scholarly journals Study of the efficiency of a peptide-based cosmetic product in topical therapy for diffuse alopecia

2020 ◽  
Vol 23 (3) ◽  
pp. 188-193
Author(s):  
Tatiana N. Korolkova ◽  
E. E. Kharitonova ◽  
I. A. Shepilova ◽  
D. S. Nesterovich
Keyword(s):  
Hair Loss ◽  
Initial Level ◽  
Subjective Evaluation ◽  
Objective Assessment ◽  
Topical Therapy ◽  
Cosmetic Product ◽  
Drug Of Choice ◽  
Anagen Hair ◽  
Group 2 ◽  
Group 1

Background: Hair loss is a significant health problem; hence, individuals experiencing hair loss immediately visit a doctor for treatment. Diffuse (symptomatic) alopecia can be the result of various external and internal factors. A doctor should determine the cause of the hair loss and prescribe treatment, including topical agents. Aim: to study the clinical efficacy of hair spray with peptides in the treatment of patients with diffuse alopecia and its effect on the trichogramma parameters. Materials and methods: Thirty female patients with diffuse alopecia, aged from 18 to 59 years, were monitored in the Center of Medical Cosmetology of the I.I. Mechnikov North-Western State Medical University. In a controlled comparative study, the patients were divided into two equal groups. In group 1 (main), the drug of choice was a spray based on peptides; while in group 2 (comparison), a cosmetic product based on enzymes was applied. The drugs were used topically for 3 months. Patients were examined using questionnaires (objective assessment by the doctor and subjective evaluation by the patient) and photographs and by assessing the morphometric parameters of hair growth before treatment, 3 months after the start of treatment, and 1 month after treatment termination. Results: In group 1, in the parietal zone, the hair density increased significantly by 19% after 3 months and by 23% after 4 months. The number of anagen hair increased by 8% after 3 months and by 16% after 4 months, with a corresponding decrease in the number of telogen hair compared to the initial level. In the occipital zone, the number of anagen hair increased by 7% after 3 months and by 13% after 4 months, with the corresponding dynamics of telogen hair compared to the initial level. The cosmetic product has been shown to be tolerated well, and no allergic reactions were noted. Conclusion: The peptide-based spray can be recommended for patients with diffuse alopecia as a topical therapy.

scholarly journals Objective assessment of stiffness in Achilles tendinopathy: a novel approach using the MyotonPRO

2018 ◽  
Vol 4 (1) ◽  
pp. e000446 ◽  
Author(s):  
Gafin Ericson Morgan ◽  
Rhodri Martin ◽  
Lisa Williams ◽  
Owen Pearce ◽  
Keith Morris
Keyword(s):  
Dynamic Stiffness ◽  
Objective Assessment ◽  
Weight Bearing ◽  
Achilles Tendinopathy ◽  
Control Group ◽  
Asymptomatic Group ◽  
Musculotendinous Junction ◽  
Significant Difference ◽  
Group 2 ◽  
Group 1

ObjectivesThe aim of this study was to establish quantitative values for asymptomatic and symptomatic Achilles tendons.DesignCohort study with a single (cross-sectional) time point of patients diagnosed with unilateral Achilles tendinopathy and an asymptomatic group with comparative homogeneity.MethodsA sample of 50 participants: 25 diagnosed with symptomatic unilateral Achilles tendinopathy (AT group) and 25 with asymptomatic Achilles tendons (control group 2). The asymptomatic side of the AT group was used as a control (control group 1). Measurements at 2 cm intervals on the tendon from its insertion at the calcaneum up to the musculotendinous junction were taken non-weight bearing (NWB) and weight bearing (WB) using the MyotonPRO.ResultsThere was a significant (p<0.005) decrease in natural oscillation frequency (F) at points 2, 3 and 4 of the AT group (NWB condition) and points 2 and 3 for the WB condition. There was a significant (p<0.005) increase in logarithmic decrement (D) at points 2 and 3 signifying a decrease in elasticity. Dynamic stiffness (S) was significantly (p<0.005) reduced in the AT group at points 2 and 3 WB and point 3 WB. There was no significant difference in creep (C) observed between the symptomatic and asymptomatic tendons. There was a significant (p<0.005) increase in mechanical stress relaxation time (R) at point 2 NWB.There was a correlation between body weight and gender on tendon mechanics, with the symptomatic tendons. No significant differences were observed between the control group 1 and control group 2.ConclusionsThe MyotonPRO measured decreased stiffness over a section of the tendon corresponding clinically with Achilles tendinopathy. This may have potential in identifying risk of injury and informing rehabilitation, however further extensive research is required to generate baseline data for specific population groups monitoring variables over time. Age, gender and body mass index appear to have some bearing on the mechanical properties of the tendon but mainly in the tendinopathy group.

