Survival Analysis of Geriatric Patients with Low Digestive Hemorrhage Attending an Emergency Department

Gerontology ◽  
2021 ◽  
pp. 1-6
Author(s):  
Ana Fernandez-Suárez ◽  
Oriol Yuguero Torres
Keyword(s):  
Emergency Department ◽  
Survival Analysis ◽  
Retrospective Study ◽  
Survival Rate ◽  
Life Expectancy ◽  
Antiplatelet Therapy ◽  
Geriatric Patients ◽  
Digestive Hemorrhage ◽  
Kaplan Meier ◽  
Number Of Individuals

<b><i>Background:</i></b> The increase in life expectancy and low mortality have doubled the number of individuals older than 65 in the last 30 years. <b><i>Methods:</i></b> We conducted a retrospective study of 101 patients older than 80 years of age treated by low digestive hemorrhage (LDH) in an emergency department during 2018. Sociodemographic variables were evaluated, as well as comorbidity and survival at 18 months. Survival was assessed by a Kaplan-Meier test. <b><i>Results:</i></b> 52.5% of the subjects were women. The average comorbidity of the sample was 1.97. The survival rate per year was 60%. The finding on colonoscopy shows no association with mortality. However, those patients on anticoagulant/antiplatelet therapy have a higher survival rate. <b><i>Conclusion:</i></b> Survival per year is high, so urgent colonoscopy for an LDH should be performed after evaluating the patient’s stability and functional status in a scheduled and outpatient manner.

scholarly journals Mean platelet volume and platelet distribution width serve as prognostic biomarkers in skull base chordoma: a retrospective study

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Mingxuan Li ◽  
Jiwei Bai ◽  
Shuai Wang ◽  
Yixuan Zhai ◽  
Shuheng Zhang ◽  
...  
Keyword(s):  
Overall Survival ◽  
Survival Analysis ◽  
Retrospective Study ◽  
Skull Base ◽  
Mean Platelet Volume ◽  
Platelet Distribution Width ◽  
Platelet Volume ◽  
Distribution Width ◽  
Kaplan Meier ◽  
Skull Base Chordoma

Abstract Background Increasing studies have demonstrated that activated platelets play an essential role in tumour progression. However, the level and prognostic role of platelet indices in chordoma patients remain unclear. The aim of the current study was to characterize the prognostic performance of platelet count (PLT), mean platelet volume (MPV) and platelet distribution width (PDW) in skull base chordoma patients. Methods 187 primary skull base chordoma patients between January 2008 and September 2014 were enrolled in this retrospective study. The optimal cut-off values were determined by X-tile software, and the correlations between PLT, MPV, PDW and clinicopathological features were further analysed. Kaplan-Meier curve and Cox regression analysis were used for survival analysis. Results The values of preoperative PTL, MPV and PDW ranged from 104 to 501 × 109/L, 6.7 to 14.2 fl, and 7.8 to 26.2%, respectively. Elevated PLT was associated with larger tumour volume (p = 0.002). Kaplan-Meier survival analysis revealed that increased MPV and PDW were associated with shorter overall survival (p = 0.022 and 0.008, respectively). Importantly, multivariate Cox analysis demonstrated that elevated PDW was an independent unfavourable predictive factor for overall survival (hazard ratio (HR), 2.154, 95% confidence interval (CI), 1.258–3.688, p = 0.005). Conclusions Our data show that elevated MPV and PDW are associated with poor outcomes in skull base chordoma and that PDW may be helpful to identify patients with high risk.

scholarly journals Análise de sobrevida de mulheres com câncer de mama

2018 ◽  
Vol 12 (1) ◽  
pp. 59
Author(s):  
Jenika Ferreira Dias ◽  
Natália Silva Martins ◽  
Clícia Valim Côrtes Gradim
Keyword(s):  
Breast Cancer ◽  
Survival Analysis ◽  
Survival Rate ◽  
Cáncer De Mama ◽  
Exact Test ◽  
Screening Programs ◽  
Kaplan Meier ◽  
Las Mujeres ◽  
Quantitative Descriptive ◽  
Project Data

