Giant Pedunculated Hepatic Hemangioma: A Case Report and Literature Review

Hepatic hemangioma is the most common benign hepatic tumor, and most of them are small in size and asymptomatic. Giant hepatic hemangiomas are uncommon, but pedunculated giant hemangiomas are even rarer and often difficult to diagnose because of their exophytic development. We report here on a 48-year-old man with a symptomatic pedunculated giant hepatic hemangioma and hepatic angiomatosis, mimicking a gastric gastrointestinal stromal tumor with liver metastases. The preoperative diagnosis was suspected on imaging including CT scan and MRI. The patient was successfully operated (left hepatic lobectomy), without any complication, and the pathological analysis confirmed the diagnosis. We reviewed the English literature, and to our knowledge, our case represents the largest case reported so far when compared with the 19 other informative cases.

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Proton beam therapy for a giant hepatic hemangioma: A case report and literature review

Clinical and Translational Radiation Oncology ◽

10.1016/j.ctro.2021.01.014 ◽

2021 ◽

Vol 27 ◽

pp. 152-156

Author(s):

Shosei Shimizu ◽

Masashi Mizumoto ◽

Toshiyuki Okumura ◽

Yinuo Li ◽

Keiichirou Baba ◽

...

Keyword(s):

Case Report ◽

Literature Review ◽

Proton Beam ◽

Proton Beam Therapy ◽

Hepatic Hemangioma ◽

Giant Hepatic Hemangioma

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Giant Hepatic Hemangioma Regressed Significantly Without Surgical Management: A Case Report and Literature Review

Frontiers in Medicine ◽

10.3389/fmed.2021.712324 ◽

2021 ◽

Vol 8 ◽

Author(s):

Jingcong Zhang ◽

Zuyang Ye ◽

Lei Tan ◽

Jinmei Luo

Keyword(s):

Cell Proliferation ◽

Liver Transplantation ◽

Case Report ◽

Literature Review ◽

Lymphatic Vessels ◽

Vascular Anomaly ◽

Endothelial Cell Proliferation ◽

Hepatic Hemangioma ◽

Specific Drug ◽

Giant Hepatic Hemangioma

Hepatic hemangioma (HH) is a congenital vascular anomaly comprising networks of abnormal blood and/or lymphatic vessels with endothelial cell proliferation. Their pathophysiology is not fully understood, and no specific drug is available to treat them. Conservative management, which limits observation, is preferred for most patients. A HH larger than 4 cm is considered a giant HH that may be treated using surgery ranging from embolization to hepatic resection or liver transplantation. Here, we describe a case with multiple and giant HHs that regressed significantly after treatment with azithromycin (AZM). A systematic literature review of HH and the effects of AZM on angiogenesis was then conducted.

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Orthotophic Liver Transplantation in Giant Hepatic Hemangioma: A Case Report and Literature Review

Open Journal of Organ Transplant Surgery ◽

10.4236/ojots.2013.33009 ◽

2013 ◽

Vol 03 (03) ◽

pp. 47-49

Author(s):

Jessica Casella ◽

Carla Lemos Gottgroy ◽

Carlos Rocha Maia ◽

Felipe Pedreira Tavares de Mello ◽

Samanta Teixeira Basto ◽

...

Keyword(s):

Liver Transplantation ◽

Case Report ◽

Literature Review ◽

Hepatic Hemangioma ◽

Giant Hepatic Hemangioma

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Russell Body Typhlitis: A Case Report and Literature Review

International Journal of Surgical Pathology ◽

10.1177/10668969211008251 ◽

2021 ◽

pp. 106689692110082

Author(s):

Sarah Al-Rawaf ◽

Salem Alowami ◽

Robert Riddell ◽

Asghar Naqvi

Keyword(s):

Case Report ◽

Literature Review ◽

Light Chain ◽

Plasma Cells ◽

Gastrointestinal Disease ◽

English Literature ◽

The Other ◽

Tubulovillous Adenoma ◽

Inflammatory Polyp ◽

Intracytoplasmic Inclusions

Russell bodies are accumulation of immunoglobulin in plasma cells forming intracytoplasmic inclusions. Russell body colitis is rare with only 3 cases described in the English literature up to date. We report a 78-year-old male with cirrhosis showing prominent cecal infiltration of Russell body containing plasma cells. Plasma cells showed no nuclear atypia or mitoses, and no evidence of light chain restriction. In this article, we report a fourth case of Russell body colitis, that is unique in being localized to the cecum in contrast to the other 3, 1 of which was in an inflammatory polyp in the sigmoid colon, 1 in a rectal tubulovillous adenoma and 1 as part of diffuse gastrointestinal disease. This is therefore the first report of localized Russell body typhlitis, occurring in a cirrhotic patient in whom an adjacent erosion was likely nonsteroidal anti-inflammatory drug-associated, a combination that may have facilitated the formation of Russell bodies.