scholarly journals Pengaruh Penggunaan Buah Alpukat dan Virgin Coconut Oil (VCO) Terhadap Perawatan Rambut Rontok

2020 ◽  
Vol 11 (02) ◽  
pp. 74
Author(s):  
Syannaz Rizka Usman ◽  
Yuliana Yuliana
Keyword(s):  
Hair Loss ◽  
Coconut Oil ◽  
Primary Data ◽  
Control Group ◽  
Research Subjects ◽  
Significant Difference ◽  
Group 3 ◽  
Group 2 ◽  
Experimental Group ◽  
Group 1

Excessive hair loss will cause baldness. It can will influence someone’s confidence. that is why, hair loss treatment is needed to be done. One of them is by using avocados and VCO. They have good function to stimulate hair growth and make them healthier. This study aims to analyze the effect of avocados and VCO toward hair loss treatment. The research was done by observing the mount of hair loss everyday. this study was conducted with a quasi-experimental method with a quasi exsperiment to explain the influence of using avocados and VCO on the treatment of hair loss. The research subjects were a collection of women who lived in the Parak Laweh area of ​​Lubuk Begalung subdistrict which improved hair loss at the level of 40-100 strands per day. The sample in this study amounted to 12 people used by the technique of taking documentation and interviews. This study consisted of 4 different groups, namely the control group (X0), experimental group 1 (X1), experimental group 2 (X2), and experimental group 3 (X3).The data gathered is primary data. It is directly taken from samples that fill in the research format provided. Data analysis using analysis of variance (anava) and continued with Duncan test, the results of this study show a significant difference in the indicator of the amount of hair detached from the scalp with the number of strands of hair falling after treatment in the control group (X0) (80.50), experimental group 1 (X1) (60.50), experimental group 2 (X2) (58.83) and experimental group 3 (X3) (58.67). So it can be said that for the indicator of the amount of hair loss in the experimental group did not show a statistically significant difference, but there was a significant difference in the treatment of hair loss in the control group. Keywords: hair loss, avocados, VCO

scholarly journals EVALUATING THE BODY RESPONSE TO A 15-MINUTE WORKOUT PROPOSED AS AN ALTERNATIVE TO GYM TRAINING DURING LOCKDOWN CAUSED BY THE COVID-19 PANDEMIC

2021 ◽  
pp. 80-85
Author(s):  
Dariusz Boguszewsk ◽  
Agata Szymańska ◽  
Justyna Wielgosz ◽  
Aleksandra Hanc ◽  
Jakub Grzegorz Adamczyk ◽  
...  
Keyword(s):  
Subjective Evaluation ◽  
Interval Training ◽  
The Body ◽  
Abdominal Muscles ◽  
High Intensity Interval Training ◽  
Physically Active ◽  
Muscle Groups ◽  
Group 2 ◽  
High Intensity Interval ◽  
Group 1