RESUMOObjetivo: avaliar a sobrevida, em cinco anos, de mulheres com câncer de mama. Método: estudo quantitativo, descritivo, exploratório, documental, constituído de 62 prontuários de mulheres atendidas em um Projeto de Extensão. Os dados foram analisados pelo Teste Exato de Fisher, Curva de Kaplan Meier e software R. Resultados: 61,29% (n=38) tiveram câncer de mama com idade entre 50-69 anos; 35,49% (n=22) foram acometidas por metástase; 37,1% (n=23) delas morreram, sendo que a maior causa foi o câncer de mama 87% (n=54). A sobrevida foi de 80%, com tempo médio de 11,27 anos. As mulheres que tiveram metástase possuíam 3,67 mais chances de morrer (p=0,00658), por isso, elas tiveram uma sobrevida menor (p= 00171). Conclusão: a incidência do câncer de mama foi maior em pacientes com faixa etária de 50-69 anos, o que está em acordo com a cobertura de programas de rastreamento preconizados pelo Ministério da Saúde. Descritores: Neoplasias da Mama; Análise de Sobrevida; Enfermagem Oncológica.  ABSTRACTObjective: to evaluate the survival, in five years, of women with breast cancer. Method: quantitative, descriptive, exploratory, documental study, consisting of 62 charts of women attended in an Extension Project. Data were analyzed by Fisher's Exact Test, Kaplan Meier Curve and software R. Results: 61.29% (n = 38) had breast cancer aged 50-69 years; 35.49% (n = 22) were metastasized; 37.1% (n = 23) of them died, and the greatest cause was 87% breast cancer (n = 54). The survival rate was 80%, with an average time of 11.27 years. Women who had metastases had 3.67 more chances of dying (p = 0.00658), therefore, they had a shorter survival (p = 00171). Conclusion: the incidence of breast cancer was higher in patients aged 50-69 years, which is in agreement with the coverage of screening programs recommended by the Ministry of Health. Descriptors: Breast neoplasms; Survival analysis; Oncology Nursing.RESUMENObjetivo: evaluar la supervivencia, en cinco años, de mujeres con cáncer de mama. Método: estudio cuantitativo, descriptivo, exploratorio, documental, constituido de 62 prontuarios de mujeres atendidas en un Proyecto de Extensión. Los datos fueron analizados por la Prueba Exacta de Fisher, Curva de Kaplan Meier y software R. Resultados: 61.29% (n = 38) tuvieron cáncer de mama con edad de 50-69 años; El 35.49% (n = 22) fueron acometidas por metástasis; 37.1% (n = 23) de ellas murieron, siendo que la mayor causa fue el cáncer de mama 87% (n = 54). La sobrevida fue del 80%, con tiempo promedio de 11.27 años. Las mujeres que tuvieron metástasis tenían 3.67 más veces de morir (p = 0.00658), por lo, que tuvieron una supervivencia menor (p = 00171). Conclusión: la incidencia del cáncer de mama fue mayor en pacientes con edades de 50-69 años, lo que está en acuerdo con la cobertura de programas de rastreo preconizados por el Ministerio de Salud. Descriptores: Neoplasias de la Mama; Análisis de la Supervivência; Enferméria Oncológica.

scholarly journals Prognostic Significance of ALDH1, Bmi1, and OCT4 Expression in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma

2020 ◽  
Vol 27 (1) ◽  
pp. 107327482090495
Author(s):  
Roopa S. Rao ◽  
Lizbeth Raju K ◽  
Dominic Augustine ◽  
Shankargouda Patil
Keyword(s):  
Squamous Cell Carcinoma ◽  
Survival Analysis ◽  
Survival Rate ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Oral Epithelial Dysplasia ◽  
Oct4 Expression ◽  
Kaplan Meier ◽  
Oral Epithelial

