Entrepreneurial Human Capital and Firm Dynamics

This paper shows that entrepreneurial human capital is a key driver of firm dynamics using administrative panel data on the universe of firms and workers in Portugal. Firms started by more educated entrepreneurs are larger at entry and exhibit higher life cycle growth. Consistent with an effect on growth, the thickness of the right tail of the size distribution increases with entrepreneur schooling. The evidence points to several underlying mechanisms, with technology adoption playing the most important part. I develop and estimate a model of firm dynamics that can parsimoniously account for these findings, and use it to draw aggregate implications. Accounting for the effect of entrepreneurial human capital on firm dynamics can substantially increase aggregate returns to schooling and the fraction of cross-country income differences explained by human and physical capital.

Commercializing-based Rural Poverty Alleviation Model (CBRPA Model) and Internal Cycle Growth

This paper explores and brings forth a persistent resilient self-motivated or self-growth-driven rural poverty alleviation model based on the commercializing-based rural poverty alleviation (CBRPA) model. The CBRPA model encompasses systems or mechanisms of integrated contract farming, regional integrated processing, and agricultural association. Although China has made brilliant achievements in rural poverty alleviation since opening-up in 1978, it still lacks a self-growth-driven rural poverty alleviation system or mechanism. Thus, this paper discusses the rural poverty alleviation achievements and policies of China. It explores various solutions, formulates proper structure, and proposes a CBRPA model. Implementation of the CBRPA model requires the establishment of the agricultural association, integrated contract farming companies (ICFCs), and regional integrated processing companies (RIPCs). The paper also discussed the importance and contribution of rural poverty alleviation to economic growth as well as China’s major economic strategy of double cycle growth. As the CBRPA Model generates a self-growth-driven rural poverty alleviation pattern that is implemented all over the country, it makes an important strategy for internal cycle growth to mutually facilitate external cycle growth.

Studies on natural gas reserves multi-cycle growth law in Sichuan Basin based on multi-peak identification and peak parameter prediction

Research on predicting the growth trend of natural gas reserves will help provide theoretical guidance for natural gas exploration in Sichuan Basin. The growth trend of natural gas reserves in Sichuan Basin is multi-cycle and complex. The multi-cyclic peak is screened by the original multi-cyclic peak judgment standard. Metabolically modified GM(1,3) gray prediction method is used to predict the multi-cycle model parameters. The multi-cycle Hubbert model and Gauss model are used to predict the growth trend of natural gas reserves. The research results show that: (1) The number of cycles of natural gas reserves curve during 1956–2018 is 13. Natural gas reserves will maintain the trend of rapid growth in the short term. (2) Metabolism modified GM(1,3) gray prediction model can improve the accuracy of model prediction. The prediction accuracy of Hubbert model is higher than that of Gauss model. By 2030, the cumulative proven level of natural gas will reach 52.34%. The Sichuan Basin will reach its peak of proven lifetime reserves in the next few years.

Ultraviolet Transparency of Plastic Films Determines the Quality of Lettuce (Lactuca sativa L.) Grown in a Greenhouse

The quality of red lettuce is based on the content of anthocyanin pigments, and the content of these pigments increases when the plant receives ultraviolet radiation. Lettuce crops are increasingly being grown in greenhouses to provide better quality fresh lettuce; however, both quality and productivity are affected by the type of cover used. The effects of UV-transparent and UV-blocking plastic films on the growth and quality of three lettuce cultivars (‘Casabella’ and ‘Vera’, which are both green leaf, and ‘Lollo Rosso’, which is red leaf) were investigated. The crop was cultivated at an altitude of 2576 m a.s.l. to naturally expose it to high ultraviolet radiation. The height and diameter of plants, fresh and dry weight, leaf area index, chlorophyll fluorescence, and leaf colour were determined throughout the crop cycle. Growth characteristics were not significantly influenced by the plastic film in all cultivars, probably due to the high altitude and the high solar radiation received. The UV-transparent film could increase the red colour in ‘Lollo Rosso’, and a higher commercial quality was achieved. No effect of the plastic film on the yield component was observed in the ‘Casabella’ and ‘Vera’ cultivars. The findings of this study provide guidance on what cultivar and plastic film must be used in high-altitude areas where the solar and UV radiation is high.

Long non-coding RNAs bind to proteins relevant to the ethanol tolerance in yeast: a systems biology view

The ethanol disturbs the cell cycle, transcription, translation, protein folding, cell wall, membranes, and many Saccharomyces cerevisiae metabolic processes. Long non-coding RNAs (lncRNAs) are regulatory molecules binding onto the genome or proteins. The number of lncRNAs described for yeast is still scarce, and little is known concerning their roles in the system. There is a lack of knowledge concerning how lncRNAs are responsive to the ethanol tolerance in yeast and whether they act in this tolerance. Hence, by using RNA-Seq data from S. cerevisiae strains with different ethanol tolerance phenotypes, we found the severe ethanol responsive lncRNAs. We modeled how they participate in the ethanol tolerance by analyzing lncRNA-protein interactions. The results showed that the EtOH tolerance responsive lncRNAs, in both higher tolerant and lower tolerant phenotypes, work on different pathways: cell wall, cell cycle, growth, longevity, cell surveillance, ribosome biogenesis, intracellular transport, trehalose metabolism, transcription, and nutrient shifts. In summary, lncRNAs seems to interconnect essential systems’ modules to overcome the ethanol stress. Finally, here we also found the most extensive catalog of lncRNAs in yeast.