The aim of the work was to study the body reaction to high intensity interval training. The study included 92 women aged 18 to -35. People who have been engaged in organised, regular physical activity (at least twice a week) were qualified to Group 1. Group 2 were physically inactive persons. All subjects performed interval training in the Tabata formula - two 4-minute sequences. The exercise carried out in the first part is elevating the legs from the “plank” position, in the second part, the hands were elevated from the same position. The pulse rate, the Borg Scale and the VAS pain rate scale (24, 48, 72 and 96 h after exercise) were used to assess the exercise intensity. The respondents from both groups performed the training at a similar intensity: the average heart rate after workout was 131 beats per minute. The highest pain of all muscle groups (when added together) was recorded 24 hours after training. The highest pain intensity during the four days after the training concerned the back and abdominal muscles in Group 1 and the muscles of the abdomen, back and arms (front and back). The intensity of abdominal and arm muscle pain (front) was significantly higher in Group 2. The proposed 15-minute workout planned in the form of Tabata evoked similar cardiovascular reactions in both groups and a similar subjective evaluation of intensity. Individuals who were physically active before the introduction of restrictions related to the COVID-19 pandemic had less pain in the muscular system after the applied training.

Assessment of the effectiveness of physiotherapeutic methods for management of early menopause disorders

2020 ◽  
Vol 19 (4) ◽  
pp. 58-62
Author(s):  
N.V. Kotenko ◽  
◽  
G.N. Barashkov ◽  
G.E. Salamadina ◽  
О.О. Borisevich ◽  
...  
Keyword(s):  
Objective Assessment ◽  
Early Menopause ◽  
Complex Composition ◽  
Flux Motion ◽  
Menopause Transition ◽  
Adaptogenic Effect ◽  
Group 2 ◽  
Microcirculation Parameter ◽  
Group 1 ◽  
Full Body

Objective. Assessment of the effectiveness of pelotherapy in combination with phytoaromatic baths in women during menopause transition. Patients and methods. We examined 26 women aged 52 ± 2.4 years. All women with vegetative-vascular manifestations of the climacteric syndrome were randomly assigned to 2 groups for comparison: group 1 – 12 patients, who received full-body “rapa” baths, inhalation phytoaromatherapy with a complex composition including phytoestrogens; group 2 – 14 patients, who received pelotherapy with applications of Saki lake mud on the «panty» zone and hydrodynamic phytoaromatic baths with a complex composition including phytoestrogens. Results. After therapy, a significant improvement of the parameters of climacteric disorders was noted in group 2. Severe disorders were practically absent in the second group – 2% (65 ± 6.1 scores), whereas mild changes prevailed – 64% (18 ± 5.3 scores). Changes in the microcirculation parameter were found, which increased by 19%, an increased contribution of endothelial oscillations to the total flux motion level, an increase of the amplitude of neurogenic and myogenic oscillations, a decrease of respiratory rates on average from 9.2 to 5.51 perf. units. In the first group, no significant changes were recorded. Conclusion. The use of pelotherapy in combination with hydrodynamic phytoaromatic baths permits to improve the parameters of microcirculation, venous and lymph output, trophism and oxygenation of tissues, and also ensures an adaptogenic effect. Key words: balneothaerpy, menopause transition, pelotherapy, rehabilitation

The significance of ultrasound biomicroscopy in the objective assessment of post-trabeculectomy bleb success

2021 ◽  
pp. 112067212199058
Author(s):  
Bediz Özen ◽  
Berna Yüce ◽  
Hakan Öztürk
Keyword(s):  
Risk Factors ◽  
Intraocular Pressure ◽  
Drug Use ◽  
Clinical Characteristics ◽  
Objective Assessment ◽  
Ultrasound Biomicroscopy ◽  
Potential Risk Factors ◽  
Group 2 ◽  
Antiglaucoma Drug ◽  
Group 1

