ◽

Brain Natriuretic Peptide ◽

Natriuretic Peptide ◽

Body Mass ◽

Acute Dyspnea ◽

Amino Terminal

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Differential diagnosis of various forms of functional hypothalamic amenorrhea

GYNECOLOGY ◽

10.26442/20795696.2019.3.190525 ◽

2019 ◽

Vol 21 (4) ◽

pp. 14-18

Author(s):

Dmitry V Gusev ◽

Sergey Yu Kuznetsov ◽

Tatyana Yu Ivanets ◽

Galina E Chernukha

Keyword(s):

Body Mass Index ◽

Differential Diagnosis ◽

Adipose Tissue ◽

Body Mass ◽

Stressful Events ◽

Hypothalamic Amenorrhea ◽

Differential Index ◽

Functional Hypothalamic Amenorrhea ◽

Group 2 ◽

Group 1

Aim. To investigate the usefulness of differential diagnostic criteria of functional hypothalamic amenorrhea (FHA) related to energy deficiency and stress. Materials and methods. There were provided clinical and laboratory examination of 56 patients with FHA associated with stressful events (group 1) and 64 patients with FHA on the background of eating disorders (group 2), including assessment of adipose tissue, determination of leptin level, adipose tissue index and differential index. Results. Patients of group 2 were distinguished by a more significant deficiency of body mass index, total body fat, and leptin levels in comparison with patients of group 1. The differential index [AUC=0.907 (0.84-0.97)] turned out to be the most informative indicator in the differential diagnosis of various forms of FHA, its threshold value was 21.4, the least informative - body mass index [AUC=0.78 (0.71-0.87)]. Conclusion. The differential index can be considered as an informative differential diagnostic criterion for various forms of FHA.

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Investigation of the effect of body mass index (BMI) on semen parameters and male reproductive system hormones

Archivio Italiano di Urologia e Andrologia ◽

10.4081/aiua.2017.3.219 ◽

2017 ◽

Vol 89 (3) ◽

pp. 219 ◽

Cited By ~ 4

Author(s):

Mehmet Zeynel Keskin ◽

Salih Budak ◽

Evrim Emre Aksoy ◽

Cem Yücel ◽

Serkan Karamazak ◽

...

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Sperm Count ◽

Reproductive Hormones ◽

Semen Parameters ◽

Total Testosterone ◽

Significant Difference ◽

Group 3 ◽

Group 2 ◽

Group 1

Aim: To evaluate the effects of body mass index (BMI) ratio on semen parameters and serum reproductive hormones. Materials and methods: The data of 454 patients who prsented to male infertility clinics in our hospital between 2014 and 2015 were analyzed retrospectively. Weight, height, serum hormone levels and semen analysis results of the patients were obtained. BMI values were calculated by using the weight and height values of the patients and they were classified as group 1 for BMI values ≤ 25 kg/m2, as group 2 for BMI values 25-30 kg/m2 and as group 3 for BMI values ≥ 30 kg/m2. Results: The mean values of BMI, semen volume, concentration, total motility, progressive motility, total progressive motile sperm count (TPMSC), normal morphology according to Kruger, head abnormality, neck abnormality, tail abnormality, FSH, LH, prolactin, T/E2, total testosterone and estradiol parameters of the patients were considered. Patients were divided according to BMI values in Group 1 (n = 165), Group 2 (n = 222) and Group 3 (n = 56). There was no statistically significant difference in terms of all variables between the groups. Conclusions: We analyzed the relationship between BMI level and semen parameters and reproductive hormones, demonstrating no relationship between BMI and semen parameters. In our study, BMI does not affect semen parameters although it shows negative correlation with prolactin and testosterone levels.

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Gender Dimorphic Associations between N-Terminal Pro-Brain Natriuretic Peptide, Body Mass Index and Blood Pressure in Children and Adolescents

Hormone Research in Paediatrics ◽

10.1159/000308166 ◽

2010 ◽

Vol 73 (5) ◽

pp. 341-348 ◽

Cited By ~ 11

Author(s):

Panagiota Pervanidou ◽

Athanassios Akalestos ◽

Sophia Sakka ◽

Christina Kanaka-Gantenbein ◽

Ioannis Papassotiriou ◽

...