Antitumor Effect of 5-Fluorouracil-Loaded Liposomes Containing n-3 Polyunsaturated Fatty Acids in Two Different Colorectal Cancer Cell Lines

It has been shown that long-chain n-3 polyunsaturated fatty acids (n-3 PUFAs) could act synergistically with 5-fluorouracil (5-FU) to kill cancer cells. To facilitate their simultaneous transport in the bloodstream, we synthesized, for the first time, liposomes (LIPUFU) containing 5-FU in the aqueous core and docosahexaenoic acid (DHA)/eicosapentaenoic acid (EPA) at a ratio of 1:2 in the lipid bilayer. LIPUFU werestable with uniform size of 154 ± 4 nm, PDI of 0.19 ± 0.03 and zeta potential of -41 ± 2 mV. They contained 557 ± 210 μmol/l DHA, 1467 ± 362 μmol/l EPA, and 9.8 ± 1.1 μmol/l 5-FU. Control liposomes without (LIP) or with only 5-FU (LIFU) or n-3 PUFAs (LIPU) were produced in a similar way. The effects of these different liposomal formulations on the cell cycle, growth, and apoptosis were evaluated in two human colorectal cancer (CRC) cell lines differing in sensitivity to 5-FU, using fluorescence-activated cell sorting analyses. LIPUFU were more cytotoxic than LIP, LIFU, and LIPU in both LS174T (p53+/+, bax−/−) and HT-29 (p53−/0, bax+/+) cell lines. Similar to LIFU, LIPUFU increased the percentage of cells in S phase, apoptosis, and/or necrosis. The cytotoxic potential of LIPUFU was confirmed in vivo by tumor growth inhibition in the chicken chorioallantoic membrane model. These results suggest that LIPUFU could be considered to facilitate the simultaneous transport of 5-FU and n-3 PUFAs to the tumor site, in particular in case of CRC liver metastases.

Transcriptional regulation of structural and functional adaptations in a developing adulthood myocardium

The development of the heart follows a synergic action of several signaling pathways during gestational, pre- & postnatal stages. The current study aimed to investigate whether the myocardium experiences transcriptional changes during the transition from post-natal to adult hood stages. Herein, we used C57/Bl6/J mice at 4 (28-days; post-natal/PN) and 20 weeks (adulthood/AH) of ages and employed the next generation RNAseq (NGS) to profile the transcriptome and echocardiography analysis to monitor the structural/functional changes in the heart. NGS-based RNA-seq revealed that 1215 genes were significantly upregulated and 2549 were down regulated in the AH versus PN hearts, indicating a significant transcriptional change during this transition. A synchronized cardiac transcriptional regulation through cell cycle, growth hormones, redox homeostasis and metabolic pathways was noticed in both PN and AH hearts. Echocardiography reveals significant structural and functional (i.e. systolic/diastolic) changes during the transition of PN to adult stage. Particularly, a progressive decline in ejection fraction (EF) and cardiac output was observed in AH hearts. These structural adaptations are in line with critical signaling pathways that drive the maturation of heart during AH. Overall, we have presented a comprehensive transcriptomic analysis along with structural-functional relationship during the myocardial development in adult mice.

Weeds Associated with Banana Crops in Magdalena Department, Colombia

ABSTRACT: This study was conducted to determine the richness and composition of weed communities associated with banana plantations in Magdalena department, Colombia. Between September 2016 and May 2017, a total of 164 hectares were assessed over four agroecological zones (Alta, Media, Baja and Norte); in each zone, three representative farms were selected where, through zigzag paths, botanical collections were made in cultivated lots. Information on life cycle, growth habit and origin of each species was included. The floristic composition was represented by 204 species distributed among 143 genera and 54 families. Poaceae, with 31 species, was the family with the highest species richness, followed by Fabaceae (12) and Asteraceae (11). From the total species recorded, 113 are perennial (55%) and 91 are annual (45%); 141 species are herbaceous (68%), 38 are climbers (20%), and 25 are arboreal or shrubby (12%). Native species predominate over introduced species. The species richness does not differ significantly between the sampling zones, but the weed community composition does. The presence of common species reported as important weeds worldwide was recorded in the four zones. However, some species were recorded in only one of the zones, generating a differential composition pattern. Comparison with local inventories showed changes in the composition of the weed complex over time. The presence of various species not previously considered weeds in the banana crops of this region is highlighted.