Background: Increasing evidence suggests the involvement of cancer stem cells (CSCs) in both oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). Among the various CSC markers, aldehyde dehydrogenase (ALDH) 1, B cell-specific Moloney murine leukaemia virus integration site 1 (Bmi1), and octamer-binding protein 4 (OCT4) have been noted to increase in OSCC. The aim of the study was to analyze ALDH1, Bmi1, and OCT4 expression in OED and OSCC with clinicopathologic correlation and survival analysis. Methods: A total of 40 cases each of OED and OSCC were retrieved from departmental archives. Expression of ALDH1, Bmi1, and OCT4 was analyzed using immunohistochemistry and was correlated with clinicopathological parameters. A follow-up ranging from 6 to 52 months was considered for Kaplan-Meier survival analysis. The log-rank test was performed to analyze significant difference in survival rates. Results: The expression levels of ALDH1, Bmi1, and OCT4 increased significantly from OED through OSCC ( P < .05). The expression of ALDH1 and OCT4 showed a significant correlation with lymph node metastasis. Positive cases of ALDH1 showed a significantly reduced survival rate compared to cases showing negative expression. Kaplan-Meier survival analysis showed a significant reduction of survival rate ( P = .00) in patients showing a positive expression for all the 3 markers. Conclusion: ALDH1 and OCT4 could be used as individual prognostic markers for assessing prognosis. ALDH1, Bmi1, and OCT4 could be used as a collective panel of markers to enable surgeons in predicting the prognosis of patients and thereby carry out prompt follow-up for such cases.

scholarly journals The Prognostic Value of the CA19-9/TBIL Ratio in Patients With Biliary Tract Cancers (BTCs): A Retrospective Study

2020 ◽  
Author(s):  
Jianchun Xiao ◽  
Li Wang ◽  
Tao Hong ◽  
Binglu Li ◽  
Wei Liu ◽  
...  
Keyword(s):  
Survival Analysis ◽  
Retrospective Study ◽  
Biliary Tract ◽  
Prognostic Significance ◽  
Survival Duration ◽  
Clinical Parameters ◽  
Operating Characteristics ◽  
Cox Regression Analysis ◽  
Biliary Tract Cancers ◽  
Kaplan Meier

Abstract Introduction: Incidence of biliary tract cancers (BTCs) in China is high, and surgery is the only curative option. Preoperative CA19-9 has been identified as a predictor for survival in patients with resectable BTCs, but more potential predictors need to be studied. This retrospective study aimed to establish the prognostic significance of CA19-9/TBIL ratio (CTR) in patients with BTCs.Methods: A retrospective analysis was performed in patients who diagnosed with BTCs and received surgical resection between 2013 and 2018 at PUMCH. Demographic and clinical parameters were collected. Preoperative CA19-9 and CTR were classified as elevated (> 58.6 and > 0.83) according to the receiver operating characteristics (ROC) analysis. Demographic and clinical parameters were compared between the groups using Student’s t-test, chi-square, or Fisher’s exact test. Survival analysis was performed by the Kaplan-Meier methods and the relationship between variables and survival was assessed by the log-rank test. Cox regression analysis was conducted to identify potential risk factors for overall survival.Results: In total 109 participants were involved in the final analysis. The overall survival rate was 18.0% at 5 years, with a median survival duration of 1.58 years. The Kaplan-Meier analysis indicated that higher CTR was associated with shorter OS (15 vs. 50, p < 0.01). Univariate survival analysis identified TNM staging, CA19-9, and CTR as statistically significant prognostic factors. In a multiple COX analysis, only CTR was proved as a significantly independent prognostic factor.Conclusion: CTR acts as an independent prognostic predictor for patients with biliary tract cancer.

scholarly journals PERCUTANEUS NEPHROSTOMY IN PATIENTS WITH OBSTRUCTIVE UROPATHY DUE TO MALIGNANCY: A SURVIVAL ANALYSIS

2016 ◽  
Vol 23 (2) ◽  
Author(s):  
Prahara Yuri ◽  
Sungsang Rochadi
Keyword(s):  
Survival Analysis ◽  
Survival Rate ◽  
Obstructive Uropathy ◽  
Percutaneous Nephrostomy ◽  
Rank Test ◽  
Log Rank Test ◽  
Kaplan Meier ◽  
Hospitalization Period ◽  
The Mean ◽  
Related Mortality