Keyword(s):

Blood Pressure ◽

Body Mass Index ◽

Brain Natriuretic Peptide ◽

Children And Adolescents ◽

Natriuretic Peptide ◽

Body Mass

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The importance of laboratory tests and Body Mass Index in the diagnosis of acute appendicitis

Polish Journal of Surgery ◽

10.5604/01.3001.0014.3579 ◽

2020 ◽

Vol 92 (5) ◽

pp. 1-5

Author(s):

Atakan Ozkan ◽

Aylin Hande Gokce ◽

Feridun Suat Gokce

Keyword(s):

Body Mass Index ◽

Acute Appendicitis ◽

Body Mass ◽

The Body ◽

Distribution Width ◽

Lymphocyte Ratio ◽

Group 4 ◽

Group 3 ◽

Group 2 ◽

Group 1

Background: Acute appendicitis is the most common cause of acute abdomen. Delay in diagnosis increases the mortality and morbidity. Aim: In this study, we aimed to investigate whether the body mass index is useful in diagnosis and whether the neutrophil /lymphocyte and platelet/lymphocyte ratios can help in determining the inflammation level of acute appendicitis. Meterial and Methods: Cases of appendectomy performed between June 2012 and December 2018 in our clinic were analyzed retrospectively. Based on the pathology results of the cases included in the study, 4 groups were formed, i.e.: Group 1 (initial stage), Group 2 (catarrhal stage), Group 3 (phlegmonous-gangrenous stage) and Group 4 (perforation). The study compared age, body mass index, leukocyte values, red cell distribution width (RDW), neutrophil/lymphocyte ratio (NLR), platelet /lymphocyte ratio (PLR), and mean platelet volume (MPV) between groups. Results: 828 cases were included in the study. When compared between groups, the values of Group 3 and Group 4 were higher than those of Group 1 and Group 2 for PLR and NLR. There was no difference in RDW and MPV values in the blood. When Body Mass Index (BMI) was compared between groups, it was found to be significantly higher with increasing histopathological stage. Conclusion: In acute appendicitis, the blood leukocyte value, elevated PLR and NLR are helpful in diagnosis. We aimed to emphasize that the diagnosis of acute appendicitis is delayed in patients with a BMI above 30 and/or at age of over 40 years, with the perforation rate being determined more frequently.

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Diabetes during Pregnancy: Influence of Body Mass Index on Composite Morbidity

American Journal of Perinatology Reports ◽

10.1055/s-0037-1603913 ◽

2017 ◽

Vol 07 (02) ◽

pp. e128-e133

Author(s):

Amy O'Neil Dudley ◽

Zachary Jenner ◽

Hector Mendez-Figueroa ◽

Viviana Ellis ◽

Suneet Chauhan

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Fourth Degree ◽

Arterial Ph ◽

Maternal And Neonatal Outcomes ◽

Group 3 ◽

Group 2 ◽

Umbilical Arterial Ph ◽

Diabetes And Obesity ◽

Group 1

Objective This study aims to compare composite maternal and neonatal morbidities (MM, NM) among pregnant women with diabetes mellitus whose body mass index (BMI) at delivery was < 30 (group 1), 30.0 to 39.9 (group 2), and ≥ 40 kg/m2 (group 3). We hypothesized that increased BMI class at delivery would be associated with worsening maternal and neonatal outcomes. Methods This is a retrospective cohort study. MM was defined as: chorioamnionitis, wound infection, eclampsia, diabetic ketoacidosis, hypoglycemia admission, third/fourth degree laceration, and/or death. NM was defined as umbilical arterial pH < 7.0, 5 minute Apgar < 4, respiratory distress syndrome, mechanical ventilation, neonatal sepsis, stillbirth, and/or death. Odds ratios were adjusted for possible confounders. Results MM was noted in 8, 13, and 24% of groups 1, 2, and 3, respectively, and significantly more common in group 2 versus 1 (adjusted odds ratio [aOR]: 1.66) and group 3 versus 1 (aOR: 3.06). NM was noted in 7, 8, and 15% of each BMI group, respectively, and differed significantly between group 3 vs. 2 (aOR: 1.77). Conclusions The increased rate of morbidities between the BMI groups is useful to inform diabetic women and highlights the need for further investigation of diabetes and obesity as comorbidities in pregnancy.

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