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Preoperative Diagnosis and Treatment of Middle Ear Adenoma: A Case Report and Literature Review

Ear Nose & Throat Journal ◽

10.1177/01455613211000295 ◽

2021 ◽

pp. 014556132110002

Author(s):

Aleksander Zwierz ◽

Krystyna Masna ◽

Paweł Burduk

Keyword(s):

Case Report ◽

Surgical Treatment ◽

Literature Review ◽

Middle Ear ◽

Surgical Procedures ◽

Preoperative Diagnosis ◽

Proper Treatment ◽

Second Stage ◽

Middle Ear Adenoma ◽

Histopathological Results

Most reported cases of middle ear adenoma (MEA) have focused on histopathology because MEA is usually diagnosed postoperatively, which is considered as a major setback. We focused on the surgical aspect of the disease to facilitate a preoperative diagnosis, resulting in prompt and proper treatment, without requiring a second stage of surgical treatment. In this report, we present the differential diagnoses in a 40-year-old man with MEA requiring surgical treatment. Preoperatively, the patient was suspected to have an MEA. An analysis of the surgical procedures in similar misdiagnosed tumors has enabled us to assess surgical procedures in cases wherein the preoperative diagnosis does not coincide with the postoperative histopathological results.

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Safety and effectiveness of laparoscopic intratumoral resection facilitated by coagulation of giant hepatic hemangioma: a matched case–control study and literature review

Surgical Endoscopy ◽

10.1007/s00464-021-08891-3 ◽

2021 ◽

Author(s):

Shaohong Wang ◽

Ruize Gao ◽

Shuchao Zhao ◽

Huaqiang Zhu ◽

Wenxuan Zhang ◽

...

Keyword(s):

Literature Review ◽

Case Control Study ◽

Case Control ◽

Hepatic Hemangioma ◽

Matched Case ◽

Giant Hepatic Hemangioma ◽

Matched Case Control Study ◽

Control Study

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Giant Hepatic Hemangioma With Kasabach–Merritt Syndrome: Is the Appropriate Treatment Enucleation or Liver Transplantation?

HPB Surgery ◽

10.1155/2000/25954 ◽

2000 ◽

Vol 11 (6) ◽

pp. 413-419 ◽

Cited By ~ 30

Author(s):

Steven N. Hochwald ◽

Leslie H. Blumgart

Keyword(s):

Liver Transplantation ◽

Hepatic Hemangioma ◽

Preoperative Preparation ◽

Abdominal Girth ◽

Disseminated Intravascular Coagulopathy ◽

Postoperative Course ◽

Appropriate Treatment ◽

Intravascular Coagulopathy ◽

Giant Hepatic Hemangioma ◽

Hepatic Hemangiomas

We present a case of giant cavernous hemangioma of the liver with disseminated intravascular coagulopathy (Kasabach–Merritt syndrome) which was cured by enucleation. The 51 year old woman presented with increased abdominal girth and easy bruisability. Workup elsewhere revealed a massive hepatic hemangioma and she was started on radiation therapy to the lesion and offered an orthotopic liver transplant. After careful preoperative preparation, we felt that resection was possible and she underwent a successful enucleation. The operation and postoperative course were complicated by bleeding but she recovered and remains well in followup after 6 months. All coagulation parameters have returned to normal. Enucleation should be considered the treatment of choice for hepatic hemangiomas, including those presenting with Kasabach–Merritt syndrome. The benefits of enucleation as compared to liver transplantation for these lesions are discussed.

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Preoperative diagnosis of a mediastinal granular cell tumor by EUS-FNA : A case report and review of the literature

CytoJournal ◽

10.1186/1742-6413-2-8 ◽

2005 ◽

Vol 2 ◽

pp. 8 ◽

Cited By ~ 12

Author(s):

Sarah M Bean ◽

Mohamad A Eloubeidi ◽

Isam A Eltoum ◽

Robert J Cerfolio ◽

Darshana N Jhala

Keyword(s):

Case Report ◽

Preoperative Diagnosis ◽

Granular Cell Tumor ◽

English Literature ◽

Granular Cell ◽

Needle Aspiration ◽

Cell Tumor ◽

Prior History ◽

Cell Block ◽

First Case

We report the first case of a posterior mediastinal granular cell tumor initially diagnosed on cytologic material obtained via endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) in a 51-year-old male with a prior history of colon cancer. Aspirates obtained were cellular and composed of polygonal cells with abundant granular cytoplasm and small, round dark nuclei. An immunoperoxidase stain performed on the cell block for antibodies to S-100 protein showed strong, diffuse staining of the cytoplasmic granules. Electron microscopy performed on the cell block revealed numerous cytoplasmic lysosomes. This is the first case report in the English literature of a definitive preoperative diagnosis of a mediastinal granular cell tumor utilizing material obtained via EUS-FNA.

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