Objective:To find out effectiveness of percutaneous nephrostomy (PCN) and patient survival rate as palliative decompression of the obstructed urinary system due to malignancy (urogenital neoplasias). Materials & Methods: A cohort retrospective study was performed with 76 patients (58 female and 18 male) with malignancy process who were undergoing percutaneous nephrostomy during January 2009 – December 2012, in Sardjito General Hospital Yogyakarta. Survival analysis was done by Kaplan-Meier method and differences were assessed using the log-rank test. Results:There was no procedure-related mortality. The mean of age was 49.14 years. The primary tumoral site was the uterine cervix in 56.6 %, the bladder in 17.1 %, the prostate in 2.6% and other sites (intestinal, ovarium and other malignancies caused obstructive uropathy) in 23.7%. The patients died during the hospitalization period due to advanced neoplasia are 17.1%. The mortality rate was higher in patients with interval between diagnose of obstructive uropathy and nephrostomy > 7 days (HR=5.7; 95%CI 4.5-6.9; p = 0.001) and in those who required hemodialysis before the procedure (HR=6.1; 95%CI 4.7-7.4; p = 0.001). The survival rate was 55.2% (42/76) at 6 months and 32.9% (25/76) at 12 months. The percentage of the lifetime spent in hospitalization was 17.1% (13/76). There are no differences on survival rate in that patients based on neoplasias type and age.Conclusion: The urinary obstruction must be immediately relieved. The percutaneous nephrostomy is a safe and effective method for relief the obstruction. Patient with hemodialysis before the procedure had a poor prognosis.

scholarly journals Potential Predictors and Survival Analysis of the Relapse of HIV-Associated Cryptococcal Meningitis: A Retrospective Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Yao Li ◽  
Yanqiu Lu ◽  
Jingmin Nie ◽  
Min Liu ◽  
Jing Yuan ◽  
...  
Keyword(s):  
Survival Analysis ◽  
Retrospective Study ◽  
Symptom Onset ◽  
Cryptococcal Meningitis ◽  
Clinical Symptoms ◽  
Chinese Patients ◽  
Art Initiation ◽  
Cell Counts ◽  
Kaplan Meier ◽  
Baseline Demographic

Objective: We intend to investigate the relapse of HIV-associated cryptococcal meningitis (CM), assess potential predictors and conduct survival analysis, with a view to establishing a valid reference for the management of the relapse of CM.Method: This is a retrospective study in Chinese patients with HIV-associated CM and those who experience relapse of CM. Baseline demographic, laboratory and clinical characteristics of patients with HIV-associated CM were collected. Predictors for relapse of HIV-associated CM were analyzed using univariate and multivariate logistic regression. Survival probability in relapse cases was determined by Kaplan-Meier survival curves.Results: During the study period, 87 of 348 (25.0%) HIV patients experienced the relapse of CM. CD4+ T-cell counts, antiretroviral therapy (ART) status and the time from symptom onset to presentation were all statistically associated with the relapse of CM (p = 0.013, 0.018 and 0.042, respectively). The overall survival among 46 HIV CM relapse patients whose survival information were obtained, was 78.3%. The proportion of patients who died after antifungal treatment for CM was greater in those whose interval from symptom onset to presentation ≥4 weeks, compared with those &lt;4 weeks (p = 0.0331).Conclusions: In order to reduce the relapse of CM and increase the survival possibility of these patients, we can promote the importance of ART before CM occurs, emphasize timely consultation when any CM-associated clinical symptoms occurs, and individualized the timing of ART initiation according to indicators which can reflect the severity of CM.

scholarly journals Prognostic Significance of EIF4G1 in Patients with Pancreatic Ductal Adenocarcinoma

