Anagen Effluvium after Therapeutic Scalp Surgery: Unreported Phenomenon

2021 ◽  
Vol 7 (4) ◽  
pp. 311-314
Author(s):  
Leticia Arsie Contin ◽  
Leopoldo Duailibe Nogueira Santos ◽  
Ivan José Netto Pereira ◽  
Vanessa Barreto Rocha
Keyword(s):  
Hair Loss ◽  
Spontaneous Recovery ◽  
Case Reports ◽  
Practical Importance ◽  
Transient Ischemia ◽  
Melanocytic Nevi ◽  
Scarring Alopecia ◽  
Anagen Hair ◽  
Time Required

<b><i>Introduction:</i></b> Many procedures are performed on the scalp, such as excision of pilar and sebaceous cysts, melanocytic nevi, and reduction surgery for scarring alopecia, among others. In hair transplants, telogen effluvium is often reported 3 months after surgery; however, hair loss usually happens much earlier, around second week after the procedure, not compatible with the time required for hair to enter telogen and exogenous phases in normal conditions. <b><i>Case Reports:</i></b> We report 3 cases of anagen hair loss 4 weeks after surgeries, with perilesional trichoscopy suggesting anagen effluvium, with typical signs such as black dots and exclamation hairs. <b><i>Discussion:</i></b> There are only a few reports about hair loss around operated areas. The cause of this postoperative anagen effluvium is probably a transient ischemia. <b><i>Conclusion:</i></b> The practical importance of this phenomenon is to properly orient patients because most of the hair will be lost, since 85% of them are anagens, and also will have spontaneous recovery in the next 3 months.

scholarly journals 451 Spironolactone for treatment of concomitant female pattern hair loss in scarring alopecia patients

2021 ◽  
Vol 141 (5) ◽  
pp. S78
Author(s):  
K.E. Flanagan ◽  
J.T. Pathoulas ◽  
C.J. Walker ◽  
I. M. Pupo Wiss ◽  
M.M. Senna
Keyword(s):  
Hair Loss ◽  
Scarring Alopecia ◽  
Female Pattern Hair Loss

scholarly journals Trade-offs between driving nodes and time-to-control in complex networks

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Sérgio Pequito ◽  
Victor M. Preciado ◽  
Albert-László Barabási ◽  
George J. Pappas
Keyword(s):  
Complex Networks ◽  
Time Window ◽  
Empirical Studies ◽  
Practical Importance ◽  
Network Models ◽  
Small Time ◽  
Synthetic Network ◽  
Trade Offs ◽  
Minimum Number ◽  
Time Required

Abstract Recent advances in control theory provide us with efficient tools to determine the minimum number of driving (or driven) nodes to steer a complex network towards a desired state. Furthermore, we often need to do it within a given time window, so it is of practical importance to understand the trade-offs between the minimum number of driving/driven nodes and the minimum time required to reach a desired state. Therefore, we introduce the notion of actuation spectrum to capture such trade-offs, which we used to find that in many complex networks only a small fraction of driving (or driven) nodes is required to steer the network to a desired state within a relatively small time window. Furthermore, our empirical studies reveal that, even though synthetic network models are designed to present structural properties similar to those observed in real networks, their actuation spectra can be dramatically different. Thus, it supports the need to develop new synthetic network models able to replicate controllability properties of real-world networks.

Repair of Isolated Axillary Nerve Lesions after Infraclavicular Brachial Plexus Injuries: Case Reports

Neurosurgery ◽  
1990 ◽  
Vol 27 (3) ◽  
pp. 403-407 ◽  
Author(s):  
Allan H. Friedman ◽  
James A. Nunley ◽  
James R. Urbaniak ◽  
Richard D. Goldner
Keyword(s):  
Brachial Plexus ◽  
Muscle Function ◽  
Sural Nerve ◽  
Spontaneous Recovery ◽  
Case Reports ◽  
Deltoid Muscle ◽  
Axillary Nerve ◽  
Shoulder Abduction ◽  
Surgical Exploration ◽  
Nerve Grafts

Abstract Stretch injuries of the infraclavicular brachial plexus have a much better prognosis for spontaneous recovery than do their supraclavicular counterparts. We present three patients with stretch injuries of the infraclavicular brachial plexus who had spontaneous restoration of function in all muscles except the deltoid. Decreased shoulder abduction was a serious handicap to these individuals. At surgical exploration, each patient had an isolated, complete axillary nerve disruption at the quadrilateral space. Deltoid muscle function was restored in all three patients by repair of the axillary nerve with sural nerve grafts across the quadrilateral space.