Purpose: To compare clinical characteristics and ultrasound biomicroscopy (UBM) measurements of cases with functional and non-functional blebs, and to identify potential risk factors capable of affecting UBM parameters. Methods: Thirty-one patients aged 40–79 were included. Following trabeculectomy, cases were divided into two groups as those with functional bleb (Group 1, n = 20) and those with non-functional bleb (Group 2, n = 11). UBM was performed. Results: In Group 1 compared to Group 2, lower postoperative intraocular pressure (IOP) (12.1 ± 1.7 vs 27.2 ± 3.2 mmHg, p < 0.001), greater bleb height (1.0 ± 0.2 vs 0.5 ± 0.3 mm, p < 0.001), greater scleral route visibility [16/20 (80%) vs 4/11 (36.4%), p = 0.023] and lower bleb reflectivity (1.8 ± 0.2 vs 2.4 ± 0.4, p = 0.015) were observed. In Group 1, as postoperative IOP decreased, bleb height and scleral route visibility increased ( r = −0.387, p = 0.029 for bleb height; r = −0.374, p = 0.033 for scleral route), and bleb reflectivity decreased ( r = 0.359, p = 0.042). In Group 1, as duration of preoperative antiglaucoma drug use increased, bleb reflectivity increased ( r = 0.348, p = 0.046). Preoperative IOP and number of preoperative antiglaucoma drug use had no effect on UBM parameters in groups ( p > 0.05). Conclusion: UBM is useful in assessing bleb success. Lower bleb reflectivity, greater bleb height and greater scleral route visibility indicate that the bleb is functional. To the best of our knowledge, this is the first study investigating effects of preoperative IOP, number and duration of preoperative antiglaucoma drug use on UBM parameters. In cases with functional bleb, duration of preoperative drug use affects only bleb reflectivity, while postoperative IOP affects bleb height, scleral route visibility and bleb reflectivity.

scholarly journals Characteristics of the emissive prosody of children with autism spectrum disorder

Revista CEFAC ◽  
2018 ◽  
Vol 20 (5) ◽  
pp. 565-572
Author(s):  
Patrícia Aparecida Zuanetti ◽  
Kelly da Silva ◽  
Ângela Cristina Pontes-Fernandes ◽  
Rodrigo Dornelas ◽  
Marisa Tomoe Hebihara Fukuda
Keyword(s):  
Autism Spectrum Disorder ◽  
Subjective Evaluation ◽  
Video Recording ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Stressed Syllable ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

ABSTRACT Objective: to analyze the prosodic aspects of speech in children with Autism Spectrum Disorder. Methods: 21 children aged 3 to 6 years participated and were divided into three groups: Group 1 - children with Autism Spectrum Disorder; Group 2 - children with language delay; Group 3 - children with typical language development. Three judges performed a subjective evaluation of the emissive prosody (characterization of pitch, loudness, sentence stress, stressed syllable and others) of the children during interaction time (video recording and use of specific protocols). The equality of proportions test was applied for group comparison (α=0.01). Results: the prevalence of a history of delay for speaking the first words was high in Groups 1 and 2. Regarding the prosodic characteristics, all Group 1 children had difficulties in the use of the stressed syllable, and some in the accentuation of the sentence. On the other hand, no Group 3 children showed these changes and few Group 2 children presented excessively stressed syllable. Conclusion: inappropriate stressing of words seems to be one of the features in the differential diagnosis of verbal children with Autism Spectrum Disorder.

scholarly journals The relationship between digital ultrasonographic image echotexture parameters of the uterus and preovulatory follicle development and ovulation in purebred Arabian mares

2021 ◽  
Vol 91 (3) ◽  
pp. 261-268
Author(s):  
Ömer Korkmaz ◽  
◽  
Tuğra Akkuş ◽  
Birten Emre ◽  
Abuzer K. Zonturlu
Keyword(s):  
Ovarian Follicle ◽  
Objective Assessment ◽  
Computer Assisted ◽  
Follicle Development ◽  
Preovulatory Follicle ◽  
Significant Difference ◽  
The Difference ◽  
Group 2 ◽  
The Relationship ◽  
Group 1