2019 ◽  
Author(s):  
Tae Sik Goh ◽  
Mihyang Ha ◽  
Jung Sub Lee ◽  
Dae Cheon Jeong ◽  
Eun Sang Jung ◽  
...  
Keyword(s):  
Gene Expression ◽  
Survival Analysis ◽  
Survival Rate ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Prognostic Biomarker ◽  
Prognostic Significance ◽  
Ductal Adenocarcinoma ◽  
Operating Characteristics ◽  
Cox Regression Analysis ◽  
Kaplan Meier

Background: The advances of genomics have greatly improved the survival rate cancer patients. However, due to genetic heterogeneity, pancreatic ductal adenocarcinoma (PDAC) is still difficult to diagnose early and the survival rate is extremely low. Therefore, we identified biomarkers that predict the prognosis of PDAC patients by using independent cohort data. Methods: To develop a novel prognostic biomarker, we used gene expression and clinical data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). In Kaplan-Meier survival curve using median values of genes as cut off, the only statistically significant gene in the three cohorts was EIF4G1. We analyzed prognostic significance of EIF4G1 using the time-dependent area under the curve (AUC) of the Uno's C-index, the AUC value of the receiver operating characteristics (ROC) at 3 years, and multivariate cox analysis. Also, we compare EIF4G1 levels between tumor and matched non-tumor. Results: EIF4G1 is the only prognostic gene patients with PDAC which was selected by Kaplan-Meier survival analysis. Kaplan-Meier survival analysis showed that high expression of EIF4G1 was associated with poor prognosis of PDAC with good discriminative ability in 3 independent cohorts. Risk stratifying ability of EIF4G1 was demonstrated by analyzing C-indices and AUC values. Multivariate cox regression analysis confirmed its prognostic significance. EIF4G1 expression was significantly higher in the PDAC tissues than in the matched normal tissues. Conclusions: Herein, the novel prognostic biomarker EIF4G1 could be used as prognostic maker for PDAC and determining suitable treatment options.

scholarly journals The Prognostic Value of the CA19-9/TBIL Ratio in Patients with Biliary Tract Cancers (BTCs): A Retrospective Study

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Jianchun Xiao ◽  
Li Wang ◽  
Tao Hong ◽  
Binglu Li ◽  
Wei Liu ◽  
...  
Keyword(s):  
Overall Survival ◽  
Survival Analysis ◽  
Retrospective Study ◽  
Biliary Tract ◽  
Prognostic Significance ◽  
Survival Duration ◽  
Clinical Parameters ◽  
Cox Regression Analysis ◽  
Biliary Tract Cancers ◽  
Kaplan Meier

Background. Incidence of biliary tract cancers (BTCs) in China is high, and surgery is the only curative option. Preoperative CA19-9 has been identified as a predictor for survival in patients with resectable BTCs, but more potential predictors need to be studied. This retrospective study aimed to establish the prognostic significance of CA19-9/TBIL ratio (CTR) in patients with BTCs. Methods. A retrospective analysis was performed in patients who were diagnosed with BTCs and received surgical resection between 2013 and 2018 at PUMCH. Demographic and clinical parameters were collected. Preoperative CA19-9 and CTR were classified as elevated (>58.6 and >0.83) according to the receiver operating characteristic (ROC) analysis. Demographic and clinical parameters were compared between the groups using Student’s t-test, chi-square, or Fisher’s exact test. Survival analysis was performed by the Kaplan–Meier methods, and the relationship between variables and survival was assessed by the log-rank test. Cox regression analysis was conducted to identify potential risk factors for overall survival. Results. In total, 109 participants were involved in the final analysis. The overall survival rate was 18.0% at 5 years, with a median survival duration of 1.58 years. The Kaplan–Meier analysis indicated that higher CTR was associated with shorter OS (15 vs. 50, p < 0.01 ). Univariate survival analysis identified TNM staging, CA19-9, and CTR as statistically significant prognostic factors. In a multiple Cox analysis, only CTR was proved as a significantly independent prognostic factor. Conclusion. CTR acts as an independent prognostic predictor for patients with biliary tract cancer.

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