Clinical Characteristics in Neonates with Alloimmune Neutropenia: Significance of the Detection of Antineutrophil Antibodies

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 4647-4647
Author(s):  
Yoko Mizoguchi ◽  
Kazuhiro Nakamura ◽  
Shuhei Karakawa ◽  
Takashi Sato ◽  
Rie Onodera ◽  
...  
Keyword(s):  
Japanese Population ◽  
Clinical Characteristics ◽  
Spontaneous Recovery ◽  
Clinical Course ◽  
Case Reports ◽  
High Strength ◽  
Long Duration ◽  
Control Serum ◽  
The Mean

Abstract Neonate alloimmune neutropenia (NAIN) is caused by the transplacental transfer of maternal alloantibodies directed against antigens on the infant’s neutrophils. To date, there are scant studies about its clinical characteristics and characterization of antineutrophil antibodies though some case reports are found. In this study we analyzed 11 cases with NAIN from January 2005 to December 2007. The diagnosis of NAIN was confirmed by the transient neutropenia less than 500/μl of absolute neutrophil count (ANC), the detection of maternal antineutrophil antibody, the incompatibility of neutrophil antigens between parents, and their mothers without autoimmune diseases. Antineutrophil antibodies were detected by granulocyte indirect immunofluorescence test using flow cytometry. To quantify the strength of the antibodies, the ratio of the mean fluorescence channel of each sample to that of control serum was expressed as relative fluorescence intensity according to the method reported previously (Blood99: 3468, 2002). The median age at diagnosis in NAIN patients was 8 days after birth ranged from 0 to 30 days. The average of ANC at the presentation was 170/μl ranged from 0 to 500/μl. All antineutrophil antibodies detected in sera of both neonates and their mothers were against HNA-1 antigens. The alloantibody against HNA-1a was found in 2 cases, that against HNA-1b was in 6 cases, and that against FcγR IIIb was found in 3 cases. The fact that the frequencies of homozygote of HNA-1a and HNA-1b in Japanese population were approximately 50% and 12%, respectively may reflect the frequency of alloantibody specificity in NAIN. During the neutropenic period, 7 cases with NAIN showed mild to moderate infections associated with neutropenia, such as pyrexia and pyodermia. In contrast, 4 of 11 cases with NAIN did not have any infectious episodes in their clinical course. In all patients, the spontaneous recovery of neutropenia with the disappearance of alloantibody was observed within 6 months (median 85 days ranged from 3 weeks to 6 months). The duration until spontaneous resolution of neutropenia was dependent on the strength of alloantibody found in sera of the mothers and neonates. Two patients with significantly high strength of alloantibodies had the relatively long duration to restore the neutropenia(4 months and 6 months). In conclusion, the specificity of antineutrophil antibodies in patients with alloimmune neutropenia is dependent on the frequencies of neutrophil antigens in Japanese population. The quantification of alloantibodies in neonates and their mothers may be useful in considering the clinical course of neutropenia in neonates.

scholarly journals Study of the efficiency of a peptide-based cosmetic product in topical therapy for diffuse alopecia

2020 ◽  
Vol 23 (3) ◽  
pp. 188-193
Author(s):  
Tatiana N. Korolkova ◽  
E. E. Kharitonova ◽  
I. A. Shepilova ◽  
D. S. Nesterovich
Keyword(s):  
Hair Loss ◽  
Initial Level ◽  
Subjective Evaluation ◽  
Objective Assessment ◽  
Topical Therapy ◽  
Cosmetic Product ◽  
Drug Of Choice ◽  
Anagen Hair ◽  
Group 2 ◽  
Group 1