Objective assessment of ultrasonographic images is only possible using computer-assisted echotexture analysis. This study investigated the relationship between cyclic digital echotexture analysis of ultrasonographic uterine images, and preovulatory follicle development and ovulation in 48 cyclic purebred Arabian mares during the breeding season. When the mares’ ovarian follicle diameters exceeded 30 mm, ultrasonographic examinations were performed and ultrasonographic images recorded with uterine endometrial edema degrees following follicle development until ovulation day. Echotexture measurements, including mean grayness value (MGV), heterogeneity (HET) and contrast (CON) parameters, were performed on the days when ovarian follicle diameters reached 30 mm (Group 1, n = 12), 35 mm (Group 2, n = 12), 40 mm (Group 3, n = 12) and 45 mm (Group 4, n = 12) in images recorded the day before ovulation and on the day of ovulation. MGV was the lowest in Group 2 and the difference from the other groups was statistically significant (P<0.001). CON was significantly higher in Group 2 than Groups 3 and 4 (P<0.01). However, there was no significant difference compared to Group 1 (P>0.05). Variations in HOM (P<0.05), contrast (P<0.05) and MGV (P<0.01) were statistically significant on the day before ovulation and ovulation day. Thus, uterine ultrasonographic echotexture parameters are associated with preovulatory follicle development in mares, which suggests that these parameters can indicate the day of ovulation in purebred Arabian mares.

scholarly journals Surgical Treatment of Idiopathic Macular Hole Using Different Types of Tamponades and Different Postoperative Positioning Regimens

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
M. Veith ◽  
J. Vránová ◽  
J. Němčanský ◽  
J. Studnička ◽  
M. Penčák ◽  
...  
Keyword(s):  
Macular Hole ◽  
Prone Position ◽  
Subjective Evaluation ◽  
Idiopathic Macular Hole ◽  
Ilm Peeling ◽  
Intraocular Tamponade ◽  
Different Types ◽  
Air Tamponade ◽  
Group 2 ◽  
Group 1

Purpose. To compare the effect of different types of intraocular tamponade and different types of postoperative positioning on the closure of idiopathic macular hole (IMH). Methods. Prospective randomized clinical trial enrolling 104 eyes of 100 patients (age, 57–87 years) undergoing MH surgery. All patients were operated on by an experienced surgeon using 25-gauge pars plana vitrectomy (PPV) and internal limiting membrane (ILM) peeling. Patients were randomized according to the type of intraocular tamponade and postoperative positioning into the following four groups: SF6 + nonsupine reading position (n = 26) (group 1), air + nonsupine reading position (n = 25) (group 2), air + prone position (n = 26) (group 3), or SF6 + prone position (n = 27) (group 4). The follow-up period was 6 months. Results. MH closure was achieved in 87 eyes (83.7 %) in the overall sample after the first surgery, with closure rates of 100%, 56%, 84.6%, and 92.6% in groups 1, 2, 3, and 4, respectively. The group 2 was significantly less successful compared to the other three groups ( p  < 0.05). MH of sizes ≤400 µm was closed in 97.2% of cases after the first surgery, with no significant differences between groups ( p  = 0.219). MH with sizes over 400 µm was closed in 70.9% of cases after the first surgery, with both groups with air tamponade being significantly less successful than group 1. The nonsupine reading position was subjected to a better subjective evaluation in terms of postoperative comfort and quality of sleep, with no differences between air and SF6 tamponade tolerance. Conclusion. PPV with ILM peeling, intraocular tamponade, and positioning remains the basic surgical approach in the treatment of IMH. For MH ≤ 400 µm, a high closure rate can be achieved by combining air tamponade and nonsupine reading position. For macular holes >400 µm, the greatest anatomical success can be achieved by using the SF6 tamponade in combination with the nonsupine reading position.

scholarly journals Effects of Citicoline, Homotaurine, and Vitamin E on Contrast Sensitivity and Visual-Related Quality of Life in Patients with Primary Open-Angle Glaucoma: A Preliminary Study

Molecules ◽  
2020 ◽  
Vol 25 (23) ◽  
pp. 5614
Author(s):  
Pier Marino ◽  
Gemma Rossi ◽  
Giuseppe Campagna ◽  
Decio Capobianco ◽  
Ciro Costagliola ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Vitamin E ◽  
Contrast Sensitivity ◽  
Fixed Combination ◽  
Open Angle Glaucoma ◽  
Topical Therapy ◽  
Related Quality ◽  
Group 2 ◽  
Group 1

