scholarly journals Growth Hormone and Insulin-Like Growth Factor Dysregulation in Pediatric Chronic Kidney Disease

2021 ◽  
pp. 1-10
Author(s):  
Denver D. Brown ◽  
Andrew Dauber
Keyword(s):  
Chronic Kidney Disease ◽  
Growth Hormone ◽  
Growth Factor ◽  
Kidney Disease ◽  
Common Finding ◽  
Insulin Like Growth Factor ◽  
Contributing Factors ◽  
Poor Growth ◽  
Negative Effect ◽  
Pediatric Ckd

Poor growth is a common finding in children with chronic kidney disease (CKD) that has been associated with poor long-term outcomes. The etiology of poor growth in this population is multifactorial and includes dysregulation of the growth hormone (GH) and insulin-like growth factor (IGF) axis. In this review, we describe the data on GH resistance or insensitivity and inappropriate levels or reduced bioactivity of IGF proposed as contributing factors of growth impairment in children with CKD. Additionally, we describe the theorized negative effect of metabolic acidosis, another frequent finding in pediatric CKD, on the GH/IGF axis and growth. Last, we present the current and potential therapies for the treatment of short stature in pediatric CKD that target the GH/IGF hormonal axis.

scholarly journals Endocrine Abnormalities in Patients with Chronic Kidney Disease

PRILOZI ◽  
2015 ◽  
Vol 36 (2) ◽  
pp. 109-118 ◽  
Author(s):  
Piotr Kuczera ◽  
Marcin Adamczak ◽  
Andrzej Wiecek
Keyword(s):  
Chronic Kidney Disease ◽  
Growth Hormone ◽  
Metabolic Acidosis ◽  
Growth Factor ◽  
Kidney Disease ◽  
Endocrine System ◽  
Bone Diseases ◽  
Insulin Like Growth Factor ◽  
Pathological Conditions ◽  
Clinical Consequences

Abstract In patients with chronic kidney disease the alterations of the endocrine system may arise from several causes. The kidney is the site of degradation as well as synthesis of many different hormones. Moreover, a number of concomitant pathological conditions such as inflammation, metabolic acidosis and malnutrition may participate in the pathogenesis of endocrine abnormalities in this group of patients. The most pronounced endocrine abnormalities in patients with chronic kidney disease are the deficiencies of: calcitriol, testosterone, insulin-like growth factor and, erythropoietin (EPO). Additionally accumulation of several hormones, such as: prolactin, growth hormone and insulin frequently also occur. The clinical consequences of the abovementioned endocrine abnormalities are among others: anemia, infertility and bone diseases.

scholarly journals Influence of diet and β-agonist administration on plasma concentrations of growth hormone and insulin-like growth factor-1 in young steers

1993 ◽  
Vol 70 (1) ◽  
pp. 93-102 ◽  
Author(s):  
J. M. Dawson ◽  
J. Craigon ◽  
P. J. Buttery ◽  
D. E. Beever
Keyword(s):  
Growth Hormone ◽  
Growth Rate ◽  
Growth Factor ◽  
Plasma Concentrations ◽  
Insulin Like Growth Factor ◽  
Poor Growth ◽  
Treatment Groups ◽  
Gh Secretion ◽  
Young Cattle ◽  
Plasma Gh

The effect of feeding grass silage or a forage–concentrate (dried grass–barley) diet ad lib. to young cattle on growth rate, plasma growth hormone (GH) and insulin-like growth factor-1 (IGF-1) concentrations was examined. The effect of including the β-adrenergic agonist cimaterol in the forage–concentrate diet was also investigated. Significantly higher growth rates were observed in animals fed on the forage–concentrate diet than in those fed on the silage diet (P < 0·001), and these were further enhanced by dietary inclusion of cimaterol (P < 0·05). Plasma GH levels were higher in the silage-fed animals (P < 0·001) but IGF-1 levels were significantly lower (P < 0·001) than in the forage–concentrate-fed animals. Cimaterol had no effect on mean plasma GH and IGF-1 concentrations. Nevertheless, plasma IGF-1 levels correlated positively with growth rate across all three treatments (r 0·84, P < 0·001, n 17). Spectral analysis of the GH data obtained for each animal was used to determine whether regular periodicities could be detected in the 24 h profile and whether they differed between the three treatment groups. Regular periodicities of four-five cycles/d were detected in the averaged GH profiles of the silage-fed and the control forage–concentrate-fed animals. In contrast, in animals given cimaterol regular GH cycles were not detectable at any of the frequencies tested. This suggests that cimaterol disrupts the rhythm of GH secretion without altering the overall mean concentrations. The data also suggest that due to an inadequate nutrient supply, the GH–IGF-1 regulatory mechanism was uncoupled in the cattle fed on silage, which may have contributed to the poor growth response of these animals.

scholarly journals Molecular Mechanisms of the Negative Effect of Insulin-Like Growth Factor-I on Growth Hormone Gene Expression in MtT/S Somatotroph Cells

Endocrinology ◽  
1999 ◽  
Vol 140 (1) ◽  
pp. 344-349 ◽  
Author(s):  
Akiko Niiori-Onishi ◽  
Yasumasa Iwasaki ◽  
Noriko Mutsuga ◽  
Yutaka Oiso ◽  
Kinji Inoue ◽  
...  
Keyword(s):  
Gene Expression ◽  
Growth Hormone ◽  
Growth Factor ◽  
Molecular Mechanisms ◽  
Growth Hormone Gene ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Negative Effect ◽  
Growth Factor I
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