Background: Hair loss is a significant health problem; hence, individuals experiencing hair loss immediately visit a doctor for treatment. Diffuse (symptomatic) alopecia can be the result of various external and internal factors. A doctor should determine the cause of the hair loss and prescribe treatment, including topical agents. Aim: to study the clinical efficacy of hair spray with peptides in the treatment of patients with diffuse alopecia and its effect on the trichogramma parameters. Materials and methods: Thirty female patients with diffuse alopecia, aged from 18 to 59 years, were monitored in the Center of Medical Cosmetology of the I.I. Mechnikov North-Western State Medical University. In a controlled comparative study, the patients were divided into two equal groups. In group 1 (main), the drug of choice was a spray based on peptides; while in group 2 (comparison), a cosmetic product based on enzymes was applied. The drugs were used topically for 3 months. Patients were examined using questionnaires (objective assessment by the doctor and subjective evaluation by the patient) and photographs and by assessing the morphometric parameters of hair growth before treatment, 3 months after the start of treatment, and 1 month after treatment termination. Results: In group 1, in the parietal zone, the hair density increased significantly by 19% after 3 months and by 23% after 4 months. The number of anagen hair increased by 8% after 3 months and by 16% after 4 months, with a corresponding decrease in the number of telogen hair compared to the initial level. In the occipital zone, the number of anagen hair increased by 7% after 3 months and by 13% after 4 months, with the corresponding dynamics of telogen hair compared to the initial level. The cosmetic product has been shown to be tolerated well, and no allergic reactions were noted. Conclusion: The peptide-based spray can be recommended for patients with diffuse alopecia as a topical therapy.

scholarly journals Changes in the hair growth cycle in women with non-scarring alopecia

2019 ◽  
Vol 94 (5) ◽  
pp. 39-49
Author(s):  
A. A. Kubanov ◽  
Y. A. Gallyamova ◽  
O. A. Korableva
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Hair Loss ◽  
Reference Group ◽  
Growth Cycle ◽  
Punch Biopsy ◽  
Androgenetic Alopecia ◽  
Pharmacological Agents ◽  
Scarring Alopecia ◽  
Cycle Growth

One of the key elements in the pathophysiological process of androgenetic alopecia and telogen hair loss is the change of hair cycle. Growth factors controlling the development and cycle of the hair follicle have thus far been established. However, the role of growth factors in the pathogenesis of alopecia remains to be revealed.Objective.This study was aimed at investigating the expression of the VEGF, KGF, EGF and TGF-01 growth factors in women with androgenetic alopecia and telogen hair loss, as well as their role in the development of alopecia.Materials and methods. 60 female patients diagnosed with telogen hair loss (30 women) and androgenetic alopecia (30 women) were observed. In order to investigate the expression of the VEGF, KGF, EGF and TGF-01 growth factors, we conducted an immunofluorescent analysis of skin samples obtained by punch biopsy (4 mm) from the frontoparietal scalp area of patients with androgenetic alopecia and telogen hair loss. 15 samples obtained from healthy people were used as a reference group.Results.A change in the expression of the VEGF, KGF and TGF-01 growth factors in women with androgenetic alopecia and telogen hair loss was established in comparison with healthy individuals. A correlation was found between the expression of the growth factors under study, age (p ≤ 0.05), as well as the character and duration of the disease (p ≤ 0.05) in women with non-scarring alopecia. The expression of the growth factors is found to be dependent on the clinical form of alopecia (p < 0.001).Conclusion.The VEGF growth factor is established to have the most significant effect on the development of androgenetic alopecia in women, with the KGF, TGF-01 and EGF factors being less significant as the predictors of this disorder. The VEGF growth factor is shown to affect telogen hair loss to a greater extent compared to the EGF factor. Our study confirms differences in the pathogenesis of androgenetic alopecia and telogen hair loss in women. The findings suggest that the VEGF and KGF growth factors, as well as TGF-01 inhibitors may be used as potential pharmacological agents for treating patients suffering from androgenetic alopecia and telogen hair loss.

scholarly journals Pseudopelade of Brock: clinical observation

2020 ◽  
Vol 24 (4) ◽  
pp. 368-372
Author(s):  
S. K. Ryabov ◽  
O. A. Mesnyankina
Keyword(s):  
Histological Examination ◽  
Rare Variant ◽  
Hair Loss ◽  
Clinical Observation ◽  
Detailed Examination ◽  
Close Attention ◽  
Scarring Alopecia ◽  
Skin Biopsies

The article presents clinical observation of a rare variant of scarring alopecia - pseudopelade Brock. The presented case demonstrates the important role of detailed examination and close attention to patients with long-term foci of hair loss in the absence of positive dynamics from the therapy, maintaining clinical alertness and conducting a broad differential diagnostic search to exclude rare dermatoses, and also confirms the need for histological examination of skin biopsies to verify the diagnosis.

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