The aim of the present study was to evaluate the effects of supplementation with a fixed combination of citicoline 500 mg, homotaurine 50 mg, and vitamin E 12 mg (CIT/HOMO/VITE) on contrast sensitivity and visual-related quality of life in patients with primary open-angle glaucoma (POAG) in mild stage. This was a multicenter, observational, cross-over, short-term, pilot study on POAG patients with stable controlled intraocular pressure (IOP). Patients were randomly assigned to Group 1 (current topical therapy for 4 months and then current topical therapy plus CIT/HOMO/VITE for 4 months) or Group 2 (CIT/HOMO/VITE in addition to current topical therapy for 4 months and then topical therapy alone for 4 months). Best-corrected visual acuity, IOP, visual field, and the Spaeth/Richman contrast sensitivity (SPARCS) test score were recorded at baseline and after 4 and 8 months. The Glaucoma Quality of Life-15 (GQL-15) questionnaire was administered at each check time. Forty-four patients were assigned to Group 1 and 65 to Group 2. Over the follow-up period, there were no significant changes in IOP or visual field findings, whereas SPARCS and GQL-15 findings significantly varied from baseline, both being improved in subjects treated with CIT/HOMO/VITE fixed combination. These results demonstrate that a daily intake of a fixed combination of citicoline, homotaurine, and vitamin E in addition to the topical medical treatment significantly increased the total score of the contrast sensitivity test and the quality of life in patients with POAG.

scholarly journals The effectiveness of the combined use of fractional microneedle rf-therapy and pharmacophoresis of hyaluronic acid in the treatment of patients with atrophic scars

2020 ◽  
Vol 19 (1) ◽  
pp. 32-39
Author(s):  
A. M. Talybova ◽  
A. G. Stenko ◽  
L. S. Kruglova
Keyword(s):  
Hyaluronic Acid ◽  
Topical Therapy ◽  
Scar Tissue ◽  
Skin Defect ◽  
Combined Use ◽  
Radiofrequency Therapy ◽  
Injection Methods ◽  
Atrophic Scars ◽  
Group 2 ◽  
Group 1

Background. The formation of scar tissue is a fairly physiological process, in most cases aimed at closing the skin defect in order to preserve the bodys homeostasis. Correction methods for atrophic scars include laser technology, radiofrequency therapy, injection methods and topical therapy. Arm: the formation of scar tissue is a fairly physiological process, in most cases aimed at closing the skin defect in order to preserve the bodys homeostasis. Correction methods for atrophic scars include laser technology, radiofrequency therapy, injection methods and topical therapy. Methods. There were 56 patients with atrophic scar. Depending on the therapeutic complex for the correction of аtrophic scar, 3 groups were formed: group 1 ― the combined use of RF-therapy for the pharmacophoresis of hyaluronic acid, group 2 ― radio frequency microneedle therapy, group 3 ― the pharmacophoresis of hyaluronic acid. In the work, the Dermatological Symptom Scale Index (DSSI), which was assessed before and after treatment, was adapted to evaluate clinical symptoms. Results. In accordance with the total value of the DSSI, a more significant dynamics was observed in group 1, regardless of the type of AR (subgroups 1A and 1B). DSSI in the 1A subgroup decreased by 80.8% (p0.01), in the 1B group by 82.4% (p0.01). DSSI in the 2A subgroup decreased by 32.3% (p0.01), in the 2B group by 61.4% (p0.01). DSSI in the 3A subgroup decreased by 62.3% (p0.01), in the 3B group by 33.7% (p0.01). In group 1, where the combined treatment was carried out, a more pronounced efficacy was noted than when applying the components of the technique, which did not depend on the type of cicatricial deformity. In group 2, after the application of RF-therapy, the effectiveness was expressed to a much lesser extent, and the most significant results were obtained in patients with post-traumatic atrophic scars. In group 3, after a course of pharmacophoresis of a hyaluronic acid preparation, positive dynamics was observed to a greater extent with hormone-dependent scars. Conclusions. The results of the study showed that the most effective method is the combined use of RF-therapy and the pharmacology of hyaluronic acid, at the same time with post-inflammatory (post-traumatic) atrophic scars, monotherapy with the use of radiofrequency microneedles is possible, with hormone-dependent atrophic scars, monotherapy of pharmacophoresis of hyaluronic acid is possible.

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